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Sabita Diana Stöckle
Equine Clinic: Surgery and Radiology, Freie Universität Berlin, 14163 Berlin, Germany

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Journal article
Published: 16 May 2021 in Antibiotics
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Background: For surgical interventions classified as clean or clean-contaminated, including laparotomy, guidelines in human and veterinary medicine recommend a short-term perioperative antibiotic prophylaxis (PAP). In equine colic surgery, however, PAP commonly exceeds 24 h. Objectives: The aim of this study was to compare a single-shot to a 5-day lasting PAP considering surgical site infections (SSI) and other adverse effects probably associated with the particular antimicrobial regimen. Study design: The study was designed as a randomised non-inferiority pilot study including horses subjected to colic surgery while receiving one of two distinct PAP regimens. Methods: All horses (n = 67) included in the study received the standard physical examination before and after surgery. Colic surgery was performed according to the current standard of the clinic. Horses were randomly assigned to two groups, receiving either the “single-shot” or the “5-day lasting” antibiotic prophylaxis. The “single-shot” group (n = 30) received penicillin and gentamicin only once before and, if needed, during surgery, whereas the “5-day lasting” group (n = 37) received antibiotics for five days. In addition to the standard laboratory examinations, serum amyloid A and fibrinogen were determined preoperatively and during five days after surgery. SSI, postoperative colitis and haemolytic anaemia were classified as postoperative complications potentially related to antibiotic use. Results: The outcome of this preliminary non-inferiority clinical trial showed that the occurrence of postoperative adverse events (i.e., SSI, postoperative colitis and haemolytic anaemia) lacked significant differences between the study groups. Main limitations: The main limitations of this study are the limited group sizes and our inability to blind the study. Conclusions: Single-shot PAP seems to be an alternative approach considering the 5-day lasting protocol commonly used in equine abdominal surgery. However, a proper hygiene management together with a close clinical and laboratory monitoring of the equine patient is indispensable.

ACS Style

Sabita Stöckle; Dania Kannapin; Anne Kauter; Antina Lübke-Becker; Birgit Walther; Roswitha Merle; Heidrun Gehlen. A Pilot Randomised Clinical Trial Comparing a Short-Term Perioperative Prophylaxis Regimen to a Long-Term Standard Protocol in Equine Colic Surgery. Antibiotics 2021, 10, 587 .

AMA Style

Sabita Stöckle, Dania Kannapin, Anne Kauter, Antina Lübke-Becker, Birgit Walther, Roswitha Merle, Heidrun Gehlen. A Pilot Randomised Clinical Trial Comparing a Short-Term Perioperative Prophylaxis Regimen to a Long-Term Standard Protocol in Equine Colic Surgery. Antibiotics. 2021; 10 (5):587.

Chicago/Turabian Style

Sabita Stöckle; Dania Kannapin; Anne Kauter; Antina Lübke-Becker; Birgit Walther; Roswitha Merle; Heidrun Gehlen. 2021. "A Pilot Randomised Clinical Trial Comparing a Short-Term Perioperative Prophylaxis Regimen to a Long-Term Standard Protocol in Equine Colic Surgery." Antibiotics 10, no. 5: 587.

Journal article
Published: 08 December 2020 in Animals
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Appropriate medical care for donkeys is challenging despite being important working animals in non-industrialized countries and pets in first world countries. Although the same principles of diagnosis and therapy as in horses are commonly applied, there are differences in reference values and physiologic reaction to dynamic tests. However, donkeys seem to suffer from typical equine diseases, such as metabolic syndrome and pituitary pars intermedia dysfunction (PPID). Asinine metabolic syndrome (AMS) comprises obesity, insulin dysregulation, and laminitis. The principles of diagnosis are similar to horses. Donkey-specific reference ranges for insulin and glucose have been evaluated previously. Examinations regarding dynamic testing revealed differences in the intravenous glucose tolerance test and the combined insulin tolerance test compared to horses. The therapy of AMS is based mainly on weight loss and exercise. There are conflicting data regarding the incidence of PPID in donkeys. Laminitis and hypertrichosis were described as the main clinical signs. Species-specific and seasonal reference ranges were defined to diagnose PPID in donkeys. Furthermore, the dexamethasone suppression test, the thyrotropin releasing hormone (TRH) test and the combined dexamethasone suppression/TRH test were evaluated. Pergolide is commonly recommended for treatment.

ACS Style

Heidrun Gehlen; Bianca Schwarz; Claus Bartmann; Jennifer Gernhardt; Sabita D. Stöckle. Pituitary Pars Intermedia Dysfunction and Metabolic Syndrome in Donkeys. Animals 2020, 10, 2335 .

AMA Style

Heidrun Gehlen, Bianca Schwarz, Claus Bartmann, Jennifer Gernhardt, Sabita D. Stöckle. Pituitary Pars Intermedia Dysfunction and Metabolic Syndrome in Donkeys. Animals. 2020; 10 (12):2335.

Chicago/Turabian Style

Heidrun Gehlen; Bianca Schwarz; Claus Bartmann; Jennifer Gernhardt; Sabita D. Stöckle. 2020. "Pituitary Pars Intermedia Dysfunction and Metabolic Syndrome in Donkeys." Animals 10, no. 12: 2335.

