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Dr. Abd El-Zaher MUSTAFA
king Saud university

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0 Genetic Diversity
0 Molecular and Chemical Ecology.
0 plant systematics
0 plant genetic resources
0 Plant Phylogeny

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Journal article
Published: 17 June 2021 in Molecules
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The present research investigated the chemical characterization and insecticidal activity of n-Hexane extracts of Epaltes divaricata (NH-EDx) along with their chief derivatives n-Hexadecanoic acid (n-HDa) and n-Octadecanoic acid (n-ODa) against the dengue vector Aedes aegypti and lepidopteran pest Spodoptera litura. Chemical screening of NH-EDx through GC–MS analysis delivered nine major derivatives, and the maximum peak area percentage was observed in n-Hexadecanoic acid (14.63%) followed by n-Octadecadienoic acid (6.73%). The larvicidal activity of NH-EDx (1000 ppm), n-HDa (5 ppm), and n-ODa (5 ppm) against the A. aegypti and S. litura larvae showed significant mortality rate in a dose-dependent way across all the instars. The larvicidal activity was profound in the A. aegypti as compared to the S. litura across all the larval instars. The sublethal dosages of NH-EDx (500 ppm), n-HDa (2.5 ppm), and n-ODa (2.5 ppm) also showed alterations in the larval/pupal durations and adult longevity in both the insect pests. The enzyme activity revealed that the α- and β-carboxylesterase levels were decreased significantly in both the insect pests, whereas the levels of GST and CYP450 uplifted in a dose-dependent manner of NH-EDx, n-HDa, and n-ODa. Correspondingly, midgut tissues such as the epithelial layer (EL), gut lumen (GL), peritrophic matrix (Pm), and brush border membrane (BBM) were significantly altered in their morphology across both A. aegypti and S. litura against the NH-EDx and their bioactive metabolites. NH-EDx and their bioactive metabolites n-HDa and n-ODa showed significant larvicidal, growth retardant, enzyme inhibition, and midgut toxicity effects against two crucial agriculturally and medically challenging insect pest of ecological importance.

ACS Style

Kesavan Amala; Sengodan Karthi; Raja Ganesan; Narayanaswamy Radhakrishnan; Kumaraswamy Srinivasan; Abd Mostafa; Abdullah Al-Ghamdi; Jawaher Alkahtani; Mohamed Elshikh; Sengottayan Senthil-Nathan; Prabhakaran Vasantha-Srinivasan; Patcharin Krutmuang. Bioefficacy of Epaltes divaricata (L.) n-Hexane Extracts and Their Major Metabolites against the Lepidopteran Pests Spodoptera litura (fab.) and Dengue Mosquito Aedes aegypti (Linn.). Molecules 2021, 26, 3695 .

AMA Style

Kesavan Amala, Sengodan Karthi, Raja Ganesan, Narayanaswamy Radhakrishnan, Kumaraswamy Srinivasan, Abd Mostafa, Abdullah Al-Ghamdi, Jawaher Alkahtani, Mohamed Elshikh, Sengottayan Senthil-Nathan, Prabhakaran Vasantha-Srinivasan, Patcharin Krutmuang. Bioefficacy of Epaltes divaricata (L.) n-Hexane Extracts and Their Major Metabolites against the Lepidopteran Pests Spodoptera litura (fab.) and Dengue Mosquito Aedes aegypti (Linn.). Molecules. 2021; 26 (12):3695.

Chicago/Turabian Style

Kesavan Amala; Sengodan Karthi; Raja Ganesan; Narayanaswamy Radhakrishnan; Kumaraswamy Srinivasan; Abd Mostafa; Abdullah Al-Ghamdi; Jawaher Alkahtani; Mohamed Elshikh; Sengottayan Senthil-Nathan; Prabhakaran Vasantha-Srinivasan; Patcharin Krutmuang. 2021. "Bioefficacy of Epaltes divaricata (L.) n-Hexane Extracts and Their Major Metabolites against the Lepidopteran Pests Spodoptera litura (fab.) and Dengue Mosquito Aedes aegypti (Linn.)." Molecules 26, no. 12: 3695.

