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Prof. Francesca Giampieri
University of Vigo, Spain

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0 Biochemistry
0 Inflammation
0 Nutrition
0 Oxidative Stress
0 natural compounds

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Oxidative Stress
Inflammation
Nutrition
natural compounds

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Review
Published: 25 August 2021 in Molecules
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Presently, biopreservation through protective bacterial cultures and their antimicrobial products or using antibacterial compounds derived from plants are proposed as feasible strategies to maintain the long shelf-life of products. Another emerging category of food biopreservatives are bacteriophages or their antibacterial enzymes called “phage lysins” or “enzybiotics”, which can be used directly as antibacterial agents due to their ability to act on the membranes of bacteria and destroy them. Bacteriophages are an alternative to antimicrobials in the fight against bacteria, mainly because they have a practically unique host range that gives them great specificity. In addition to their potential ability to specifically control strains of pathogenic bacteria, their use does not generate a negative environmental impact as in the case of antibiotics. Both phages and their enzymes can favor a reduction in antibiotic use, which is desirable given the alarming increase in resistance to antibiotics used not only in human medicine but also in veterinary medicine, agriculture, and in general all processes of manufacturing, preservation, and distribution of food. We present here an overview of the scientific background of phages and enzybiotics in the food industry, as well as food applications of these biopreservatives.

ACS Style

José Ramos-Vivas; María Elexpuru-Zabaleta; María Luisa Samano; Alina Pascual Barrera; Tamara Y. Forbes-Hernández; Francesca Giampieri; Maurizio Battino. Phages and Enzybiotics in Food Biopreservation. Molecules 2021, 26, 5138 .

AMA Style

José Ramos-Vivas, María Elexpuru-Zabaleta, María Luisa Samano, Alina Pascual Barrera, Tamara Y. Forbes-Hernández, Francesca Giampieri, Maurizio Battino. Phages and Enzybiotics in Food Biopreservation. Molecules. 2021; 26 (17):5138.

Chicago/Turabian Style

José Ramos-Vivas; María Elexpuru-Zabaleta; María Luisa Samano; Alina Pascual Barrera; Tamara Y. Forbes-Hernández; Francesca Giampieri; Maurizio Battino. 2021. "Phages and Enzybiotics in Food Biopreservation." Molecules 26, no. 17: 5138.

Journal article
Published: 17 August 2021 in Cells
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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive regression and memory loss. Dysfunctions of both glucose metabolism and mitochondrial dynamics have been recognized as the main upstream events of the degenerative processes leading to AD. It has been recently found that correcting cell metabolism by providing alternative substrates can prevent neuronal injury by retaining mitochondrial function and reducing AD marker levels. Here, we induced an AD-like phenotype by using the glycolysis inhibitor glyceraldehyde (GA) and explored whether L-carnitine (4-N-trimethylamino-3-hydroxybutyric acid, LC) could mitigate neuronal damage, both in SH-SY5Y neuroblastoma cells and in rat primary cortical neurons. We have already reported that GA significantly modified AD marker levels; here we demonstrated that GA dramatically compromised cellular bioenergetic status, as revealed by glycolysis and oxygen consumption rate (OCR) evaluation. We found that LC ameliorated cell survival, improved OCR and ATP synthesis, prevented the loss of the mitochondrial membrane potential (Δψm) and reduced the formation of reactive oxygen species (ROS). Of note, the beneficial effect of LC did not rely on the glycolytic pathway rescue. Finally, we noticed that LC significantly reduced the increase in pTau levels induced by GA. Overall, these findings suggest that the use of LC can promote cell survival in the setting of the metabolic impairments commonly observed in AD. Our data suggest that LC may act by maintaining mitochondrial function and by reducing the pTau level.

ACS Style

Simona Magi; Alessandra Preziuso; Silvia Piccirillo; Francesca Giampieri; Danila Cianciosi; Monia Orciani; Salvatore Amoroso. The Neuroprotective Effect of L-Carnitine against Glyceraldehyde-Induced Metabolic Impairment: Possible Implications in Alzheimer’s Disease. Cells 2021, 10, 2109 .

AMA Style

Simona Magi, Alessandra Preziuso, Silvia Piccirillo, Francesca Giampieri, Danila Cianciosi, Monia Orciani, Salvatore Amoroso. The Neuroprotective Effect of L-Carnitine against Glyceraldehyde-Induced Metabolic Impairment: Possible Implications in Alzheimer’s Disease. Cells. 2021; 10 (8):2109.

Chicago/Turabian Style

Simona Magi; Alessandra Preziuso; Silvia Piccirillo; Francesca Giampieri; Danila Cianciosi; Monia Orciani; Salvatore Amoroso. 2021. "The Neuroprotective Effect of L-Carnitine against Glyceraldehyde-Induced Metabolic Impairment: Possible Implications in Alzheimer’s Disease." Cells 10, no. 8: 2109.

Review article
Published: 07 July 2021 in Neuroscience & Biobehavioral Reviews
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Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked to the development of neurodegenerative diseases. Interestingly, various scientific evidence reported that an altered gut microbiota composition may contribute to the development of neuroinflammatory disorders. This leads to the proposal of the concept of the gut-brain-immune axis. In this scenario, polyphenols play a pivotal role due to their ability to exert neuroprotective, immunomodulatory and microbiota-remodeling activities. In the present review, we summarized the available literature to provide a scientific evidence regarding this neuroprotective and immunomodulatory effects and the interaction with gut microbiota of polyphenols and, the main signaling pathways involved that can explain their potential therapeutic application in neurodegenerative diseases.

ACS Style

Giuseppe Annunziata; Antoni Sureda; Ilkay Erdogan Orhan; Maurizio Battino; Angela Arnone; Manuel Jiménez-García; Xavier Capó; Joan Cabot; Nima Sanadgol; Francesca Giampieri; Gian Carlo Tenore; Hamid Reza Khayat Kashani; Ana Sanches Silva; Solomon Habtemariam; Seyed Fazel Nabavi. The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota. Neuroscience & Biobehavioral Reviews 2021, 128, 437 -453.

AMA Style

Giuseppe Annunziata, Antoni Sureda, Ilkay Erdogan Orhan, Maurizio Battino, Angela Arnone, Manuel Jiménez-García, Xavier Capó, Joan Cabot, Nima Sanadgol, Francesca Giampieri, Gian Carlo Tenore, Hamid Reza Khayat Kashani, Ana Sanches Silva, Solomon Habtemariam, Seyed Fazel Nabavi. The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota. Neuroscience & Biobehavioral Reviews. 2021; 128 ():437-453.

