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Prof. Dr. Ji-Sun Kim
Eunpyeong St. Mary’s hospital

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0 Allergy
0 rhinology
0 Particulate Matter
0 Otorhinolaryngology-Head and Neck Surgery
0 Rhinosinuisitis

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Journal article
Published: 06 April 2021 in Journal of Clinical Medicine
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Objectives: To identify the relationship between pulmonary function and subjective olfactory dysfunction in middle-aged and older adults. Materials and Methods: We used Korea National Health and Nutrition Examination Survey data from 2010 to 2012 to analyze 6191 participants in their 50s or older. Results: The frequency of olfactory dysfunction was 6.8% among the subjects with normal pulmonary function tests, but was significantly more frequent in those diagnosed with restrictive (9.6%) or obstructive (10.1%) pulmonary function. Forced volume vital capacity, forced expiratory volume (FEV)1, FEV6, and peak expiratory flow were significantly lower in the olfactory dysfunction group. The risk of olfactory dysfunction was significantly associated with obstructive pulmonary function (odds ratio (OR) [95% confidence interval (CI)]: 1.449 [1.010–2.081]) after adjusting for confounders (sex, rhinitis, chronic rhinosinusitis, hypertension, dyslipidemia, education level, stress, depressed mood, and suicidal ideation). Conclusion: Middle-aged and older adults with obstructive pulmonary function had a higher incidence of subjective olfactory dysfunction than the normal pulmonary function group. Early olfactory testing may improve the quality of life of patients with obstructive pulmonary function.

ACS Style

Ji-Sun Kim; Jun-Ook Park; Dong-Hyun Lee; Ki-Hong Chang; Byung Kim. Association of Olfactory and Pulmonary Function in Middle-Aged and Older Adults: The Korea National Health and Nutrition Examination Survey. Journal of Clinical Medicine 2021, 10, 1535 .

AMA Style

Ji-Sun Kim, Jun-Ook Park, Dong-Hyun Lee, Ki-Hong Chang, Byung Kim. Association of Olfactory and Pulmonary Function in Middle-Aged and Older Adults: The Korea National Health and Nutrition Examination Survey. Journal of Clinical Medicine. 2021; 10 (7):1535.

Chicago/Turabian Style

Ji-Sun Kim; Jun-Ook Park; Dong-Hyun Lee; Ki-Hong Chang; Byung Kim. 2021. "Association of Olfactory and Pulmonary Function in Middle-Aged and Older Adults: The Korea National Health and Nutrition Examination Survey." Journal of Clinical Medicine 10, no. 7: 1535.

Journal article
Published: 18 February 2021 in Toxics
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Background: Eupatilin is an active flavon extracted from the Artemisia species and has properties such as antioxidant, anti-inflammatory, and anti-cancer. We examined the effect of eupatilin using fine particulate matter (FPM) and human bronchial epithelial cell line (BEAS-2B) to confirm the potential of eupatilin as a therapeutic agent for respiratory diseases caused by FPM. Methods: Reactive oxygen species (ROS) levels were checked by flow cytometry to identify if FPM and eupatilin affect ROS production. Western blotting was performed to identify the mechanism of action of eupatilin in FPM-exposed BEAS-2B cells. Results: When cells were exposed to FPM above 12.5 μg/mL concentration for 24 h, ROS production increased significantly compared to the control. When eupatilin was added to cells exposed to FPM, the ROS level decreased proportionally with the eupatilin dose. The phosphorylation of Akt, NF-κB p65, and p38 MAPK induced by FPM was significantly reduced by eupatilin, respectively. Conclusion: FPM cause respiratory disease by producing ROS in bronchial epithelial cells. Eupatilin has been shown to inhibit ROS production through altering signaling pathways. The ROS inhibiting property of eupatilin can be exploited in FPM induced respiratory disorders.

