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Dr. Joby Jacob
Plant Lipids (P) Ltd

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0 Natural active substance
0 Nutraceauticals
0 herbal and medicinal plants
0 Biomaterial research
0 Natural active substances in antiaging and well being

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Research article
Published: 17 February 2021 in ACS Omega
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L-ascorbic acid (AA) or vitamin C is a crucial nutrient needed for optimal health. However, being unable to be synthesized by the body, it is thus necessary to be included in health care products. Moreover, AA is one of the antioxidants that occur naturally, which is used in pharmaceutical and food products as an antioxidant additive. However, AA is vulnerable to environmental settings and undergoes oxidative degradation to dehydroascorbic acid and further to inactive products. Therefore, new research strategies and approaches are required to augment its stability. The objective of this study is to develop and characterize a fiber-reinforced-phospholipid (FRP) matrix-based vehicle, Zeal-AA, for the delivery of AA and optimize the oral bioavailability of the obtained AA powder using an efficacy study by open-label, randomized, single-dose, two-treatment, two-sequence, two-period, two-way crossover. The structural and surface morphologies were analyzed by Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, and differential scanning calorimetry studies. Encapsulation efficiency, mean particle size, size distribution, ζ-potential measurements, and ADMET profiling revealed the potential delivery system for AA. AUC0–t was found to be 55.23 (mg/dL) for Zeal-AA, whereas it was 9.38 (mg/dL) for AA, and Cmax was found to be 6.69 (mg/dL) for Zeal-AA, whereas it was 1.23 (mg/dL) for AA, with a fold difference of bioavailability in terms of AUC found to be 5.9 fold. The results show that a single oral dose of Zeal-AA is capable of rising the AA levels in the body relative to the control up to 24 h.

ACS Style

Joby Jacob; Nimisha Pulikkal Sukumaran; Shintu Jude. Fiber-Reinforced-Phospholipid Vehicle-Based Delivery of l-Ascorbic Acid: Development, Characterization, ADMET Profiling, and Efficacy by a Randomized, Single-Dose, Crossover Oral Bioavailability Study. ACS Omega 2021, 6, 5560 -5568.

AMA Style

Joby Jacob, Nimisha Pulikkal Sukumaran, Shintu Jude. Fiber-Reinforced-Phospholipid Vehicle-Based Delivery of l-Ascorbic Acid: Development, Characterization, ADMET Profiling, and Efficacy by a Randomized, Single-Dose, Crossover Oral Bioavailability Study. ACS Omega. 2021; 6 (8):5560-5568.

Chicago/Turabian Style

Joby Jacob; Nimisha Pulikkal Sukumaran; Shintu Jude. 2021. "Fiber-Reinforced-Phospholipid Vehicle-Based Delivery of l-Ascorbic Acid: Development, Characterization, ADMET Profiling, and Efficacy by a Randomized, Single-Dose, Crossover Oral Bioavailability Study." ACS Omega 6, no. 8: 5560-5568.

Review
Published: 02 January 2019 in Biomolecules
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Over the past decades curcuminoids have been extensively studied for their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypotensive, antihypocholesteremic, and anticancer activities. With the perception of limited toxicity and cost, these compounds forms an integral part of cancer research and is well established as a potential anticancer agent. However, only few studies have focused on the other bioactive molecules of turmeric, known as non-curcuminoids, which are also equally potent as curcuminoids. This review aims to explore the comprehensive potency including the identification, physicochemical properties, and anticancer mechanism inclusive of molecular docking studies of non-curcuminoids such as turmerones, elemene, furanodiene (FN), bisacurone, germacrone, calebin A (CA), curdione, and cyclocurcumin. An insight into the clinical studies of these curcumin-free compounds are also discussed which provides ample evidence that favors the therapeutic potential of these compounds. Like curcuminoids, limited solubility and bioavailability are the most fragile domain, which circumscribe further applications of these compounds. Thus, this review credits the encapsulation of non-curcuminoid components in diverse drug delivery systems such as co-crystals, solid lipid nanoparticles, liposomes, microspheres, polar-non-polar sandwich (PNS) technology, which help abolish their shortcomings and flaunt their ostentatious benefits as anticancer activities.

ACS Style

Akhila Nair; Augustine Amalraj; Joby Jacob; Ajaikumar B. Kunnumakkara; Sreeraj Gopi. Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations. Biomolecules 2019, 9, 13 .

AMA Style

Akhila Nair, Augustine Amalraj, Joby Jacob, Ajaikumar B. Kunnumakkara, Sreeraj Gopi. Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations. Biomolecules. 2019; 9 (1):13.

Chicago/Turabian Style

Akhila Nair; Augustine Amalraj; Joby Jacob; Ajaikumar B. Kunnumakkara; Sreeraj Gopi. 2019. "Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations." Biomolecules 9, no. 1: 13.

