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Dr. Sallie Permar is the Nancy C. Paduano Professor and Chair of Pediatrics at Weill Cornell Medicine and Pediatrician-in-Chief at NewYork-Presbyterian/Weill Cornell Medical Center. Dr. Permar has a PhD in Microbiology/Immunology from Johns Hopkins Bloomberg School of Public Health in Baltimore, an M.D. from Harvard Medical School and completed her clinical training in pediatric infectious diseases at Children’s Hospital in Boston. As a physician-scientist focusing on the prevention and treatment of neonatal viral infections, Dr. Permar leads a research laboratory investigating immune protection against vertical transmission of neonatal viral pathogens, namely HIV and cytomegalovirus (CMV).
Human cytomegalovirus (HCMV), one of the most prevalent viruses across the globe, is a common cause of morbidity and mortality for immunocompromised individuals. Recent clinical observations have demonstrated that mixed strain infections are common and may lead to more severe disease progression. This clinical observation illustrates the complexity of the HCMV genome and emphasizes the importance of taking a population-level view of genotypic evolution. Here we review frequently sampled polymorphisms in the glycoproteins of HCMV, comparing the variable regions, and summarizing their corresponding geographic distributions observed to date. The related strain-specific immunity, including neutralization activity and antigen-specific cellular immunity, is also discussed. Given that these glycoproteins are common targets for vaccine design and anti-viral therapies, this observed genetic variation represents an important resource for future efforts to combat HCMV infections.
Hsuan-Yuan Wang; Sarah Valencia; Susanne Pfeifer; Jeffrey Jensen; Timothy Kowalik; Sallie Permar. Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity. Viruses 2021, 13, 1106 .
AMA StyleHsuan-Yuan Wang, Sarah Valencia, Susanne Pfeifer, Jeffrey Jensen, Timothy Kowalik, Sallie Permar. Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity. Viruses. 2021; 13 (6):1106.
Chicago/Turabian StyleHsuan-Yuan Wang; Sarah Valencia; Susanne Pfeifer; Jeffrey Jensen; Timothy Kowalik; Sallie Permar. 2021. "Common Polymorphisms in the Glycoproteins of Human Cytomegalovirus and Associated Strain-Specific Immunity." Viruses 13, no. 6: 1106.