ACS Style

Dong Lee; Jeong-Min Oh; Hyunsu Choi; Sung Kim; Soo Kim; Byung Kim; Jin Cho; Joohyung Lee; Ji-Sun Kim. Eupatilin Inhibits Reactive Oxygen Species Generation via Akt/NF-κB/MAPK Signaling Pathways in Particulate Matter-Exposed Human Bronchial Epithelial Cells. Toxics 2021, 9, 38 .

AMA Style

Dong Lee, Jeong-Min Oh, Hyunsu Choi, Sung Kim, Soo Kim, Byung Kim, Jin Cho, Joohyung Lee, Ji-Sun Kim. Eupatilin Inhibits Reactive Oxygen Species Generation via Akt/NF-κB/MAPK Signaling Pathways in Particulate Matter-Exposed Human Bronchial Epithelial Cells. Toxics. 2021; 9 (2):38.

Chicago/Turabian Style

Dong Lee; Jeong-Min Oh; Hyunsu Choi; Sung Kim; Soo Kim; Byung Kim; Jin Cho; Joohyung Lee; Ji-Sun Kim. 2021. "Eupatilin Inhibits Reactive Oxygen Species Generation via Akt/NF-κB/MAPK Signaling Pathways in Particulate Matter-Exposed Human Bronchial Epithelial Cells." Toxics 9, no. 2: 38.

Review
Published: 01 August 2020 in Clinical and Experimental Otorhinolaryngology
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Objectives. Although osteotomy is an important part of rhinoplasty, it is known to be closely related to postoperative eyelid edema and ecchymosis. We aimed to evaluate the effects of periosteal elevation prior to osteotomy on eyelid edema and ecchymosis.Methods. Two authors reviewed studies in the Medline, Scopus, and Cochrane databases published through May 2019. Randomized controlled trials comparing periosteal elevation (subperiosteal tunneling) with periosteal preservation that reported eyelid edema or ecchymosis or subconjunctival hemorrhage as outcomes of interest were included. From each study, the baseline characteristics of the study subjects, the quality of the study, the number of patients in the treatment and control groups, and outcomes were extracted.Results. Data for meta-analysis were identified in six studies with a total of 208 patients. Eyelid ecchymosis and edema within 3 days postoperatively were significantly more common in the periosteal elevation group than in the preservation group, although such an association was not found for edema on postoperative day 7 (standardized mean difference [SMD], 0.21; 95% confidence interval [CI], –0.09 to 0.50; I2 =0%). There was no significant difference in subconjunctival hemorrhage on day 1 (SMD, 0.31; 95% CI, –0.09 to 0.72; I2 =0%).Conclusion. Periosteal preservation during lateral osteotomy may reduce eyelid edema and ecchymosis compared to periosteal elevation. Further studies with rigorous research methods should be carried out to determine the effectiveness of different techniques in lateral osteotomy.

ACS Style

Ji-Sun Kim; Sun Hong Kim; Hyesook Lee; Byung Guk Kim; Se Hwan Hwang. Effects of Periosteal Elevation Before Lateral Osteotomy in Rhinoplasty: A Meta-Analysis of Randomized Controlled Trials. Clinical and Experimental Otorhinolaryngology 2020, 13, 268 -273.

AMA Style

Ji-Sun Kim, Sun Hong Kim, Hyesook Lee, Byung Guk Kim, Se Hwan Hwang. Effects of Periosteal Elevation Before Lateral Osteotomy in Rhinoplasty: A Meta-Analysis of Randomized Controlled Trials. Clinical and Experimental Otorhinolaryngology. 2020; 13 (3):268-273.

Chicago/Turabian Style

Ji-Sun Kim; Sun Hong Kim; Hyesook Lee; Byung Guk Kim; Se Hwan Hwang. 2020. "Effects of Periosteal Elevation Before Lateral Osteotomy in Rhinoplasty: A Meta-Analysis of Randomized Controlled Trials." Clinical and Experimental Otorhinolaryngology 13, no. 3: 268-273.

