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Dr. Ricardo Ferraz
LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, P-4169-007 Porto, Portugal

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0 Ionic Liquids
0 Malaria
0 Medicinal Chemistry
0 peptide
0 bacterial resistance

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Ionic Liquids
Malaria
Medicinal Chemistry
peptide
bacterial resistance

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Review
Published: 16 June 2021 in Marine Drugs
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Neurodegenerative diseases (NDs) represent a drawback in society given the ageing population. Dementias are the most prevalent NDs, with Alzheimer’s disease (AD) representing around 70% of all cases. The current pharmaceuticals for AD are symptomatic and with no effects on the progression of the disease. Thus, research on molecules with therapeutic relevance has become a major focus for the scientific community. Cyanobacteria are a group of photosynthetic prokaryotes rich in biomolecules with confirmed activity in pathologies such as cancer, and with feasible potential in NDs such as AD. In this review, we aimed to compile the research works focused in the anti-AD potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (BACE1) as a fundamental enzyme in the generation of β-amyloid (Aβ), the inhibition of the enzyme acetylcholinesterase (AChE) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms.

ACS Style

Andrea Castaneda; Ricardo Ferraz; Mónica Vieira; Isabel Cardoso; Vitor Vasconcelos; Rosário Martins. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease. Marine Drugs 2021, 19, 343 .

AMA Style

Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martins. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease. Marine Drugs. 2021; 19 (6):343.

Chicago/Turabian Style

Andrea Castaneda; Ricardo Ferraz; Mónica Vieira; Isabel Cardoso; Vitor Vasconcelos; Rosário Martins. 2021. "Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease." Marine Drugs 19, no. 6: 343.

Review
Published: 27 April 2021 in ChemMedChem
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The relevance of Ionic Liquids (ILs) is now well established in many fields, since their unique properties make them appealing as (i) greener alternatives to organic solvents (first‐generation ILs), (ii) tunable task‐specific materials (second‐generation ILs), and (iii) multi‐functional players in Life and Pharmaceutical Sciences (third generation ILs). This third wave of ILs encompasses a wide range of compounds, from bioactive molecules with single or even dual therapeutic action, to potential ingredient molecules for the drug formulation and transport systems. In this context, the focus of this review is the emergent role of surface‐active ionic liquids (SAILs) in drug development and delivery.

ACS Style

Ana Teresa Silva; Cátia Teixeira; Eduardo F. Marques F. Marques; Cristina Prudêncio; Paula Gomes; Ricardo Ferraz. Surfing the Third Wave of Ionic Liquids: A Brief Review on the Role of Surface‐Active Ionic Liquids in Drug Development and Delivery. ChemMedChem 2021, 1 .

AMA Style

Ana Teresa Silva, Cátia Teixeira, Eduardo F. Marques F. Marques, Cristina Prudêncio, Paula Gomes, Ricardo Ferraz. Surfing the Third Wave of Ionic Liquids: A Brief Review on the Role of Surface‐Active Ionic Liquids in Drug Development and Delivery. ChemMedChem. 2021; ():1.

Chicago/Turabian Style

Ana Teresa Silva; Cátia Teixeira; Eduardo F. Marques F. Marques; Cristina Prudêncio; Paula Gomes; Ricardo Ferraz. 2021. "Surfing the Third Wave of Ionic Liquids: A Brief Review on the Role of Surface‐Active Ionic Liquids in Drug Development and Delivery." ChemMedChem , no. : 1.

Paper
Published: 16 April 2021 in RSC Advances
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Antifungal susceptibility assays and molecular dynamics simulation studies reveal a novel cetylpyridinium amphotericin B ionic liquid formulation with dual functionality: antifungal and antibacterial activities.

ACS Style

Diego O. Hartmann; Karina Shimizu; Maika Rothkegel; Marija Petkovic; Ricardo Ferraz; Željko Petrovski; Luís C. Branco; José N. Canongia Lopes; Cristina Silva Pereira. Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs. RSC Advances 2021, 11, 14441 -14452.

