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Healthy Diet and physical activity may play important roles in the maintenance of muscle health during aging. The aim of the present study was to explore the impact of adherence to healthy dietary patterns on sarcopenia risk in a sample of physically active older men and women, while considering adherence to guidelines on muscle strengthening activities (MSA) and protein intake. Based on a sample of 191 physically active men and women (65–70 years), dietary intake was assessed using a 90-items food-frequency-questionnaire (FFQ) and Healthy Diet Score (HDS) was calculated. Physical activity was assessed by accelerometry and self-report. A sarcopenia risk score (SRS) was derived based on three indicators of muscle health: muscle mass was assessed using bioelectrical impedance and handgrip strength and 5 times sit-to-stand (5-STS) were determined by standardized procedures. Analysis of covariance (ANCOVA) was used to examine differences in SRS and its components across sex-specific tertiles of HDS, with adjustments for covariates including total energy intake, protein intake and MSA. A significant main effect (p< 0.05) of HDS on SRS was observed, where those belonging to the highest HDS tertile had lower SRS compared to those in the lowest tertile. A corresponding significant effect was observed for 5-STS performance, with better performance in those with the highest HDS adherence compared to those with the lowest. The present study supports guidelines emphasizing diet quality beyond amounts of macro- and micronutrients in the prevention of age-related deterioration of muscle health. Importantly, the benefits from healthy dietary patterns are evident in older adults who already adhere to guidelines for health-enhancing physical activity.
Konstantinos-Georgios Papaioannou; Andreas Nilsson; Lena Maria Nilsson; Fawzi Kadi. Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults. Nutrients 2021, 13, 2813 .
AMA StyleKonstantinos-Georgios Papaioannou, Andreas Nilsson, Lena Maria Nilsson, Fawzi Kadi. Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults. Nutrients. 2021; 13 (8):2813.
Chicago/Turabian StyleKonstantinos-Georgios Papaioannou; Andreas Nilsson; Lena Maria Nilsson; Fawzi Kadi. 2021. "Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults." Nutrients 13, no. 8: 2813.
Climate change in the Arctic affects both environmental, animal, and human health, as well as human wellbeing and societal development. Women and men, and girls and boys are affected differently. Sex-disaggregated data collection is increasingly carried out as a routine in human health research and in healthcare analysis. This study involved a literature review and used a case study design to analyze gender differences in the roles and responsibilities of men and women residing in the Arctic. The theoretical background for gender-analysis is here described together with examples from the Russian Arctic and a literature search. We conclude that a broader gender-analysis of sex-disaggregated data followed by actions is a question of human rights and also of economic benefits for societies at large and of the quality of services as in the health care.
Arja Rautio; Natalia Kukarenko; Lena Maria Nilsson; Birgitta Evengard. Climate Change in the Arctic—The Need for a Broader Gender Perspective in Data Collection. International Journal of Environmental Research and Public Health 2021, 18, 628 .
AMA StyleArja Rautio, Natalia Kukarenko, Lena Maria Nilsson, Birgitta Evengard. Climate Change in the Arctic—The Need for a Broader Gender Perspective in Data Collection. International Journal of Environmental Research and Public Health. 2021; 18 (2):628.
Chicago/Turabian StyleArja Rautio; Natalia Kukarenko; Lena Maria Nilsson; Birgitta Evengard. 2021. "Climate Change in the Arctic—The Need for a Broader Gender Perspective in Data Collection." International Journal of Environmental Research and Public Health 18, no. 2: 628.
The role of dairy products in cancer is unclear. We assessed consumption of fermented milk, non-fermented milk, cheese, and butter, estimated from semi-quantitative food frequency questionnaires, in relation to prospective risk of breast, prostate, colorectal, smoking-, and obesity-related cancers in 101,235 subjects, including 12,552 cancer cases, in the population-based Northern Sweden Health and Disease Study. Most analyses (n = 20) rendered null results. In men, we observed an increased prostate cancer risk among high-consumers of cheese (hazard ratio (HR) for highest vs. lowest quintile (Q5-Q1), 1.11; 95% CI, 0.97-1.27; Ptrend = 0.013). In women, high-consumers of cheese had a decreased risk of overall cancer (HR Q5-Q1, 0.95; 95% CI, 0.88-1.04; Ptrend = 0.039), smoking-related (HR Q5-Q1, 0.84; 95% CI, 0.72-0.97; Ptrend ≤ 0.001), and colorectal cancers (HR Q5-Q1, 0.82; 95% CI, 0.63-1.07; Ptrend = 0.048). Butter yielded a weak decreased obesity-related cancer risk in women (HR Q5-Q1, 0.91; 95% CI, 0.81-1.02; Ptrend = 0.049). Fermented milk yielded HRs below zero in women, but with no clear linear associations. In conclusion, this study does not support any major adverse or beneficial effects of fermented milk, non-fermented milk, cheese, and butter in the diet from a cancer risk perspective.
Lena M. Nilsson; Anna Winkvist; Anders Esberg; Jan-Håkan Jansson; Patrik Wennberg; Bethany Van Guelpen; Ingegerd Johansson. Dairy Products and Cancer Risk in a Northern Sweden Population. Nutrition and Cancer 2019, 72, 409 -420.
AMA StyleLena M. Nilsson, Anna Winkvist, Anders Esberg, Jan-Håkan Jansson, Patrik Wennberg, Bethany Van Guelpen, Ingegerd Johansson. Dairy Products and Cancer Risk in a Northern Sweden Population. Nutrition and Cancer. 2019; 72 (3):409-420.
Chicago/Turabian StyleLena M. Nilsson; Anna Winkvist; Anders Esberg; Jan-Håkan Jansson; Patrik Wennberg; Bethany Van Guelpen; Ingegerd Johansson. 2019. "Dairy Products and Cancer Risk in a Northern Sweden Population." Nutrition and Cancer 72, no. 3: 409-420.
Background: There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition). Methods: In this prospective study of 409 885 men and women in 9 European countries, diet was assessed with validated questionnaires and calibrated with 24-hour recalls. Lipids and blood pressure were measured in a subsample. During a mean of 12.6 years of follow-up, 7198 participants had a myocardial infarction or died of IHD. The relationships of animal foods with risk were examined with Cox regression with adjustment for other animal foods and relevant covariates. Results: The hazard ratio (HR) for IHD was 1.19 (95% CI, 1.06–1.33) for a 100-g/d increment in intake of red and processed meat, and this remained significant after exclusion of the first 4 years of follow-up (HR, 1.25 [95% CI, 1.09–1.42]). Risk was inversely associated with intakes of yogurt (HR, 0.93 [95% CI, 0.89–0.98] per 100-g/d increment), cheese (HR, 0.92 [95% CI, 0.86–0.98] per 30-g/d increment), and eggs (HR, 0.93 [95% CI, 0.88–0.99] per 20-g/d increment); the associations with yogurt and eggs were attenuated and nonsignificant after exclusion of the first 4 years of follow-up. Risk was not significantly associated with intakes of poultry, fish, or milk. In analyses modeling dietary substitutions, replacement of 100 kcal/d from red and processed meat with 100 kcal/d from fatty fish, yogurt, cheese, or eggs was associated with ≈20% lower risk of IHD. Consumption of red and processed meat was positively associated with serum non–high-density lipoprotein cholesterol concentration and systolic blood pressure, and consumption of cheese was inversely associated with serum non–high-density lipoprotein cholesterol. Conclusions: Risk for IHD was positively associated with consumption of red and processed meat and inversely associated with consumption of yogurt, cheese, and eggs, although the associations with yogurt and eggs may be influenced by reverse causation bias. It is not clear whether the associations with red and processed meat and cheese reflect causality, but they were consistent with the associations of these foods with plasma non–high-density lipoprotein cholesterol and for red and processed meat with systolic blood pressure, which could mediate such effects.