Journal article
Published: 30 June 2020 in Sleep Medicine Research
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ACS Style

Ji-Sun Kim; Yun Jin Kang; Chan-Soon Park; Jae Hyung Hwang; Yeon Ji Kim. Clinical Parameters Related to the Duration of Automatic Positive Airway Pressure Titration. Sleep Medicine Research 2020, 11, 31 -37.

AMA Style

Ji-Sun Kim, Yun Jin Kang, Chan-Soon Park, Jae Hyung Hwang, Yeon Ji Kim. Clinical Parameters Related to the Duration of Automatic Positive Airway Pressure Titration. Sleep Medicine Research. 2020; 11 (1):31-37.

Chicago/Turabian Style

Ji-Sun Kim; Yun Jin Kang; Chan-Soon Park; Jae Hyung Hwang; Yeon Ji Kim. 2020. "Clinical Parameters Related to the Duration of Automatic Positive Airway Pressure Titration." Sleep Medicine Research 11, no. 1: 31-37.

Journal article
Published: 30 June 2020 in Journal of Clinical Otolaryngology Head and Neck Surgery
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임상이비인후과(Journal of Clinical Otolaryngology Head and Neck Surgery)

ACS Style

Doyeon Kim; Jun-Ook Park; Byung Guk Kim; Ji-Sun Kim. A Case of Nasopharyngeal Branchial Cleft Cyst in a 72-Year-Old Patient. Journal of Clinical Otolaryngology Head and Neck Surgery 2020, 31, 94 -97.

AMA Style

Doyeon Kim, Jun-Ook Park, Byung Guk Kim, Ji-Sun Kim. A Case of Nasopharyngeal Branchial Cleft Cyst in a 72-Year-Old Patient. Journal of Clinical Otolaryngology Head and Neck Surgery. 2020; 31 (1):94-97.

Chicago/Turabian Style

Doyeon Kim; Jun-Ook Park; Byung Guk Kim; Ji-Sun Kim. 2020. "A Case of Nasopharyngeal Branchial Cleft Cyst in a 72-Year-Old Patient." Journal of Clinical Otolaryngology Head and Neck Surgery 31, no. 1: 94-97.

Journal article
Published: 30 March 2020 in BMC Complementary Medicine and Therapies
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Background Particulate matter (PM) can cause various negative acute and chronic diseases of the respiratory system, including the upper airways. Curcumin has been reported to have anti-inflammatory and anti-oxidative effects; therefore, we investigated the effects of curcumin on nasal fibroblasts exposed to urban PM (UPM). Methods Samples of inferior turbinate tissue were obtained from six patients. Flow cytometry was used to assess the levels of reactive oxygen species (ROS) following the treatment of nasal fibroblasts with UPM and/or curcumin. We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting. Results When UPM was applied to nasal fibroblasts, ROS production was significantly increased in a dose-dependent manner. UPM-exposed fibroblasts caused the activation of ERK to increase HO-1 expression and decrease SOD2 expression. Treatment with curcumin reduced the UPM-mediated increase in ROS; this decrease in ROS occurred in a dose-dependent manner. The UPM-induced activation of ERK was inhibited by curcumin. Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin. Conclusion Curcumin reduced ROS production caused by UPM in human nasal fibroblasts in a dose-dependent manner, suggesting that curcumin has anti-oxidative effects and may be useful in the treatment of nasal diseases caused by UPM, such as allergic and chronic rhinitis.

ACS Style

Ji-Sun Kim; Jeong-Min Oh; Hyunsu Choi; Sung Won Kim; Soo Whan Kim; Byung Guk Kim; Jin Hee Cho; Joohyung Lee; Dong Chang Lee. Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter. BMC Complementary Medicine and Therapies 2020, 20, 101 -8.

