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Colitis-complex diarrhea (CCD) in pigs can be defined as a type of diarrhea, which is associated with colonic inflammation and disrupted colonic gut barrier functionality in growing pigs (4–16 weeks post-weaning). It is a challenge for the pig industry as it is associated with the high use of antibiotics, reduced animal welfare, and depressed growth rate. The exact etiology of CCD is still unclear; however, pathogens including Brachyspira (B.) hyodysenteriae, B. pilosicoli, and swine whipworms such as Trichuris (T.) suis have been involved in specific colitis (SC). In the absence of specific pathogens, dietary factors, such as high levels of protein, pelleted feedstuffs, and lack of sufficient antioxidants, can result in non-specific colitis (NSC). On the other hand, supplement of polyunsaturated fatty acids (PUFA) and polyphenols, sufficient supply of essential amino acids (e.g., threonine, cysteine, and proline), short-chain fatty acids (SCFA; especially butyrate), and resistant starch have shown to confer preventing/ameliorating effects on CCD. Different putative biomarkers associated with CCD have been presented. It is anticipated that a comprehensive picture of the possible causes of CCD and potential dietary interventions could cast light on the direction of future studies aimed at developing preventive and curative strategies against CCD in growing pigs.
Farhad Panah; Charlotte Lauridsen; Ole Højberg; Tina Nielsen. Etiology of Colitis-Complex Diarrhea in Growing Pigs: A Review. Animals 2021, 11, 2151 .
AMA StyleFarhad Panah, Charlotte Lauridsen, Ole Højberg, Tina Nielsen. Etiology of Colitis-Complex Diarrhea in Growing Pigs: A Review. Animals. 2021; 11 (7):2151.
Chicago/Turabian StyleFarhad Panah; Charlotte Lauridsen; Ole Højberg; Tina Nielsen. 2021. "Etiology of Colitis-Complex Diarrhea in Growing Pigs: A Review." Animals 11, no. 7: 2151.
This study investigates two levels of dietary selenium (Se) and vitamin E in combination on their status in sows and their progeny, and influence on antioxidant status and immunological responses of the piglets at weaning. Female pigs (n = 6) were provided LOW or HIGH antioxidant nutrition (Se and vitamin E) from mating until weaning of their off-spring. The HIGH treatment elevated the concentration of Se (p = 0.015) and α-tocopherol (p = 0.023) in plasma of piglets compared with piglets of the LOW treatment. Treatments also affected the concentrations of milk and sow plasma immunoglobulins. Piglets from sows on the HIGH treatment had increased (p < 0.001) activity of glutathione peroxidase, lower serum levels of C-reactive protein (p = 0.005), haptoglobin (p = 0.05) and albumin (p = 0.05), and the number of white blood cells (p = 0.023) and the ratio of NEU to LYM was lower (p = 0.025) than in piglets from sows on the LOW group. Furthermore, the dietary antioxidant level influenced responses of cytokines (interleukine (IL) 6 (p = 0.007), 12 (p = 0.01) and 18 (p = 0.01)) in piglets’ plasma. In conclusion, improved antioxidant status via dietary maternal provision improves the robustness of the offspring via immunomodulatory mechanisms.
Charlotte Lauridsen; Anna Schönherz; Søren Højsgaard. Effect of Maternal Dietary Redox Levels on Antioxidative Status and Immunity of the Suckling Off-Spring. Antioxidants 2021, 10, 478 .
AMA StyleCharlotte Lauridsen, Anna Schönherz, Søren Højsgaard. Effect of Maternal Dietary Redox Levels on Antioxidative Status and Immunity of the Suckling Off-Spring. Antioxidants. 2021; 10 (3):478.
Chicago/Turabian StyleCharlotte Lauridsen; Anna Schönherz; Søren Højsgaard. 2021. "Effect of Maternal Dietary Redox Levels on Antioxidative Status and Immunity of the Suckling Off-Spring." Antioxidants 10, no. 3: 478.