Journal article
Published: 15 October 2018 in Fibers
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Ginger residues left after the extraction of active ingredients from ginger rhizomes are considered to be a bio-waste, available in abundance and very rarely used. Extraction and isolation of natural nanofibers from the agro-waste is economical, environmentally benign, and an alternate strategy to replace synthetic fibers. Here, we report, for the first time, the isolation of ginger nanofibers (GNF) from ginger rhizomes spent by acid hydrolysis and followed by high-pressure homogenization. Scanning electron microscopy was utilized to identify the surface morphology of the GNF and the widths ranged between 130 to 200 nm. Structural analysis of GNF was identified by Fourier transform infrared spectroscopy, Differential scanning calorimetry, and X-ray diffraction methods. This GNF was used to make natural nanocomposites by the solvent-casting method reinforcement, using potato starch (PS) and tapioca starch (TS), and was characterized through various methods. These composites were prepared by the addition of 1, 3, 5, and 7 weight % of GNF with PS or TS. Among these, 5% of the GNF composites of these starches showed very high mechanical properties. The antibacterial test showed that the bionanocomposites with 5% GNF exhibited good antibacterial activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium, due to the addition of GNF in the biopolymer matrices. The viable use of GNF from the unexploited ginger agro-waste would create additional profit and it would help to diminish a large amount of waste generation. Thus, the developed bio-composite could also be employed for development of packing materials and be used in medical applications, such as wound healing pads and medical disposables.

ACS Style

Joby Jacob; Józef T. Haponiuk; Sabu Thomas; Gregary Peter; Sreeraj Gopi. Use of Ginger Nanofibers for the Preparation of Cellulose Nanocomposites and Their Antimicrobial Activities. Fibers 2018, 6, 79 .

AMA Style

Joby Jacob, Józef T. Haponiuk, Sabu Thomas, Gregary Peter, Sreeraj Gopi. Use of Ginger Nanofibers for the Preparation of Cellulose Nanocomposites and Their Antimicrobial Activities. Fibers. 2018; 6 (4):79.

Chicago/Turabian Style

Joby Jacob; Józef T. Haponiuk; Sabu Thomas; Gregary Peter; Sreeraj Gopi. 2018. "Use of Ginger Nanofibers for the Preparation of Cellulose Nanocomposites and Their Antimicrobial Activities." Fibers 6, no. 4: 79.

Review
Published: 01 September 2018 in Materials Today Chemistry
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Drug delivery systems (DDS) are used to achieve a higher therapeutic effects of a pharmaceutical drug or natural compound in a specific diseased site with minimal toxicological effect and these systems consists of liposomes, microspheres, gels, prodrugs and many. Nanotechnology is a rapidly developing multi-disciplinary science that ensures the fabrication of the polymers to nanometer scale for various medical applications. Uses of biopolymers in DDS ensure the biocompatibility, biodegradability and low immunogenicity over the synthetic ones. Biopolymers such as silk fibroins, collagen, gelatin, albumin, starch, cellulose and chitosan can be easily made into suspension that serve as delivery vehicles for both macro and mini drug molecules. There are various methods such as supercritical fluid extraction, desolvation, electrospraying, spray-drying, layer-by-layer self-assembly, freeze-drying and microemulsion introduced to make these DDS. This drug carrier systems enhance the drug delivery actively and can be used in ocular, transdermal, dental or intranasal delivery systems. This review describes the new trends in nanomaterials based drug delivery systems mainly using biopolymers such as proteins (silk fibroin, collagen, gelatin and albumin) and polysaccharides (chitosan, alginate, cellulose and starch).

ACS Style

Joby Jacob; Józef Haponiuk; Sabu Thomas; Sreeraj Gopi. Biopolymer based nanomaterials in drug delivery systems: A review. Materials Today Chemistry 2018, 9, 43 -55.

AMA Style

Joby Jacob, Józef Haponiuk, Sabu Thomas, Sreeraj Gopi. Biopolymer based nanomaterials in drug delivery systems: A review. Materials Today Chemistry. 2018; 9 ():43-55.

Chicago/Turabian Style

Joby Jacob; Józef Haponiuk; Sabu Thomas; Sreeraj Gopi. 2018. "Biopolymer based nanomaterials in drug delivery systems: A review." Materials Today Chemistry 9, no. : 43-55.

