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Dr. Ikarastika Rahayu Abdul Wahab
Faculty of Agro-based Industry, Universiti Malaysia Kelantan, Jeli Campus, 17600 Jeli, Kelantan, Malaysia

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0 Pharmacognosy
0 Ethnopharmacology
0 bioactivities
0 Natural active products

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Journal article
Published: 27 September 2020 in Water
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The contamination of water by heavy metals is a worldwide environmental problem. Phytoremediation and constructed wetlands have become increasingly popular as more sustainable and environmentally friendly techniques of removing heavy metals from the wastewater. This study, therefore, investigated the phytoremediation of nickel by Alocasia puber (A. puber) in a constructed wetlands (CW) microcosm. This study identified the optimum conditions for nickel (Ni) removal from wastewater using response surface methodology (RSM) with central composite design (CCD). Two operational variables were assessed: exposure time and initial Ni concentration. The optimum conditions for the maximum removal of Ni from water were an exposure time of 10 days and 99.76 mg/L initial Ni concentration. The results indicated that 95.6% removal was achieved under the optimized conditions, with a high correlation coefficient (R2 = 0.97) between the statistical model and the experimental data. Field emission scanning electron microscopy images showed anatomical changes in the A. puber samples due to Ni exposure, and transmission electron microscopy images revealed some internal damages in the A. puber, but visual Ni toxicity symptoms, such as necrosis and chlorosis, were not observed in the A. puber. This study demonstrated that A. puber planted in a constructed wetland microcosm was able to remediate wastewater contaminated with Ni.

ACS Style

Najaa Syuhada Mohamad Thani; Rozidaini Mohd Ghazi; Ikarastika Rahayu Abdul Wahab; Mohamad Faiz Mohd Amin; Zulhazman Hamzah; Nik Raihan Nik Yusoff. Optimization of Phytoremediation of Nickel by Alocasia puber Using Response Surface Methodology. Water 2020, 12, 2707 .

AMA Style

Najaa Syuhada Mohamad Thani, Rozidaini Mohd Ghazi, Ikarastika Rahayu Abdul Wahab, Mohamad Faiz Mohd Amin, Zulhazman Hamzah, Nik Raihan Nik Yusoff. Optimization of Phytoremediation of Nickel by Alocasia puber Using Response Surface Methodology. Water. 2020; 12 (10):2707.

Chicago/Turabian Style

Najaa Syuhada Mohamad Thani; Rozidaini Mohd Ghazi; Ikarastika Rahayu Abdul Wahab; Mohamad Faiz Mohd Amin; Zulhazman Hamzah; Nik Raihan Nik Yusoff. 2020. "Optimization of Phytoremediation of Nickel by Alocasia puber Using Response Surface Methodology." Water 12, no. 10: 2707.

Journal article
Published: 09 November 2017 in BMC Complementary and Alternative Medicine
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Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an attempt to develop a pharmaceutical product with antiulcer potential, the synergistic gastroprotective activity of methanolic extract of a mixture of MM and MC (MMMC) at various ratios was evaluated in rat models. Rats were pre-treated orally with 2% Tween 80 (vehicle), 100 mg/kg ranitidine (reference drug) or MMMC (ratios of 1:1, 1:3 and 3:1 (v/v); doses of 15, 150 or 300 mg/kg) and then subjected to the ethanol-induced gastric ulcer or pyloric ligation assays. Stomach of rats from the former assay was collected and subjected to the macroscopic and microscopic observations, and enzymatic and non-enzymatic antioxidant studies while the gastric juice content and tissue from the latter assay were subjected to the antisecretory activity study. The UHPLC analysis of MMMC was also performed. MMMC, in the ratio 1:1, demonstrated the most effective (P < 0.001) gastroprotective activity indicated by the highest reduction in ethanol-induced ulcer area formation. These macroscopic findings were supported by the microscopic observations. Except for pH and total acidity, MMMC also significantly (P < 0.001) reduced the volume of gastric content but increased the gastric wall mucus content in the pyloric-ligation test. MMMC also demonstrated remarkable antioxidant activity indicated by the highest total phenolic content (TPC) value and oxygen radical absorbance capacity (ORAC) activity with the recorded IC50 value of approximately 53 μg/mL for the 2,2- diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. MMMC also improved the catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), prostaglandin E2 (PGE2) and malondialdehyde (MDA) activities of the gastric tissue intoxicated by ethanol. UHPLC analysis of MMMC confirmed the presence several flavonoid-based bioactive compounds. MMMC, at the ratio of 1:1 (v/v), exerts gastroprotective activity partly by activating its antisecretory and antioxidant activities, and via modulation of the gastric tissue endogenous antioxidant system.

ACS Style

Siti Zawanah Halim; Zainul Amiruddin Zakaria; Maizatul Hasyima Omar; Norhafizah Mohtarrudin; Ikarastika Rahayu Abdul Wahab; Muhammad Nazrul Hakim Abdullah. Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats. BMC Complementary and Alternative Medicine 2017, 17, 488 .

AMA Style

Siti Zawanah Halim, Zainul Amiruddin Zakaria, Maizatul Hasyima Omar, Norhafizah Mohtarrudin, Ikarastika Rahayu Abdul Wahab, Muhammad Nazrul Hakim Abdullah. Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats. BMC Complementary and Alternative Medicine. 2017; 17 (1):488.

Chicago/Turabian Style

Siti Zawanah Halim; Zainul Amiruddin Zakaria; Maizatul Hasyima Omar; Norhafizah Mohtarrudin; Ikarastika Rahayu Abdul Wahab; Muhammad Nazrul Hakim Abdullah. 2017. "Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats." BMC Complementary and Alternative Medicine 17, no. 1: 488.