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Several organic salts based on the combination of two different choline derivative cations and MnCl3−, GdCl4− and TbCl4− as anions were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method.
Andreia Forte; Sandra Gago; Manuela Lopes Ribeiro Carrott; Peter J. M. Carrott; Celso Alves; Fernando Teodoro; Rui Pedrosa; Isabel M. Marrucho; Luis C. Branco. Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies. Dalton Transactions 2021, 50, 8588 -8599.
AMA StyleAndreia Forte, Sandra Gago, Manuela Lopes Ribeiro Carrott, Peter J. M. Carrott, Celso Alves, Fernando Teodoro, Rui Pedrosa, Isabel M. Marrucho, Luis C. Branco. Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies. Dalton Transactions. 2021; 50 (24):8588-8599.
Chicago/Turabian StyleAndreia Forte; Sandra Gago; Manuela Lopes Ribeiro Carrott; Peter J. M. Carrott; Celso Alves; Fernando Teodoro; Rui Pedrosa; Isabel M. Marrucho; Luis C. Branco. 2021. "Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies." Dalton Transactions 50, no. 24: 8588-8599.
Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution 1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanomaterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.
Blanca De Juan Mora; Luís Filipe; Andreia Forte; Miguel Santos; Celso Alves; Fernando Teodoro; Rui Pedrosa; Manuela Ribeiro Carrott; Luís Branco; Sandra Gago. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218 .
AMA StyleBlanca De Juan Mora, Luís Filipe, Andreia Forte, Miguel Santos, Celso Alves, Fernando Teodoro, Rui Pedrosa, Manuela Ribeiro Carrott, Luís Branco, Sandra Gago. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics. 2021; 13 (2):218.
Chicago/Turabian StyleBlanca De Juan Mora; Luís Filipe; Andreia Forte; Miguel Santos; Celso Alves; Fernando Teodoro; Rui Pedrosa; Manuela Ribeiro Carrott; Luís Branco; Sandra Gago. 2021. "Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles." Pharmaceutics 13, no. 2: 218.
Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of different fractions obtained from the brown seaweed Fucus spiralis. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant effects, fraction F10 demonstrated the highest antioxidant ability (EC50 of 38.5 µg/mL, DPPH assay), and exhibited a strong effect as an inhibitor of collagenase (0.037 µg/mL) and elastase (3.0 µg/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H2O2 (IC50 of 41.3 µg/mL) and by UVB (IC50 of 31.3 µg/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of F. spiralis for further dermatological applications.
Rafaela Freitas; Alice Martins; Joana Silva; Celso Alves; Susete Pinteus; Joana Alves; Fernando Teodoro; Helena Ribeiro; Lídia Gonçalves; Željko Petrovski; Luís Branco; Rui Pedrosa. Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications. Antioxidants 2020, 9, 611 .
AMA StyleRafaela Freitas, Alice Martins, Joana Silva, Celso Alves, Susete Pinteus, Joana Alves, Fernando Teodoro, Helena Ribeiro, Lídia Gonçalves, Željko Petrovski, Luís Branco, Rui Pedrosa. Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications. Antioxidants. 2020; 9 (7):611.
Chicago/Turabian StyleRafaela Freitas; Alice Martins; Joana Silva; Celso Alves; Susete Pinteus; Joana Alves; Fernando Teodoro; Helena Ribeiro; Lídia Gonçalves; Željko Petrovski; Luís Branco; Rui Pedrosa. 2020. "Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications." Antioxidants 9, no. 7: 611.
Joana Alves; Fernando Teodoro; Alexandra Cruz. Evaluation of the growth potential and cellulase production in Cellulomonas sp. using Ulva lactuca as carbon source. Frontiers in Marine Science 2018, 5, 1 .
AMA StyleJoana Alves, Fernando Teodoro, Alexandra Cruz. Evaluation of the growth potential and cellulase production in Cellulomonas sp. using Ulva lactuca as carbon source. Frontiers in Marine Science. 2018; 5 ():1.
Chicago/Turabian StyleJoana Alves; Fernando Teodoro; Alexandra Cruz. 2018. "Evaluation of the growth potential and cellulase production in Cellulomonas sp. using Ulva lactuca as carbon source." Frontiers in Marine Science 5, no. : 1.
Fábio Gomes; Fernando Teodoro; Joana Silva; Susete Pinteus; Celso Alves; Susana Bernardino; Rui Pedrosa. Biotechnological potential of Sulfated Polysaccharides isolated from macroalgae of the Peniche coast. Frontiers in Marine Science 2018, 5, 1 .
AMA StyleFábio Gomes, Fernando Teodoro, Joana Silva, Susete Pinteus, Celso Alves, Susana Bernardino, Rui Pedrosa. Biotechnological potential of Sulfated Polysaccharides isolated from macroalgae of the Peniche coast. Frontiers in Marine Science. 2018; 5 ():1.
Chicago/Turabian StyleFábio Gomes; Fernando Teodoro; Joana Silva; Susete Pinteus; Celso Alves; Susana Bernardino; Rui Pedrosa. 2018. "Biotechnological potential of Sulfated Polysaccharides isolated from macroalgae of the Peniche coast." Frontiers in Marine Science 5, no. : 1.
Fernando Teodoro; Fábio Gomes; Susete Pinteus; Celso Alves; Joana Silva; Susana Bernardino; Rui Pedrosa. Evaluation of the antimicrobial potential of sulfated polysaccharides from the marine invasive algae Asparagopsis armata (Harvey, 1855). Frontiers in Marine Science 2018, 5, 1 .
AMA StyleFernando Teodoro, Fábio Gomes, Susete Pinteus, Celso Alves, Joana Silva, Susana Bernardino, Rui Pedrosa. Evaluation of the antimicrobial potential of sulfated polysaccharides from the marine invasive algae Asparagopsis armata (Harvey, 1855). Frontiers in Marine Science. 2018; 5 ():1.
Chicago/Turabian StyleFernando Teodoro; Fábio Gomes; Susete Pinteus; Celso Alves; Joana Silva; Susana Bernardino; Rui Pedrosa. 2018. "Evaluation of the antimicrobial potential of sulfated polysaccharides from the marine invasive algae Asparagopsis armata (Harvey, 1855)." Frontiers in Marine Science 5, no. : 1.