Randomized controlled trial
Published: 22 June 2017 in Journal of Dietary Supplements
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Sports supplements that stimulate the production of nitric oxide (NO) are widely promoted agents in the sports nutrition domain, and nitric oxide plays an important role to enhance the cardiovascular and physical fitness of the sports participants. The purpose of the study is to investigate whether oral intake of a sports nutritional supplement (Fitnox) is able to increase nitrate (NO3−) and nitrite (NO2−) levels in blood serum and saliva of healthy adults. Fitnox is a unique blend of Kaempferia parviflora methoxy flavones, pomegranate peel polyphenols, and Moringa oleifera leaf saponins. Twenty-four healthy male adults were equally divided and underwent the double-blind, placebo-controlled clinical trial with a single oral dose of sports nutrition formulation (250 mg capsules); blood and saliva samples were analyzed at different time intervals by high-performance liquid chromatography (HPLC). After administration of Fitnox (250 mg capsule as single dose), NO3− and NO2− levels in serum and saliva were found to be significantly higher (p <.05) than in the placebo group in 24 hours. Pharmacokinetic parameters such as the area under the plasma concentration-time curve extrapolated to infinity (AUC0-inf), AUC calculated to the last measured concentration (AUC0-t), maximum drug serum concentrations (Cmax), time of maximum concentration in serum observed (Tmax), and time required for the concentration of the drug to reach half of its original value (Thalf) were also statistically significant (p <.05) compared with the placebo. The results indicate that a single oral dose of Fitnox is able to increase the NO3− and NO2− levels considerably in the body relative to placebo for at least 12 hours. Therefore, Fitnox can improve the overall performance of sport participants and enhance physical endurance.

ACS Style

Joby Jacob; Sreeraj Gopi; Chandradhara Divya. A Randomized Single Dose Parallel Study on Enhancement of Nitric Oxide in Serum and Saliva with the Use of Natural Sports Supplement in Healthy Adults. Journal of Dietary Supplements 2017, 15, 161 -172.

AMA Style

Joby Jacob, Sreeraj Gopi, Chandradhara Divya. A Randomized Single Dose Parallel Study on Enhancement of Nitric Oxide in Serum and Saliva with the Use of Natural Sports Supplement in Healthy Adults. Journal of Dietary Supplements. 2017; 15 (2):161-172.

Chicago/Turabian Style

Joby Jacob; Sreeraj Gopi; Chandradhara Divya. 2017. "A Randomized Single Dose Parallel Study on Enhancement of Nitric Oxide in Serum and Saliva with the Use of Natural Sports Supplement in Healthy Adults." Journal of Dietary Supplements 15, no. 2: 161-172.

Journal article
Published: 02 January 2017 in Journal of Liquid Chromatography & Related Technologies
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ACS Style

A. I. Charles Dorni; Gregary Peter; Shintu Jude; C. A. Arundhathy; Joby Jacob; Augustine Amalraj; Anitha Pius; Sreeraj Gopi. UHPLC–Q-ToF-MS Guided Enrichment and Purification of Triterpenoids From Centella Asiatica (L.) Extract with Macroporous Resin. Journal of Liquid Chromatography & Related Technologies 2017, 40, 13 -25.

AMA Style

A. I. Charles Dorni, Gregary Peter, Shintu Jude, C. A. Arundhathy, Joby Jacob, Augustine Amalraj, Anitha Pius, Sreeraj Gopi. UHPLC–Q-ToF-MS Guided Enrichment and Purification of Triterpenoids From Centella Asiatica (L.) Extract with Macroporous Resin. Journal of Liquid Chromatography & Related Technologies. 2017; 40 (1):13-25.

Chicago/Turabian Style

A. I. Charles Dorni; Gregary Peter; Shintu Jude; C. A. Arundhathy; Joby Jacob; Augustine Amalraj; Anitha Pius; Sreeraj Gopi. 2017. "UHPLC–Q-ToF-MS Guided Enrichment and Purification of Triterpenoids From Centella Asiatica (L.) Extract with Macroporous Resin." Journal of Liquid Chromatography & Related Technologies 40, no. 1: 13-25.

Journal article
Published: 01 January 2016 in Journal of Nutrition & Food Sciences
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Hydrogenation of curcuminoids leads to a unique combination of bio active molecules and the encapsulation of the same with beta-cyclodextrin gives a higher bioequivalency than that of curcumin in animal blood plasma. A bioequivalence study of the newly developed colorless, tasteless curcumin derivative had conducted in female Sprague Dawley rats and the blood serum was analyzed by HPLC. The relative bioavailability (Cmax) of white curcumin was significantly enhanced to about 6.76 fold (576.206%) compared with that of curcumin 95% in rat when administered the test item and reference standard through oral route. The stability of the white curcumin at normal cooking temperature (120°C - 200°C) is appreciable and there is no considerable degradation in experiments before and after cooking. As this formulation doesn’t change the taste and color of the food products, it could be easily used for increasing the nutraceutical benefits.

ACS Style

Sreeraj G; Jacob J. A Unique Formulation of Hydrogenated Curcuminoids with Higher Bio-Availability and the Application in Food Matrices. Journal of Nutrition & Food Sciences 2016, 06, 1 .

AMA Style

Sreeraj G, Jacob J. A Unique Formulation of Hydrogenated Curcuminoids with Higher Bio-Availability and the Application in Food Matrices. Journal of Nutrition & Food Sciences. 2016; 06 (02):1.

Chicago/Turabian Style

Sreeraj G; Jacob J. 2016. "A Unique Formulation of Hydrogenated Curcuminoids with Higher Bio-Availability and the Application in Food Matrices." Journal of Nutrition & Food Sciences 06, no. 02: 1.