Timothy J. Key; Paul N. Appleby; Kathryn E. Bradbury; Michael Sweeting; Angela Wood; Ingegerd Johansson; Tilman Kühn; Marinka Steur; Elisabete Weiderpass; Maria Wennberg; Anne Mette Lund Würtz; Antonio Agudo; Jonas Andersson; Larraitz Arriola; Heiner Boeing; Jolanda M.A. Boer; Fabrice Bonnet; Marie-Christine Boutron-Ruault; Amanda J. Cross; Ulrika Ericson; Guy Fagherazzi; Pietro Ferrari; Marc Gunter; José María Huerta; Verena Katzke; Kay-Tee Khaw; Vittorio Krogh; Carlo La Vecchia; Giuseppe Matullo; Conchi Moreno-Iribas; Androniki Naska; Lena Maria Nilsson; Anja Olsen; Kim Overvad; Domenico Palli; Salvatore Panico; Elena Molina-Portillo; J. Ramón Quirós; Guri Skeie; Ivonne Sluijs; Emily Sonestedt; Magdalena Stepien; Anne Tjønneland; Antonia Trichopoulou; Rosario Tumino; Ioanna Tzoulaki; Yvonne T. Van Der Schouw; W.M. Monique Verschuren; Emanuele Di Angelantonio; Claudia Langenberg; Nita Forouhi; Nick Wareham; Adam Butterworth; Elio Riboli; John Danesh. Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease. Circulation 2019, 139, 2835 -2845.
AMA StyleTimothy J. Key, Paul N. Appleby, Kathryn E. Bradbury, Michael Sweeting, Angela Wood, Ingegerd Johansson, Tilman Kühn, Marinka Steur, Elisabete Weiderpass, Maria Wennberg, Anne Mette Lund Würtz, Antonio Agudo, Jonas Andersson, Larraitz Arriola, Heiner Boeing, Jolanda M.A. Boer, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Amanda J. Cross, Ulrika Ericson, Guy Fagherazzi, Pietro Ferrari, Marc Gunter, José María Huerta, Verena Katzke, Kay-Tee Khaw, Vittorio Krogh, Carlo La Vecchia, Giuseppe Matullo, Conchi Moreno-Iribas, Androniki Naska, Lena Maria Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, Salvatore Panico, Elena Molina-Portillo, J. Ramón Quirós, Guri Skeie, Ivonne Sluijs, Emily Sonestedt, Magdalena Stepien, Anne Tjønneland, Antonia Trichopoulou, Rosario Tumino, Ioanna Tzoulaki, Yvonne T. Van Der Schouw, W.M. Monique Verschuren, Emanuele Di Angelantonio, Claudia Langenberg, Nita Forouhi, Nick Wareham, Adam Butterworth, Elio Riboli, John Danesh. Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease. Circulation. 2019; 139 (25):2835-2845.
Chicago/Turabian StyleTimothy J. Key; Paul N. Appleby; Kathryn E. Bradbury; Michael Sweeting; Angela Wood; Ingegerd Johansson; Tilman Kühn; Marinka Steur; Elisabete Weiderpass; Maria Wennberg; Anne Mette Lund Würtz; Antonio Agudo; Jonas Andersson; Larraitz Arriola; Heiner Boeing; Jolanda M.A. Boer; Fabrice Bonnet; Marie-Christine Boutron-Ruault; Amanda J. Cross; Ulrika Ericson; Guy Fagherazzi; Pietro Ferrari; Marc Gunter; José María Huerta; Verena Katzke; Kay-Tee Khaw; Vittorio Krogh; Carlo La Vecchia; Giuseppe Matullo; Conchi Moreno-Iribas; Androniki Naska; Lena Maria Nilsson; Anja Olsen; Kim Overvad; Domenico Palli; Salvatore Panico; Elena Molina-Portillo; J. Ramón Quirós; Guri Skeie; Ivonne Sluijs; Emily Sonestedt; Magdalena Stepien; Anne Tjønneland; Antonia Trichopoulou; Rosario Tumino; Ioanna Tzoulaki; Yvonne T. Van Der Schouw; W.M. Monique Verschuren; Emanuele Di Angelantonio; Claudia Langenberg; Nita Forouhi; Nick Wareham; Adam Butterworth; Elio Riboli; John Danesh. 2019. "Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease." Circulation 139, no. 25: 2835-2845.
Inflammation-related mechanisms may contribute to the link between diet and cancer. We sought to investigate the inflammatory impact of diet on cancer risk using the Dietary inflammatory index (DII) and an adapted Mediterranean diet score (MDS). This population-based, prospective cohort study used self-reported dietary data from the Västerbotten Intervention Programme, including 100,881 participants, of whom 35,393 had repeated measures. Associations between dietary patterns and cancer risk were evaluated using Cox proportional hazards regression. We also used restricted cubic splines to test for potential non-linear associations. A total of 9,250 incident cancer cases were diagnosed during a median follow-up of 15 years. The two dietary patterns were moderately correlated to each other and had similar associations with cancer risk, predominantly lung cancer in men (DII per tertile decrease: Hazard ratio (HR) 0.81 (0.66–0.99), MDS per tertile increase: HR 0.86 (0.72–1.03)), and gastric cancer in men (DII: 0.73 (0.53–0.99), MDS: 0.73 (0.56–0.96)). Associations were, in general, found to be linear. We found no longitudinal association between 10-year change in diet and cancer risk. We confirm small, but consistent and statistically significant associations between a more anti-inflammatory or healthier diet and reduced risk of cancer, including a lower risk of lung and gastric cancer in men. The dietary indexes produced similar associations with respect to the risk of cancer.
Stina Bodén; Robin Myte; Maria Wennberg; Sophia Harlid; Ingegerd Johansson; Nitin Shivappa; James R. Hébert; Bethany Van Guelpen; Lena Maria Nilsson. The inflammatory potential of diet in determining cancer risk; A prospective investigation of two dietary pattern scores. PLoS ONE 2019, 14, e0214551 .
AMA StyleStina Bodén, Robin Myte, Maria Wennberg, Sophia Harlid, Ingegerd Johansson, Nitin Shivappa, James R. Hébert, Bethany Van Guelpen, Lena Maria Nilsson. The inflammatory potential of diet in determining cancer risk; A prospective investigation of two dietary pattern scores. PLoS ONE. 2019; 14 (4):e0214551.
Chicago/Turabian StyleStina Bodén; Robin Myte; Maria Wennberg; Sophia Harlid; Ingegerd Johansson; Nitin Shivappa; James R. Hébert; Bethany Van Guelpen; Lena Maria Nilsson. 2019. "The inflammatory potential of diet in determining cancer risk; A prospective investigation of two dietary pattern scores." PLoS ONE 14, no. 4: e0214551.
Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.
Marta Solans; Yolanda Benavente; Marc Saez; Antonio Agudo; Paula Jakszyn; Sabine Naudin; Fatemeh Saberi Hosnijeh; Marc Gunter; Inge Huybrechts; Pietro Ferrari; Caroline Besson; Yahya Mahamat-Saleh; Marie-Christine Boutron-Ruault; Tilman Kühn; Rudolf Kaaks; Heiner Boeing; Maria Cristina Lasheras-Mayo; Maria-Jose Sánchez; Pilar Amiano; María Dolores Chirlaque; Eva Ardanaz; Julie A. Schmidt; Paolo Vineis; Elio Riboli; Antonia Trichopoulou; Anna Karakatsani; Elisavet Valanou; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Carlotta Sacerdote; Amalia Mattiello; Guri Skeie; Elisabete Weiderpass; Mats Jerkeman; Joana Dias; Florentin Späth; Lena Maria Nilsson; Christina Dahm; Kim Overvad; Kristina Elin Nielsen Petersen; Anne Tjonneland; Silvia De Sanjose; Roel Vermeulen; Alexandra Nieters; Delphine Casabonne. Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. European Journal of Nutrition 2019, 59, 813 -823.
AMA StyleMarta Solans, Yolanda Benavente, Marc Saez, Antonio Agudo, Paula Jakszyn, Sabine Naudin, Fatemeh Saberi Hosnijeh, Marc Gunter, Inge Huybrechts, Pietro Ferrari, Caroline Besson, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Maria Cristina Lasheras-Mayo, Maria-Jose Sánchez, Pilar Amiano, María Dolores Chirlaque, Eva Ardanaz, Julie A. Schmidt, Paolo Vineis, Elio Riboli, Antonia Trichopoulou, Anna Karakatsani, Elisavet Valanou, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, Guri Skeie, Elisabete Weiderpass, Mats Jerkeman, Joana Dias, Florentin Späth, Lena Maria Nilsson, Christina Dahm, Kim Overvad, Kristina Elin Nielsen Petersen, Anne Tjonneland, Silvia De Sanjose, Roel Vermeulen, Alexandra Nieters, Delphine Casabonne. Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. European Journal of Nutrition. 2019; 59 (2):813-823.
