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Dr. Jacopo Ciaffi
IRCCS Istituto Ortopedico Rizzoli

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0 Rheumatoid Arthritis
0 Rheumatology
0 Systemic lupus erythematosus
0 systemic sclerosis
0 Systemic autoimmune diseases

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Journal article
Published: 13 May 2021 in International Journal of Environmental Research and Public Health
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The mortality of hip fracture (HF) patients is increased by concomitant COVID-19; however, evidence is limited to only short follow-up. A retrospective matched case–control study was designed with the aim to report the 90-day mortality and determine the hazard ratio (HR) of concomitant HF and COVID-19 infection. Cases were patients hospitalized for HF and diagnosed with COVID-19. Controls were patients hospitalized for HF not meeting the criteria for COVID-19 diagnosis and were individually matched with each case through a case–control (1:3) matching algorithm. A total of 89 HF patients were treated during the study period, and 14 of them were diagnosed as COVID-19 positive (overall 15.7%). Patients’ demographic, clinical, and surgical characteristics were similar between case and control groups. At 90 days after surgery, 5 deaths were registered among the 14 COVID-19 cases (35.7%) and 4 among the 42 HF controls (9.5%). COVID-19-positive cases had a higher risk of mortality at 30 days (HR = 4.51; p = 0.0490) and 90 days (HR = 4.50; p = 0.025) with respect to controls. Patients with concomitant HF and COVID-19 exhibit high perioperative mortality, which reaches a plateau of nearly 30–35% after 30 to 45 days and is stable up to 90 days. The mortality risk is more than four-fold higher in patients with COVID-19.

ACS Style

Alberto Grassi; Luca Andriolo; Davide Golinelli; Dario Tedesco; Simona Rosa; Pasquale Gramegna; Jacopo Ciaffi; Riccardo Meliconi; Maria Landini; Giuseppe Filardo; Maria Fantini; Stefano Zaffagnini. Higher 90-Day Mortality after Surgery for Hip Fractures in Patients with COVID-19: A Case–Control Study from a Single Center in Italy. International Journal of Environmental Research and Public Health 2021, 18, 5205 .

AMA Style

Alberto Grassi, Luca Andriolo, Davide Golinelli, Dario Tedesco, Simona Rosa, Pasquale Gramegna, Jacopo Ciaffi, Riccardo Meliconi, Maria Landini, Giuseppe Filardo, Maria Fantini, Stefano Zaffagnini. Higher 90-Day Mortality after Surgery for Hip Fractures in Patients with COVID-19: A Case–Control Study from a Single Center in Italy. International Journal of Environmental Research and Public Health. 2021; 18 (10):5205.

Chicago/Turabian Style

Alberto Grassi; Luca Andriolo; Davide Golinelli; Dario Tedesco; Simona Rosa; Pasquale Gramegna; Jacopo Ciaffi; Riccardo Meliconi; Maria Landini; Giuseppe Filardo; Maria Fantini; Stefano Zaffagnini. 2021. "Higher 90-Day Mortality after Surgery for Hip Fractures in Patients with COVID-19: A Case–Control Study from a Single Center in Italy." International Journal of Environmental Research and Public Health 18, no. 10: 5205.

Journal article
Published: 01 February 2021 in International Journal of Environmental Research and Public Health
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Background: E-health tools have been used to assess the temporal variations of different health problems. The aim of our infodemiology study was to investigate the seasonal pattern of search volumes for back pain in Italy. Methods: In Italian, back pain is indicated by the medical word “lombalgia”. Using Google Trends, we selected the three search terms related to “lombalgia” with higher relative search volumes (RSV), (namely, “mal di schiena”, “dolore alla schiena” and “dolore lombare”), representing the semantic preferences of users when performing web queries for back pain in Italy. Wikipedia page view statistics were used to identify the number of visits to the page “lombalgia”. Strength and direction of secular trends were assessed using the Mann–Kendall test. Cosinor analysis was used to evaluate the potential seasonality of back pain-related RSV. Results: We found a significant upward secular trend from 2005 to 2020 for search terms “mal di schiena” (τ = 0.734, p < 0.0001), “dolore alla schiena” (τ = 0.713, p < 0.0001) and “dolore lombare” (τ = 0.628, p < 0.0001). Cosinor analysis on Google Trends RSV showed a significant seasonality for the terms “mal di schiena” (p cos < 0.001), “dolore alla schiena” (p cos < 0.0001), “dolore lombare” (p cos < 0.0001) and “lombalgia” (p cos = 0.017). Cosinor analysis performed on views for the page “lombalgia” in Wikipedia confirmed a significant seasonality (p cos < 0.0001). Both analyses demonstrated a peak of interest in winter months and decrease in spring/summer. Conclusions: Our infodemiology approach revealed significant seasonal fluctuations in search queries for back pain in Italy, with peaking volumes during the coldest months of the year.