Journal article
Published: 23 February 2021 in Sustainability
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Due to the scarcity of water, raw sewage effluents are often used to irrigate arable suburban soils in developing countries, which causes soil contamination with toxic metals. Soil microorganisms involved in biochemical transformations are sensitive to heavy metals contamination. The study was designed to investigate the effect of organic amendments on the microbial activity of cadmium (Cd), lead (Pb) and zinc (Zn) fractions and their bioavailability in soils contaminated with wastewater irrigation. Three metal contaminated soils under wastewater irrigation were collected, ground, sieved and added to incubation jars. Two organic amendments: wheat straw and chickpea straw, were applied (1% w/w) to the soil before incubation for 84 days at 25 °C. The CO2-C evolution after 1, 2, 3, 5, 7, 10 and 14 days was measured and thereafter was also measured weekly. Soil samples collected at 0, 14, 28, 42, 56, 70 and 84 days after incubation were analyzed for microbial biomass carbon (MBC). Sequential extraction for metal fractionation of samples was carried out collected at 0, 28, 56 and 84 days. Three soils differed significantly in evolved MBC and ∑CO2-C. Chickpea straw addition significantly increased soil MBC as compared to the wheat straw. Organic amendments significantly increased ∑CO2-C evolution from the soils, which was higher from chickpea straw. The addition of crop residues did not affect total Pb, Cd and Zn contents in soils. The concentration of exchangeable, carbonate bound and residual fractions of Pb, Cd and Zn decreased (6–27%), while the organic matter bound fraction increased (4–75%) with straw addition. Overall, the organic amendments improved microbial activity and reduce the bioavailability of toxic metals in wastewater irrigated soils. Furthermore, organic amendments not only reduce economic losses as they are cheap to produce but also minimize human health risks from heavy metals by hindering their entry into the food chain.

ACS Style

Kouser Malik; Khalid Khan; Shah Rukh; Ahmad Khan; Saba Akbar; Motsim Billah; Saqib Bashir; Subhan Danish; Mona Alwahibi; Mohamed Elshikh; Abdullah Al-Ghamdi; Abd Mustafa. Immobilization of Cd, Pb and Zn through Organic Amendments in Wastewater Irrigated Soils. Sustainability 2021, 13, 2392 .

AMA Style

Kouser Malik, Khalid Khan, Shah Rukh, Ahmad Khan, Saba Akbar, Motsim Billah, Saqib Bashir, Subhan Danish, Mona Alwahibi, Mohamed Elshikh, Abdullah Al-Ghamdi, Abd Mustafa. Immobilization of Cd, Pb and Zn through Organic Amendments in Wastewater Irrigated Soils. Sustainability. 2021; 13 (4):2392.

Chicago/Turabian Style

Kouser Malik; Khalid Khan; Shah Rukh; Ahmad Khan; Saba Akbar; Motsim Billah; Saqib Bashir; Subhan Danish; Mona Alwahibi; Mohamed Elshikh; Abdullah Al-Ghamdi; Abd Mustafa. 2021. "Immobilization of Cd, Pb and Zn through Organic Amendments in Wastewater Irrigated Soils." Sustainability 13, no. 4: 2392.

Perspective
Published: 12 November 2020 in Plants
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Whitefly (Bemisia tabaci)-transmitted Geminiviruses cause serious diseases of crop plants in tropical and sub-tropical regions. Plants, animals, and their microbial symbionts have evolved complex ways to interact with each other that impact their life cycles. Blocking virus transmission by altering the biology of vector species, such as the whitefly, can be a potential approach to manage these devastating diseases. Virus transmission by insect vectors to plant hosts often involves bacterial endosymbionts. Molecular chaperonins of bacterial endosymbionts bind with virus particles and have a key role in the transmission of Geminiviruses. Hence, devising new approaches to obstruct virus transmission by manipulating bacterial endosymbionts before infection opens new avenues for viral disease control. The exploitation of bacterial endosymbiont within the insect vector would disrupt interactions among viruses, insects, and their bacterial endosymbionts. The study of this cooperating web could potentially decrease virus transmission and possibly represent an effective solution to control viral diseases in crop plants.

ACS Style

Muhammad Salman Mubarik; Sultan Habibullah Khan; Aftab Ahmad; Ali Raza; Zulqurnain Khan; Muhammad Sajjad; Reda Helmy Ahmed Sammour; Abd El-Zaher M.A. Mustafa; Abdullah Ahmed Al-Ghamdi; Amal H. Alajmi; Fatin K. I. Alshamasi; Mohamed Soliman Elshikh. Controlling Geminiviruses before Transmission: Prospects. Plants 2020, 9, 1556 .

AMA Style

Muhammad Salman Mubarik, Sultan Habibullah Khan, Aftab Ahmad, Ali Raza, Zulqurnain Khan, Muhammad Sajjad, Reda Helmy Ahmed Sammour, Abd El-Zaher M.A. Mustafa, Abdullah Ahmed Al-Ghamdi, Amal H. Alajmi, Fatin K. I. Alshamasi, Mohamed Soliman Elshikh. Controlling Geminiviruses before Transmission: Prospects. Plants. 2020; 9 (11):1556.