AMA Style

Ji-Sun Kim, Jeong-Min Oh, Hyunsu Choi, Sung Won Kim, Soo Whan Kim, Byung Guk Kim, Jin Hee Cho, Joohyung Lee, Dong Chang Lee. Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter. BMC Complementary Medicine and Therapies. 2020; 20 (1):101-8.

Chicago/Turabian Style

Ji-Sun Kim; Jeong-Min Oh; Hyunsu Choi; Sung Won Kim; Soo Whan Kim; Byung Guk Kim; Jin Hee Cho; Joohyung Lee; Dong Chang Lee. 2020. "Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter." BMC Complementary Medicine and Therapies 20, no. 1: 101-8.

Review
Published: 08 February 2020 in The Laryngoscope
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Objectives Although lateral osteotomy is an important part of rhinoplasty, it is known to be closely associated with postoperative eyelid edema and ecchymosis after rhinoplasty. There is no consensus on which osteotomy methods are effective in reducing morbidity from rhinoplasty. This study compared the effects of different osteotomy methods on edema and ecchymosis after lateral osteotomy using a meta‐analysis. Study Design A literature search using MEDLINE, SCOPUS, and Cochrane databases. Methods Two authors independently reviewed the databases published until May 2019. Randomized controlled trials that compared lateral osteotomy methods (external approach) with different methods (internal approach), for which the outcomes of interest were mucosal injury, edema, and ecchymosis on postoperative days, were included. Sufficient data for meta‐analysis was found in six studies with a total of 224 patients. Results In a comparison of the external approach with the internal approach, mucosal injury was significantly lower in the external approach (odds ratio = 0.41; 95% confidence interval = [0.11; 0.99], I2 = 29%). There were significant differences between the external and internal approach in eyelid ecchymosis and edema, except for eyelid ecchymosis at 7 days postoperatively. However, all significant results showed a small effect size with a standardized mean difference near 0.2. Conclusions The external approach during lateral osteotomy had no significant advantage in edema and ecchymosis compared to the internal approach. Further studies with good research methodology should be carried out to determine the effect on the postoperative complications of different lateral osteotomy methods. Laryngoscope, 2020

ACS Style

Ji‐Sun Kim; Sun Hong Kim; Se Hwan Hwang. Method of Lateral Osteotomy to Reduce Eyelid Edema and Ecchymosis After Rhinoplasty: A Meta‐analysis. The Laryngoscope 2020, 131, 54 -58.

AMA Style

Ji‐Sun Kim, Sun Hong Kim, Se Hwan Hwang. Method of Lateral Osteotomy to Reduce Eyelid Edema and Ecchymosis After Rhinoplasty: A Meta‐analysis. The Laryngoscope. 2020; 131 (1):54-58.

Chicago/Turabian Style

Ji‐Sun Kim; Sun Hong Kim; Se Hwan Hwang. 2020. "Method of Lateral Osteotomy to Reduce Eyelid Edema and Ecchymosis After Rhinoplasty: A Meta‐analysis." The Laryngoscope 131, no. 1: 54-58.

Review
Published: 25 January 2020 in Brazilian Journal of Otorhinolaryngology
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Several surgical techniques have been used during tonsillectomy to reduce complications. To assess the effects of pillar suture in conjunction with tonsillectomy as compared to tonsillectomy without suture in children. Two authors independently searched five databases (PubMed, SCOPUS, Embase, the Web of Science, and the Cochrane database) for studies published as recent as December 2018. Of the included studies, we compared tonsillectomy and pillar suture in combination (suture groups) with tonsillectomy alone,without suture, (control group). Postoperative pain intensity and other morbidities (e.g., postoperative bleeding, palatal hematoma, discomfort, and pillar edema) were measured during the postoperative period. Postoperative bleeding [primary (OR = 0.47 [0.27; 0.81]) and secondary (OR = 0.14 [0.02; 0.78]) were significantly decreased in the pillar suture group compared to the control group. There were no significant differences between the two groups in postoperative pain at day 7 (SMD = -0.39 [-0.79; 0.00]), palatal hematoma (OR = 5.00 [0.22; 112.88]), palatal discomfort sensation (OR = 2.62 [0.60; 11.46]), site infection (OR = 5.27 [0.24; 113.35]), and velopharyngeal insufficiency (OR = 2.82 [0.11; 74.51]). By contrast, pillar edema (OR = 9.55 [4.29; 21.29]) was significantly increased in the pillar suture group compared to the control group. Pillar suture combined with tonsillectomy may reduce postoperative bleeding incidence despite increasing pillar edema in pediatric tonsillectomy. Postoperative pain-relief, palatal hematoma, palatal discomfort sensation, site infection, and velopharyngeal insufficiency were not significantly altered compared to tonsillectomy alone. However, further studies are needed to corroborate the results of this study.