Several nutritional studies have been performed to improve piglet health and resilience to infectious diseases during the lactation and post-weaning periods, and to identify alternatives to the use of antibiotics and antimicrobials as growth promoters. In the last decades, pharmacological levels of zinc oxide (ZnO) and copper have frequently been used as nutritional strategies to prevent post-weaning diarrhoea because of their antimicrobial activity. However, the use of ZnO was recently banned by the EU from 2022 because of the risk of promoting Anti-Microbial Resistance (AMR). Beyond their role as essential micronutrients, vitamins share several remarkable activities (antimicrobial, immunological and antioxidative) often referred to amongst many of the non-antibiotic feed additives commonly proposed and used for pigs. However, very little research and scientific emphasis are devoted to vitamin nutrition and its role in the gut function and health of livestock. This review discusses how fat-soluble (A, D, E and K) and water-soluble (B-group and C) vitamins may influence gastrointestinal (GI) functionality in general and with specific importance on the challenges associated with the early life of pig gut health and disease prevention. On the basis of the literature review it is suggested that future research and development of alternative strategies to antibiotics and medicinal ZnO should pay attention to the role of vitamins for GI functionality and health of pigs.
Charlotte Lauridsen; Jean Jacques Matte; Martin Lessard; Pietro Celi; Gilberto Litta. Role of vitamins for gastro-intestinal functionality and health of pigs. Animal Feed Science and Technology 2021, 273, 114823 .
AMA StyleCharlotte Lauridsen, Jean Jacques Matte, Martin Lessard, Pietro Celi, Gilberto Litta. Role of vitamins for gastro-intestinal functionality and health of pigs. Animal Feed Science and Technology. 2021; 273 ():114823.
Chicago/Turabian StyleCharlotte Lauridsen; Jean Jacques Matte; Martin Lessard; Pietro Celi; Gilberto Litta. 2021. "Role of vitamins for gastro-intestinal functionality and health of pigs." Animal Feed Science and Technology 273, no. : 114823.
In the original publication of this article [1], a figure of gene expression of Cox-2 in the Appendix 1 is missing. The correct Appendix is attached.
D. Vodolazska; C. Lauridsen. Correction to: Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets. Journal of Animal Science and Biotechnology 2020, 11, 1 -2.
AMA StyleD. Vodolazska, C. Lauridsen. Correction to: Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets. Journal of Animal Science and Biotechnology. 2020; 11 (1):1-2.
Chicago/Turabian StyleD. Vodolazska; C. Lauridsen. 2020. "Correction to: Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets." Journal of Animal Science and Biotechnology 11, no. 1: 1-2.
Fatty acids (FA) play a major role in relation to mucosal immune responses, epithelial barrier functions, oxidative stress, and inflammatory reactions. The dietary FA composition and the molecular structures (chain length and number of double bonds) influence digestion, absorption and metabolism, and the bioactivity of the FA. Piglets post-weaning having an immature intestine and not fully formed immune functions are very vulnerable to invading microorganisms. Manipulation of the milk FA composition via sow nutrition, or inclusion of dietary fat sources in the feed for newly weaned pigs, may be used as a strategic tool to enhance pig performance and their gut health and function pre- and post-weaning. Medium-chain fatty acids (MCFA) are absorbed directly into the portal blood and may contribute to immediate energy for the enterocytes. In addition, the MCFA, similarly to the short-chain fatty acids (SCFA), possess antibacterial effects and may thereby prevent overgrowth of pathogenic bacteria in the gastrointestinal tract. The essential FA, linoleic (LA) and α-linolenic (ALA) FA, form the building blocks for the long-chain polyunsaturated n-3 and n-6 FA. The conversion of ALA and LA into n-3 and n-6 eicosanoids, respectively, influences the molecular structures of metabolites and inflammatory reactions and other immune responses upon bacterial challenges. Dietary manipulation of the lactating sow influences the transfer of the n-3 and n-6 polyunsaturated fatty acids (PUFA) from the sow milk to the piglet and the incorporation of the FA into piglet enteric tissues and cell membranes, which exerts bioactivity of importance for immune responses and the epithelial barrier function. Especially, the n-3 PUFA present in fish oil seem to influence the gut health and function of pigs, and this is of importance during the transition periods such as post-weaning in which piglets are prone to inflammation. The proportion of unsaturated FA in the cell membranes influences the susceptibility to oxidative stress. Oxidative stress accompanies infectious diseases, and the development of lipid peroxides and other reactive oxygen products may be harmful to the epithelial barrier function. Fatty acid peroxides from the feed may also be absorbed with other lipid-solubles and thereby harm the intestinal function. Hence, antioxidative protection is important for the enteric cells. In conclusion, manipulation of the dietary FA composition can influence the gut health and function in pigs and may support a normal immune system and modulate resistance to infectious diseases during especially stressful phases of a pig’s life such as post-weaning.