AMA Style

Diego O. Hartmann, Karina Shimizu, Maika Rothkegel, Marija Petkovic, Ricardo Ferraz, Željko Petrovski, Luís C. Branco, José N. Canongia Lopes, Cristina Silva Pereira. Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs. RSC Advances. 2021; 11 (24):14441-14452.

Chicago/Turabian Style

Diego O. Hartmann; Karina Shimizu; Maika Rothkegel; Marija Petkovic; Ricardo Ferraz; Željko Petrovski; Luís C. Branco; José N. Canongia Lopes; Cristina Silva Pereira. 2021. "Tailoring amphotericin B as an ionic liquid: an upfront strategy to potentiate the biological activity of antifungal drugs." RSC Advances 11, no. 24: 14441-14452.

Journal article
Published: 16 December 2020 in International Journal of Molecular Sciences
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Breast (BrCa) and prostate (PCa) cancers are the most common malignancies in women and men, respectively. The available therapeutic options for these tumors are still not curative and have severe side effects. Therefore, there is an urgent need for more effective antineoplastic agents. Herein, BrCa, PCa, and benign cell lines were treated with two ionic liquids and two quinoxalines and functional experiments were performed—namely cell viability, apoptosis, cytotoxicity, and colony formation assays. At the molecular level, an array of gene expressions encompassing several molecular pathways were used to explore the impact of treatment on gene expression. Although both quinoxalines and the ionic liquid [C2OHMIM][Amp] did not show any effect on the BrCa and PCa cell lines, [C16Pyr][Amp] significantly decreased cell viability and colony formation ability, while it increased the apoptosis levels of all cell lines. Importantly, [C16Pyr][Amp] was found to be more selective for cancer cells and less toxic than cisplatin. At the molecular level, this ionic liquid was also associated with reduced expression levels of CPT2, LDHA, MCM2, and SKP2, in both BrCa and PCa cell lines. Hence, [C16Pyr][Amp] was shown to be a promising anticancer therapeutic agent for BrCa and PCa cell lines.

ACS Style

Filipa Vieira; Ângela Marques-Magalhães; Vera Miranda-Gonçalves; Ricardo Ferraz; Mónica Vieira; Cristina Prudêncio; Carmen Jerónimo; Regina Silva. The Impact of [C16Pyr][Amp] on the Aggressiveness in Breast and Prostate Cancer Cell Lines. International Journal of Molecular Sciences 2020, 21, 9584 .

AMA Style

Filipa Vieira, Ângela Marques-Magalhães, Vera Miranda-Gonçalves, Ricardo Ferraz, Mónica Vieira, Cristina Prudêncio, Carmen Jerónimo, Regina Silva. The Impact of [C16Pyr][Amp] on the Aggressiveness in Breast and Prostate Cancer Cell Lines. International Journal of Molecular Sciences. 2020; 21 (24):9584.

Chicago/Turabian Style

Filipa Vieira; Ângela Marques-Magalhães; Vera Miranda-Gonçalves; Ricardo Ferraz; Mónica Vieira; Cristina Prudêncio; Carmen Jerónimo; Regina Silva. 2020. "The Impact of [C16Pyr][Amp] on the Aggressiveness in Breast and Prostate Cancer Cell Lines." International Journal of Molecular Sciences 21, no. 24: 9584.