Chicago/Turabian StyleMarta Solans; Yolanda Benavente; Marc Saez; Antonio Agudo; Paula Jakszyn; Sabine Naudin; Fatemeh Saberi Hosnijeh; Marc Gunter; Inge Huybrechts; Pietro Ferrari; Caroline Besson; Yahya Mahamat-Saleh; Marie-Christine Boutron-Ruault; Tilman Kühn; Rudolf Kaaks; Heiner Boeing; Maria Cristina Lasheras-Mayo; Maria-Jose Sánchez; Pilar Amiano; María Dolores Chirlaque; Eva Ardanaz; Julie A. Schmidt; Paolo Vineis; Elio Riboli; Antonia Trichopoulou; Anna Karakatsani; Elisavet Valanou; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Carlotta Sacerdote; Amalia Mattiello; Guri Skeie; Elisabete Weiderpass; Mats Jerkeman; Joana Dias; Florentin Späth; Lena Maria Nilsson; Christina Dahm; Kim Overvad; Kristina Elin Nielsen Petersen; Anne Tjonneland; Silvia De Sanjose; Roel Vermeulen; Alexandra Nieters; Delphine Casabonne. 2019. "Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition." European Journal of Nutrition 59, no. 2: 813-823.
Dairy products are important constituents of most diets, and their association with adverse health outcomes remains a focus. We characterized dairy food intake and examined associations with the incidence of type 2 diabetes (T2D), myocardial infarction (MI) or stroke among 108,065 Swedish men and women. Hazard ratios (HRs) and 95% CIs were estimated using the multivariable Cox proportional hazards models in a population characterized by high milk tolerance. During a mean follow-up of 14.2 years, 11,641 first-time events occurred. Non-fermented milk intake decreased, whereas butter intake increased over the period. For high intake of non-fermented milk, the HR (95% CI) for developing T2D and MI was 1.17 (1.03, 1.34) and 1.23 (1.10, 1.37), respectively, in men. A greater intake of butter, fermented milk, and cheese tended to be associated with a reduced risk of T2D and/or MI. Non-consumers and those who chose low-fat variants of the targeted dairy products had increased risk for T2D, MI, or stroke compared to those in the non-case group. Generally, effect-sizes were small. This prospective study found that non-fermented milk was associated with an increased risk for developing T2D and MI and that subjects abstaining from dairy products or choosing low-fat variants were at greater risk. However, the overall cardiometabolic risk of non-fermented milk intake was judged as low, since the effect sizes were small.
Ingegerd Johansson; Anders Esberg; Lena M Nilsson; Jan-Håkan Jansson; Patrik Wennberg; Anna Winkvist. Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study. Nutrients 2019, 11, 284 .
AMA StyleIngegerd Johansson, Anders Esberg, Lena M Nilsson, Jan-Håkan Jansson, Patrik Wennberg, Anna Winkvist. Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study. Nutrients. 2019; 11 (2):284.
Chicago/Turabian StyleIngegerd Johansson; Anders Esberg; Lena M Nilsson; Jan-Håkan Jansson; Patrik Wennberg; Anna Winkvist. 2019. "Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study." Nutrients 11, no. 2: 284.
There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The analysis included 476,160 participants, recruited from 10 European countries between 1991 and 2001. Adherence to the MD was estimated through the adapted relative MD (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for potential confounders. During an average follow‐up of 13.9 years, 3,136 lymphomas (135 Hodgkin lymphoma [HL], 2,606 non‐HL and 395 lymphoma not otherwise specified) were identified. Overall, a 1‐unit increase in the arMED score was associated with a 2% lower risk of lymphoma (95% CI: 0.97; 1.00, p‐trend = 0.03) while a statistically nonsignificant inverse association between a high versus low arMED score and risk of lymphoma was observed (hazard ratio [HR]: 0.91 [95% CI 0.80; 1.03], p‐trend = 0.12). Analyses by lymphoma subtype did not reveal any statistically significant associations. Albeit with small numbers of cases (N = 135), a suggestive inverse association was found for HL (HR 1‐unit increase = 0.93 [95% CI: 0.86; 1.01], p‐trend = 0.07). However, the study may have lacked statistical power to detect small effect sizes for lymphoma subtype. Our findings suggest that an increasing arMED score was inversely related to the risk of overall lymphoma in EPIC but not by subtypes. Further large prospective studies are warranted to confirm these findings.
Marta Solans; Yolanda Benavente; Marc Saez; Antonio Agudo; Sabine Naudin; Fatemeh Saberi Hosnijeh; Hwayoung Noh; Heinz Freisling; Pietro Ferrari; Caroline Besson; Yahya Mahamat‐Saleh; Marie‐Christine Boutron‐Ruault; Tilman Kühn; Rudolf Kaaks; Heiner Boeing; Maria Cristina Lasheras-Mayo; Miguel Rodríguez‐Barranco; Pilar Amiano; José María Huerta; Aurelio Barricarte; Julie A. Schmidt; Paolo Vineis; Elio Riboli; Antonia Trichopoulou; Christina Bamia; Eleni Peppa; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Carlotta Sacerdote; Salvatore Panico; Guri Skeie; Elisabete Weiderpass; Mats Jerkeman; Ulrika Ericson; Florentin Späth; Lena Maria Nilsson; Christina Dahm; Kim Overvad; Anne Katrine Bolvig; Anne Tjonneland; Silvia De Sanjose; Genevieve Buckland; Roel Vermeulen; Alexandra Nieters; Delphine Casabonne. Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition. International Journal of Cancer 2018, 145, 122 -131.
AMA StyleMarta Solans, Yolanda Benavente, Marc Saez, Antonio Agudo, Sabine Naudin, Fatemeh Saberi Hosnijeh, Hwayoung Noh, Heinz Freisling, Pietro Ferrari, Caroline Besson, Yahya Mahamat‐Saleh, Marie‐Christine Boutron‐Ruault, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Maria Cristina Lasheras-Mayo, Miguel Rodríguez‐Barranco, Pilar Amiano, José María Huerta, Aurelio Barricarte, Julie A. Schmidt, Paolo Vineis, Elio Riboli, Antonia Trichopoulou, Christina Bamia, Eleni Peppa, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Guri Skeie, Elisabete Weiderpass, Mats Jerkeman, Ulrika Ericson, Florentin Späth, Lena Maria Nilsson, Christina Dahm, Kim Overvad, Anne Katrine Bolvig, Anne Tjonneland, Silvia De Sanjose, Genevieve Buckland, Roel Vermeulen, Alexandra Nieters, Delphine Casabonne. Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition. International Journal of Cancer. 2018; 145 (1):122-131.
Chicago/Turabian StyleMarta Solans; Yolanda Benavente; Marc Saez; Antonio Agudo; Sabine Naudin; Fatemeh Saberi Hosnijeh; Hwayoung Noh; Heinz Freisling; Pietro Ferrari; Caroline Besson; Yahya Mahamat‐Saleh; Marie‐Christine Boutron‐Ruault; Tilman Kühn; Rudolf Kaaks; Heiner Boeing; Maria Cristina Lasheras-Mayo; Miguel Rodríguez‐Barranco; Pilar Amiano; José María Huerta; Aurelio Barricarte; Julie A. Schmidt; Paolo Vineis; Elio Riboli; Antonia Trichopoulou; Christina Bamia; Eleni Peppa; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Carlotta Sacerdote; Salvatore Panico; Guri Skeie; Elisabete Weiderpass; Mats Jerkeman; Ulrika Ericson; Florentin Späth; Lena Maria Nilsson; Christina Dahm; Kim Overvad; Anne Katrine Bolvig; Anne Tjonneland; Silvia De Sanjose; Genevieve Buckland; Roel Vermeulen; Alexandra Nieters; Delphine Casabonne. 2018. "Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition." International Journal of Cancer 145, no. 1: 122-131.
The association between milk and dairy intake and the incidence of cardiometabolic diseases, cancer and mortality has been evaluated in many studies, but these studies have had conflicting results with no clear conclusion on causal or confounding associations. The present study aims to further address this association by cross-sectional and longitudinal evaluation of the associations between exposure to various types of dairy products and metabolic risk markers among inhabitants in northern Sweden while taking other lifestyle factors into account. Respondents in the Västerbotten Intervention Programme with complete and plausible diet data between 1991 and 2016 were included, yielding 124,934 observations from 90,512 unique subjects. For longitudinal analysis, 27,682 participants with a visit 8-12 years after the first visit were identified. All participants completed a validated Food Frequency Questionnaire. Metabolic risk markers, including body mass index (BMI), blood pressure, serum (S) cholesterol and triglycerides, and blood glucose, were measured. Participants were categorized into quintiles by intake of dairy products, and risk (odds ratios, OR) of undesirable levels of metabolic risk markers was assessed in multivariable logistic regression analyses. In longitudinal analyses, intake quintiles were related to desirable levels of metabolic risk markers at both visits or deterioration at follow-up using Cox regression analyses. The OR of being classified with an undesirable BMI decreased with increasing quintiles of total dairy, cheese and butter intake but increased with increasing non-fermented milk intake. The OR of being classified with an undesirable S-cholesterol level increased with increasing intake of total dairy, butter and high fat (3%) non-fermented milk, whereas an undesirable S-triglyceride level was inversely associated with cheese and butter intake in women. In longitudinal analyses, increasing butter intake was associated with deterioration of S-cholesterol and blood glucose levels, whereas increasing cheese intake was associated with a lower risk of deterioration of S-triglycerides. Confounding factors likely contribute to the demonstrated association between dairy intake and mortality, and other medical conditions and analyses should be stratified by dairy type.