ACS Style

Ji-Sun Kim; Byung Guk Kim; Dong-Hyun Kim; Se Hwan Hwang. Efficacy of pillar suture for post-tonsillectomy morbidity in children: a meta-analysis. Brazilian Journal of Otorhinolaryngology 2020, 1 .

AMA Style

Ji-Sun Kim, Byung Guk Kim, Dong-Hyun Kim, Se Hwan Hwang. Efficacy of pillar suture for post-tonsillectomy morbidity in children: a meta-analysis. Brazilian Journal of Otorhinolaryngology. 2020; ():1.

Chicago/Turabian Style

Ji-Sun Kim; Byung Guk Kim; Dong-Hyun Kim; Se Hwan Hwang. 2020. "Efficacy of pillar suture for post-tonsillectomy morbidity in children: a meta-analysis." Brazilian Journal of Otorhinolaryngology , no. : 1.

Journal article
Published: 24 September 2019 in BMJ Open
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Objectives We developed an edible taste film test that can be stored easily as a kit. This study was conducted to confirm the agreement between the results of the edible taste film kit test and the conventional taste solution test. Design Prospective, randomised, controlled trial. Setting Single tertiary hospital. Participants Sixty-two healthy volunteers with no self-described taste problems. Interventions A randomisation scheme was used to determine the order of use of the edible taste film kit and the taste solution test for each subject. The taste solution test was performed using a cotton swab. In the taste film kit test, an edible taste film was placed on the tongue, and the subject detected the taste after the film was dissolved by saliva. Outcome measures For each test, we measured the taste identification threshold, taste detection time and total test time. Results We confirmed the consistency of the taste identification thresholds of the two tests, and the results were consistent with each other except for the bitter taste results, which used coffee in the edible taste film kit and quinine in the taste solution test. Although the detection time for each taste quality was faster for the taste solution test, the mean total time was significantly shorter for the taste film kit test than for the taste solution test (6.16±2.27 min vs 7.04±1.98 min, respectively; p=0.004). Conclusions The edible taste film kit along with the taste solution test will be useful for quantitative taste testing. Trial registration number KCT0002865.

ACS Style

Ji-Sun Kim; Dong-Hyun Kim; Eun-Ju Jeon; Byung Guk Kim; JeongJun Yu; Hyun-Il Shin. Taste test using an edible taste film kit: a randomised controlled trial. BMJ Open 2019, 9, e029077 .

AMA Style

Ji-Sun Kim, Dong-Hyun Kim, Eun-Ju Jeon, Byung Guk Kim, JeongJun Yu, Hyun-Il Shin. Taste test using an edible taste film kit: a randomised controlled trial. BMJ Open. 2019; 9 (9):e029077.

Chicago/Turabian Style

Ji-Sun Kim; Dong-Hyun Kim; Eun-Ju Jeon; Byung Guk Kim; JeongJun Yu; Hyun-Il Shin. 2019. "Taste test using an edible taste film kit: a randomised controlled trial." BMJ Open 9, no. 9: e029077.