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Wolf–Hirschhorn syndrome (WHS), a rare disorder determined by distal 4p deletion, is characterized by a pre and postnatal growth retardation, hypotonia, intellectual disability, epilepsy, craniofacial dysmorphism, and congenital fusion anomalies. The clinical aspects are dependent on the deletion’ size. Our aim was to identify rare specific characteristics in a cohort of seven cases with 4p deletion and to assess the utility of Multiplex ligation-dependent probe amplification (MLPA) (cheap and sensitive test)—combined kits—as a diagnostic test and selection tool for cases that require other investigations (chromosomal microarray analysis—CMA, karyotype). For all cases we conducted a clinical examination with the main features identified: facial dysmorphism, intellectual disability, postnatal development delay, cardiac defects and hypotonia. In some cases, we observed seizures, structural brain abnormalities, immunodeficiencies, and renal anomalies. Prenatal growth retardation was detected in a relatively small number of cases, but postnatal growth failure was a constant feature. In all cases, the clinical diagnosis was confirmed by genetic analyses: karyotype and/or MLPA. In conclusion, renal and brain defects, as well as immunodeficiency are rare manifestations and should be looked for. Although CMA is the standard test, in our experience, MLPA is also a reliable screening method as the identified cases were either confirmed by MLPA or selected for further investigations.
Eva-Cristiana Gavril; Alina Costina Luca; Alexandrina-Stefania Curpan; Roxana Popescu; Irina Resmerita; Monica Cristina Panzaru; Lacramioara Ionela Butnariu; Eusebiu Vlad Gorduza; Mihaela Gramescu; Cristina Rusu. Wolf-Hirschhorn Syndrome: Clinical and Genetic Study of 7 New Cases, and Mini Review. Children 2021, 8, 751 .
AMA StyleEva-Cristiana Gavril, Alina Costina Luca, Alexandrina-Stefania Curpan, Roxana Popescu, Irina Resmerita, Monica Cristina Panzaru, Lacramioara Ionela Butnariu, Eusebiu Vlad Gorduza, Mihaela Gramescu, Cristina Rusu. Wolf-Hirschhorn Syndrome: Clinical and Genetic Study of 7 New Cases, and Mini Review. Children. 2021; 8 (9):751.
Chicago/Turabian StyleEva-Cristiana Gavril; Alina Costina Luca; Alexandrina-Stefania Curpan; Roxana Popescu; Irina Resmerita; Monica Cristina Panzaru; Lacramioara Ionela Butnariu; Eusebiu Vlad Gorduza; Mihaela Gramescu; Cristina Rusu. 2021. "Wolf-Hirschhorn Syndrome: Clinical and Genetic Study of 7 New Cases, and Mini Review." Children 8, no. 9: 751.
Pallister–Killian syndrome (PKS) is a rare, sporadic disorder defined by a characteristic dysmorphic face, pigmentary skin anomalies, intellectual disability, hypotonia, and seizures caused by 12p tetrasomy due to an extra isochromosome 12p. We present three cases of PKS and two cases of trisomy 12p to illustrate and discuss features rarely cited in the literature, present certain particularities that not yet been cited, and analyze the differences between entities. Moreover, we present alternative methods of diagnosis that could be easily used in daily practice. Features not yet or rarely reported in PKS literature include marked excess of hair on the forehead and ears in the first months of life, a particular eye disorder (abnormal iris color with pointed pupil), connective tissue defects, repeated episodes of infection and autonomic dysfunction, endocrine malfunction as a possible cause of postnatal growth deficit, more complex sensory impairments, and mild early myoclonic jerks. After performing different combinations of tests, we conclude that MLPA (follow-up kit P230-B1) or array CGH using DNA extracted from a buccal swab is a reliable method of diagnosis in PKS and we recommend either one as a first intention diagnostic test. In cases without major defects associated (suspicion trisomy 12p), subtelomeric MLPA should be performed first.