Review
Published: 04 September 2020 in Antibiotics
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Antibiotics are considered one of the great “miracles” of the 20th century. Now in the 21st century in the post-antibiotic era, the miracle is turning into a nightmare, due to the growing problem of the resistance of microorganisms to classic antimicrobials and the non-investment by the pharmaceutical industry in new antimicrobial agents. Unfortunately, the current COVID-19 pandemic has demonstrated the global risks associated with uncontrolled infections and the various forms of impact that such a pandemic may have on the economy and on social habits besides the associated morbidity and mortality. Therefore, there is an urgent need to recycle classic antibiotics, as is the case in the use of ionic liquids (ILs) based on antibiotics. Thus, the aim of the present review is to summarize the data on ILs, mainly those with antimicrobial action and especially against resistant strains. The main conclusions of this article are that ILs are flexible due to their ability to modulate cations and anions as a salt, making it possible to combine the properties of both and multiplying the activity of separate cations and anions. Also, these compounds have low cost methods of production, which makes it highly attractive to explore them, especially as antimicrobial agents and against resistant strains. ILs may further be combined with other therapeutic strategies, such as phage or lysine therapy, enhancing the therapeutic arsenal needed to fight this worldwide problem of antibacterial resistance. Thus, the use of ILs as antibiotics by themselves or together with phage therapy and lysine therapy are promising alternatives against pathogenic microorganisms, and may have the possibility to be used in new ways in order to restrain uncontrolled infections.

ACS Style

Cristina Prudêncio; Mónica Vieira; Seppe Van Der Auweraer; Ricardo Ferraz. Recycling Old Antibiotics with Ionic Liquids. Antibiotics 2020, 9, 578 .

AMA Style

Cristina Prudêncio, Mónica Vieira, Seppe Van Der Auweraer, Ricardo Ferraz. Recycling Old Antibiotics with Ionic Liquids. Antibiotics. 2020; 9 (9):578.

Chicago/Turabian Style

Cristina Prudêncio; Mónica Vieira; Seppe Van Der Auweraer; Ricardo Ferraz. 2020. "Recycling Old Antibiotics with Ionic Liquids." Antibiotics 9, no. 9: 578.

Communication
Published: 26 August 2020 in International Journal of Molecular Sciences
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A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.

ACS Style

Ana Gomes; Lucinda J. Bessa; Patrícia Correia; Iva Fernandes; Ricardo Ferraz; Paula Gameiro; Cátia Teixeira; Paula Gomes. “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability. International Journal of Molecular Sciences 2020, 21, 6174 .

AMA Style

Ana Gomes, Lucinda J. Bessa, Patrícia Correia, Iva Fernandes, Ricardo Ferraz, Paula Gameiro, Cátia Teixeira, Paula Gomes. “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability. International Journal of Molecular Sciences. 2020; 21 (17):6174.

Chicago/Turabian Style

Ana Gomes; Lucinda J. Bessa; Patrícia Correia; Iva Fernandes; Ricardo Ferraz; Paula Gameiro; Cátia Teixeira; Paula Gomes. 2020. "“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route Towards Improved Stability." International Journal of Molecular Sciences 21, no. 17: 6174.

Communication
Published: 27 July 2020 in International Journal of Molecular Sciences
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Ionic liquids derived from classical antimalarials are emerging as a new approach towards the cost-effective rescuing of those drugs. Herein, we disclose novel surface-active ionic liquids derived from chloroquine and natural fatty acids whose antimalarial activity in vitro was found to be superior to that of the parent drug. The most potent ionic liquid was the laurate salt of chloroquine, which presented IC50 values of 4 and 110 nM against a chloroquine-sensitive and a chloroquine-resistant strain of Plasmodium falciparum, respectively, corresponding to an 11- and 6-fold increase in potency as compared to the reference chloroquine bisphosphate salt against the same strains. This unprecedented report opens new perspectives in both the fields of malaria chemotherapy and of surface-active ionic liquids derived from active pharmaceutical ingredients.

ACS Style

Ana Teresa Silva; Lis Tavares Coelho Lobo; Isabel Oliveira; Joana Gomes; Cátia Teixeira; Fátima Nogueira; Eduardo F. Marques; Ricardo Ferraz; Paula Gomes. Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine. International Journal of Molecular Sciences 2020, 21, 5334 .