Chicago/Turabian Style

Giuseppe Annunziata; Antoni Sureda; Ilkay Erdogan Orhan; Maurizio Battino; Angela Arnone; Manuel Jiménez-García; Xavier Capó; Joan Cabot; Nima Sanadgol; Francesca Giampieri; Gian Carlo Tenore; Hamid Reza Khayat Kashani; Ana Sanches Silva; Solomon Habtemariam; Seyed Fazel Nabavi. 2021. "The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota." Neuroscience & Biobehavioral Reviews 128, no. : 437-453.

Journal article
Published: 02 July 2021 in Food Chemistry
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Thermal liquefaction is a conventional method used by beekeepers to liquefy crystallized honey. However, an abusive use of heat may affect its quality, chemical composition and bioactivity. The purpose of this study was to investigate the effect of thermal liquefaction on the quality, chemical composition and antibiofilm properties of eucalyptus honey. Thermal liquefaction (at 45 and 60 °C) did not affect the honey’s quality; however, a significant reduction in the reducing capacity, total phenolic content and hydrogen peroxide content was observed. At 60 °C, a significant reduction in the honey’s ability to inhibit biofilm formation was observed in Pseudomonas aeruginosa, as well as a reduction in its ability to remove preformed biofilms in both Staphylococcus aureus and Pseudomonas aeruginosa. Structural changes in biofilm architecture caused by honey were not affected by thermal treatment. Therefore, we recommend liquefaction at 45 °C as the most convenient for honey liquefaction without affecting its characteristics.

ACS Style

Irina Villacrés-Granda; Adrian Proaño; Dayana Coello; Alexis Debut; Karla Vizuete; Isabel Ballesteros; Genoveva Granda-Albuja; Hugo Rosero-Mayanquer; Maurizio Battino; Francesca Giampieri; José M. Alvarez-Suárez. Effect of thermal liquefaction on quality, chemical composition and antibiofilm activity against multiresistant human pathogens of crystallized eucalyptus honey. Food Chemistry 2021, 365, 130519 .

AMA Style

Irina Villacrés-Granda, Adrian Proaño, Dayana Coello, Alexis Debut, Karla Vizuete, Isabel Ballesteros, Genoveva Granda-Albuja, Hugo Rosero-Mayanquer, Maurizio Battino, Francesca Giampieri, José M. Alvarez-Suárez. Effect of thermal liquefaction on quality, chemical composition and antibiofilm activity against multiresistant human pathogens of crystallized eucalyptus honey. Food Chemistry. 2021; 365 ():130519.

Chicago/Turabian Style

Irina Villacrés-Granda; Adrian Proaño; Dayana Coello; Alexis Debut; Karla Vizuete; Isabel Ballesteros; Genoveva Granda-Albuja; Hugo Rosero-Mayanquer; Maurizio Battino; Francesca Giampieri; José M. Alvarez-Suárez. 2021. "Effect of thermal liquefaction on quality, chemical composition and antibiofilm activity against multiresistant human pathogens of crystallized eucalyptus honey." Food Chemistry 365, no. : 130519.

Review
Published: 17 June 2021 in International Journal of Molecular Sciences
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Age-related bone disorders such as osteoporosis or osteoarthritis are a major public health problem due to the functional disability for millions of people worldwide. Furthermore, fractures are associated with a higher degree of morbidity and mortality in the long term, which generates greater financial and health costs. As the world population becomes older, the incidence of this type of disease increases and this effect seems notably greater in those countries that present a more westernized lifestyle. Thus, increased efforts are directed toward reducing risks that need to focus not only on the prevention of bone diseases, but also on the treatment of persons already afflicted. Evidence is accumulating that dietary lipids play an important role in bone health which results relevant to develop effective interventions for prevent bone diseases or alterations, especially in the elderly segment of the population. This review focuses on evidence about the effects of dietary lipids on bone health and describes possible mechanisms to explain how lipids act on bone metabolism during aging. Little work, however, has been accomplished in humans, so this is a challenge for future research.

ACS Style

Jose Romero-Márquez; Alfonso Varela-López; María Navarro-Hortal; Alberto Badillo-Carrasco; Tamara Forbes-Hernández; Francesca Giampieri; Irma Domínguez; Lorena Madrigal; Maurizio Battino; José Quiles. Molecular Interactions between Dietary Lipids and Bone Tissue during Aging. International Journal of Molecular Sciences 2021, 22, 6473 .

AMA Style

Jose Romero-Márquez, Alfonso Varela-López, María Navarro-Hortal, Alberto Badillo-Carrasco, Tamara Forbes-Hernández, Francesca Giampieri, Irma Domínguez, Lorena Madrigal, Maurizio Battino, José Quiles. Molecular Interactions between Dietary Lipids and Bone Tissue during Aging. International Journal of Molecular Sciences. 2021; 22 (12):6473.

Chicago/Turabian Style

Jose Romero-Márquez; Alfonso Varela-López; María Navarro-Hortal; Alberto Badillo-Carrasco; Tamara Forbes-Hernández; Francesca Giampieri; Irma Domínguez; Lorena Madrigal; Maurizio Battino; José Quiles. 2021. "Molecular Interactions between Dietary Lipids and Bone Tissue during Aging." International Journal of Molecular Sciences 22, no. 12: 6473.

Journal article
Published: 01 June 2021 in Phytomedicine
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Oxidative stress and inflammation contribute to the etiopathogenesis of several human chronic diseases, such as cancer, diabetes, cardiovascular diseases and metabolic syndrome. Besides classic stimuli, such as reactive oxidant species, endotoxins (i.e., bacteria lipopolysaccharide), cytokines or carcinogens, oxidative stress and inflammation can be triggered by a poor diet and an excess of body fat and energy intake. Strawberry and honey are common rich sources of nutrients and bioactive compounds, widely studied for their roles exerted in health maintenance and disease prevention. This review aims to summarize and update the effects of strawberry and honey against oxidative stress and inflammation, with emphasis on metabolism and on the main molecular mechanisms involved in these effects. A wide range of literature, published in the last 10 years, elucidating the effects of strawberry and honey in preventing oxidative stress and inflammation both in vitro (whole matrix and digested fractions) and in vivo was collected from online electronic databases (PubMed, Scopus and Web of Science) and reviewed. Strawberry and honey polyphenols may potentially prevent the chronic diseases related to oxidative stress and inflammation. Several in vitro and in vivo studies reported the effects of these foods in suppressing the oxidative stress, by decreasing ROS production and oxidative biomarkers, restoring the antioxidant enzyme activities, ameliorating the mitochondrial antioxidant status and functionality, among others, and the inflammatory process, by modulating the mediators of acute and chronic inflammation essential for the onset of several human diseases. These beneficial properties are mediated in part through their ability to target multiple signaling pathways, such as p38 MAPK, AMPK, PI3K/Akt, NF-κB and Nrf2. Available scientific literature show that strawberry and honey may be effective in preventing oxidative stress and inflammation. The deep evaluation of the factors that affect their metabolism as well as the assessment of the main molecular mechanisms involved are of extreme importance for the possible therapeutic and preventive benefit against the most common human diseases. However, published literature is still scarce so that deeper studies should be performed in order to evaluate the bioavailability of these food matrices and their effects after digestion.