Aurora Arghir; Roxana Popescu; Irina Resmerita; Magdalena Budisteanu; Lacramioara Butnariu; Eusebiu Gorduza; Mihaela Gramescu; Monica Panzaru; Sorina Papuc; Adriana Sireteanu; Andreea Tutulan-Cunita; Cristina Rusu. Pallister–Killian Syndrome versus Trisomy 12p—A Clinical Study of 5 New Cases and a Literature Review. Genes 2021, 12, 811 .
AMA StyleAurora Arghir, Roxana Popescu, Irina Resmerita, Magdalena Budisteanu, Lacramioara Butnariu, Eusebiu Gorduza, Mihaela Gramescu, Monica Panzaru, Sorina Papuc, Adriana Sireteanu, Andreea Tutulan-Cunita, Cristina Rusu. Pallister–Killian Syndrome versus Trisomy 12p—A Clinical Study of 5 New Cases and a Literature Review. Genes. 2021; 12 (6):811.
Chicago/Turabian StyleAurora Arghir; Roxana Popescu; Irina Resmerita; Magdalena Budisteanu; Lacramioara Butnariu; Eusebiu Gorduza; Mihaela Gramescu; Monica Panzaru; Sorina Papuc; Adriana Sireteanu; Andreea Tutulan-Cunita; Cristina Rusu. 2021. "Pallister–Killian Syndrome versus Trisomy 12p—A Clinical Study of 5 New Cases and a Literature Review." Genes 12, no. 6: 811.
This study identifies the genetic background of familial hypercholesterolemia (FH) patients in Romania and evaluates the association between mutations and cardiovascular events. We performed a prospective observational study of 61 patients with a clinical diagnosis of FH selected based on Dutch Lipid Clinic Network (DLCN) and Simon Broome score between 2017 and 2020. Two techniques were used to identify mutations: multiplex ligation-dependent probe amplification (MLPA) and Sanger sequencing. The mutation rate was 37.7%, i.e., 23 patients with mutations were identified, of which 7 subjects had pathogenic mutations and 16 had polymorphisms. Moreover, 10 variants of the low-density lipoprotein receptor (LDLR) gene were identified in 22 patients, i.e., one variant of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene in six patients, and one variant of the apolipoprotein B (APOB) gene in three patients. Of the LDLR gene variants, four were LDLR pathogenic mutations (c.81C > G, c.502G > A, c.1618G > A mutations in exon 2, exon 4, exon 11, and exon 13–15 duplication). The PCSK9 and APOB gene variants were benign mutations. The pathogenic LDLR mutations were significant predictors of the new cardiovascular events, and the time interval for new cardiovascular events occurrence was significantly decreased, compared to FH patients without mutations. In total, 12 variants were identified, with four pathogenic variants identified in the LDLR gene, whereas 62.3% of the study population displayed no pathological mutations.
Cristiana-Elena Vlad; Liliana Foia; Roxana Popescu; Ioana Popa; Ruxandra Aanicai; Delia Reurean-Pintilei; Vasilica Toma; Laura Florea; Mehmet Kanbay; Adrian Covic. Molecular Genetic Approach and Evaluation of Cardiovascular Events in Patients with Clinical Familial Hypercholesterolemia Phenotype from Romania. Journal of Clinical Medicine 2021, 10, 1399 .
AMA StyleCristiana-Elena Vlad, Liliana Foia, Roxana Popescu, Ioana Popa, Ruxandra Aanicai, Delia Reurean-Pintilei, Vasilica Toma, Laura Florea, Mehmet Kanbay, Adrian Covic. Molecular Genetic Approach and Evaluation of Cardiovascular Events in Patients with Clinical Familial Hypercholesterolemia Phenotype from Romania. Journal of Clinical Medicine. 2021; 10 (7):1399.
Chicago/Turabian StyleCristiana-Elena Vlad; Liliana Foia; Roxana Popescu; Ioana Popa; Ruxandra Aanicai; Delia Reurean-Pintilei; Vasilica Toma; Laura Florea; Mehmet Kanbay; Adrian Covic. 2021. "Molecular Genetic Approach and Evaluation of Cardiovascular Events in Patients with Clinical Familial Hypercholesterolemia Phenotype from Romania." Journal of Clinical Medicine 10, no. 7: 1399.