AMA Style

Ana Teresa Silva, Lis Tavares Coelho Lobo, Isabel Oliveira, Joana Gomes, Cátia Teixeira, Fátima Nogueira, Eduardo F. Marques, Ricardo Ferraz, Paula Gomes. Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine. International Journal of Molecular Sciences. 2020; 21 (15):5334.

Chicago/Turabian Style

Ana Teresa Silva; Lis Tavares Coelho Lobo; Isabel Oliveira; Joana Gomes; Cátia Teixeira; Fátima Nogueira; Eduardo F. Marques; Ricardo Ferraz; Paula Gomes. 2020. "Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine." International Journal of Molecular Sciences 21, no. 15: 5334.

Journal article
Published: 02 March 2020 in Pharmaceutics
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The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichia coli and Staphylococcus aureus strains is reported. Eleven hydrolyzed β-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the neutralization of the basic ammonia buffer of antibiotics with different cation hydroxide salts. The obtained minimum inhibitory concentration (MIC) data of the prepared compounds showed a relative decrease of the inhibitory concentrations (RDIC) in the order of 100 in the case of [C2OHMIM][seco-Pen] against sensitive S. aureus ATCC25923 and, most strikingly, higher than 1000 with [C16Pyr][seco-Amx] against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. These outstanding in vitro results showcase that a straightforward transformation of standard antibiotics into hydrolyzed organic salts can dramatically change the pharmaceutical activity of a drug, including giving rise to potent formulations of antibiotics against deadly bacteria strains.

ACS Style

Ricardo Ferraz; Dário Silva; Ana Rita Dias; Vitorino Dias; Miguel M. Santos; Luís Pinheiro; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luís C. Branco. Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria. Pharmaceutics 2020, 12, 221 .

AMA Style

Ricardo Ferraz, Dário Silva, Ana Rita Dias, Vitorino Dias, Miguel M. Santos, Luís Pinheiro, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski, Luís C. Branco. Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria. Pharmaceutics. 2020; 12 (3):221.

Chicago/Turabian Style

Ricardo Ferraz; Dário Silva; Ana Rita Dias; Vitorino Dias; Miguel M. Santos; Luís Pinheiro; Cristina Prudêncio; João Paulo Noronha; Željko Petrovski; Luís C. Branco. 2020. "Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria." Pharmaceutics 12, no. 3: 221.

Review
Published: 08 January 2020 in Current Medicinal Chemistry
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: The unique properties of ionic liquids make them quite appealing for diverse applications, from “green” solvents (1st generation ionic liquids) to finely tuned materials (2nd generation ionic liquids). A decade ago, a 3rd generation of ionic liquids emerged which is focused on their prospective clinical applications, either as drugs per se or as adjuvants in drug formulations. In recent years, research focused on the use of ionic liquids for topical drug delivery has been increasing and holds great promise towards clinical application against skin cancers. This article highlights the growing relevance of ionic liquids in medicinal chemistry and pharmaceutical technology, which is opening new windows of opportunity.

ACS Style

Ana Rita Dias; João Costa-Rodrigues; Cátia Teixeira; Cristina Prudêncio; Paula Gomes; Ricardo Ferraz. Ionic Liquids for Topical Delivery in Cancer. Current Medicinal Chemistry 2020, 26, 7520 -7532.

AMA Style

Ana Rita Dias, João Costa-Rodrigues, Cátia Teixeira, Cristina Prudêncio, Paula Gomes, Ricardo Ferraz. Ionic Liquids for Topical Delivery in Cancer. Current Medicinal Chemistry. 2020; 26 (41):7520-7532.

Chicago/Turabian Style

Ana Rita Dias; João Costa-Rodrigues; Cátia Teixeira; Cristina Prudêncio; Paula Gomes; Ricardo Ferraz. 2020. "Ionic Liquids for Topical Delivery in Cancer." Current Medicinal Chemistry 26, no. 41: 7520-7532.

Review
Published: 24 December 2019 in Molecules
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Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.