ACS Style

Maurizio Battino; Francesca Giampieri; Danila Cianciosi; Johura Ansary; Xiumin Chen; Di Zhang; Emilio Gil; Tamara Forbes-Hernández. The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation. Phytomedicine 2021, 86, 153170 .

AMA Style

Maurizio Battino, Francesca Giampieri, Danila Cianciosi, Johura Ansary, Xiumin Chen, Di Zhang, Emilio Gil, Tamara Forbes-Hernández. The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation. Phytomedicine. 2021; 86 ():153170.

Chicago/Turabian Style

Maurizio Battino; Francesca Giampieri; Danila Cianciosi; Johura Ansary; Xiumin Chen; Di Zhang; Emilio Gil; Tamara Forbes-Hernández. 2021. "The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation." Phytomedicine 86, no. : 153170.

Review
Published: 29 April 2021 in Molecules
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Cancer stem cells (CSCs) are a rare tumor subpopulation with high differentiation, proliferative and tumorigenic potential compared to the remaining tumor population. CSCs were first discovered by Bonnet and Dick in 1997 in acute myeloid leukemia. The identification and isolation of these cells in this pioneering study were carried out through the flow cytometry, exploiting the presence of specific cell surface molecular markers (CD34+/CD38−). In the following years, different strategies and projects have been developed for the study of CSCs, which are basically divided into surface markers assays and functional assays; some of these techniques also allow working with a cellular model that better mimics the tumor architecture. The purpose of this mini review is to summarize and briefly describe all the current methods used for the identification, isolation and enrichment of CSCs, describing, where possible, the molecular basis, the advantages and disadvantages of each technique with a particular focus on those that offer a three-dimensional culture.

ACS Style

Danila Cianciosi; Johura Ansary; Tamara Forbes-Hernandez; Lucia Regolo; Denise Quinzi; Santos Gracia Villar; Eduardo Garcia Villena; Kilian Tutusaus Pifarre; José Alvarez-Suarez; Maurizio Battino; Francesca Giampieri. The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture. Molecules 2021, 26, 2615 .

AMA Style

Danila Cianciosi, Johura Ansary, Tamara Forbes-Hernandez, Lucia Regolo, Denise Quinzi, Santos Gracia Villar, Eduardo Garcia Villena, Kilian Tutusaus Pifarre, José Alvarez-Suarez, Maurizio Battino, Francesca Giampieri. The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture. Molecules. 2021; 26 (9):2615.

Chicago/Turabian Style

Danila Cianciosi; Johura Ansary; Tamara Forbes-Hernandez; Lucia Regolo; Denise Quinzi; Santos Gracia Villar; Eduardo Garcia Villena; Kilian Tutusaus Pifarre; José Alvarez-Suarez; Maurizio Battino; Francesca Giampieri. 2021. "The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture." Molecules 26, no. 9: 2615.

Review
Published: 07 April 2021 in Molecules
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In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals.

ACS Style

Johura Ansary; Francesca Giampieri; Tamara Forbes-Hernandez; Lucia Regolo; Denise Quinzi; Santos Gracia Villar; Eduardo Garcia Villena; Kilian Tutusaus Pifarre; José Alvarez-Suarez; Maurizio Battino; Danila Cianciosi. Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules 2021, 26, 2108 .

AMA Style

Johura Ansary, Francesca Giampieri, Tamara Forbes-Hernandez, Lucia Regolo, Denise Quinzi, Santos Gracia Villar, Eduardo Garcia Villena, Kilian Tutusaus Pifarre, José Alvarez-Suarez, Maurizio Battino, Danila Cianciosi. Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules. 2021; 26 (8):2108.

Chicago/Turabian Style

Johura Ansary; Francesca Giampieri; Tamara Forbes-Hernandez; Lucia Regolo; Denise Quinzi; Santos Gracia Villar; Eduardo Garcia Villena; Kilian Tutusaus Pifarre; José Alvarez-Suarez; Maurizio Battino; Danila Cianciosi. 2021. "Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies." Molecules 26, no. 8: 2108.

Review
Published: 26 February 2021 in Nutrients
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Modern high-throughput ‘omics’ science tools (including genomics, transcriptomics, proteomics, metabolomics and microbiomics) are currently being applied to nutritional sciences to unravel the fundamental processes of health effects ascribed to particular nutrients in humans and to contribute to more precise nutritional advice. Diet and food components are key environmental factors that interact with the genome, transcriptome, proteome, metabolome and the microbiota, and this life-long interplay defines health and diseases state of the individual. Rheumatoid arthritis (RA) is a chronic autoimmune disease featured by a systemic immune-inflammatory response, in genetically susceptible individuals exposed to environmental triggers, including diet. In recent years increasing evidences suggested that nutritional factors and gut microbiome have a central role in RA risk and progression. The aim of this review is to summarize the main and most recent applications of ‘omics’ technologies in human nutrition and in RA research, examining the possible influences of some nutrients and nutritional patterns on RA pathogenesis, following a nutrigenomics approach. The opportunities and challenges of novel ‘omics technologies’ in the exploration of new avenues in RA and nutritional research to prevent and manage RA will be also discussed.

ACS Style

Manuela Cassotta; Tamara Forbes-Hernandez; Danila Cianciosi; Maria Elexpuru Zabaleta; Sandra Sumalla Cano; Irma Dominguez; Beatriz Bullon; Lucia Regolo; Josè Alvarez-Suarez; Francesca Giampieri; Maurizio Battino. Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era. Nutrients 2021, 13, 763 .