Ingegerd Johansson; Lena Maria Nilsson; Anders Esberg; Jan-Håkan Jansson; Anna Winkvist. Dairy intake revisited – associations between dairy intake and lifestyle related cardio-metabolic risk factors in a high milk consuming population. Nutrition Journal 2018, 17, 110 .
AMA StyleIngegerd Johansson, Lena Maria Nilsson, Anders Esberg, Jan-Håkan Jansson, Anna Winkvist. Dairy intake revisited – associations between dairy intake and lifestyle related cardio-metabolic risk factors in a high milk consuming population. Nutrition Journal. 2018; 17 (1):110.
Chicago/Turabian StyleIngegerd Johansson; Lena Maria Nilsson; Anders Esberg; Jan-Håkan Jansson; Anna Winkvist. 2018. "Dairy intake revisited – associations between dairy intake and lifestyle related cardio-metabolic risk factors in a high milk consuming population." Nutrition Journal 17, no. 1: 110.
The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow‐up. Data on coffee and tea consumption were collected through validated country‐specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 mL/day and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 mL/day versus 12 mL/day) the HRs were 1.02 (95% CI, 0.94‐1.09) and 0.98 (95% CI, 0.90‐1.07) for risk of total prostate cancer, and 0.97 (95% CI, 0.79‐1.21) and 0.89 (95% CI, 0.70‐1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages. This article is protected by copyright. All rights reserved.
Abhijit Sen; Nikos Papadimitriou; Pagona Lagiou; Aurora Perez-Cornago; Ruth C. Travis; Timothy J. Key; Neil Murphy; Marc Gunter; Heinz Freisling; Ioanna Tzoulaki; David Muller; Amanda J. Cross; David S. Lopez; Manuela Bergmann; Heiner Boeing; Christina Bamia; Anastasia Kotanidou; Anna Karakatsani; Anne Tjønneland; Cecilie Kyrø; Malene Outzen; María-Luisa Redondo; Valerie Cayssials; Maria-Dolores Chirlaque; Aurelio Barricarte; Maria-Jose Sánchez; Nerea Larrañaga; Rosario Tumino; Sara Grioni; Domenico Palli; Saverio Caini; Carlotta Sacerdote; Bas Bueno-De-Mesquita; Tilman Kühn; Rudolf Kaaks; Lena Maria Nilsson; Rikard Landberg; Peter Wallström; Isabel Drake; Bodil Hammer Bech; Kim Overvad; Dagfinn Aune; Kay-Tee Khaw; Elio Riboli; Dimitrios Trichopoulos; Antonia Trichopoulou; Konstantinos K. Tsilidis. Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer 2018, 144, 240 -250.
AMA StyleAbhijit Sen, Nikos Papadimitriou, Pagona Lagiou, Aurora Perez-Cornago, Ruth C. Travis, Timothy J. Key, Neil Murphy, Marc Gunter, Heinz Freisling, Ioanna Tzoulaki, David Muller, Amanda J. Cross, David S. Lopez, Manuela Bergmann, Heiner Boeing, Christina Bamia, Anastasia Kotanidou, Anna Karakatsani, Anne Tjønneland, Cecilie Kyrø, Malene Outzen, María-Luisa Redondo, Valerie Cayssials, Maria-Dolores Chirlaque, Aurelio Barricarte, Maria-Jose Sánchez, Nerea Larrañaga, Rosario Tumino, Sara Grioni, Domenico Palli, Saverio Caini, Carlotta Sacerdote, Bas Bueno-De-Mesquita, Tilman Kühn, Rudolf Kaaks, Lena Maria Nilsson, Rikard Landberg, Peter Wallström, Isabel Drake, Bodil Hammer Bech, Kim Overvad, Dagfinn Aune, Kay-Tee Khaw, Elio Riboli, Dimitrios Trichopoulos, Antonia Trichopoulou, Konstantinos K. Tsilidis. Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 2018; 144 (2):240-250.
Chicago/Turabian StyleAbhijit Sen; Nikos Papadimitriou; Pagona Lagiou; Aurora Perez-Cornago; Ruth C. Travis; Timothy J. Key; Neil Murphy; Marc Gunter; Heinz Freisling; Ioanna Tzoulaki; David Muller; Amanda J. Cross; David S. Lopez; Manuela Bergmann; Heiner Boeing; Christina Bamia; Anastasia Kotanidou; Anna Karakatsani; Anne Tjønneland; Cecilie Kyrø; Malene Outzen; María-Luisa Redondo; Valerie Cayssials; Maria-Dolores Chirlaque; Aurelio Barricarte; Maria-Jose Sánchez; Nerea Larrañaga; Rosario Tumino; Sara Grioni; Domenico Palli; Saverio Caini; Carlotta Sacerdote; Bas Bueno-De-Mesquita; Tilman Kühn; Rudolf Kaaks; Lena Maria Nilsson; Rikard Landberg; Peter Wallström; Isabel Drake; Bodil Hammer Bech; Kim Overvad; Dagfinn Aune; Kay-Tee Khaw; Elio Riboli; Dimitrios Trichopoulos; Antonia Trichopoulou; Konstantinos K. Tsilidis. 2018. "Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition." International Journal of Cancer 144, no. 2: 240-250.
Sápmi is the Sami homeland in northernmost Fennoscandia and the Kola Peninsula of Russia. The traditional diet in Sápmi is based on wild plants and animals available in this Arctic area. From a micronutrient perspective, this means a diet rich in fat and protein and poor in carbohydrates and fiber; thus there is a discrepancy between the traditional diet in Sápmi and current dietary recommendations. Despite this, the Sami people are known to be the healthiest indigenous population worldwide. If this, fully or partly, can be explained by dietary factors, it is still unclear. Nutrition epidemiology studies focusing specifically on traditional Sami dietary patterns as determinants of health are rare. This chapter summarizes current knowledge on the health aspects of some dietary patterns, food items, and preparation techniques of relevance in Sápmi.
Lena Maria Nilsson. Food, Nutrition, and Health in Sápmi. Nutritional and Health Aspects of Food in Nordic Countries 2018, 179 -195.
AMA StyleLena Maria Nilsson. Food, Nutrition, and Health in Sápmi. Nutritional and Health Aspects of Food in Nordic Countries. 2018; ():179-195.
Chicago/Turabian StyleLena Maria Nilsson. 2018. "Food, Nutrition, and Health in Sápmi." Nutritional and Health Aspects of Food in Nordic Countries , no. : 179-195.
Phytoestrogens may influence prostate cancer development. This study aimed to examine the association between prediagnostic circulating concentrations of isoflavones (genistein, daidzein, equol) and lignans (enterolactone and enterodiol) and the risk of prostate cancer. Individual participant data were available from seven prospective studies (two studies from Japan with 241 cases and 503 controls and five studies from Europe with 2,828 cases and 5,593 controls). Because of the large difference in circulating isoflavone concentrations between Japan and Europe, analyses of the associations of isoflavone concentrations and prostate cancer risk were evaluated separately. Prostate cancer risk by study‐specific fourths of circulating concentrations of each phytoestrogen was estimated using multivariable‐adjusted conditional logistic regression. In men from Japan, those with high compared to low circulating equol concentrations had a lower risk of prostate cancer (multivariable‐adjusted OR for upper quartile [Q4] vs. Q1 = 0.61, 95% confidence interval [CI] = 0.39–0.97), although there was no significant trend (OR per 75 percentile increase = 0.69, 95 CI = 0.46–1.05, ptrend = 0.085); Genistein and daidzein concentrations were not significantly associated with risk (ORs for Q4 vs. Q1 = 0.70, 0.45–1.10 and 0.71, 0.45–1.12, respectively). In men from Europe, circulating concentrations of genistein, daidzein and equol were not associated with risk. Circulating lignan concentrations were not associated with the risk of prostate cancer, overall or by disease aggressiveness or time to diagnosis. There was no strong evidence that prediagnostic circulating concentrations of isoflavones or lignans are associated with prostate cancer risk, although further research is warranted in populations where isoflavone intakes are high.