Chicago/Turabian Style

Muhammad Salman Mubarik; Sultan Habibullah Khan; Aftab Ahmad; Ali Raza; Zulqurnain Khan; Muhammad Sajjad; Reda Helmy Ahmed Sammour; Abd El-Zaher M.A. Mustafa; Abdullah Ahmed Al-Ghamdi; Amal H. Alajmi; Fatin K. I. Alshamasi; Mohamed Soliman Elshikh. 2020. "Controlling Geminiviruses before Transmission: Prospects." Plants 9, no. 11: 1556.

Journal article
Published: 30 September 2020 in Chemosphere
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Di-(2-ethylhexyl) phthalic acid (DEHP) is the most extensively practiced plasticizer compound and a representative endocrine disrupting pollutant. Recently, the environmental impact and toxicological causes of DHEP on human health have been extensively investigated. DEHP uptake by plants is most significant biotransformation process of DEHP in environment. In this study, Helianthus annuus (H.annuus), vastly efficient in phytoremediation of polluted soil was selected to study the uptake and phytoremediation of DEHP in contaminated soil. In addition, the effect of citric acid on enhanced uptake and removal of DEHP was also investigated. The orders of biomass concentrations showed in the CA treatments were 200 mM (60.5 g) ˃ 150 mM (54.5) ˃ 100 mM (50.2 g) ˃ 50 mM (46.5 g). The maximum shoot accumulation of DHEP (20 mg/kg) was observed at 200 mM citric acid treatment compared to all other treatments (50, 100, and 150 mM). Significant difference of the antioxidant enzymes activity (CAT, 25.7, POD, 22.5 (μmol H2O2/min/g FW) and COD 5.6 U/g FW) was observed between control and CA treatments as well as different concentrations of CA treated plants. The maximum ALP (0.17 mg.g−1soil.24 h−1) and urease activities (1.65 mg.g−1soil.24 h−1) were observed at 200 mM CA amended soils. The application of citric acid was significantly enhanced the H.annuus growth as well as uptake of DEHP. The results explored that the citric acid has excellent potential for the enhanced uptake of DEHP in contaminated soil.

ACS Style

Abd El-Zaher M. A. Mustafa; Jawaher Alkahtani; Mohamed Soliman Elshikh; Manal M. Al Shaqhaa; Mona S. Alwahibi. Enhanced uptake of di-(2-ethylhexyl) phthalate by the influence of citric acid in Helianthus annuus cultivated in artificially contaminated soil. Chemosphere 2020, 264, 128485 .

AMA Style

Abd El-Zaher M. A. Mustafa, Jawaher Alkahtani, Mohamed Soliman Elshikh, Manal M. Al Shaqhaa, Mona S. Alwahibi. Enhanced uptake of di-(2-ethylhexyl) phthalate by the influence of citric acid in Helianthus annuus cultivated in artificially contaminated soil. Chemosphere. 2020; 264 ():128485.

Chicago/Turabian Style

Abd El-Zaher M. A. Mustafa; Jawaher Alkahtani; Mohamed Soliman Elshikh; Manal M. Al Shaqhaa; Mona S. Alwahibi. 2020. "Enhanced uptake of di-(2-ethylhexyl) phthalate by the influence of citric acid in Helianthus annuus cultivated in artificially contaminated soil." Chemosphere 264, no. : 128485.

Journal article
Published: 02 August 2020 in Journal of Infection and Public Health
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Biofilm forming ability of Pseudomonas aeruginosa make them vulnerable, because it makes them recalcitrant against various antibiotics. Quorum sensing (QS) is cell density based signaling that helps in bacterial cell–cell communication, which regulated various virulence factors such as pigment and biofilm formation that contribute in the establishment of chronic infections. The interruption of QS is one of the effective approach to control various virulence factors. Present study was intended with the aim to authenticate antibiofilm potential in different solvents based extracts of selected medicinal plant species viz. Berginia ciliata, Clematis grata and Clematis viticella traditionally used by the inhabitants of Himalayan region of Pakistan to treat various pathogenic diseases. P. aeruginosa PAO1, an opportunistic pathogen and involves in various life-threatening infections specifically in immune deficient patients was used as a model pathogen. Plants were extracted in various organic (ethanol, methanol, acetone, ethyl acetate, hexane, chloroform) as well as in aqueous solvents and their ability to inhibit biofilm was measured. Biofilm of PAO1 was grown in Jensen's medium while growing at 30 °C and crystal violet assay was performed to assess the biofilm inhibiting activity of plant extracts. Solvents play a vital role in extraction of plant components and it was found that the plants in various solvents exhibit different activity against the PAO1 biofilm. Comparatively, 1% methanolic extract of B. ciliata (rhizome with skin), showed more than 80% inhibition of biofilm formation without effecting on the growth of the bacterium. Significant correlation between flavonoids content and antibiofilm activity in methanolic extract revealed the contribution of secondary metabolites in P. aeruginosa (PAO1) biofilm inhibition. Our study revealed that plants under investigation more specifically B. ciliata could be a potential candidate for drug discovery to treat P. aeruginosa PAO1, induced infectious diseases especially for its biofilm treatment.

