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Cecilia Acuti Martellucci
Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy

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Journal article
Published: 10 June 2021 in Vaccines
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This retrospective cohort study compared the rates of virologically-confirmed SARS-CoV-2 infections, symptomatic or lethal COVID-19 among the residents of the Italian province of Pescara who received one or two doses of COVID-19 vaccines, versus the unvaccinated. The official data of the National Health System were used, and a total of 69,539 vaccinated adults were compared with 175,687 unvaccinated. Among the subjects who received at least one vaccine dose, 85 infections (0.12%), 18 severe and 3 lethal COVID-19 cases were recorded after an average follow-up of 38 days. Among the unvaccinated, the numbers were 6948 (4.00%), 933 (0.53%) and 241 (0.14%), respectively. The serious adverse event reports—yet unconfirmed—were 24 out of 102,394 administered doses. In a Cox model, adjusting for age, gender, and selected comorbidities, the effectiveness of either BNT162b2, ChAdOx1 nCoV-19 or mRNA-1273 vaccines was higher than 95% in preventing infections (mostly due to B.1.1.7 variant), symptomatic or lethal COVID-19. No differences were observed across genders, and among the 691 subjects who received the second dose of vaccine later than the recommended date. Although preliminary, these findings support current immunization policies and may help reducing vaccine hesitancy.

ACS Style

Maria Flacco; Graziella Soldato; Cecilia Acuti Martellucci; Roberto Carota; Rossano Di Luzio; Antonio Caponetti; Lamberto Manzoli. Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province. Vaccines 2021, 9, 628 .

AMA Style

Maria Flacco, Graziella Soldato, Cecilia Acuti Martellucci, Roberto Carota, Rossano Di Luzio, Antonio Caponetti, Lamberto Manzoli. Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province. Vaccines. 2021; 9 (6):628.

Chicago/Turabian Style

Maria Flacco; Graziella Soldato; Cecilia Acuti Martellucci; Roberto Carota; Rossano Di Luzio; Antonio Caponetti; Lamberto Manzoli. 2021. "Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province." Vaccines 9, no. 6: 628.

Better way of working
Published: 29 April 2021 in BMJ Sexual & Reproductive Health
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ACS Style

Cecilia Acuti Martellucci; Margherita Morettini; Maria Elena Flacco; Lamberto Manzoli; Matthew Palmer; Giusi Giacomini; Francesca Pasqualini. Delivering cervical cancer screening during the COVID-19 emergency. BMJ Sexual & Reproductive Health 2021, 1 .

AMA Style

Cecilia Acuti Martellucci, Margherita Morettini, Maria Elena Flacco, Lamberto Manzoli, Matthew Palmer, Giusi Giacomini, Francesca Pasqualini. Delivering cervical cancer screening during the COVID-19 emergency. BMJ Sexual & Reproductive Health. 2021; ():1.

Chicago/Turabian Style

Cecilia Acuti Martellucci; Margherita Morettini; Maria Elena Flacco; Lamberto Manzoli; Matthew Palmer; Giusi Giacomini; Francesca Pasqualini. 2021. "Delivering cervical cancer screening during the COVID-19 emergency." BMJ Sexual & Reproductive Health , no. : 1.

Journal article
Published: 14 April 2021 in Journal of Food Protection
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The aim of the present study was to evaluate the contamination levels of some classes of persistent organic pollutants in free-range hen eggs and to estimate the related human dietary exposure in a site of national interest, characterized by a serious state of environmental pollution in the Bussi sul Tirino area in central Italy. For these purposes, 17 samples of free-range hen eggs collected in home-producing farms located in the site of national interest territory were analyzed for 17 polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), 12 dioxin-like polychlorinated biphenyls (dl-PCBs), and 6 non–dioxin-like PCBs (ndl-PCBs). Dietary exposure was assessed assuming a standard consumption of eggs per week. The concentration of ∑PCDD/Fs plus dl-PCBs ranged from 0.463 to 8.028 pg toxic equivalent g−1 fat, whereas the mean contamination level of the ∑ndl-PCBs ranged from 0.234 to 7.741 ng toxic equivalent g−1 fat. PCDD/Fs and PCBs contamination levels were lower than maximum values established by the Commission Regulation (European Union) 1259/2011, except for one sample. The estimated weekly intake, calculated to evaluate the contribution in terms of the monitored pollutants of the locally produced eggs to the diet, was lower than the tolerable weekly intake established by the European Food Safety Authority. HIGHLIGHTS

ACS Style

Federica Castellani; Lamberto Manzoli; Cecilia Acuti Martellucci; Maria Elena Flacco; Maria Luisa Astolfi; Leila Fabiani; Riccardo Mastrantonio; Pasquale Avino; Carmela Protano; Matteo Vitali. Levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls in Free-Range Hen Eggs in Central Italy and Estimated Human Dietary Exposure. Journal of Food Protection 2021, 84, 1455 -1462.