Background: We have investigated the main genetic causes for non-syndromic hearing impairment (NSHI) in the hearing impairment individuals from the North-Eastern Romania and proposed a cost-effective diagnosis protocol. Methods: MLPA followed by Sanger Sequencing were used for all 291 patients included in this study. Results: MLPA revealed abnormal results in 141 cases (48.45%): 57 (40.5%) were c.35delG homozygous, 26 (18.44%) were c.35delG heterozygous, 14 (9.93%) were compound heterozygous and 16 (11.35%) had other types of variants. The entire coding region of GJB2 was sequenced and out of 150 patients with normal results at MLPA, 29.33% had abnormal results: variants in heterozygous state: c.71G>A (28%), c.457G>A (20%), c.269T>C (12%), c.109G>A (12%), c.100A>T (12%), c.551G>C (8%). Out of 26 patients with c.35delG in heterozygous state, 38.46% were in fact compound heterozygous. Conclusions: We identified two variants: c.109G>A and c.100A>T that have not been reported in any study from Romania. MLPA is an inexpensive, rapid and reliable technique that could be a cost-effective diagnosis method, useful for patients with hearing impairment. It can be adaptable for the mutation spectrum in every population and followed by Sanger sequencing can provide a genetic diagnosis for patients with different degrees of hearing impairment.
Irina Resmerita; Romica Sebastian Cozma; Roxana Popescu; Luminita Mihaela Radulescu; Monica Cristina Panzaru; Lacramioara Ionela Butnariu; Lavinia Caba; Ovidiu-Dumitru Ilie; Eva-Cristiana Gavril; Eusebiu Vlad Gorduza; Cristina Rusu. Genetics of Hearing Impairment in North-Eastern Romania—A Cost-Effective Improved Diagnosis and Literature Review. Genes 2020, 11, 1506 .
AMA StyleIrina Resmerita, Romica Sebastian Cozma, Roxana Popescu, Luminita Mihaela Radulescu, Monica Cristina Panzaru, Lacramioara Ionela Butnariu, Lavinia Caba, Ovidiu-Dumitru Ilie, Eva-Cristiana Gavril, Eusebiu Vlad Gorduza, Cristina Rusu. Genetics of Hearing Impairment in North-Eastern Romania—A Cost-Effective Improved Diagnosis and Literature Review. Genes. 2020; 11 (12):1506.
Chicago/Turabian StyleIrina Resmerita; Romica Sebastian Cozma; Roxana Popescu; Luminita Mihaela Radulescu; Monica Cristina Panzaru; Lacramioara Ionela Butnariu; Lavinia Caba; Ovidiu-Dumitru Ilie; Eva-Cristiana Gavril; Eusebiu Vlad Gorduza; Cristina Rusu. 2020. "Genetics of Hearing Impairment in North-Eastern Romania—A Cost-Effective Improved Diagnosis and Literature Review." Genes 11, no. 12: 1506.
The coexistence of t(9;22) and inv(16) has been described in a very limited number of cases of CML, de novo or therapy-related AML. We report a patient with CML who presented both inversion of chromosome 16 and Philadelphia chromosome and evolved towards the blast phase under treatment with Imatinib. Laboratory diagnosis and monitoring was made by flow cytometry, conventional cytogenetics and molecular genetics techniques. The inv(16), detected by karyotyping in the Philadelphia chromosome positive clone at the moment of the blast transformation, was retrospectively assessed by means of real-time PCR, and was proved to have been present since diagnosis. The bone marrow biopsy performed in the blast phase of CML confirmed the presence of blasts belonging to the myeloid lineage, with indications of monocytic differentiation, frequently associated with inv(16). Moreover, the case also associated a F359V tyrosine kinase domain mutation, resulting in intermediate resistance to Imatinib and Nilotinib, which imposed therapy-switch to Dasatinib. In our case the evolution was progressive, followed by death due to lack of response to tyrosine kinase inhibitors, 18 months after diagnosis. The coexistence of t(9;22) and inv(16) in CML seems to be associated with an aggressive clinical evolution and resistance to tyrosine kinase inhibitor therapy. Due to the very small number of cases described in literature, therapeutic decisions are still difficult for patients displaying these abnormalities
Roxana Popescu; Angela Dascalescu; Catalin Danaila; Doramina Ghiorghiu; Mihaela Zlei; Anca Ivanov; Adriana Sireteanu; Eusebiu Vlad Gorduza; Doina Azoicǎi. Co-expression of the CBFβ-MYH11 and BCR-ABL fusion genes in chronic myeloid leukaemia / Coexistenţa genelor de fuziune CBFβ-MYH11 şi BCR-ABL în leucemia mieloidă cronică. Revista Romana de Medicina de Laborator 2015, 23, 1 .