AMA Style

Manuela Cassotta, Tamara Forbes-Hernandez, Danila Cianciosi, Maria Elexpuru Zabaleta, Sandra Sumalla Cano, Irma Dominguez, Beatriz Bullon, Lucia Regolo, Josè Alvarez-Suarez, Francesca Giampieri, Maurizio Battino. Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era. Nutrients. 2021; 13 (3):763.

Chicago/Turabian Style

Manuela Cassotta; Tamara Forbes-Hernandez; Danila Cianciosi; Maria Elexpuru Zabaleta; Sandra Sumalla Cano; Irma Dominguez; Beatriz Bullon; Lucia Regolo; Josè Alvarez-Suarez; Francesca Giampieri; Maurizio Battino. 2021. "Nutrition and Rheumatoid Arthritis in the ‘Omics’ Era." Nutrients 13, no. 3: 763.

Contributors
Published: 29 January 2021 in Cancer
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ACS Style

Behnaz Abiri; Sadia Afrin; Yolanda Aguilera; Mazhar Al Zoubi; Alaa Aljabali; Anmar Al-Taie; Tsukuru Amano; Pilar Amiano; Ayca Ant; Mahboobeh Ashrafi; Charles Elias Assmann; Arzu Atalay; Luigi Avallone; Khaled Aziz; Margarete Dulce Bagatini; Giuseppina Barrera; Saime Batırel; Maurizio Battino; Onur Bender; Daniel Pereira Bezerra; Ranjana Bhandari; Marco Bisoffi; Bianka Bojková; Chanchai Boonla; Garry R. Buettner; David Bynum; Viola Calabrò; Gloria M. Calaf; Domenico Carotenuto; Rory S. Carroll; Tokuhiro Chano; Matthew Cheesman; Rong-Jane Chen; Francesca Ciani; Natascia Cocchia; Ian Edwin Cock; João G. Costa; Marie Angele Cucci; Joseph J. Cullen; Jéssica Righi Da Rosa; Beatriz Da Silva Rosa Bonadiman; Sreemanti Das; Christophe Deben; Andrea Devecchi; Valentina D'onofrio; Sepideh Elyasi; Fatma Ceyla Eraldemir; Luigi Esposito; Maurizio Fadda; Bianca Cristine Favero-Santos; Ana S. Fernandes; Cíntia Ferreira-Pêgo; Concetta Finocchiaro; Cesira Foppoli; Tamara Y. Forbes-Hernández; Laurie Freire Boullosa; Jessica Gambardella; Belén García-Villanova; Alexandros G. Georgakilas; Francesca Giampieri; Yolanda Gilaberte; Maria Cristina Cintra Gomes-Marcondes; Salvador Gonzalez; Elvira Gonzalez De Mejia; Luis Goya; Margherita Grattarola; Eduardo Jesús Guerra-Hernández; Marta Halasa; Zuhair Mohammad Hassan; Vasiliki I. Hatzi; Cristan A. Herbert; Guido Iaccarino; Mirko Ippolito; Fikret Vehbi Izzettin; Angeles Juarranz; Daehee Kang; Rui Kang; Garima Khanna; Anisur Rahman Khuda-Bukhsh; Tuğcan Korak; Anurag Kuhad; Natalia Kurhaluk; Byoung-Mog Kwon; Sang-Ah Lee; Jinthe Van Loenhout; Wei Sheng Joshua Loke; Pâmela Longhi; Olga A. Martin; Maria Angeles Martín; Maria A. Martín-Cabrejas; Lucianna Maruccio; Emmanuel Mfotie Njoya; Natalia Angelo Da Silva Miyaguti; Mahdieh Molanouri Shamsi; Esther Molina-Montes; Amir Mousapasandi; Somaira Nowsheen; Justin M. O’Neill; Jane O’Sullivan; Karolina Okla; Melina De Moraes Santos Oliveira; Nuno G. Oliveira; Sarah Christine Pereira De Oliveira; Audrei De Oliveira Alves; Concepción Parrado; Vinood B. Patel; Marzia Perluigi; Rumana Pervin; Neena Philips; Costanza Pira; Stefania Pizzimenti; Moyen Uddin Pk; Alessandra Pollice; Sahdeo Prasad; Victor R. Preedy; Matiar Rahman; Rajkumar Rajendram; Sonia Ramos; Miguel Rebollo-Hernanz; Richard Richardson; Santu Kumar Saha; Sweta Sharma Saha; Carla De Moraes Salgado; Mesut Sancar; Woo-Kyoung Shin; Masaki Shiota; Tahoora Shomali; Halyna Siomyk; Shankar Siva; Daniela Sorriento; Sanjay K. Srivastava; Hidekazu Suzuki; Simona Tafuri; Daolin Tang; Paul S. Thomas; Ioanna Tremi; Hitoshi Tsugawa; Malgorzata Tyszka-Czochara; Mohammadreza Vafa; Jessica Ventura; Laís Rosa Viana; Bojana B. Vidović; Ying-Jan Wang; Anna Wawruszak; Grazielle Castagna Cezimbra Weis; Pawel J. Winklewski; Yae Jin Yoon. Contributors. Cancer 2021, 1 .