Aurora Perez-Cornago; Paul N. Appleby; Heiner Boeing; Leire Gil; Cecilie Kyrø; Fulvio Ricceri; Neil Murphy; Antonia Trichopoulou; Konstantinos K. Tsilidis; Kay-Tee Khaw; Robert N. Luben; Randi E Gislefoss; Hilde Langseth; Isabel Drake; Emily Sonestedt; Peter Wallström; Pär Stattin; Anders Johansson; Rikard Landberg; Lena Maria Nilsson; Kotaro Ozasa; Akiko Tamakoshi; Kazuya Mikami; Tatsuhiko Kubo; Norie Sawada; Shoichiro Tsugane; Timothy J. Key; Naomi E. Allen; Ruth C. Travis. Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls. International Journal of Cancer 2018, 143, 2677 -2686.
AMA StyleAurora Perez-Cornago, Paul N. Appleby, Heiner Boeing, Leire Gil, Cecilie Kyrø, Fulvio Ricceri, Neil Murphy, Antonia Trichopoulou, Konstantinos K. Tsilidis, Kay-Tee Khaw, Robert N. Luben, Randi E Gislefoss, Hilde Langseth, Isabel Drake, Emily Sonestedt, Peter Wallström, Pär Stattin, Anders Johansson, Rikard Landberg, Lena Maria Nilsson, Kotaro Ozasa, Akiko Tamakoshi, Kazuya Mikami, Tatsuhiko Kubo, Norie Sawada, Shoichiro Tsugane, Timothy J. Key, Naomi E. Allen, Ruth C. Travis. Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls. International Journal of Cancer. 2018; 143 (11):2677-2686.
Chicago/Turabian StyleAurora Perez-Cornago; Paul N. Appleby; Heiner Boeing; Leire Gil; Cecilie Kyrø; Fulvio Ricceri; Neil Murphy; Antonia Trichopoulou; Konstantinos K. Tsilidis; Kay-Tee Khaw; Robert N. Luben; Randi E Gislefoss; Hilde Langseth; Isabel Drake; Emily Sonestedt; Peter Wallström; Pär Stattin; Anders Johansson; Rikard Landberg; Lena Maria Nilsson; Kotaro Ozasa; Akiko Tamakoshi; Kazuya Mikami; Tatsuhiko Kubo; Norie Sawada; Shoichiro Tsugane; Timothy J. Key; Naomi E. Allen; Ruth C. Travis. 2018. "Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls." International Journal of Cancer 143, no. 11: 2677-2686.
Background: Coffee and tea are among the most commonly consumed nonalcoholic beverages worldwide, but methodological differences in assessing intake often hamper comparisons across populations. We aimed to (i) describe coffee and tea intakes and (ii) assess their contribution to intakes of selected nutrients in adults across 10 European countries. Method: Between 1995 and 2000, a standardized 24-h dietary recall was conducted among 36,018 men and women from 27 European Prospective Investigation into Cancer and Nutrition (EPIC) study centres. Adjusted arithmetic means of intakes were estimated in grams (=volume) per day by sex and centre. Means of intake across centres were compared by sociodemographic characteristics and lifestyle factors. Results: In women, the mean daily intake of coffee ranged from 94 g/day (~0.6 cups) in Greece to 781 g/day (~4.4 cups) in Aarhus (Denmark), and tea from 14 g/day (~0.1 cups) in Navarra (Spain) to 788 g/day (~4.3 cups) in the UK general population. Similar geographical patterns for mean daily intakes of both coffee and tea were observed in men. Current smokers as compared with those who reported never smoking tended to drink on average up to 500 g/day more coffee and tea combined, but with substantial variation across centres. Other individuals’ characteristics such as educational attainment or age were less predictive. In all centres, coffee and tea contributed to less than 10% of the energy intake. The greatest contribution to total sugar intakes was observed in Southern European centres (up to ~20%). Conclusion: Coffee and tea intake and their contribution to energy and sugar intake differed greatly among European adults. Variation in consumption was mostly driven by geographical region.
Edwige Landais; Aurélie Moskal; Amy Mullee; Geneviève Nicolas; Marc J. Gunter; Inge Huybrechts; Kim Overvad; Nina Roswall; Aurélie Affret; Guy Fagherazzi; Yahya Mahamat-Saleh; Verena Katzke; Tilman Kühn; Carlo La Vecchia; Antonia Trichopoulou; Elissavet Valanou; Calogero Saieva; Maria Santucci De Magistris; Sabina Sieri; Tonje Braaten; Guri Skeie; Elisabete Weiderpass; Eva Ardanaz; Maria-Dolores Chirlaque; Jose Ramon Garcia; Paula Jakszyn; Miguel Rodríguez-Barranco; Louise Brunkwall; Ena Huseinovic; Lena Nilsson; Peter Wallström; Bas Bueno-De-Mesquita; Petra H. Peeters; Dagfinn Aune; Tim Key; Marleen Lentjes; Elio Riboli; Nadia Slimani; Heinz Freisling. Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries: Benchmark Data from the Late 1990s. Nutrients 2018, 10, 725 .
AMA StyleEdwige Landais, Aurélie Moskal, Amy Mullee, Geneviève Nicolas, Marc J. Gunter, Inge Huybrechts, Kim Overvad, Nina Roswall, Aurélie Affret, Guy Fagherazzi, Yahya Mahamat-Saleh, Verena Katzke, Tilman Kühn, Carlo La Vecchia, Antonia Trichopoulou, Elissavet Valanou, Calogero Saieva, Maria Santucci De Magistris, Sabina Sieri, Tonje Braaten, Guri Skeie, Elisabete Weiderpass, Eva Ardanaz, Maria-Dolores Chirlaque, Jose Ramon Garcia, Paula Jakszyn, Miguel Rodríguez-Barranco, Louise Brunkwall, Ena Huseinovic, Lena Nilsson, Peter Wallström, Bas Bueno-De-Mesquita, Petra H. Peeters, Dagfinn Aune, Tim Key, Marleen Lentjes, Elio Riboli, Nadia Slimani, Heinz Freisling. Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries: Benchmark Data from the Late 1990s. Nutrients. 2018; 10 (6):725.
Chicago/Turabian StyleEdwige Landais; Aurélie Moskal; Amy Mullee; Geneviève Nicolas; Marc J. Gunter; Inge Huybrechts; Kim Overvad; Nina Roswall; Aurélie Affret; Guy Fagherazzi; Yahya Mahamat-Saleh; Verena Katzke; Tilman Kühn; Carlo La Vecchia; Antonia Trichopoulou; Elissavet Valanou; Calogero Saieva; Maria Santucci De Magistris; Sabina Sieri; Tonje Braaten; Guri Skeie; Elisabete Weiderpass; Eva Ardanaz; Maria-Dolores Chirlaque; Jose Ramon Garcia; Paula Jakszyn; Miguel Rodríguez-Barranco; Louise Brunkwall; Ena Huseinovic; Lena Nilsson; Peter Wallström; Bas Bueno-De-Mesquita; Petra H. Peeters; Dagfinn Aune; Tim Key; Marleen Lentjes; Elio Riboli; Nadia Slimani; Heinz Freisling. 2018. "Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries: Benchmark Data from the Late 1990s." Nutrients 10, no. 6: 725.
Potatoes have been a staple food in many countries throughout the years. Potatoes have a high glycaemic index (GI) score, and high GI has been associated with several chronic diseases and cancers. Still, the research on potatoes and health is scarce and contradictive, and we identified no prospective studies that had investigated the association between potatoes as a single food and the risk of pancreatic cancer. The aim of this study was to prospectively investigate the association between potato consumption and pancreatic cancer among 114 240 men and women in the prospective HELGA cohort, using Cox proportional hazard models. Information on diet (validated FFQ’s), lifestyle and health was collected by means of a questionnaire, and 221 pancreatic cancer cases were identified through cancer registries. The mean follow-up time was 11·4 (95 % CI 0·3, 16·9) years. High consumption of potatoes showed a non-significantly higher risk of pancreatic cancer in the adjusted model (hazard ratio (HR) 1·44; 95 % CI 0·93, 2·22,Pfor trend0·030) when comparing the highestv.the lowest quartile of potato consumption. In the sex-specific analyses, significant associations were found for females (HR 2·00; 95 % CI 1·07, 3·72,Pfor trend0·020), but not for males (HR 1·01; 95 % CI 0·56, 1·84,Pfor trend0·34). In addition, we explored the associations by spline regression, and the absence of dose–response effects was confirmed. In this study, high potato consumption was not consistently associated with a higher risk of pancreatic cancer. Further studies with larger populations are needed to explore the possible sex difference.