AMA StyleRoxana Popescu, Angela Dascalescu, Catalin Danaila, Doramina Ghiorghiu, Mihaela Zlei, Anca Ivanov, Adriana Sireteanu, Eusebiu Vlad Gorduza, Doina Azoicǎi. Co-expression of the CBFβ-MYH11 and BCR-ABL fusion genes in chronic myeloid leukaemia / Coexistenţa genelor de fuziune CBFβ-MYH11 şi BCR-ABL în leucemia mieloidă cronică. Revista Romana de Medicina de Laborator. 2015; 23 (2):1.
Chicago/Turabian StyleRoxana Popescu; Angela Dascalescu; Catalin Danaila; Doramina Ghiorghiu; Mihaela Zlei; Anca Ivanov; Adriana Sireteanu; Eusebiu Vlad Gorduza; Doina Azoicǎi. 2015. "Co-expression of the CBFβ-MYH11 and BCR-ABL fusion genes in chronic myeloid leukaemia / Coexistenţa genelor de fuziune CBFβ-MYH11 şi BCR-ABL în leucemia mieloidă cronică." Revista Romana de Medicina de Laborator 23, no. 2: 1.
Adriana Sireteanu; Elena Braha; Roxana Popescu; Mihaela Gramescu; E V Gorduza; Cristina Rusu. Inverted duplication deletion of 8P: characterization by standard cytogenetic and SNP array analyses. Revista Medico-Chirurgicala 2014, 117, 1 .
AMA StyleAdriana Sireteanu, Elena Braha, Roxana Popescu, Mihaela Gramescu, E V Gorduza, Cristina Rusu. Inverted duplication deletion of 8P: characterization by standard cytogenetic and SNP array analyses. Revista Medico-Chirurgicala. 2014; 117 (3):1.
Chicago/Turabian StyleAdriana Sireteanu; Elena Braha; Roxana Popescu; Mihaela Gramescu; E V Gorduza; Cristina Rusu. 2014. "Inverted duplication deletion of 8P: characterization by standard cytogenetic and SNP array analyses." Revista Medico-Chirurgicala 117, no. 3: 1.
Lăcrămioara Butnariu; Cristina Rusu; Lavinia Caba; Monica Pânzaru; Elena Braha; Mihaela Grămescu; Roxana Popescu; C Bujoranu; E V Gorduza. Genotype- phenotype correlation in trisomy X: a retrospective study of a selected group of 36 patients and review of literature. Revista Medico-Chirurgicala 2014, 117, 1 .
AMA StyleLăcrămioara Butnariu, Cristina Rusu, Lavinia Caba, Monica Pânzaru, Elena Braha, Mihaela Grămescu, Roxana Popescu, C Bujoranu, E V Gorduza. Genotype- phenotype correlation in trisomy X: a retrospective study of a selected group of 36 patients and review of literature. Revista Medico-Chirurgicala. 2014; 117 (3):1.
Chicago/Turabian StyleLăcrămioara Butnariu; Cristina Rusu; Lavinia Caba; Monica Pânzaru; Elena Braha; Mihaela Grămescu; Roxana Popescu; C Bujoranu; E V Gorduza. 2014. "Genotype- phenotype correlation in trisomy X: a retrospective study of a selected group of 36 patients and review of literature." Revista Medico-Chirurgicala 117, no. 3: 1.