AMA Style

Behnaz Abiri, Sadia Afrin, Yolanda Aguilera, Mazhar Al Zoubi, Alaa Aljabali, Anmar Al-Taie, Tsukuru Amano, Pilar Amiano, Ayca Ant, Mahboobeh Ashrafi, Charles Elias Assmann, Arzu Atalay, Luigi Avallone, Khaled Aziz, Margarete Dulce Bagatini, Giuseppina Barrera, Saime Batırel, Maurizio Battino, Onur Bender, Daniel Pereira Bezerra, Ranjana Bhandari, Marco Bisoffi, Bianka Bojková, Chanchai Boonla, Garry R. Buettner, David Bynum, Viola Calabrò, Gloria M. Calaf, Domenico Carotenuto, Rory S. Carroll, Tokuhiro Chano, Matthew Cheesman, Rong-Jane Chen, Francesca Ciani, Natascia Cocchia, Ian Edwin Cock, João G. Costa, Marie Angele Cucci, Joseph J. Cullen, Jéssica Righi Da Rosa, Beatriz Da Silva Rosa Bonadiman, Sreemanti Das, Christophe Deben, Andrea Devecchi, Valentina D'onofrio, Sepideh Elyasi, Fatma Ceyla Eraldemir, Luigi Esposito, Maurizio Fadda, Bianca Cristine Favero-Santos, Ana S. Fernandes, Cíntia Ferreira-Pêgo, Concetta Finocchiaro, Cesira Foppoli, Tamara Y. Forbes-Hernández, Laurie Freire Boullosa, Jessica Gambardella, Belén García-Villanova, Alexandros G. Georgakilas, Francesca Giampieri, Yolanda Gilaberte, Maria Cristina Cintra Gomes-Marcondes, Salvador Gonzalez, Elvira Gonzalez De Mejia, Luis Goya, Margherita Grattarola, Eduardo Jesús Guerra-Hernández, Marta Halasa, Zuhair Mohammad Hassan, Vasiliki I. Hatzi, Cristan A. Herbert, Guido Iaccarino, Mirko Ippolito, Fikret Vehbi Izzettin, Angeles Juarranz, Daehee Kang, Rui Kang, Garima Khanna, Anisur Rahman Khuda-Bukhsh, Tuğcan Korak, Anurag Kuhad, Natalia Kurhaluk, Byoung-Mog Kwon, Sang-Ah Lee, Jinthe Van Loenhout, Wei Sheng Joshua Loke, Pâmela Longhi, Olga A. Martin, Maria Angeles Martín, Maria A. Martín-Cabrejas, Lucianna Maruccio, Emmanuel Mfotie Njoya, Natalia Angelo Da Silva Miyaguti, Mahdieh Molanouri Shamsi, Esther Molina-Montes, Amir Mousapasandi, Somaira Nowsheen, Justin M. O’Neill, Jane O’Sullivan, Karolina Okla, Melina De Moraes Santos Oliveira, Nuno G. Oliveira, Sarah Christine Pereira De Oliveira, Audrei De Oliveira Alves, Concepción Parrado, Vinood B. Patel, Marzia Perluigi, Rumana Pervin, Neena Philips, Costanza Pira, Stefania Pizzimenti, Moyen Uddin Pk, Alessandra Pollice, Sahdeo Prasad, Victor R. Preedy, Matiar Rahman, Rajkumar Rajendram, Sonia Ramos, Miguel Rebollo-Hernanz, Richard Richardson, Santu Kumar Saha, Sweta Sharma Saha, Carla De Moraes Salgado, Mesut Sancar, Woo-Kyoung Shin, Masaki Shiota, Tahoora Shomali, Halyna Siomyk, Shankar Siva, Daniela Sorriento, Sanjay K. Srivastava, Hidekazu Suzuki, Simona Tafuri, Daolin Tang, Paul S. Thomas, Ioanna Tremi, Hitoshi Tsugawa, Malgorzata Tyszka-Czochara, Mohammadreza Vafa, Jessica Ventura, Laís Rosa Viana, Bojana B. Vidović, Ying-Jan Wang, Anna Wawruszak, Grazielle Castagna Cezimbra Weis, Pawel J. Winklewski, Yae Jin Yoon. Contributors. Cancer. 2021; ():1.

Chicago/Turabian Style

Behnaz Abiri; Sadia Afrin; Yolanda Aguilera; Mazhar Al Zoubi; Alaa Aljabali; Anmar Al-Taie; Tsukuru Amano; Pilar Amiano; Ayca Ant; Mahboobeh Ashrafi; Charles Elias Assmann; Arzu Atalay; Luigi Avallone; Khaled Aziz; Margarete Dulce Bagatini; Giuseppina Barrera; Saime Batırel; Maurizio Battino; Onur Bender; Daniel Pereira Bezerra; Ranjana Bhandari; Marco Bisoffi; Bianka Bojková; Chanchai Boonla; Garry R. Buettner; David Bynum; Viola Calabrò; Gloria M. Calaf; Domenico Carotenuto; Rory S. Carroll; Tokuhiro Chano; Matthew Cheesman; Rong-Jane Chen; Francesca Ciani; Natascia Cocchia; Ian Edwin Cock; João G. Costa; Marie Angele Cucci; Joseph J. Cullen; Jéssica Righi Da Rosa; Beatriz Da Silva Rosa Bonadiman; Sreemanti Das; Christophe Deben; Andrea Devecchi; Valentina D'onofrio; Sepideh Elyasi; Fatma Ceyla Eraldemir; Luigi Esposito; Maurizio Fadda; Bianca Cristine Favero-Santos; Ana S. Fernandes; Cíntia Ferreira-Pêgo; Concetta Finocchiaro; Cesira Foppoli; Tamara Y. Forbes-Hernández; Laurie Freire Boullosa; Jessica Gambardella; Belén García-Villanova; Alexandros G. Georgakilas; Francesca Giampieri; Yolanda Gilaberte; Maria Cristina Cintra Gomes-Marcondes; Salvador Gonzalez; Elvira Gonzalez De Mejia; Luis Goya; Margherita Grattarola; Eduardo Jesús Guerra-Hernández; Marta Halasa; Zuhair Mohammad Hassan; Vasiliki I. Hatzi; Cristan A. Herbert; Guido Iaccarino; Mirko Ippolito; Fikret Vehbi Izzettin; Angeles Juarranz; Daehee Kang; Rui Kang; Garima Khanna; Anisur Rahman Khuda-Bukhsh; Tuğcan Korak; Anurag Kuhad; Natalia Kurhaluk; Byoung-Mog Kwon; Sang-Ah Lee; Jinthe Van Loenhout; Wei Sheng Joshua Loke; Pâmela Longhi; Olga A. Martin; Maria Angeles Martín; Maria A. Martín-Cabrejas; Lucianna Maruccio; Emmanuel Mfotie Njoya; Natalia Angelo Da Silva Miyaguti; Mahdieh Molanouri Shamsi; Esther Molina-Montes; Amir Mousapasandi; Somaira Nowsheen; Justin M. O’Neill; Jane O’Sullivan; Karolina Okla; Melina De Moraes Santos Oliveira; Nuno G. Oliveira; Sarah Christine Pereira De Oliveira; Audrei De Oliveira Alves; Concepción Parrado; Vinood B. Patel; Marzia Perluigi; Rumana Pervin; Neena Philips; Costanza Pira; Stefania Pizzimenti; Moyen Uddin Pk; Alessandra Pollice; Sahdeo Prasad; Victor R. Preedy; Matiar Rahman; Rajkumar Rajendram; Sonia Ramos; Miguel Rebollo-Hernanz; Richard Richardson; Santu Kumar Saha; Sweta Sharma Saha; Carla De Moraes Salgado; Mesut Sancar; Woo-Kyoung Shin; Masaki Shiota; Tahoora Shomali; Halyna Siomyk; Shankar Siva; Daniela Sorriento; Sanjay K. Srivastava; Hidekazu Suzuki; Simona Tafuri; Daolin Tang; Paul S. Thomas; Ioanna Tremi; Hitoshi Tsugawa; Malgorzata Tyszka-Czochara; Mohammadreza Vafa; Jessica Ventura; Laís Rosa Viana; Bojana B. Vidović; Ying-Jan Wang; Anna Wawruszak; Grazielle Castagna Cezimbra Weis; Pawel J. Winklewski; Yae Jin Yoon. 2021. "Contributors." Cancer , no. : 1.