Charlotte Lauridsen. Effects of dietary fatty acids on gut health and function of pigs pre- and post-weaning. Journal of Animal Science 2020, 98, 1 .
AMA StyleCharlotte Lauridsen. Effects of dietary fatty acids on gut health and function of pigs pre- and post-weaning. Journal of Animal Science. 2020; 98 (4):1.
Chicago/Turabian StyleCharlotte Lauridsen. 2020. "Effects of dietary fatty acids on gut health and function of pigs pre- and post-weaning." Journal of Animal Science 98, no. 4: 1.
The oil from industrial hemp seeds (Cannabis sativa) is an ideal source of stearidonic acid, which is a precursor fatty acid for the long-chained n-3 polyunsaturated fatty acids. These fatty acids are important for neonatal development, health and immunity. Hemp seed oil has been investigated for the influence on human health, but research on the impact in pig nutrition is scarce. The aim of our research was to study the effect of dietary hemp seed oil relative to soybean oil to lactating sows on the transfer of fatty acids to the off-spring and the effect on piglets’ immune and nutritional status. The fatty acid composition of the hemp seed and the soybean oil influenced the fatty acid composition of sow plasma, colostrum and mature milk. The highest proportion of C18:3n-3, C18:4n-3 and C20:4n-6 was obtained in mature milk fat of sows fed 5% hemp seed oil diet when compared to the other dietary fat sources (5% soybean oil or a 50:50 mix of hemp and soybean oil at 5%). The effect of dietary oil supplementation to sows was reflected in the plasma fatty acids profile of piglets. Notably the proportion of C20:5n-3 and C22:5n-3 was the highest in plasma of piglets suckling sows fed hemp seed oil-containing diets, whereas no C18:4n-3 could be detected hence indicating conversion of α-linolenic acid (ALA) and stearidonic acid (SDA) to the longer chained n-3 polyunsaturated fatty acids. Dietary fat source also influenced number of born piglets, their weight gain during first week, plasma concentration of glucose and IgG, and haematological profile. The hemp seed oil resulted in direct maternal supply with n-3 long-chain polyunsaturated fatty acids (LCPUFA), especially ALA and SDA, and piglets were able to convert these fatty acids obtained via the sow milk intake to C20:5n-3 and C22:5n-3. Furthermore, some interesting effects of the 5% hemp seed oil was obtained with regard to piglet initial body weight gain and glucose, which could be of interest for further research, i.e., the capability of hemp seed oil to benefit piglets during early life.
D. Vodolazska; C. Lauridsen. Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets. Journal of Animal Science and Biotechnology 2020, 11, 1 -18.
AMA StyleD. Vodolazska, C. Lauridsen. Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets. Journal of Animal Science and Biotechnology. 2020; 11 (1):1-18.
Chicago/Turabian StyleD. Vodolazska; C. Lauridsen. 2020. "Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets." Journal of Animal Science and Biotechnology 11, no. 1: 1-18.