Dizabilitatea intelectuală (DI) este o afecțiune frecventă, cu consecințe majore pentru individ, familie și societate. Datorită heterogenității sale clinice și genetice, în aproximativ 50% din cazuri etiologia bolii nu poate fi stabilită. Scopul acestui studiu a fost evaluarea capacității de stabilire a diagnosticului etiologic la 369 pacienți cu DI sindromic și rezultat normal sau incert la cariotip folosind o combinație de kituri MLPA. Toţi pacienţii au fost investigaţi prin metoda MLPA, folosind fie kiturile SALSA MLPA P064 sau P096, dacă fenotipul a fost sugestiv pentru un sindrom cu microdeleţie (subgrupul A - 186 pacienți), fie kiturile subtelomerice P036 și P070, dacă fenotipul nu a fost sugestiv pentru un sindrom cu microdeleţie sau rezultatul la cariotipul standard a fost incert (subgrupul B - 183 pacienți). Rezultatele anormale detectate de aceste kituri au fost caracterizate folosind kiturile MLPA corespunzătoare de urmărire (Telomere Follow-up set, P029-A1, P250-B2, ME028-B1). În subgrupul A am identificat 25 de pacienți cu microdeleții (13,4%). Folosind kiturile de screening subtelomeric și de urmărire la subgrupul B am detectat rearanjări criptice în 7,5% din cazuri și am identificat originea materialului suplimentar observat la cariotipul standard la 10 din 11 pacienți. Sumarizând datele obţinute din cele două loturi, folosirea combinată a seturilor MLPA a dus la stabilirea diagnosticului la 10,6% (38/358) dintre pacienții cu cariotip normal. Folosirea seturilor MLPA de urmărire a permis atât confirmarea prezenţei anomaliei, cât şi determinarea dimensiunii ei, ceea ce a facilitat interpretarea semnificaţiei clinice a rearanjărilor. Pentru laboratoarele care nu au acces la tehnologiile bazate pe microarray, folosirea mai multor kituri MLPA reprezintă o strategie eficientă pentru stabilirea diagnosticului etiologic la pacienţii cu DI
Adriana Sireteanu; Roxana Popescu; Elena Emanuela Braha; Cornel Bujoran; Lăcrămioara Butnariu; Lavinia Caba; Elena Graur; Eusebiu Vlad Gorduza; Mihaela Grămescu; Iuliu Ivanov; Monica Pânzaru; Cristina Rusu. Detection of chromosomal imbalances using combined MLPA kits in patients with syndromic intellectual disability. Revista Romana de Medicina de Laborator 2014, 22, 157 -164.
AMA StyleAdriana Sireteanu, Roxana Popescu, Elena Emanuela Braha, Cornel Bujoran, Lăcrămioara Butnariu, Lavinia Caba, Elena Graur, Eusebiu Vlad Gorduza, Mihaela Grămescu, Iuliu Ivanov, Monica Pânzaru, Cristina Rusu. Detection of chromosomal imbalances using combined MLPA kits in patients with syndromic intellectual disability. Revista Romana de Medicina de Laborator. 2014; 22 (2):157-164.
Chicago/Turabian StyleAdriana Sireteanu; Roxana Popescu; Elena Emanuela Braha; Cornel Bujoran; Lăcrămioara Butnariu; Lavinia Caba; Elena Graur; Eusebiu Vlad Gorduza; Mihaela Grămescu; Iuliu Ivanov; Monica Pânzaru; Cristina Rusu. 2014. "Detection of chromosomal imbalances using combined MLPA kits in patients with syndromic intellectual disability." Revista Romana de Medicina de Laborator 22, no. 2: 157-164.