ACS Style

Khan Alam; Dunia A. Al Farraj; Syeda Mah-E-Fatima; Muhammad Arfat Yameen; Mohamed Soliman Elshikh; Roua M. Alkufeidy; Abd El-Zaher M.A. Mustafa; Pramod Bhasme; Maryam K. Alshammari; Noorah A. Alkubaisi; Arshad Mehmood Abbasi; Tatheer Alam Naqvi. Anti-biofilm activity of plant derived extracts against infectious pathogen-Pseudomonas aeruginosa PAO1. Journal of Infection and Public Health 2020, 13, 1734 -1741.

AMA Style

Khan Alam, Dunia A. Al Farraj, Syeda Mah-E-Fatima, Muhammad Arfat Yameen, Mohamed Soliman Elshikh, Roua M. Alkufeidy, Abd El-Zaher M.A. Mustafa, Pramod Bhasme, Maryam K. Alshammari, Noorah A. Alkubaisi, Arshad Mehmood Abbasi, Tatheer Alam Naqvi. Anti-biofilm activity of plant derived extracts against infectious pathogen-Pseudomonas aeruginosa PAO1. Journal of Infection and Public Health. 2020; 13 (11):1734-1741.

Chicago/Turabian Style

Khan Alam; Dunia A. Al Farraj; Syeda Mah-E-Fatima; Muhammad Arfat Yameen; Mohamed Soliman Elshikh; Roua M. Alkufeidy; Abd El-Zaher M.A. Mustafa; Pramod Bhasme; Maryam K. Alshammari; Noorah A. Alkubaisi; Arshad Mehmood Abbasi; Tatheer Alam Naqvi. 2020. "Anti-biofilm activity of plant derived extracts against infectious pathogen-Pseudomonas aeruginosa PAO1." Journal of Infection and Public Health 13, no. 11: 1734-1741.

Journal article
Published: 30 June 2020 in Saudi Journal of Biological Sciences
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Amygdalin a naturally occurring compound, predominantly in the bitter kernels of apricot, almond, apple and other members of Rosaceae family. Though, amygdalin is used as an alternative therapy to treat various types of cancer but its role in cancer pathways has rarely been explored yet. Therefore, present study was intended with the aim to investigate the alleged anti-cancerous effects of amygdalin specifically on PI3K–AKT–mTOR and Ras pathways of cancer in human body. Computational modelling and simulation techniques were used to assess the effect of amygdalin on PI3K-AKT-mTOR and Ras pathways using different level of dosage. It was observed that amygdalin had direct and substantial contribution to regulate PI3K-mTOR activities on threshold levels while the other caner pathways were effected indirectly. Consequently, amygdalin is a down-regulator of a cancer within a specified amount and contribute considerably to reduce various types of cancer in human. Furthermore, in-vitro and in-vivo analyses of amygdalin could be of helpful to authenticate its pharmacological effects.

ACS Style

Zainab Ayaz; Bibi Zainab; Sajid Khan; Arshad Mehmood Abbasi; Mohamed S. Elshikh; Anum Munir; Abdullah Ahmed Al-Ghamdi; Amal H. Alajmi; Qasi D. Alsubaie; Abd El-Zaher M.A. Mustafa. In silico authentication of amygdalin as a potent anticancer compound in the bitter kernels of family Rosaceae. Saudi Journal of Biological Sciences 2020, 27, 2444 -2451.

AMA Style

Zainab Ayaz, Bibi Zainab, Sajid Khan, Arshad Mehmood Abbasi, Mohamed S. Elshikh, Anum Munir, Abdullah Ahmed Al-Ghamdi, Amal H. Alajmi, Qasi D. Alsubaie, Abd El-Zaher M.A. Mustafa. In silico authentication of amygdalin as a potent anticancer compound in the bitter kernels of family Rosaceae. Saudi Journal of Biological Sciences. 2020; 27 (9):2444-2451.

Chicago/Turabian Style

Zainab Ayaz; Bibi Zainab; Sajid Khan; Arshad Mehmood Abbasi; Mohamed S. Elshikh; Anum Munir; Abdullah Ahmed Al-Ghamdi; Amal H. Alajmi; Qasi D. Alsubaie; Abd El-Zaher M.A. Mustafa. 2020. "In silico authentication of amygdalin as a potent anticancer compound in the bitter kernels of family Rosaceae." Saudi Journal of Biological Sciences 27, no. 9: 2444-2451.