ACS Style

Ana Teresa Silva; Clara M. Bento; Ana Pena; Luísa M. Figueiredo; Cristina Prudêncio; Luísa Aguiar; Tânia Silva; Ricardo Ferraz; Maria Salomé Gomes; Cátia Teixeira; Paula Gomes. Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs. Molecules 2019, 25, 66 .

AMA Style

Ana Teresa Silva, Clara M. Bento, Ana Pena, Luísa M. Figueiredo, Cristina Prudêncio, Luísa Aguiar, Tânia Silva, Ricardo Ferraz, Maria Salomé Gomes, Cátia Teixeira, Paula Gomes. Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs. Molecules. 2019; 25 (1):66.

Chicago/Turabian Style

Ana Teresa Silva; Clara M. Bento; Ana Pena; Luísa M. Figueiredo; Cristina Prudêncio; Luísa Aguiar; Tânia Silva; Ricardo Ferraz; Maria Salomé Gomes; Cátia Teixeira; Paula Gomes. 2019. "Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs." Molecules 25, no. 1: 66.

Conference paper
Published: 12 November 2019 in Proceedings of 5th International Electronic Conference on Medicinal Chemistry
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Bacterial resistance to current antibiotics has a major impact on worldwide human health, leading to 700K deaths every year. The development of novel antibiotics did not present significant progress, namely regarding clinical trials, over the last years due to low returns. Thus, innovative alternatives must be devised to tackle the continuous rise of antimicrobial resistance. Ionic Liquids and Organic Salts from Active Pharmaceutical Ingredients (API-OSILs) have risen in academia for over 10 years as an efficient formulation for drugs with low bioavailability and permeability, as well as reduction or elimination of polymorphism, thereby potentially enhancing their pharmaceutical efficiency. To the best of our knowledge, our group is the first to perform research on the development of API-OSILs from antibiotics as a way to improve their efficiency. More specifically, we have successfully combined ampicillin, penicillin and amoxicillinas anions with biocompatible organic cations such as choline, alkylpyridiniums and alkylimidazoliums. Furthermore, we have also combined fluoroquinolones (ciprofloxacin and norfloxacin) as cations with biocompatible carboxylic and sulfonic acids. In this communication, we present our latest developments in the synthesis and spectroscopic (NMR, FTIR) and physicochemical (DSC) characterization of ionic liquids and organic salts from these antibiotics, in addition to in vitro antimicrobial activity data, in particular towards Methicillin Resistant Staphylococcus aureus and multi-resistant Escherichia coli, as well as sensitive strains of gram-positive and gram-negative bacteria.

ACS Style

Miguel Santos; Inês Grilo; Ricardo Ferraz; Diogo Madeira; Bárbara Soares; Núria Inácio; Luís Pinheiro; Zeljko Petrovski; Cristina Prudêncio; Rita Sobral; Luís Branco. Tackling bacterial resistance using antibiotics as ionic liquids and organic salts. Proceedings of 5th International Electronic Conference on Medicinal Chemistry 2019, 1 .

AMA Style

Miguel Santos, Inês Grilo, Ricardo Ferraz, Diogo Madeira, Bárbara Soares, Núria Inácio, Luís Pinheiro, Zeljko Petrovski, Cristina Prudêncio, Rita Sobral, Luís Branco. Tackling bacterial resistance using antibiotics as ionic liquids and organic salts. Proceedings of 5th International Electronic Conference on Medicinal Chemistry. 2019; ():1.

Chicago/Turabian Style

Miguel Santos; Inês Grilo; Ricardo Ferraz; Diogo Madeira; Bárbara Soares; Núria Inácio; Luís Pinheiro; Zeljko Petrovski; Cristina Prudêncio; Rita Sobral; Luís Branco. 2019. "Tackling bacterial resistance using antibiotics as ionic liquids and organic salts." Proceedings of 5th International Electronic Conference on Medicinal Chemistry , no. : 1.