Important intestinal diseases in young pigs and chickens, such as diarrhea and enteritis, may be associated with oxidative stress and inflammatory reactions. Especially enteric infectious diseases of weaned pigs and broiler chickens are responsible for a high antibiotic consumption, and there is a major request for alternative strategies to enhance animal disease resistance and robustness. The aim of this presentation was to address the role of oxidative stress and inflammation to combat infectious pathogens, and to elucidate how the reactive processes will contribute to normal immune defense mechanisms of the animal. Furthermore, factors that can enhance oxidative stress (e.g., intensive production, heat stress, polyunsaturated fatty acids, and impaired fat quality), uncontrolled inflammatory reactions (e.g., high ratio of n-6 and n-3 in cellular membranes), and limited immune development (such as micronutrient deficiency) are addressed. In addition, the presentation reviews how micronutrient supplementation during critical phases can support a normal immune system and modulate resistance to infectious diseases of pigs and poultry. The mechanisms concern especially modulation of signal transduction in leukocytes (fat-soluble vitamins and fatty acids) and protection against immunopathology, as exerted by the antioxidative vitamins and selenium. Substantial advances in optimized gut health could be expected by increasing our understanding on how to foster or inhibit production of reactive oxygen species and inflammatory reaction; the relation to enteric pathogens, and how to monitor the effect of disease prevention in farm animals by the use of antioxidant therapy and antibacterial feed components.
Charlotte Lauridsen. From oxidative stress to inflammation: redox balance and immune system. Poultry Science 2019, 98, 4240 -4246.
AMA StyleCharlotte Lauridsen. From oxidative stress to inflammation: redox balance and immune system. Poultry Science. 2019; 98 (10):4240-4246.
Chicago/Turabian StyleCharlotte Lauridsen. 2019. "From oxidative stress to inflammation: redox balance and immune system." Poultry Science 98, no. 10: 4240-4246.
The enterotoxigenic Escherichia coli (ETEC) expressing F4 and F18 fimbriae are the two main pathogens associated with post-weaning diarrhea (PWD) in piglets. The growing global concern regarding antimicrobial resistance (AMR) has encouraged research into the development of nutritional and feeding strategies as well as vaccination protocols in order to counteract the PWD due to ETEC. A valid approach to researching effective strategies is to implement piglet in vivo challenge models with ETEC infection. Thus, the proper application and standardization of ETEC F4 and F18 challenge models represent an urgent priority. The current review provides an overview regarding the current piglet ETEC F4 and F18 challenge models; it highlights the key points for setting the challenge protocols and the most important indicators which should be included in research studies to verify the effectiveness of the ETEC challenge. Based on the current review, it is recommended that the setting of the model correctly assesses the choice and preconditioning of pigs, and the timing and dosage of the ETEC inoculation. Furthermore, the evaluation of the ETEC challenge response should include both clinical parameters (such as the occurrence of diarrhea, rectal temperature and bacterial fecal shedding) and biomarkers for the specific expression of ETEC F4/F18 (such as antibody production, specific F4/F18 immunoglobulins (Igs), ETEC F4/F18 fecal enumeration and analysis of the F4/F18 receptors expression in the intestinal brush borders). On the basis of the review, the piglets’ response upon F4 or F18 inoculation differed in terms of the timing and intensity of the diarrhea development, on ETEC fecal shedding and in the piglets’ immunological antibody response. This information was considered to be relevant to correctly define the experimental protocol, the data recording and the sample collections. Appropriate challenge settings and evaluation of the response parameters will allow future research studies to comply with the replacement, reduction and refinement (3R) approach, and to be able to evaluate the efficiency of a given feeding, nutritional or vaccination intervention in order to combat ETEC infection.
Diana Luise; Charlotte Lauridsen; Paolo Bosi; Paolo Trevisi. Methodology and application of Escherichia coli F4 and F18 encoding infection models in post-weaning pigs. Journal of Animal Science and Biotechnology 2019, 10, 1 -20.
AMA StyleDiana Luise, Charlotte Lauridsen, Paolo Bosi, Paolo Trevisi. Methodology and application of Escherichia coli F4 and F18 encoding infection models in post-weaning pigs. Journal of Animal Science and Biotechnology. 2019; 10 (1):1-20.
Chicago/Turabian StyleDiana Luise; Charlotte Lauridsen; Paolo Bosi; Paolo Trevisi. 2019. "Methodology and application of Escherichia coli F4 and F18 encoding infection models in post-weaning pigs." Journal of Animal Science and Biotechnology 10, no. 1: 1-20.