Book chapter
Published: 29 January 2021 in Cancer
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Manuka honey (MH) is a rich source of several biological and pharmacological bioactive compounds, as well as natural antioxidants. The phenolic compounds of MH are significantly correlated with its antioxidant capacity and its beneficial effect in human health is becoming more apparent. This chapter focuses on the antioxidant and anticancer activity of MH in in vitro and in vivo models. A rising amount of evidence indicates that MH exerts protective effects against oxidative damage through scavenging or quenching of oxygen free radicals, protecting biomolecules, activating antioxidant enzymes, and increasing antioxidant responsive element expressions both in in vitro and in vivo models. In colon cancer cells, MH induced preventive and therapeutic effects by suppressing cancer cells proliferation, activating apoptosis, inducing oxidative stress, and inhibiting metastatic processes through altering multiple molecular targets. Additionally, the anticancer effectiveness of 5-fluorouracil chemotherapy was augmented in the presence of MH at less doses.

ACS Style

Sadia Afrin; Tamara Y. Forbes-Hernández; Francesca Giampieri; Maurizio Battino. Manuka honey, oxidative stress, 5-fluorouracil treatment, and colon cancer cells. Cancer 2021, 407 -415.

AMA Style

Sadia Afrin, Tamara Y. Forbes-Hernández, Francesca Giampieri, Maurizio Battino. Manuka honey, oxidative stress, 5-fluorouracil treatment, and colon cancer cells. Cancer. 2021; ():407-415.

Chicago/Turabian Style

Sadia Afrin; Tamara Y. Forbes-Hernández; Francesca Giampieri; Maurizio Battino. 2021. "Manuka honey, oxidative stress, 5-fluorouracil treatment, and colon cancer cells." Cancer , no. : 407-415.

Journal article
Published: 12 January 2021 in Biomolecules
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Plant-derived exosome-like nanovesicles (EPDENs) have recently been isolated and evaluated as potential bioactive nutraceutical biomolecules. It has been hypothesized that EPDENs may exert their activity on mammalian cells through their specific cargo. In this study, we isolated and purified EPDENs from the strawberry juice of Fragaria x ananassa (cv. Romina), a new cultivar characterized by a high content of anthocyanins, folic acid, flavonols, and vitamin C and an elevated antioxidant capacity. Fragaria-derived EPDENs were purified by a series of centrifugation and filtration steps. EPDENs showed size and morphology similar to mammalian extracellular nanovesicles. The internalization of Fragaria-derived EPDENs by human mesenchymal stromal cells (MSCs) did not negatively affect their viability, and the pretreatment of MSCs with Fragaria-derived EPDENs prevented oxidative stress in a dose-dependent manner. This is possibly due to the presence of vitamin C inside the nanovesicle membrane. The analysis of EPDEN cargo also revealed the presence of small RNAs and miRNAs. These findings suggest that Fragaria-derived EPDENs may be considered nanoshuttles contained in food, with potential health-promoting activity.

ACS Style

Francesca Perut; Laura Roncuzzi; Sofia Avnet; Annamaria Massa; Nicoletta Zini; Silvia Sabbadini; Francesca Giampieri; Bruno Mezzetti; Nicola Baldini. Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells. Biomolecules 2021, 11, 87 .

AMA Style

Francesca Perut, Laura Roncuzzi, Sofia Avnet, Annamaria Massa, Nicoletta Zini, Silvia Sabbadini, Francesca Giampieri, Bruno Mezzetti, Nicola Baldini. Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells. Biomolecules. 2021; 11 (1):87.

Chicago/Turabian Style

Francesca Perut; Laura Roncuzzi; Sofia Avnet; Annamaria Massa; Nicoletta Zini; Silvia Sabbadini; Francesca Giampieri; Bruno Mezzetti; Nicola Baldini. 2021. "Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells." Biomolecules 11, no. 1: 87.

Journal article
Published: 12 January 2021 in Pharmaceutics
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The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2–4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed that when cells were exposed to ultra-small iron nanoparticles, their subcellular fate was mainly mitochondria, affecting its respiratory and glycolytic parameters, inducing the migration of the cellular state towards quiescence, and promoting and triggering the autophagic process. These effects support the potential use of nanoparticles as therapeutic agents using mitochondria as a target for cancer and other treatments for mitochondria-dependent pathologies.

ACS Style

Lorenzo Rivas-García; José Luis Quiles; Alfonso Varela-López; Francesca Giampieri; Maurizio Battino; Jörg Bettmer; María Montes-Bayón; Juan Llopis; Cristina Sánchez-González. Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration. Pharmaceutics 2021, 13, 90 .

AMA Style

Lorenzo Rivas-García, José Luis Quiles, Alfonso Varela-López, Francesca Giampieri, Maurizio Battino, Jörg Bettmer, María Montes-Bayón, Juan Llopis, Cristina Sánchez-González. Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration. Pharmaceutics. 2021; 13 (1):90.

Chicago/Turabian Style

Lorenzo Rivas-García; José Luis Quiles; Alfonso Varela-López; Francesca Giampieri; Maurizio Battino; Jörg Bettmer; María Montes-Bayón; Juan Llopis; Cristina Sánchez-González. 2021. "Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration." Pharmaceutics 13, no. 1: 90.