Communication
Published: 26 September 2019 in ChemMedChem
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Novel ionic liquids and organic salts based on mono‐ or dianionic zoledronate and protonated superbases, choline and n‐alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate‐based ionic compounds, those containing choline [Ch] and methoxyethylmethylimidazolium [C3OMIM] cations appear to have significant cytotoxicity against human osteosarcoma cells (MG63) and low toxicity toward healthy skin fibroblast cells. Because osteosarcoma is a bone pathology characterized by an increase in bone turnover rate, the results presented herein may be a promising starting point for the development of new ionic pharmaceutical drugs against osteosarcoma.

ACS Style

Sónia Teixeira; Miguel M. Santos; Ricardo Ferraz; Cristina Prudêncio; Maria H. Fernandes; João Costa‐Rodrigues; Luís C. Branco. A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid. ChemMedChem 2019, 14, 1767 -1770.

AMA Style

Sónia Teixeira, Miguel M. Santos, Ricardo Ferraz, Cristina Prudêncio, Maria H. Fernandes, João Costa‐Rodrigues, Luís C. Branco. A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid. ChemMedChem. 2019; 14 (20):1767-1770.

Chicago/Turabian Style

Sónia Teixeira; Miguel M. Santos; Ricardo Ferraz; Cristina Prudêncio; Maria H. Fernandes; João Costa‐Rodrigues; Luís C. Branco. 2019. "A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid." ChemMedChem 14, no. 20: 1767-1770.

Original research article
Published: 02 April 2019 in Journal of Cellular Physiology
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Antiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Shortly, valproic acid stimulated either osteoclastogenesis and osteoblastogenesis, whereas carbamazepine, gabapentin, and lamotrigine revealed an opposite behavior; topiramate elicited a decrease of osteoclast development and an increase in osteoblast differentiation. This is the first report describing the direct effects of different AED on human primary bone cells, which is a very important issue, because these drugs are usually consumed in long‐term therapeutics, with acknowledged in vivo effects in bone tissue.

ACS Style

Sara Rocha; Ricardo Ferraz; Cristina Prudêncio; Maria Helena Fernandes; João Costa‐Rodrigues. Differential effects of antiepileptic drugs on human bone cells. Journal of Cellular Physiology 2019, 234, 19691 -19701.

AMA Style

Sara Rocha, Ricardo Ferraz, Cristina Prudêncio, Maria Helena Fernandes, João Costa‐Rodrigues. Differential effects of antiepileptic drugs on human bone cells. Journal of Cellular Physiology. 2019; 234 (11):19691-19701.

Chicago/Turabian Style

Sara Rocha; Ricardo Ferraz; Cristina Prudêncio; Maria Helena Fernandes; João Costa‐Rodrigues. 2019. "Differential effects of antiepileptic drugs on human bone cells." Journal of Cellular Physiology 234, no. 11: 19691-19701.

Short communication
Published: 21 March 2019 in Tetrahedron Letters
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A multi-step synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.

ACS Style

Mélanie Fonte; Natália Fagundes; Ana Gomes; Ricardo Ferraz; Cristina Prudêncio; Maria João Araújo; Paula Gomes; Cátia Teixeira. Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials. Tetrahedron Letters 2019, 60, 1166 -1169.

AMA Style

Mélanie Fonte, Natália Fagundes, Ana Gomes, Ricardo Ferraz, Cristina Prudêncio, Maria João Araújo, Paula Gomes, Cátia Teixeira. Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials. Tetrahedron Letters. 2019; 60 (17):1166-1169.

Chicago/Turabian Style

Mélanie Fonte; Natália Fagundes; Ana Gomes; Ricardo Ferraz; Cristina Prudêncio; Maria João Araújo; Paula Gomes; Cátia Teixeira. 2019. "Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials." Tetrahedron Letters 60, no. 17: 1166-1169.