In pigs, the alpha-(1,2) fucosyltransferase (FUT1) gene has been highlighted for its properties in controlling the intestinal expression of enterotoxigenic E. coli (ETEC) F18 receptors; a pathogen causing edema disease and post-weaning diarrhoea. In this study, we hypothesized that pigs with different genotypes (ETEC F18 resistant (FUT1AA) versus susceptible (FUT1AG)) differed in following systemic and enteric responses: growth performance, plasma metabolic profiles, expression of candidate genes for intestinal mucosal homeostasis and immunity, number of selected bacteria and the concentration of short-chain fatty acids (SCFA) in faeces and digesta in piglets pre and post-weaning, and on the ETEC F18 adherence ex vivo. Genotype had the strongest impact on plasma metabolomic profile on day 7 and 28 of age. FUT1AG piglets had higher level of N-methyl-2-pyrrolidinone, hippuric acid, oxindole, and 3-oxo-5-beta-chol-7-en-24-oic acid on day 7, and a higher level of guanosine on day 28 than that in the FUT1AA piglets. FUT1AA piglets had a higher level of betaine on day 7 and 3-methylguanine on day 28. On day 34 of age, the FUT1AA pigs had higher levels of S-2-hydroxyglutarate, L-phenylalanine, tauroursodeoxycholic acid and an undetermined PC/LysoPC, while Ile Glu Phe Gly peptide and genistein 5-O-glucuronide, and PC (18:0/0:0) were at higher levels in the FUT1AG piglets. FUT1 genotype did not affect the growth performance and expression of candidate genes. FUT1AG piglets had a higher number of haemolytic bacteria in faeces and in digesta than that in FUT1AA at 34 days of age. The colonic acetic acid concentration was highest in FUT1AG piglets. FUT1 genotype may influence not only the expression of E. coli F18 receptors but could potentially impact the gut homeostasis and metabotype of piglets pre and post-weaning. Further investigations on the relation between FUT1 genotype and these aspects including the intestinal commensal microbiota will expand the knowledge on factors affecting the intestinal ecosystem.
Ann-Sofie Riis Poulsen; Diana Luise; Mihai Victor Curtasu; Sugiharto Sugiharto; Nuria Canibe; Paolo Trevisi; Charlotte Lauridsen. Effects of alpha-(1,2)-fucosyltransferase genotype variants on plasma metabolome, immune responses and gastrointestinal bacterial enumeration of pigs pre- and post-weaning. PLOS ONE 2018, 13, e0202970 .
AMA StyleAnn-Sofie Riis Poulsen, Diana Luise, Mihai Victor Curtasu, Sugiharto Sugiharto, Nuria Canibe, Paolo Trevisi, Charlotte Lauridsen. Effects of alpha-(1,2)-fucosyltransferase genotype variants on plasma metabolome, immune responses and gastrointestinal bacterial enumeration of pigs pre- and post-weaning. PLOS ONE. 2018; 13 (8):e0202970.
Chicago/Turabian StyleAnn-Sofie Riis Poulsen; Diana Luise; Mihai Victor Curtasu; Sugiharto Sugiharto; Nuria Canibe; Paolo Trevisi; Charlotte Lauridsen. 2018. "Effects of alpha-(1,2)-fucosyltransferase genotype variants on plasma metabolome, immune responses and gastrointestinal bacterial enumeration of pigs pre- and post-weaning." PLOS ONE 13, no. 8: e0202970.
Selenium is an essential nutrient for poultry and pigs, and is important for a number of physiological processes including regulation and function of the immune system. Through its incorporation into selenoproteins, Se is involved in the regulation of oxidative stress, redox mechanisms, and other crucial cellular processes involved in innate and adaptive immune response. This review provides current knowledge on the mechanisms by which selenium can modulate the resilience to infectious diseases, and how this micronutrient can influence the capacity of the bird or the pig to maintain its productivity during an infectious challenge. In relation to the most frequent and economically important infectious diseases in poultry and pig production, the present paper considers the influence of different selenium sources (organic vs. inorganic Se) as well as dietary concentrations on the immune responses of poultry and pigs with major emphasis on the potential beneficial impact on animal resilience to common infectious diseases.