ACS Style

Jacopo Ciaffi; Riccardo Meliconi; Maria Landini; Luana Mancarella; Veronica Brusi; Cesare Faldini; Francesco Ursini. Seasonality of Back Pain in Italy: An Infodemiology Study. International Journal of Environmental Research and Public Health 2021, 18, 1325 .

AMA Style

Jacopo Ciaffi, Riccardo Meliconi, Maria Landini, Luana Mancarella, Veronica Brusi, Cesare Faldini, Francesco Ursini. Seasonality of Back Pain in Italy: An Infodemiology Study. International Journal of Environmental Research and Public Health. 2021; 18 (3):1325.

Chicago/Turabian Style

Jacopo Ciaffi; Riccardo Meliconi; Maria Landini; Luana Mancarella; Veronica Brusi; Cesare Faldini; Francesco Ursini. 2021. "Seasonality of Back Pain in Italy: An Infodemiology Study." International Journal of Environmental Research and Public Health 18, no. 3: 1325.

Journal article
Published: 29 November 2020 in Behavioral Sciences
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Background: Resilience is defined as the capacity to cope successfully with change or adversity. The aims of our study were to investigate levels of resilience in Italian healthcare professionals (HCPs) during the Coronavirus disease 2019 (COVID-19) pandemic and to identify potential predictors of resilience. Methods: We performed a web-based survey of HCPs (n = 1009) working in Italian hospitals during the COVID-19 pandemic. The survey contained a 14-item resilience scale (RS14) and questionnaires to evaluate depression and anxiety symptoms. Non-HCP individuals (n = 375) from the general population were used for comparison. Results: HCPs showed significantly lower resilience compared to the control group (p = 0.001). No significant differences were observed after stratification for geographical area, work setting, role, or suspected/confirmed diagnosis of COVID-19. In a linear regression analysis, RS14 was inversely correlated with depression (R2 = 0.227, p < 0.001) and anxiety (R2 = 0.117, p < 0.001) and directly correlated with age (R2 = 0.012, p < 0.001) but not with body mass index (BMI, R2 = 0.002, p = 0.213). In male HCPs, higher depression score (odds ratio (OR) 1.147, p < 0.001) or BMI (OR 1.136, p = 0.011) significantly predicted having low resilience. In female HCPs, higher depression score (OR 1.111, p < 0.0001) and working in a COVID-19 free setting (OR 2.308, p = 0.002) significantly predicted having low resilience. HCPs satisfied with personal protective equipment had higher levels of resilience (p < 0.010). Conclusions: Our findings suggest that resilience was lower in Italian HCPs than in the general population after the first COVID-19 wave. Specific factors can be identified, and targeted interventions may have an important role to foster resilience of HCPs.

ACS Style

Lucia Lisi; Jacopo Ciaffi; Antonella Bruni; Luana Mancarella; Veronica Brusi; Pasquale Gramegna; Claudio Ripamonti; Elisabetta Quaranta; Elena Borlandelli; Gaetano Gallo; Eugenio Garofalo; Agostino Chiaravalloti; Pasquale Viola; Piero Ruscitti; Giacomo Caio; Martina D’Onghia; Andrea D’Amuri; Antonio Cimellaro; Giancarlo Facchini; Micaela La Regina; Luca Spinardi; Roberto de Giorgio; Roberto Giacomelli; Maria Paola Landini; Domenico Berardi; Riccardo Meliconi; Francesco Ursini. Levels and Factors Associated with Resilience in Italian Healthcare Professionals during the COVID-19 Pandemic: A Web-Based Survey. Behavioral Sciences 2020, 10, 183 .