Duchenne and Becker muscular dystrophies (DMD/BMD) are X-linked progressive muscle disorders determined by mutations of the dystrophin (DMD) gene. Multiplex Ligation - Dependent Probe Amplification (MLPA) is a simple, inexpensive and reliable test for molecular diagnosis of DMD gene mutations. It identifies exonic copy number variations in the DMD gene, but the test should be completed with sequencing analysis in case of single exon deletions/duplications. The aim of this study was to evaluate the efficiency of MLPA as a DMD mutation screening tool in affected males and carrier females, as well as to appreciate the frequency of different types of mutations and to check the validity of the “reading frame rule”. We have used MLPA for the detection of deletions/ duplications in DMD gene in 53 individuals (30 affected males and 23 asymptomatic female relatives) referred for evaluation and genetic counseling due to the clinical suspicion of DMD/BMD. In the affected males (21 DMD and 9 BMD) MLPA had a detection rate of 63.5% (53.5% deletions and 10% duplications). The most frequently deleted exon was exon 45 and the most frequent duplication involved exons 3-5, confirming the presence of the two hotspot mutation regions reported in the literature. Mutations detected in our study have a slightly different location compared to literature data. Reading frame rule was valid in 84% of our cases.
Cristina Rusu; Adriana Sireteanu; Lăcrămioara Butnariu; Monica Pânzaru; Elena Braha; Doina Mihaila; Roxana Popescu. Identification of Exonic Copy Number Variations in Dystrophin Gene Using Mlpa / Identificarea Variaţiilor Numărului de Copii în Gena Distrofinei Folosind Metoda Mlpa. Revista Romana de Medicina de Laborator 2014, 22, 1 .
AMA StyleCristina Rusu, Adriana Sireteanu, Lăcrămioara Butnariu, Monica Pânzaru, Elena Braha, Doina Mihaila, Roxana Popescu. Identification of Exonic Copy Number Variations in Dystrophin Gene Using Mlpa / Identificarea Variaţiilor Numărului de Copii în Gena Distrofinei Folosind Metoda Mlpa. Revista Romana de Medicina de Laborator. 2014; 22 (4):1.
Chicago/Turabian StyleCristina Rusu; Adriana Sireteanu; Lăcrămioara Butnariu; Monica Pânzaru; Elena Braha; Doina Mihaila; Roxana Popescu. 2014. "Identification of Exonic Copy Number Variations in Dystrophin Gene Using Mlpa / Identificarea Variaţiilor Numărului de Copii în Gena Distrofinei Folosind Metoda Mlpa." Revista Romana de Medicina de Laborator 22, no. 4: 1.
Lavinia Caba; Cristina Rusu; Lacramioara Butnariu; Monica Panzaru; Elena Braha; M Volosciuc; Roxana Popescu; Mihaela Gramescu; C Bujoran; Violeta Martiniuc; M Covic; E V Gorduza. Phenotypic variability in Patau syndrome. Revista Medico-Chirurgicala 2013, 117, 1 .
AMA StyleLavinia Caba, Cristina Rusu, Lacramioara Butnariu, Monica Panzaru, Elena Braha, M Volosciuc, Roxana Popescu, Mihaela Gramescu, C Bujoran, Violeta Martiniuc, M Covic, E V Gorduza. Phenotypic variability in Patau syndrome. Revista Medico-Chirurgicala. 2013; 117 (2):1.
Chicago/Turabian StyleLavinia Caba; Cristina Rusu; Lacramioara Butnariu; Monica Panzaru; Elena Braha; M Volosciuc; Roxana Popescu; Mihaela Gramescu; C Bujoran; Violeta Martiniuc; M Covic; E V Gorduza. 2013. "Phenotypic variability in Patau syndrome." Revista Medico-Chirurgicala 117, no. 2: 1.
Irina Iuliana Costache; Cristina Rusu; I Ivanov; Roxana Popescu; Antoniu Petris. Impact of clopidogrel response on the clinical evolution in patients with acute coronary syndromes. Revista Medico-Chirurgicala 2013, 116, 1 .