Journal article
Published: 13 September 2019 in Toxins
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The detection of borderline oxacillin-resistant Staphylococcus aureus (BORSA) represents a challenge to both, veterinary and human laboratories. Between 2015 and 2017, 19 equine S. aureus with elevated minimal inhibitory concentrations for oxacillin were detected in routine diagnostics. The aim of this study was to characterize these isolates to identify factors possibly associated with the BORSA phenotype. All S. aureus were subjected to antimicrobial susceptibility testing and whole genome sequencing (WGS). A quantifiable β-lactamase activity assay was performed for a representative subset of 13 isolates. The WGS data analysis of the 19 BORSA isolates identified two different genomic lineages, sequence type (ST) 1 and ST1660. The core genome multilocus sequence typing (cgMLST) revealed a close relatedness of all isolates belonging to either ST1 or ST1660. The WGS analysis identified the resistance genes aadD, dfrG, tet(L), and/or blaZ and aacA-aphD. Phenotypic resistance to penicillins, aminoglycosides, tetracyclines, fluoroquinolones and sulfamethoxazole/trimethoprim was observed in the respective isolates. For the penicillin-binding proteins 1–4, amino acid substitutions were predicted using WGS data. Since neither transglycosylase nor transpeptidase domains were affected, these alterations might not explain the BORSA phenotype. Moreover, β-lactamase activity was found to be associated with an inducible blaZ gene. The lineage-specific differences regarding the expression profiles were noted.

ACS Style

Anissa D. Scholtzek; Dennis Hanke; Birgit Walther; Inga Eichhorn; Sabita D. Stöckle; Katja-Sophia Klein; Heidrun Gehlen; Antina Lübke-Becker; Stefan Schwarz; Andrea T. Feßler; Lübke- Becker. Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility. Toxins 2019, 11, 535 .

AMA Style

Anissa D. Scholtzek, Dennis Hanke, Birgit Walther, Inga Eichhorn, Sabita D. Stöckle, Katja-Sophia Klein, Heidrun Gehlen, Antina Lübke-Becker, Stefan Schwarz, Andrea T. Feßler, Lübke- Becker. Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility. Toxins. 2019; 11 (9):535.

Chicago/Turabian Style

Anissa D. Scholtzek; Dennis Hanke; Birgit Walther; Inga Eichhorn; Sabita D. Stöckle; Katja-Sophia Klein; Heidrun Gehlen; Antina Lübke-Becker; Stefan Schwarz; Andrea T. Feßler; Lübke- Becker. 2019. "Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility." Toxins 11, no. 9: 535.

Journal article
Published: 01 April 2018 in Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere
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Summary Objective: Retrospective analysis of postoperative complications in equines after clean, orthopaedic surgical procedures in order to detect differences between animals treated with antibiotics and horses without receiving these drugs. Material and methods: Details on 652 patients, surgical procedures and surgery-associated complications were compiled from horses being operated between June 2011 and January 2015. Antibiotic-receiving patients (n = 259) were tested for differences in complication rates and characteristics to controls (n = 393). Results: The total complication rate was 39.1 %. Increased swelling was observed most often (25.6 %), followed by exudation (7.5 %), fever without incisional alterations (2.3 %), suture dehiscence (1.8 %), and seroma (0.8 %). Seven patients (five treated, two controls) developed septic arthritis within a total of 463 arthroscopies (1.5 %). There were no significant differences in the development of postoperative complications, which were seen in 97/259 (37.5 %) antibiotic receiving patients and in 158/393 (40.2 %) controls. The application of perioperative antibiotics was significantly influenced by surgeon (p < 0.0001) and type of surgery (p = 0.0007) and increased with the number of surgical lesions (p = 0.03). In patients undergoing tendovaginoscopy/ bursoscopy, fasciotomy and neurectomy (n = 98), antibiotic prophylaxis was initiated less frequently than in other surgeries, e. g. combinations of surgeries, splint bone extraction, tenotomy, and arthroscopy (n = 554). Conclusion: Severe complications in equine clean orthopaedic surgery are rare and complication rates in patients either receiving perioperative antibiotics or not were not significantly different. Clinical relevance: Based on the results the use of antibiotics appears to be non-essential in uncomplicated elective orthopaedic interventions in the horse.

ACS Style

Klaus Failing; Marc Koene; Kerstin Fey; Sabita Diana Stöckle. Postoperative complications in equine elective, clean orthopaedic surgery with/without antibiotic prophylaxis. Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 2018, 46, 81 -86.

AMA Style

Klaus Failing, Marc Koene, Kerstin Fey, Sabita Diana Stöckle. Postoperative complications in equine elective, clean orthopaedic surgery with/without antibiotic prophylaxis. Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere. 2018; 46 (02):81-86.

Chicago/Turabian Style

Klaus Failing; Marc Koene; Kerstin Fey; Sabita Diana Stöckle. 2018. "Postoperative complications in equine elective, clean orthopaedic surgery with/without antibiotic prophylaxis." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 46, no. 02: 81-86.