Lene A. Åsli; Tonje Braaten; Anja Olsen; Anne Tjønneland; Kim Overvad; Lena Maria Nilsson; Frida Renström; Eiliv Lund; Guri Skeie. Potato consumption and risk of pancreatic cancer in the HELGA cohort. British Journal of Nutrition 2018, 119, 1408 -1415.
AMA StyleLene A. Åsli, Tonje Braaten, Anja Olsen, Anne Tjønneland, Kim Overvad, Lena Maria Nilsson, Frida Renström, Eiliv Lund, Guri Skeie. Potato consumption and risk of pancreatic cancer in the HELGA cohort. British Journal of Nutrition. 2018; 119 (12):1408-1415.
Chicago/Turabian StyleLene A. Åsli; Tonje Braaten; Anja Olsen; Anne Tjønneland; Kim Overvad; Lena Maria Nilsson; Frida Renström; Eiliv Lund; Guri Skeie. 2018. "Potato consumption and risk of pancreatic cancer in the HELGA cohort." British Journal of Nutrition 119, no. 12: 1408-1415.
Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99–1.14) or in men (HRlog2 = 0.97, 95% CI 0.90–1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85–0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02–1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.
Raul Zamora-Ros; Valerie Cayssials; Mazda Jenab; Joseph A. Rothwell; Veronika Fedirko; Krasimira Aleksandrova; Anne Tjønneland; Cecilie Kyrø; Kim Overvad; Marie-Christine Boutron-Ruault; Franck Carbonnel; Yahya Mahamat-Saleh; Rudolf Kaaks; Tilman Kühn; Heiner Boeing; Antonia Trichopoulou; Elissavet Valanou; Effie Vasilopoulou; Giovanna Masala; Valeria Pala; Salvatore Panico; Rosario Tumino; Fulvio Ricceri; Elisabete Weiderpass; Marko Lukic; Torkjel M. Sandanger; Cristina Lasheras; Antonio Agudo; Maria-Jose Sánchez; Pilar Amiano; Carmen Navarro; Eva Ardanaz; Emily Sonestedt; Bodil Ohlsson; Lena Maria Nilsson; Martin Rutegård; Bas Bueno-De-Mesquita; Petra H. Peeters; Kay-Thee Khaw; Nicholas J. Wareham; Kathryn Bradbury; Heinz Freisling; Isabelle Romieu; Amanda J. Cross; Paolo Vineis; Augustin Scalbert. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. European Journal of Epidemiology 2018, 33, 1063 -1075.
AMA StyleRaul Zamora-Ros, Valerie Cayssials, Mazda Jenab, Joseph A. Rothwell, Veronika Fedirko, Krasimira Aleksandrova, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Marie-Christine Boutron-Ruault, Franck Carbonnel, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elissavet Valanou, Effie Vasilopoulou, Giovanna Masala, Valeria Pala, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Elisabete Weiderpass, Marko Lukic, Torkjel M. Sandanger, Cristina Lasheras, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Bodil Ohlsson, Lena Maria Nilsson, Martin Rutegård, Bas Bueno-De-Mesquita, Petra H. Peeters, Kay-Thee Khaw, Nicholas J. Wareham, Kathryn Bradbury, Heinz Freisling, Isabelle Romieu, Amanda J. Cross, Paolo Vineis, Augustin Scalbert. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. European Journal of Epidemiology. 2018; 33 (11):1063-1075.
Chicago/Turabian StyleRaul Zamora-Ros; Valerie Cayssials; Mazda Jenab; Joseph A. Rothwell; Veronika Fedirko; Krasimira Aleksandrova; Anne Tjønneland; Cecilie Kyrø; Kim Overvad; Marie-Christine Boutron-Ruault; Franck Carbonnel; Yahya Mahamat-Saleh; Rudolf Kaaks; Tilman Kühn; Heiner Boeing; Antonia Trichopoulou; Elissavet Valanou; Effie Vasilopoulou; Giovanna Masala; Valeria Pala; Salvatore Panico; Rosario Tumino; Fulvio Ricceri; Elisabete Weiderpass; Marko Lukic; Torkjel M. Sandanger; Cristina Lasheras; Antonio Agudo; Maria-Jose Sánchez; Pilar Amiano; Carmen Navarro; Eva Ardanaz; Emily Sonestedt; Bodil Ohlsson; Lena Maria Nilsson; Martin Rutegård; Bas Bueno-De-Mesquita; Petra H. Peeters; Kay-Thee Khaw; Nicholas J. Wareham; Kathryn Bradbury; Heinz Freisling; Isabelle Romieu; Amanda J. Cross; Paolo Vineis; Augustin Scalbert. 2018. "Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort." European Journal of Epidemiology 33, no. 11: 1063-1075.
BackgroundChronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation.ObjectiveWe assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers.DesignA total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders.ResultsThe inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively.ConclusionsOur results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach.This study is listed on the ISRCTN registry as ISRCTN12136108.
Antonio Agudo; Valerie Cayssials; Catalina Bonet; Anne Tjønneland; Kim Overvad; Marie-Christine Boutron-Ruault; Aurélie Affret; Guy Fagherazzi; Verena Katzke; Ruth Schübel; Antonia Trichopoulou; Anna Karakatsani; Carlo La Vecchia; Domenico Palli; Sara Grioni; Rosario Tumino; Fulvio Ricceri; Salvatore Panico; Bas Bueno-De-Mesquita; Petra H Peeters; Elisabete Weiderpass; Guri Skeie; Therese Haugdahl Nøst; Maria Cristina Lasheras-Mayo; Miguel Rodriguez-Barranco; Pilar Amiano; María-Dolores Chirlaque; Eva Ardanaz; Bodil Ohlsson; Joana Dias; Lena Maria Nilsson; Robin Myte; Kay-Tee Khaw; Aurora Perez-Cornago; Marc Gunter; Inge Huybrechts; Amanda J Cross; Kostas Tsilidis; Elio Riboli; Paula Jakszyn. Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American Journal of Clinical Nutrition 2018, 107, 607 -616.
AMA StyleAntonio Agudo, Valerie Cayssials, Catalina Bonet, Anne Tjønneland, Kim Overvad, Marie-Christine Boutron-Ruault, Aurélie Affret, Guy Fagherazzi, Verena Katzke, Ruth Schübel, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Domenico Palli, Sara Grioni, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, Bas Bueno-De-Mesquita, Petra H Peeters, Elisabete Weiderpass, Guri Skeie, Therese Haugdahl Nøst, Maria Cristina Lasheras-Mayo, Miguel Rodriguez-Barranco, Pilar Amiano, María-Dolores Chirlaque, Eva Ardanaz, Bodil Ohlsson, Joana Dias, Lena Maria Nilsson, Robin Myte, Kay-Tee Khaw, Aurora Perez-Cornago, Marc Gunter, Inge Huybrechts, Amanda J Cross, Kostas Tsilidis, Elio Riboli, Paula Jakszyn. Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American Journal of Clinical Nutrition. 2018; 107 (4):607-616.
Chicago/Turabian StyleAntonio Agudo; Valerie Cayssials; Catalina Bonet; Anne Tjønneland; Kim Overvad; Marie-Christine Boutron-Ruault; Aurélie Affret; Guy Fagherazzi; Verena Katzke; Ruth Schübel; Antonia Trichopoulou; Anna Karakatsani; Carlo La Vecchia; Domenico Palli; Sara Grioni; Rosario Tumino; Fulvio Ricceri; Salvatore Panico; Bas Bueno-De-Mesquita; Petra H Peeters; Elisabete Weiderpass; Guri Skeie; Therese Haugdahl Nøst; Maria Cristina Lasheras-Mayo; Miguel Rodriguez-Barranco; Pilar Amiano; María-Dolores Chirlaque; Eva Ardanaz; Bodil Ohlsson; Joana Dias; Lena Maria Nilsson; Robin Myte; Kay-Tee Khaw; Aurora Perez-Cornago; Marc Gunter; Inge Huybrechts; Amanda J Cross; Kostas Tsilidis; Elio Riboli; Paula Jakszyn. 2018. "Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study." The American Journal of Clinical Nutrition 107, no. 4: 607-616.