AMA Style

Federica Castellani, Lamberto Manzoli, Cecilia Acuti Martellucci, Maria Elena Flacco, Maria Luisa Astolfi, Leila Fabiani, Riccardo Mastrantonio, Pasquale Avino, Carmela Protano, Matteo Vitali. Levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls in Free-Range Hen Eggs in Central Italy and Estimated Human Dietary Exposure. Journal of Food Protection. 2021; 84 (8):1455-1462.

Chicago/Turabian Style

Federica Castellani; Lamberto Manzoli; Cecilia Acuti Martellucci; Maria Elena Flacco; Maria Luisa Astolfi; Leila Fabiani; Riccardo Mastrantonio; Pasquale Avino; Carmela Protano; Matteo Vitali. 2021. "Levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls in Free-Range Hen Eggs in Central Italy and Estimated Human Dietary Exposure." Journal of Food Protection 84, no. 8: 1455-1462.

Original article
Published: 10 August 2020 in BJOG: An International Journal of Obstetrics & Gynaecology
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Objective To assess the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities identified at subsequent screening. Design Retrospective cohort study using administrative health data. Setting General population of Ferrara Province, Italy. Population Female residents born in 1986–1993 and participating in the organized cervical screening programme in 2011–2018, who were eligible for HPV vaccination in catch‐up cohorts. Methods Logistic regression to evaluate the potential association between abnormal cervical cytology and one, two, three or at least one dose of HPV vaccine. Main outcome measures Cervical abnormalities, as predicted by low‐grade or high‐grade cytology, by number of vaccine doses, stratified by age. Results The sample consisted of 7785 women (mean age 27.5 years, SD 2.3). Overall, 391 (5.0%) were vaccinated with ≥1 dose and 893 (11.5%) had abnormal cytology. Women receiving at least one vaccine dose were significantly less likely to have an abnormal cytology (adjusted odds ratio 0.52; 95% confidence interval 0.34–0.79). Similar results were observed for women receiving a single dose, for both bivalent and quadrivalent vaccines, and applying buffer periods (excluding cytological outcomes within 1 month, 6 months and 1 year of the first dose). Conclusions In the context of an organised cervical screening programme in Italy, catch‐up HPV vaccination almost halved the risk of cytological abnormalities. Tweetable abstract Among Ferrara women, vaccination against human papillomavirus halved the risk of screening cervical abnormalities.

ACS Style

C Acuti Martellucci; Shuhei Nomura; D Yoneoka; P Ueda; Jml Brotherton; K Canfell; M Palmer; L Manzoli; P Giorgi Rossi; A De Togni; C Palmonari; A Califano; E Saito; M Hashizume; K Shibuya. Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study. BJOG: An International Journal of Obstetrics & Gynaecology 2020, 128, 532 -539.

AMA Style

C Acuti Martellucci, Shuhei Nomura, D Yoneoka, P Ueda, Jml Brotherton, K Canfell, M Palmer, L Manzoli, P Giorgi Rossi, A De Togni, C Palmonari, A Califano, E Saito, M Hashizume, K Shibuya. Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 2020; 128 (3):532-539.

Chicago/Turabian Style

C Acuti Martellucci; Shuhei Nomura; D Yoneoka; P Ueda; Jml Brotherton; K Canfell; M Palmer; L Manzoli; P Giorgi Rossi; A De Togni; C Palmonari; A Califano; E Saito; M Hashizume; K Shibuya. 2020. "Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study." BJOG: An International Journal of Obstetrics & Gynaecology 128, no. 3: 532-539.

Research article
Published: 24 June 2020 in PLOS ONE
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This retrospective case-control study was aimed at identifying potential independent predictors of severe/lethal COVID-19, including the treatment with Angiotensin-Converting Enzyme inhibitors (ACEi) and/or Angiotensin II Receptor Blockers (ARBs). All adults with SARS-CoV-2 infection in two Italian provinces were followed for a median of 24 days. ARBs and/or ACEi treatments, and hypertension, diabetes, cancer, COPD, renal and major cardiovascular diseases (CVD) were extracted from clinical charts and electronic health records, up to two years before infection. The sample consisted of 1603 subjects (mean age 58.0y; 47.3% males): 454 (28.3%) had severe symptoms, 192 (12.0%) very severe or lethal disease (154 deaths; mean age 79.3 years; 70.8% hypertensive, 42.2% with CVD). The youngest deceased person aged 44 years. Among hypertensive subjects (n = 543), the proportion of those treated with ARBs or ACEi were 88.4%, 78.7% and 80.6% among patients with mild, severe and very severe/lethal disease, respectively. At multivariate analysis, no association was observed between therapy and disease severity (Adjusted OR for very severe/lethal COVID-19: 0.87; 95% CI: 0.50–1.49). Significant predictors of severe disease were older age (with AORs largely increasing after 70 years of age), male gender (AOR: 1.76; 1.40–2.23), diabetes (AOR: 1.52; 1.05–2.18), CVD (AOR: 1.88; 1.32–2.70) and COPD (AOR: 1.88; 1.11–3.20). Only gender, age and diabetes also predicted very severe/lethal disease. No association was found between COVID-19 severity and treatment with ARBs and/or ACEi, supporting the recommendation to continue medication for all patients unless otherwise advised by their physicians.