Journal article
Published: 09 January 2021 in Seminars in Cancer Biology
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Evidence demonstrates the importance of lipid metabolism and signaling in cancer cell biology. De novo lipogenesis is an important source of lipids for cancer cells, but exogenous lipid uptake remains essential for many cancer cells. Dietary lipids can modify lipids present in tumor microenvironment affecting cancer cell metabolism. Clinical trials have shown that diets rich in polyunsaturated fatty acids (PUFA) can negatively affect tumor growth. However, certain n-6 PUFAs can also contribute to cancer progression. Identifying the molecular mechanisms through which lipids affect cancer progression will provide an opportunity for focused dietary interventions that could translate into the development of personalized diets for cancer control. However, the effective mechanisms of action of PUFAs have not been fully clarified yet. Mitochondria controls ATP generation, redox homeostasis, metabolic signaling, apoptotic pathways and many aspects of autophagy, and it has been recognized to play a key role in cancer. The purpose of this review is to summarize the current evidence linking dietary lipids effects on mitochondrial aspects with consequences for cancer progression and the molecular mechanisms that underlie this association.

ACS Style

Alfonso Varela-López; Laura Vera-Ramírez; Francesca Giampieri; María D. Navarro-Hortal; Tamara Y. Forbes-Hernández; Maurizio Battino; José L. Quiles. The central role of mitochondria in the relationship between dietary lipids and cancer progression. Seminars in Cancer Biology 2021, 73, 86 -100.

AMA Style

Alfonso Varela-López, Laura Vera-Ramírez, Francesca Giampieri, María D. Navarro-Hortal, Tamara Y. Forbes-Hernández, Maurizio Battino, José L. Quiles. The central role of mitochondria in the relationship between dietary lipids and cancer progression. Seminars in Cancer Biology. 2021; 73 ():86-100.

Chicago/Turabian Style

Alfonso Varela-López; Laura Vera-Ramírez; Francesca Giampieri; María D. Navarro-Hortal; Tamara Y. Forbes-Hernández; Maurizio Battino; José L. Quiles. 2021. "The central role of mitochondria in the relationship between dietary lipids and cancer progression." Seminars in Cancer Biology 73, no. : 86-100.

Review
Published: 08 January 2021 in Trends in Food Science & Technology
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An increasing number of epidemiological studies highlights a remarkable association between a diet rich in fruits and vegetables and a lower incidence of different inflammatory-related pathologies. Berries represent an interesting source of phytochemicals and nutrients, widely investigated for their role in health promotion and disease prevention. the aim of this review was to summarize and update the effect of different berry extracts, their fractions and single bioactive compounds against the inflammatory status promoted by the Gram-negative bacteria endotoxin lipopolysaccharide (LPS). The main molecular mechanisms involved have been elucidated, focusing particular attention on the biological response evoked in different in vitro and in vivo models. the inhibition of inflammatory response mediated by MAPK and NF-kB is the main molecular pathway involved in berries anti-inflammatory role, especially in grape and blueberry which represent the main investigated fruits, improving antioxidant defence and exerting beneficial effects in the maintenance of healthy conditions in LPS-treated models.

ACS Style

Massimiliano Gasparrini; Tamara Y. Forbes-Hernandez; Danila Cianciosi; José L. Quiles; Bruno Mezzetti; Jianbo Xiao; Francesca Giampieri; Maurizio Battino. The efficacy of berries against lipopolysaccharide-induced inflammation: A review. Trends in Food Science & Technology 2021, 1 .

AMA Style

Massimiliano Gasparrini, Tamara Y. Forbes-Hernandez, Danila Cianciosi, José L. Quiles, Bruno Mezzetti, Jianbo Xiao, Francesca Giampieri, Maurizio Battino. The efficacy of berries against lipopolysaccharide-induced inflammation: A review. Trends in Food Science & Technology. 2021; ():1.

Chicago/Turabian Style

Massimiliano Gasparrini; Tamara Y. Forbes-Hernandez; Danila Cianciosi; José L. Quiles; Bruno Mezzetti; Jianbo Xiao; Francesca Giampieri; Maurizio Battino. 2021. "The efficacy of berries against lipopolysaccharide-induced inflammation: A review." Trends in Food Science & Technology , no. : 1.

Review
Published: 04 January 2021 in Trends in Food Science & Technology
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Mushrooms are traditionally used as a food ingredient and in folk medicine. Many in vitro and animal studies have reported their potential health effects, but without any clear application in human health. Although they have a worldwide history of use in dishes and folk medicine, mushroom extracts are commonly taken as supplements but need to be evaluated regarding clinical effects and safety, in particular among patients searching for further efficacy for their disease beside pharmacological treatments already prescribed. this review summarizes available data from the scientific literature about the nutritional and effects of mushrooms on human health by selecting clinical studies on humans in English. At the same time, the safety profile and unwanted effects were highlighted. in spite of their wide use among populations, data on humans were scant and did not justify extensive use without more well-designed trials on mushroom efficacy. Overall, their use seems to be safe, but with some side effects, easily reversible after intake interruption. Nutritional use seems promising for coping with the energy surplus of the Western countries and could be useful for some nutritional aspects.

ACS Style

Gianluca Rizzo; Silvia Goggi; Francesca Giampieri; Luciana Baroni. A review of mushrooms in human nutrition and health. Trends in Food Science & Technology 2021, 1 .

AMA Style

Gianluca Rizzo, Silvia Goggi, Francesca Giampieri, Luciana Baroni. A review of mushrooms in human nutrition and health. Trends in Food Science & Technology. 2021; ():1.

Chicago/Turabian Style

Gianluca Rizzo; Silvia Goggi; Francesca Giampieri; Luciana Baroni. 2021. "A review of mushrooms in human nutrition and health." Trends in Food Science & Technology , no. : 1.

Journal article
Published: 30 November 2020 in Seminars in Cancer Biology
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Fasting, caloric restriction and foods or compounds mimicking the biological effects of caloric restriction, known as caloric restriction mimetics, have been associated with a lower risk of age-related diseases, including cardiovascular diseases, cancer and cognitive decline, and a longer lifespan. Reduced calorie intake has been shown to stimulate cancer immunosurveillance, reducing the migration of immunosuppressive regulatory T cells towards the tumor bulk. Autophagy stimulation via reduction of lysine acetylation, increased sensitivity to chemo- and immunotherapy, along with a reduction of insulin-like growth factor 1 and reactive oxygen species have been described as some of the major effects triggered by caloric restriction. Fasting and caloric restriction have also been shown to beneficially influence gut microbiota composition, modify host metabolism, reduce total cholesterol and triglyceride levels, lower diastolic blood pressure and elevate morning cortisol level, with beneficial modulatory effects on cardiopulmonary fitness, body fat and weight, fatigue and weakness, and general quality of life. Moreover, caloric restriction may reduce the carcinogenic and metastatic potential of cancer stem cells, which are generally considered responsible of tumor formation and relapse. Here, we reviewed in vitro and in vivo studies describing the effects of fasting, caloric restriction and some caloric restriction mimetics on immunosurveillance, gut microbiota, metabolism, and cancer stem cell growth, highlighting the molecular and cellular mechanisms underlying these effects. Additionally, studies on caloric restriction interventions in cancer patients or cancer risk subjects are discussed. Considering the promising effects associated with caloric restriction and caloric restriction mimetics, we think that controlled-randomized large clinical trials are warranted to evaluate the inclusion of these non-pharmacological approaches in clinical practice.