Journal article
Published: 21 March 2019 in ACS Omega
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ACS Style

Ana Teresa Silva; Maria João Cerqueira; Cristina Prudêncio; Maria Helena Fernandes; João Costa-Rodrigues; Cátia Teixeira; Paula Gomes; Ricardo Ferraz. Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells. ACS Omega 2019, 4, 5682 -5689.

AMA Style

Ana Teresa Silva, Maria João Cerqueira, Cristina Prudêncio, Maria Helena Fernandes, João Costa-Rodrigues, Cátia Teixeira, Paula Gomes, Ricardo Ferraz. Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells. ACS Omega. 2019; 4 (3):5682-5689.

Chicago/Turabian Style

Ana Teresa Silva; Maria João Cerqueira; Cristina Prudêncio; Maria Helena Fernandes; João Costa-Rodrigues; Cátia Teixeira; Paula Gomes; Ricardo Ferraz. 2019. "Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells." ACS Omega 4, no. 3: 5682-5689.

Article
Published: 01 November 2018 in Antimicrobial Agents and Chemotherapy
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The impact of Pneumocystis pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection.

ACS Style

Ana Gomes; Ricardo Ferraz; Lauren Ficker; Margaret S. Collins; Cristina Prudêncio; Melanie T. Cushion; Cátia Teixeira; Paula Gomes. Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial Agents and Chemotherapy 2018, 62, 1 .

AMA Style

Ana Gomes, Ricardo Ferraz, Lauren Ficker, Margaret S. Collins, Cristina Prudêncio, Melanie T. Cushion, Cátia Teixeira, Paula Gomes. Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial Agents and Chemotherapy. 2018; 62 (11):1.

Chicago/Turabian Style

Ana Gomes; Ricardo Ferraz; Lauren Ficker; Margaret S. Collins; Cristina Prudêncio; Melanie T. Cushion; Cátia Teixeira; Paula Gomes. 2018. "Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens." Antimicrobial Agents and Chemotherapy 62, no. 11: 1.

Review
Published: 18 October 2017 in Molecules
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As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections.

ACS Style

Ana Gomes; Cátia Teixeira; Ricardo Ferraz; Cristina Prudêncio; Paula Gomes. Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries. Molecules 2017, 22, 1743 .

AMA Style

Ana Gomes, Cátia Teixeira, Ricardo Ferraz, Cristina Prudêncio, Paula Gomes. Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries. Molecules. 2017; 22 (10):1743.

Chicago/Turabian Style

Ana Gomes; Cátia Teixeira; Ricardo Ferraz; Cristina Prudêncio; Paula Gomes. 2017. "Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries." Molecules 22, no. 10: 1743.

Book chapter
Published: 14 September 2017 in Functional Polymer Composites with Nanoclays
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Ionic liquids are well-known for their remarkable physical and chemical properties, which triggered their use as green-solvents and materials with unique and tuneable characteristics. This tuneability frequently relies on just selecting suitable ions for a specific need rather than on complex covalent modifications, making ionic liquids attractive for diverse research areas, from materials science to electrochemistry and from catalysis to medicinal chemistry. Still, although ionic liquids currently enjoy a plethora of applications in various domains, their use in the life sciences has been less explored. Therefore, the present work is focused on some biological activities that have been reported for ionic liquids.

ACS Style

Ricardo Ferraz; Cátia Teixeira; Paula Gomes; Cristina Prudêncio. CHAPTER 16. Bioactivity of Ionic Liquids. Functional Polymer Composites with Nanoclays 2017, 404 -422.

AMA Style

Ricardo Ferraz, Cátia Teixeira, Paula Gomes, Cristina Prudêncio. CHAPTER 16. Bioactivity of Ionic Liquids. Functional Polymer Composites with Nanoclays. 2017; ():404-422.

Chicago/Turabian Style

Ricardo Ferraz; Cátia Teixeira; Paula Gomes; Cristina Prudêncio. 2017. "CHAPTER 16. Bioactivity of Ionic Liquids." Functional Polymer Composites with Nanoclays , no. : 404-422.