AMA StyleIrina Iuliana Costache, Cristina Rusu, I Ivanov, Roxana Popescu, Antoniu Petris. Impact of clopidogrel response on the clinical evolution in patients with acute coronary syndromes. Revista Medico-Chirurgicala. 2013; 116 (4):1.
Chicago/Turabian StyleIrina Iuliana Costache; Cristina Rusu; I Ivanov; Roxana Popescu; Antoniu Petris. 2013. "Impact of clopidogrel response on the clinical evolution in patients with acute coronary syndromes." Revista Medico-Chirurgicala 116, no. 4: 1.
Eusebiu V. Gorduza; Roxana Popescu; Lavinia Caba; Iuliu Ivanov; Violeta Martiniuc; Florina Nedelea; Mariela Militaru; Demetra G. Socolov. Prenatal diagnosis of 21 trisomy by quantification of methylated fetal DNA in maternal blood: study on 10 pregnancies. Revista Romana de Medicina de Laborator 2013, 21, 1 .
AMA StyleEusebiu V. Gorduza, Roxana Popescu, Lavinia Caba, Iuliu Ivanov, Violeta Martiniuc, Florina Nedelea, Mariela Militaru, Demetra G. Socolov. Prenatal diagnosis of 21 trisomy by quantification of methylated fetal DNA in maternal blood: study on 10 pregnancies. Revista Romana de Medicina de Laborator. 2013; 21 (3):1.
Chicago/Turabian StyleEusebiu V. Gorduza; Roxana Popescu; Lavinia Caba; Iuliu Ivanov; Violeta Martiniuc; Florina Nedelea; Mariela Militaru; Demetra G. Socolov. 2013. "Prenatal diagnosis of 21 trisomy by quantification of methylated fetal DNA in maternal blood: study on 10 pregnancies." Revista Romana de Medicina de Laborator 21, no. 3: 1.
Irina Luliana Costache; Cristina Rusu; Iuliu Ivanov; Roxana Popescu; Antoniu Petris. [Clopidogrel resistance--risk factor in patients with acute coronary syndromes]. Revista Medico-Chirurgicala 2012, 116, 1 .
AMA StyleIrina Luliana Costache, Cristina Rusu, Iuliu Ivanov, Roxana Popescu, Antoniu Petris. [Clopidogrel resistance--risk factor in patients with acute coronary syndromes]. Revista Medico-Chirurgicala. 2012; 116 (2):1.
Chicago/Turabian StyleIrina Luliana Costache; Cristina Rusu; Iuliu Ivanov; Roxana Popescu; Antoniu Petris. 2012. "[Clopidogrel resistance--risk factor in patients with acute coronary syndromes]." Revista Medico-Chirurgicala 116, no. 2: 1.
Monica Pânzaru; Cristina Rusu; M Voloşciuc; Elena Braha; Lăcrămioara Butnariu; Iuliu Ivanov; Mihaela Grămescu; Roxana Popescu; Lavinia Caba; Adriana Sireteanu; M Macovei; M Covic; E V Gorduza. [Improvement of genetic diagnostic strategy in velo-cardio-facial syndrome]. Revista Medico-Chirurgicala 2011, 115, 1 .
AMA StyleMonica Pânzaru, Cristina Rusu, M Voloşciuc, Elena Braha, Lăcrămioara Butnariu, Iuliu Ivanov, Mihaela Grămescu, Roxana Popescu, Lavinia Caba, Adriana Sireteanu, M Macovei, M Covic, E V Gorduza. [Improvement of genetic diagnostic strategy in velo-cardio-facial syndrome]. Revista Medico-Chirurgicala. 2011; 115 (3):1.
Chicago/Turabian StyleMonica Pânzaru; Cristina Rusu; M Voloşciuc; Elena Braha; Lăcrămioara Butnariu; Iuliu Ivanov; Mihaela Grămescu; Roxana Popescu; Lavinia Caba; Adriana Sireteanu; M Macovei; M Covic; E V Gorduza. 2011. "[Improvement of genetic diagnostic strategy in velo-cardio-facial syndrome]." Revista Medico-Chirurgicala 115, no. 3: 1.