ACS Style

Francesca Pistollato; Tamara Yuliett Forbes-Hernandez; Ruben Calderón Iglesias; Roberto Ruiz; Maria Elexpuru Zabaleta; Irma Dominguez; Danila Cianciosi; Josè L. Quiles; Francesca Giampieri; Maurizio Battino. Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment. Seminars in Cancer Biology 2020, 73, 45 -57.

AMA Style

Francesca Pistollato, Tamara Yuliett Forbes-Hernandez, Ruben Calderón Iglesias, Roberto Ruiz, Maria Elexpuru Zabaleta, Irma Dominguez, Danila Cianciosi, Josè L. Quiles, Francesca Giampieri, Maurizio Battino. Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment. Seminars in Cancer Biology. 2020; 73 ():45-57.

Chicago/Turabian Style

Francesca Pistollato; Tamara Yuliett Forbes-Hernandez; Ruben Calderón Iglesias; Roberto Ruiz; Maria Elexpuru Zabaleta; Irma Dominguez; Danila Cianciosi; Josè L. Quiles; Francesca Giampieri; Maurizio Battino. 2020. "Effects of caloric restriction on immunosurveillance, microbiota and cancer cell phenotype: Possible implications for cancer treatment." Seminars in Cancer Biology 73, no. : 45-57.

Review
Published: 13 November 2020 in Food & Function
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While interest in vegetarian nutrition has been steadily increasing, some aspects have not yet been consistently investigated.

ACS Style

Luciana Baroni; Gianluca Rizzo; Silvia Goggi; Francesca Giampieri; Maurizio Battino. Vegetarian diets during pregnancy: effects on the mother's health. A systematic review. Food & Function 2020, 12, 466 -493.

AMA Style

Luciana Baroni, Gianluca Rizzo, Silvia Goggi, Francesca Giampieri, Maurizio Battino. Vegetarian diets during pregnancy: effects on the mother's health. A systematic review. Food & Function. 2020; 12 (2):466-493.

Chicago/Turabian Style

Luciana Baroni; Gianluca Rizzo; Silvia Goggi; Francesca Giampieri; Maurizio Battino. 2020. "Vegetarian diets during pregnancy: effects on the mother's health. A systematic review." Food & Function 12, no. 2: 466-493.

Review
Published: 22 September 2020 in Molecules
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Periodontitis represents a complex inflammatory disease that compromises the integrity of the tooth-supporting tissue through the interaction of specific periodontal pathogens and the host’s immune system. Experimental data help to outline the idea that the molecular way towards periodontitis initiation and progression presents four key steps: bacterial infection, inflammation, oxidative stress, and autophagy. The aim of this review is to outline the autophagy involvement in the pathogenesis and evolution of periodontitis from at least three points of view: periodontal pathogen invasion control, innate immune signaling pathways regulation and apoptosis inhibition in periodontal cells. The exact roles played by reactive oxygen species (ROS) inside the molecular mechanisms for autophagy initiation in periodontitis still require further investigation. However, clarifying the role and the mechanism of redox regulation of autophagy in the periodontitis context may be particularly beneficial for the elaboration of new therapeutic strategies.

ACS Style

Maria Greabu; Francesca Giampieri; Marina Melescanu Imre; Maria Mohora; Alexandra Totan; Silviu Mirel Pituru; Ecaterina Ionescu. Autophagy, One of the Main Steps in Periodontitis Pathogenesis and Evolution. Molecules 2020, 25, 4338 .

AMA Style

Maria Greabu, Francesca Giampieri, Marina Melescanu Imre, Maria Mohora, Alexandra Totan, Silviu Mirel Pituru, Ecaterina Ionescu. Autophagy, One of the Main Steps in Periodontitis Pathogenesis and Evolution. Molecules. 2020; 25 (18):4338.

Chicago/Turabian Style

Maria Greabu; Francesca Giampieri; Marina Melescanu Imre; Maria Mohora; Alexandra Totan; Silviu Mirel Pituru; Ecaterina Ionescu. 2020. "Autophagy, One of the Main Steps in Periodontitis Pathogenesis and Evolution." Molecules 25, no. 18: 4338.

Review articles
Published: 14 August 2020 in Food Frontiers
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Myrtle (Myrtus communis L.) is a typical plant of the coasts of Mediterranean area, which grows spontaneously as a shrub or a small tree. Myrtle berries, leaves, seeds, and essential oils are natural sources of several nutrients and bioactive compounds with marked health effects. In the ancient medicine, it has been indeed used for treating several common diseases, including gastrointestinal, urinary, and skin disorders, whereas currently it is widely employed in food, cosmetic, and pharmaceutical industries. This review aims to describe the nutritional and the phytochemical compositions of different parts of myrtle plant, as well as their antioxidant activities. In addition, several in vitro, in vivo, and ex vivo studies are also presented to give a general overview of the potential effects of myrtle on human health. Finally, a critical analysis of the limitations related to the current research on myrtle is given.

ACS Style

Francesca Giampieri; Danila Cianciosi; Tamara Y. Forbes‐Hernández. Myrtle (Myrtus communisL.) berries, seeds, leaves, and essential oils: New undiscovered sources of natural compounds with promising health benefits. Food Frontiers 2020, 1, 276 -295.

AMA Style

Francesca Giampieri, Danila Cianciosi, Tamara Y. Forbes‐Hernández. Myrtle (Myrtus communisL.) berries, seeds, leaves, and essential oils: New undiscovered sources of natural compounds with promising health benefits. Food Frontiers. 2020; 1 (3):276-295.

Chicago/Turabian Style

Francesca Giampieri; Danila Cianciosi; Tamara Y. Forbes‐Hernández. 2020. "Myrtle (Myrtus communisL.) berries, seeds, leaves, and essential oils: New undiscovered sources of natural compounds with promising health benefits." Food Frontiers 1, no. 3: 276-295.