Journal article
Published: 01 September 2017 in Bioorganic & Medicinal Chemistry Letters
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Primaquine-based ionic liquids, obtained by acid-base reaction between parent primaquine and cinnamic acids, were recently found as triple-stage antimalarial hits. These ionic compounds displayed significant activity against both liver- and blood-stage Plasmodium parasites, as well as against stage V P. falciparum parasites. Remarkably, blood-stage activity of the ionic liquids against both chloroquine-sensitive (3D7) and resistant (Dd2) P. falciparum strains was clearly superior to those of the respective covalent (amide) analogues and of parent primaquine. Having hypothesized that such behaviour might be ascribed to an enhanced ability of the ionic compounds to permeate into Plasmodium-infected erythrocytes, we have carried out a differential scanning calorimetry-based study of the interactions between the ionic liquids and membrane models. Results provide evidence, at the molecular level, that the primaquine-derived ionic liquids may contribute to an increased permeation of the parent drug into malaria-infected erythrocytes, which has relevant implications towards novel antimalarial approaches based on ionic liquids.

ACS Style

Ricardo Ferraz; Marina Pinheiro; Ana Gomes; Cátia Teixeira; Cristina Prudêncio; Salette Reis; Paula Gomes. Effects of novel triple-stage antimalarial ionic liquids on lipid membrane models. Bioorganic & Medicinal Chemistry Letters 2017, 27, 4190 -4193.

AMA Style

Ricardo Ferraz, Marina Pinheiro, Ana Gomes, Cátia Teixeira, Cristina Prudêncio, Salette Reis, Paula Gomes. Effects of novel triple-stage antimalarial ionic liquids on lipid membrane models. Bioorganic & Medicinal Chemistry Letters. 2017; 27 (17):4190-4193.

Chicago/Turabian Style

Ricardo Ferraz; Marina Pinheiro; Ana Gomes; Cátia Teixeira; Cristina Prudêncio; Salette Reis; Paula Gomes. 2017. "Effects of novel triple-stage antimalarial ionic liquids on lipid membrane models." Bioorganic & Medicinal Chemistry Letters 27, no. 17: 4190-4193.

Review
Published: 13 December 2016 in ChemMedChem
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Nowadays, many of the challenges that pharmaceutical industry faces impose the need to innovative and effective therapies. The investigation of alternative and effective therapies at the level of cancer is an actual goal of pharmaceutical industry. Ionic Liquids (ILs) appear recently as potential target of study by pharmaceutical industry on search of new therapeutic agents. They are, by definition, organic salts with melting point below 100°C only composed by ions. Their man advantage, is the numerous combinations made between the cation and the anion, which allow adjustments in their physicochemical properties. The combination between ILs and Active Pharmaceutical Ingredients (APIs) may improve the properties of APIs. In addition, antitumor properties of these compounds have been described. Several studies have been reported the use of ILs for biomedical applications as therapeutic agents, namely as anti-tumor agents. This review describes the recent proposed applications of ILs as anti-tumor agents.

ACS Style

Ana Rita Dias; João Costa-Rodrigues; Maria Helena Fernandes; Ricardo Ferraz; Cristina Prudêncio. The Anticancer Potential of Ionic Liquids. ChemMedChem 2016, 12, 11 -18.

AMA Style

Ana Rita Dias, João Costa-Rodrigues, Maria Helena Fernandes, Ricardo Ferraz, Cristina Prudêncio. The Anticancer Potential of Ionic Liquids. ChemMedChem. 2016; 12 (1):11-18.

Chicago/Turabian Style

Ana Rita Dias; João Costa-Rodrigues; Maria Helena Fernandes; Ricardo Ferraz; Cristina Prudêncio. 2016. "The Anticancer Potential of Ionic Liquids." ChemMedChem 12, no. 1: 11-18.