AMA Style

Lucia Lisi, Jacopo Ciaffi, Antonella Bruni, Luana Mancarella, Veronica Brusi, Pasquale Gramegna, Claudio Ripamonti, Elisabetta Quaranta, Elena Borlandelli, Gaetano Gallo, Eugenio Garofalo, Agostino Chiaravalloti, Pasquale Viola, Piero Ruscitti, Giacomo Caio, Martina D’Onghia, Andrea D’Amuri, Antonio Cimellaro, Giancarlo Facchini, Micaela La Regina, Luca Spinardi, Roberto de Giorgio, Roberto Giacomelli, Maria Paola Landini, Domenico Berardi, Riccardo Meliconi, Francesco Ursini. Levels and Factors Associated with Resilience in Italian Healthcare Professionals during the COVID-19 Pandemic: A Web-Based Survey. Behavioral Sciences. 2020; 10 (12):183.

Chicago/Turabian Style

Lucia Lisi; Jacopo Ciaffi; Antonella Bruni; Luana Mancarella; Veronica Brusi; Pasquale Gramegna; Claudio Ripamonti; Elisabetta Quaranta; Elena Borlandelli; Gaetano Gallo; Eugenio Garofalo; Agostino Chiaravalloti; Pasquale Viola; Piero Ruscitti; Giacomo Caio; Martina D’Onghia; Andrea D’Amuri; Antonio Cimellaro; Giancarlo Facchini; Micaela La Regina; Luca Spinardi; Roberto de Giorgio; Roberto Giacomelli; Maria Paola Landini; Domenico Berardi; Riccardo Meliconi; Francesco Ursini. 2020. "Levels and Factors Associated with Resilience in Italian Healthcare Professionals during the COVID-19 Pandemic: A Web-Based Survey." Behavioral Sciences 10, no. 12: 183.

Review
Published: 27 June 2020 in Microvascular Research
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The role of nailfold capillaroscopy (NC) in common non-rheumatic conditions has not been systematically reported. The aim of this review is to outline NC features observed in frequent non-rheumatic conditions, providing a practical tool to support rheumatologists for the interpretation of capillaroscopic abnormalities in patients with no established connective tissue disease (CTD). We undertook a systematic search in PubMed and Web of Science databases. Studies reporting adults or children with common non-rheumatic diseases or conditions in which quantitative and/or qualitative assessment of morphological nailbed capillary findings was obtained, were included. The presence of a control group composed by subjects not affected by the studied condition and direct comparison of findings between groups were needed. We included 25 articles. Diabetes mellitus (11 studies), glaucoma (7 studies) and essential hypertension (3 studies) were the most represented diseases. Reduced capillary density, tortuosity, dilated capillaries, microhaemorrhages, ramified capillaries and avascular areas can be observed in diabetic patients. Association was reported between poor glycaemic control or longer duration of diabetes, or presence of microvascular complications as retinopathy and neuropathy, and more severe capillaroscopic abnormalities. Decreased capillary density, tortuosity, microhaemorrhages, dilated capillaries, avascular areas and ramifications might also be present in glaucoma, while in essential hypertension a reduced capillary density might be expected. Abnormal capillaroscopic findings are not uncommon even in individuals with no CTD. Therefore, presence of comorbidities known to potentially affect the microvascular array should always be investigated in patients undergoing NC and the interpretation of findings might be weighted accordingly.

ACS Style

Jacopo Ciaffi; Nerenxa Ajasllari; Luana Mancarella; Veronica Brusi; Riccardo Meliconi; Francesco Ursini. Nailfold capillaroscopy in common non-rheumatic conditions: A systematic review and applications for clinical practice. Microvascular Research 2020, 131, 104036 .

AMA Style

Jacopo Ciaffi, Nerenxa Ajasllari, Luana Mancarella, Veronica Brusi, Riccardo Meliconi, Francesco Ursini. Nailfold capillaroscopy in common non-rheumatic conditions: A systematic review and applications for clinical practice. Microvascular Research. 2020; 131 ():104036.

Chicago/Turabian Style

Jacopo Ciaffi; Nerenxa Ajasllari; Luana Mancarella; Veronica Brusi; Riccardo Meliconi; Francesco Ursini. 2020. "Nailfold capillaroscopy in common non-rheumatic conditions: A systematic review and applications for clinical practice." Microvascular Research 131, no. : 104036.