Tina S. Dalgaard; Mickaël Briens; Ricarda M. Engberg; Charlotte Lauridsen. The influence of selenium and selenoproteins on immune responses of poultry and pigs. Animal Feed Science and Technology 2018, 238, 73 -83.
AMA StyleTina S. Dalgaard, Mickaël Briens, Ricarda M. Engberg, Charlotte Lauridsen. The influence of selenium and selenoproteins on immune responses of poultry and pigs. Animal Feed Science and Technology. 2018; 238 ():73-83.
Chicago/Turabian StyleTina S. Dalgaard; Mickaël Briens; Ricarda M. Engberg; Charlotte Lauridsen. 2018. "The influence of selenium and selenoproteins on immune responses of poultry and pigs." Animal Feed Science and Technology 238, no. : 73-83.
Silver nanoparticles (AgNP) have gained much attention in recent years due to their biomedical applications, especially as antimicrobial agents. AgNP may be used in poultry production as an alternative to the use of antibiotic growth promoter. However, little is known about the impact of oral administration of AgNP on the gut microbiota and the immune system. The aim of the present study was to investigate the effects of AgNP on growth, hematological and immunological profile as well as intestinal microbial composition in broilers challenged with Campylobacter jejuni (C. jejuni). AgNP did not affect the intestinal microbial profile of birds. The body weight gain and the relative weights of bursa and spleen were reduced when supplemented with AgNP. There was no difference with respect to packed cell volume. However, the plasma concentrations of IgG and IgM were lower in birds receiving AgNP compared to the non-supplemented control group. The expression of TNF-α and NF-kB at mRNA level was significantly higher in birds receiving AgNP. The application of AgNP via the drinking water in the concentration of 50 ppm reduced broiler growth, impaired immune functions and had no antibacterial effect on different intestinal bacterial groups, which may limit the applicability of AgNP against C. jejuni in broiler chickens.
Krishna Prasad Vadalasetty; Charlotte Lauridsen; Ricarda Margarete Engberg; Radhika Vadalasetty; Marta Kutwin; André Chwalibog; Ewa Sawosz. Influence of silver nanoparticles on growth and health of broiler chickens after infection with Campylobacter jejuni. BMC Veterinary Research 2018, 14, 1 -11.
AMA StyleKrishna Prasad Vadalasetty, Charlotte Lauridsen, Ricarda Margarete Engberg, Radhika Vadalasetty, Marta Kutwin, André Chwalibog, Ewa Sawosz. Influence of silver nanoparticles on growth and health of broiler chickens after infection with Campylobacter jejuni. BMC Veterinary Research. 2018; 14 (1):1-11.
Chicago/Turabian StyleKrishna Prasad Vadalasetty; Charlotte Lauridsen; Ricarda Margarete Engberg; Radhika Vadalasetty; Marta Kutwin; André Chwalibog; Ewa Sawosz. 2018. "Influence of silver nanoparticles on growth and health of broiler chickens after infection with Campylobacter jejuni." BMC Veterinary Research 14, no. 1: 1-11.
The present study investigated the effect of feeding bovine colostrum (BC) to piglets in comparison with feeding a milk replacer (MR) and conventional rearing by the sow on the intestinal immune system and number of enterotoxigenic Escherichia coli (ETEC) colonising the intestinal tissue. Piglets (23-d-old) were allocated to one of the following four groups: (1) killed at the beginning of the experiment (Base); (2) separated from the sow and fed BC (BC-fed); (3) separated from the sow and fed a MR (MR-fed); (4) kept with the sow (Sow-Milk). Blood was sampled on days 1 and 8, and faecal samples were collected on days 1, 3, 5 and 8. On day 8, piglets were killed and gastrointestinal digesta and intestinal segments were collected. The frequency of diarrhoea was found to be higher (P≤ 0·019) in MR-fed piglets than in BC-fed and Sow-Milk piglets. Piglets from the MR-fed group had the lowest lactic acid bacteria:haemolytic E. coli ratio (P treat= 0·064) in the faeces. The number of E. coli colonising the intestinal tissue was higher (P< 0·001) in piglets from the MR-fed group than in those from the BC-fed and Sow-Milk groups. Piglets from the Sow-Milk group had a higher (P= 0·020) mucosal IgG concentration than those from the MR-fed group, but did not exhibit any difference when compared with piglets from the Base and BC-fed groups. Piglets from the BC-fed group exhibited a reduced (P≤ 0·037) expression level of Toll-like receptor-4 in the intestinal mucosa when compared with those from the MR-fed and Sow-Milk groups. The expression level of IL-2 was higher (P≤ 0·051) in piglets from the MR-fed group than in those from the other treatment groups. In conclusion, feeding BC rather than MR to the piglets reduced the colonisation of intestine by ETEC and modulated the intestinal immune system, whereas no differences were observed in piglets fed BC and conventionally reared by the sows.