Studies on the association between heavy coffee consumption and risk of less frequently diagnosed cancers are scarce. We aimed to quantify the association between filtered, boiled, and total coffee consumption and the risk of bladder, esophageal, kidney, pancreatic, and stomach cancers. We used data from the Norwegian Women and Cancer Study and the Northern Sweden Health and Disease Study. Information on coffee consumption was available for 193,439 participants. We used multivariable Cox proportional hazards models to calculate hazard ratios (HR) with 95% confidence intervals (CI) for the investigated cancer sites by category of total, filtered, and boiled coffee consumption. Heavy filtered coffee consumers (≥ 4 cups/day) had a multivariable adjusted HR of 0.74 of being diagnosed with pancreatic cancer (95% CI 0.57–0.95) when compared with light filtered coffee consumers (≤ 1 cup/day). We did not observe significant associations between total or boiled coffee consumption and any of the investigated cancer sites, neither in the entire study sample nor in analyses stratified by sex. We found an increased risk of bladder cancer among never smokers who were heavy filtered or total coffee consumers, and an increased risk of stomach cancer in never smokers who were heavy boiled coffee consumers. Our data suggest that increased filtered coffee consumption might reduce the risk of pancreatic cancer. We did not find evidence of an association between coffee consumption and the risk of esophageal or kidney cancer. The increased risk of bladder and stomach cancer was confined to never smokers.
Marko Lukic; Lena Maria Nilsson; Guri Skeie; Bernt Lindahl; Tonje Braaten. Coffee consumption and risk of rare cancers in Scandinavian countries. European Journal of Epidemiology 2018, 33, 287 -302.
AMA StyleMarko Lukic, Lena Maria Nilsson, Guri Skeie, Bernt Lindahl, Tonje Braaten. Coffee consumption and risk of rare cancers in Scandinavian countries. European Journal of Epidemiology. 2018; 33 (3):287-302.
Chicago/Turabian StyleMarko Lukic; Lena Maria Nilsson; Guri Skeie; Bernt Lindahl; Tonje Braaten. 2018. "Coffee consumption and risk of rare cancers in Scandinavian countries." European Journal of Epidemiology 33, no. 3: 287-302.
Smoking has been associated with colorectal cancer (CRC) incidence and mortality in previous studies and might also be associated with prognosis after CRC diagnosis. However, current evidence on smoking in association with CRC prognosis is limited. For this individual patient data meta-analysis, sociodemographic and smoking behavior information of 12 414 incident CRC patients (median age at diagnosis: 64.3 years), recruited within 14 prospective cohort studies among previously cancer-free adults, was collected at baseline and harmonized across studies. Vital status and causes of death were collected for a mean follow-up time of 5.1 years following cancer diagnosis. Associations of smoking behavior with overall and CRC-specific survival were evaluated using Cox regression and standard meta-analysis methodology. A total of 5229 participants died, 3194 from CRC. Cox regression revealed significant associations between former [hazard ratio (HR) = 1.12; 95 % confidence interval (CI) = 1.04–1.20] and current smoking (HR = 1.29; 95% CI = 1.04–1.60) and poorer overall survival compared with never smoking. Compared with current smoking, smoking cessation was associated with improved overall (HR<10 years = 0.78; 95% CI = 0.69–0.88; HR≥10 years = 0.78; 95% CI = 0.63–0.97) and CRC-specific survival (HR≥10 years = 0.76; 95% CI = 0.67–0.85). In this large meta-analysis including primary data of incident CRC patients from 14 prospective cohort studies on the association between smoking and CRC prognosis, former and current smoking were associated with poorer CRC prognosis compared with never smoking. Smoking cessation was associated with improved survival when compared with current smokers. Future studies should further quantify the benefits of nonsmoking, both for cancer prevention and for improving survival among CRC patients, in particular also in terms of treatment response.
José Manuel Ordóñez-Mena; V. Walter; Ben Schöttker; Mazda Jenab; M.G. O’Doherty; F. Kee; B. Bueno-De-Mesquita; P.H.M. Peeters; B.H. Stricker; R. Ruiter; A. Hofman; Stefan Söderberg; P. Jousilahti; Kari Kuulasmaa; N.D. Freedman; T. Wilsgaard; A. Wolk; Lena Maria Nilsson; A. Tjønneland; J.R. Quirós; F J B van Duijnhoven; P.D. Siersema; P. Boffetta; A. Trichopoulou; Hermann Brenner. Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium. Annals of Oncology 2017, 29, 472 -483.
AMA StyleJosé Manuel Ordóñez-Mena, V. Walter, Ben Schöttker, Mazda Jenab, M.G. O’Doherty, F. Kee, B. Bueno-De-Mesquita, P.H.M. Peeters, B.H. Stricker, R. Ruiter, A. Hofman, Stefan Söderberg, P. Jousilahti, Kari Kuulasmaa, N.D. Freedman, T. Wilsgaard, A. Wolk, Lena Maria Nilsson, A. Tjønneland, J.R. Quirós, F J B van Duijnhoven, P.D. Siersema, P. Boffetta, A. Trichopoulou, Hermann Brenner. Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium. Annals of Oncology. 2017; 29 (2):472-483.
Chicago/Turabian StyleJosé Manuel Ordóñez-Mena; V. Walter; Ben Schöttker; Mazda Jenab; M.G. O’Doherty; F. Kee; B. Bueno-De-Mesquita; P.H.M. Peeters; B.H. Stricker; R. Ruiter; A. Hofman; Stefan Söderberg; P. Jousilahti; Kari Kuulasmaa; N.D. Freedman; T. Wilsgaard; A. Wolk; Lena Maria Nilsson; A. Tjønneland; J.R. Quirós; F J B van Duijnhoven; P.D. Siersema; P. Boffetta; A. Trichopoulou; Hermann Brenner. 2017. "Impact of prediagnostic smoking and smoking cessation on colorectal cancer prognosis: a meta-analysis of individual patient data from cohorts within the CHANCES consortium." Annals of Oncology 29, no. 2: 472-483.
Other than the influence of ionizing radiation and benign thyroid disease, little is known about the risk factors for differentiated thyroid cancer (TC) which is an increasing common cancer worldwide. Consistent evidence shows that body mass is positively associated with TC risk. As excess weight is a state of chronic inflammation, we investigated the relationship between concentrations of leptin, adiponectin, C‐reactive protein, interleukin (IL)‐6, IL‐10 and tumor necrosis factor (TNF)‐α and the risk of TC. A case‐control study was nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study and included 475 first primary incident TC cases (399 women and 76 men) and 1,016 matched cancer‐free cohort participants. Biomarkers were measured in serum samples using validated and highly sensitive commercially available immunoassays. Odds ratios (ORs) of TC by levels of each biomarker were estimated using conditional logistic regression models, adjusting for BMI and alcohol consumption. Adiponectin was inversely associated with TC risk among women (ORT3vs.T1 = 0.69, 95% CI: 0.49–0.98, Ptrend = 0.04) but not among men (ORT3vs.T1 = 1.36, 95% CI: 0.67–2.76, Ptrend = 0.37). Increasing levels of IL‐10 were positively associated with TC risk in both genders and significantly so in women (ORT3vs.T1 = 1.59, 95% CI: 1.13–2.25, Ptrend = 0.01) but not in men (ORT3vs.T1 = 1.78, 95% CI: 0.80–3.98, Ptrend = 0.17). Leptin, CRP, IL‐6 and TNF‐α were not associated with TC risk in either gender. These results indicate a positive association of TC risk with IL‐10 and a negative association with adiponectin that is probably restricted to women. Inflammation may play a role in TC in combination with or independently of excess weight.
Laure Dossus; Silvia Franceschi; Carine Biessy; Anne-Sophie Navionis; Ruth C. Travis; Elisabete Weiderpass; Augustin Scalbert; Isabelle Romieu; Anne Tjonneland; Anja Olsen; Kim Overvad; Marie-Christine Boutron-Ruault; Fabrice Bonnet; Agnès Fournier; Renée Fortner; Rudolf Kaaks; Krasimira Aleksandrova; Antonia Trichopoulou; Carlo La Vecchia; Eleni Peppa; Rosario Tumino; Salvatore Panico; Domenico Palli; Claudia Agnoli; Paolo Vineis; H. B(As) Bueno‐De‐Mesquita; Petra H. Peeters; Guri Skeie; Raul Zamora-Ros; María-Dolores Chirlaque; Eva Ardanaz; Maria-Jose Sánchez; Jose Ramón Quirós; Miren Dorronsoro; Maria Sandström; Lena Maria Nilsson; Julie A. Schmidt; Kay-Tee Khaw; Konstantinos K. Tsilidis; Dagfinn Aune; Elio Riboli; Sabina Rinaldi. Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study. International Journal of Cancer 2017, 142, 1332 -1342.
AMA StyleLaure Dossus, Silvia Franceschi, Carine Biessy, Anne-Sophie Navionis, Ruth C. Travis, Elisabete Weiderpass, Augustin Scalbert, Isabelle Romieu, Anne Tjonneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Agnès Fournier, Renée Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Antonia Trichopoulou, Carlo La Vecchia, Eleni Peppa, Rosario Tumino, Salvatore Panico, Domenico Palli, Claudia Agnoli, Paolo Vineis, H. B(As) Bueno‐De‐Mesquita, Petra H. Peeters, Guri Skeie, Raul Zamora-Ros, María-Dolores Chirlaque, Eva Ardanaz, Maria-Jose Sánchez, Jose Ramón Quirós, Miren Dorronsoro, Maria Sandström, Lena Maria Nilsson, Julie A. Schmidt, Kay-Tee Khaw, Konstantinos K. Tsilidis, Dagfinn Aune, Elio Riboli, Sabina Rinaldi. Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study. International Journal of Cancer. 2017; 142 (7):1332-1342.
Chicago/Turabian StyleLaure Dossus; Silvia Franceschi; Carine Biessy; Anne-Sophie Navionis; Ruth C. Travis; Elisabete Weiderpass; Augustin Scalbert; Isabelle Romieu; Anne Tjonneland; Anja Olsen; Kim Overvad; Marie-Christine Boutron-Ruault; Fabrice Bonnet; Agnès Fournier; Renée Fortner; Rudolf Kaaks; Krasimira Aleksandrova; Antonia Trichopoulou; Carlo La Vecchia; Eleni Peppa; Rosario Tumino; Salvatore Panico; Domenico Palli; Claudia Agnoli; Paolo Vineis; H. B(As) Bueno‐De‐Mesquita; Petra H. Peeters; Guri Skeie; Raul Zamora-Ros; María-Dolores Chirlaque; Eva Ardanaz; Maria-Jose Sánchez; Jose Ramón Quirós; Miren Dorronsoro; Maria Sandström; Lena Maria Nilsson; Julie A. Schmidt; Kay-Tee Khaw; Konstantinos K. Tsilidis; Dagfinn Aune; Elio Riboli; Sabina Rinaldi. 2017. "Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study." International Journal of Cancer 142, no. 7: 1332-1342.
How coffee consumption relates to mortality in diverse European populations, with variable coffee preparation methods and customs, is unclear. To examine whether coffee consumption is associated with all-cause and cause-specific mortality in men and women. Prospective cohort study. Ten European countries. A total of 521,330 men and women enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC). Multivariable hazard ratios (HRs) and 95% confidence intervals(CIs) estimated using multivariable Cox proportional hazards models. The association of coffee with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers sub-cohort (n=14,800). During a mean follow-up of 16.4 years, 41,693 deaths occurred. Compared with non-consumers, participants in the highest quartile of coffee consumption experienced statistically significant lower all-cause mortality (Men: HR=0.88, 95%CI: 0.82–0.95; P-trend<0.001; Women: HR=0.93, 95%CI: 0.87–0.98; P-trend=0.009). These findings did not vary significantly by country. Inverse associations were observed for digestive disease mortality for men (HR=0.41, 95%CI: 0.32–0.54; P-trend<0.0001) and women (HR=0.60, 95%CI: 0.46–0.78; P-trend<0.0001). Among women only, there was a statistically significant inverse association between coffee and circulatory disease mortality, (HR=0.78, 95%CI: 0.68–0.90; P-trend<0.001), cerebrovascular disease mortality (HR=0.70, 95%CI: 0.55–0.90; P-trend=0.002), and a positive association between coffee and ovarian cancer mortality (HR 1.12, 95% CI: 1.02–1.23 P-trend 0.001). In the EPIC-biomarkers sub-cohort, higher coffee consumption was associated with lower serum alkaline phosphatase, alanine transaminase, aspartate transaminase, and C-reactive protein. Reverse causality may have led to spurious findings; however, results did not differ following exclusion of participants who died within 8-years of baseline. The study is also limited by a single assessment of coffee drinking habits at baseline. These results confirm prior findings on the reduced risk of mortality associated with coffee drinking but additionally show that this relationship does not vary by country where coffee preparation and drinking habits may differ. The study also reports novel inverse relationships between coffee drinking and digestive disease mortality.
Marc J. Gunter; Neil Murphy; Amanda J. Cross; Laure Dossus; Laureen Dartois; Guy Fagherazzi; Rudolf Kaaks; Tilman Kühn; Heiner Boeing; Krasimira Aleksandrova; Anne Tjonneland; Anja Olsen; Kim Overvad; Sofus C. Larsen; Maria Luisa Redondo Cornejo; Antonio Agudo; Maria Jose Sanchez-Perez; Jone Miren Altzibar; Carmen Navarro; Eva Ardanaz; Kay-Tee Khaw; Adam Butterworth; Kathryn Bradbury; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Domenico Palli; Sara Grioni; Paolo Vineis; Salvatore Panico; Rosario Tumino; Bas Bueno-De-Mesquita; Peter Siersema; Max Leenders; Joline W.J. Beulens; Cuno U. Uiterwaal; Peter Wallström; Lena Maria Nilsson; Rikard Landberg; Elisabete Weiderpass; Guri Skeie; Tonje Braaten; Paul Brennan; Idlir Licaj; David Muller; Rashmi Sinha; Nick Wareham; Elio Riboli. Coffee Drinking and Mortality in 10 European Countries. Annals of Internal Medicine 2017, 167, 236 -247.
AMA StyleMarc J. Gunter, Neil Murphy, Amanda J. Cross, Laure Dossus, Laureen Dartois, Guy Fagherazzi, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Krasimira Aleksandrova, Anne Tjonneland, Anja Olsen, Kim Overvad, Sofus C. Larsen, Maria Luisa Redondo Cornejo, Antonio Agudo, Maria Jose Sanchez-Perez, Jone Miren Altzibar, Carmen Navarro, Eva Ardanaz, Kay-Tee Khaw, Adam Butterworth, Kathryn Bradbury, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sara Grioni, Paolo Vineis, Salvatore Panico, Rosario Tumino, Bas Bueno-De-Mesquita, Peter Siersema, Max Leenders, Joline W.J. Beulens, Cuno U. Uiterwaal, Peter Wallström, Lena Maria Nilsson, Rikard Landberg, Elisabete Weiderpass, Guri Skeie, Tonje Braaten, Paul Brennan, Idlir Licaj, David Muller, Rashmi Sinha, Nick Wareham, Elio Riboli. Coffee Drinking and Mortality in 10 European Countries. Annals of Internal Medicine. 2017; 167 (4):236-247.
Chicago/Turabian StyleMarc J. Gunter; Neil Murphy; Amanda J. Cross; Laure Dossus; Laureen Dartois; Guy Fagherazzi; Rudolf Kaaks; Tilman Kühn; Heiner Boeing; Krasimira Aleksandrova; Anne Tjonneland; Anja Olsen; Kim Overvad; Sofus C. Larsen; Maria Luisa Redondo Cornejo; Antonio Agudo; Maria Jose Sanchez-Perez; Jone Miren Altzibar; Carmen Navarro; Eva Ardanaz; Kay-Tee Khaw; Adam Butterworth; Kathryn Bradbury; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Domenico Palli; Sara Grioni; Paolo Vineis; Salvatore Panico; Rosario Tumino; Bas Bueno-De-Mesquita; Peter Siersema; Max Leenders; Joline W.J. Beulens; Cuno U. Uiterwaal; Peter Wallström; Lena Maria Nilsson; Rikard Landberg; Elisabete Weiderpass; Guri Skeie; Tonje Braaten; Paul Brennan; Idlir Licaj; David Muller; Rashmi Sinha; Nick Wareham; Elio Riboli. 2017. "Coffee Drinking and Mortality in 10 European Countries." Annals of Internal Medicine 167, no. 4: 236-247.