Sugiharto Sugiharto; Ann-Sofie Riis Poulsen; Nuria Canibe; Charlotte Lauridsen. Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets. British Journal of Nutrition 2015, 113, 923 -934.
AMA StyleSugiharto Sugiharto, Ann-Sofie Riis Poulsen, Nuria Canibe, Charlotte Lauridsen. Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets. British Journal of Nutrition. 2015; 113 (6):923-934.
Chicago/Turabian StyleSugiharto Sugiharto; Ann-Sofie Riis Poulsen; Nuria Canibe; Charlotte Lauridsen. 2015. "Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets." British Journal of Nutrition 113, no. 6: 923-934.
This study evaluated the potential of silver nanoparticles (AgNano) as an antimicrobial growth-promoting supplement for broiler chickens. One hundred forty-four seven-day-old broiler chicks were distributed randomly to AgNano treatments at 0, 10 and 20 mg/kg (Control, Group AgNano10, and Group AgNano20, respectively) provided via the drinking water from day 7 to 36 post-hatching. Body weight and feed consumption were measured weekly. In addition, balance and respiration experiments were carried out to determine nitrogen (N) utilisation and energy retention. At days 22 and 36, blood samples and intestinal content were collected to evaluate the effects of AgNano on plasma concentration of immunoglobulins and the intestinal microflora, repectively. The provision of water solutions containing different concentrations of AgNano had no effect on postnatal growth performance and the energy metabolism of broiler chickens. However, in Group AgNano10 N intake (p = 0.05) and retention (p = 0.03) was increased, but N excretion and efficiency of utilisation was not affected. The populations of bacteria in the intestinal samples were not affected by AgNano supplementation. The concentration of immunoglobulin (IgG) in the blood plasma of broilers supplemented with AgNano decreased at day 36 (p = 0.012). The results demonstrated that AgNano affects N utilisation and plasma IgG concentration; however, it does not influence the microbial populations in the digestive tract, the energy metabolism and growth performance of chickens.
Lane Pineda; Andre Chwalibog; Ewa Sawosz; Charlotte Lauridsen; Ricarda Engberg; Jan Elnif; Anna Hotowy; Filip Sawosz; Yuhong Gao; Abdalla Ali; Heshmat Sepehri Moghaddam. Effect of silver nanoparticles on growth performance, metabolism and microbial profile of broiler chickens. Archives of Animal Nutrition 2012, 66, 416 -429.
AMA StyleLane Pineda, Andre Chwalibog, Ewa Sawosz, Charlotte Lauridsen, Ricarda Engberg, Jan Elnif, Anna Hotowy, Filip Sawosz, Yuhong Gao, Abdalla Ali, Heshmat Sepehri Moghaddam. Effect of silver nanoparticles on growth performance, metabolism and microbial profile of broiler chickens. Archives of Animal Nutrition. 2012; 66 (5):416-429.
Chicago/Turabian StyleLane Pineda; Andre Chwalibog; Ewa Sawosz; Charlotte Lauridsen; Ricarda Engberg; Jan Elnif; Anna Hotowy; Filip Sawosz; Yuhong Gao; Abdalla Ali; Heshmat Sepehri Moghaddam. 2012. "Effect of silver nanoparticles on growth performance, metabolism and microbial profile of broiler chickens." Archives of Animal Nutrition 66, no. 5: 416-429.