ACS Style

Francesca Bravi; Maria Elena Flacco; Tiziano Carradori; Carlo Alberto Volta; Giuseppe Cosenza; Aldo De Togni; Cecilia Acuti Martellucci; Giustino Parruti; Lorenzo Mantovani; Lamberto Manzoli. Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens. PLOS ONE 2020, 15, e0235248 .

AMA Style

Francesca Bravi, Maria Elena Flacco, Tiziano Carradori, Carlo Alberto Volta, Giuseppe Cosenza, Aldo De Togni, Cecilia Acuti Martellucci, Giustino Parruti, Lorenzo Mantovani, Lamberto Manzoli. Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens. PLOS ONE. 2020; 15 (6):e0235248.

Chicago/Turabian Style

Francesca Bravi; Maria Elena Flacco; Tiziano Carradori; Carlo Alberto Volta; Giuseppe Cosenza; Aldo De Togni; Cecilia Acuti Martellucci; Giustino Parruti; Lorenzo Mantovani; Lamberto Manzoli. 2020. "Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens." PLOS ONE 15, no. 6: e0235248.

Review
Published: 17 June 2020 in Advances in Biological Regulation
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By the end of May 2020, SARS-CoV-2 pandemic caused more than 350,000 deaths worldwide. In the first months, there have been uncertainties on almost any area: infection transmission route, virus origin and persistence in the environment, diagnostic tests, therapeutic approach, high-risk subjects, lethality, and containment policies. We provide an updated summary of the current knowledge on the pandemic, discussing the available evidence on the effectiveness of the adopted mitigation strategies.

ACS Style

Cecilia Acuti Martellucci; Maria Elena Flacco; Rosaria Cappadona; Francesca Bravi; Lorenzo Mantovani; Lamberto Manzoli. SARS-CoV-2 pandemic: An overview. Advances in Biological Regulation 2020, 77, 100736 -100736.

AMA Style

Cecilia Acuti Martellucci, Maria Elena Flacco, Rosaria Cappadona, Francesca Bravi, Lorenzo Mantovani, Lamberto Manzoli. SARS-CoV-2 pandemic: An overview. Advances in Biological Regulation. 2020; 77 ():100736-100736.

Chicago/Turabian Style

Cecilia Acuti Martellucci; Maria Elena Flacco; Rosaria Cappadona; Francesca Bravi; Lorenzo Mantovani; Lamberto Manzoli. 2020. "SARS-CoV-2 pandemic: An overview." Advances in Biological Regulation 77, no. : 100736-100736.

Research article
Published: 20 November 2019 in Journal of Medical Screening
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Objective To assess the effectiveness of the current cervical cancer screening tools in Western Kazakhstan. Methods Smears taken through (i) conventional cytology using azur-eosin staining and (ii) liquid-based cytology (LBC) ‘Cell Scan’ in the general female population and in women first diagnosed with cervical cancer were collected throughout the region. ROC-analysis with curve construction and weighted Cohen's κ calculation were applied. A total of 494 cytological pairs were collected, including 94 sets with histology findings. Results The conventional (azur-eosin staining) technique contained 0.2% non-informative material and LBC ‘Cell Scan’ had 5.9%. Area under the curve was 0.95 for the conventional technique and 0.92 for ‘Cell Scan’ ( p > 0.05). The conventional smears showed κ 0.62, sensitivity 90.4% at specificity 90.0% for CIN2+, while LBC ‘Cell Scan’ smears showed κ 0.47, sensitivity 83.3% at specificity 92.5%. Conclusions In this analysis it was not possible to prove that the LBC ‘Cell Scan’ technique was superior to its predecessor, azur-eosin staining. These findings highlight the need to modify the current screening programme according to updated international scientific evidence on effective screening design, such as the use of HPV DNA testing with Pap smear triage in women aged 30 or older. Further research, and a Health Technology Assessment, are necessary if we wish to establish a national standardized screening programme using the available technology appropriately.

ACS Style

Saule Balmagambetova; Giovanni Gabutti; Arip Koyshybaev; Cecilia Acuti Martellucci; Olzhas Urazayev; Kanshaiym Sakiyeva; Karlygash Bekova. Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining. Journal of Medical Screening 2019, 27, 90 -95.

AMA Style

Saule Balmagambetova, Giovanni Gabutti, Arip Koyshybaev, Cecilia Acuti Martellucci, Olzhas Urazayev, Kanshaiym Sakiyeva, Karlygash Bekova. Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining. Journal of Medical Screening. 2019; 27 (2):90-95.

Chicago/Turabian Style

Saule Balmagambetova; Giovanni Gabutti; Arip Koyshybaev; Cecilia Acuti Martellucci; Olzhas Urazayev; Kanshaiym Sakiyeva; Karlygash Bekova. 2019. "Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining." Journal of Medical Screening 27, no. 2: 90-95.

Journal article
Published: 30 August 2019 in Acta Obstetricia et Gynecologica Scandinavica
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To explore the strength of association and the diagnostic accuracy of umbilical (UA), middle cerebral (MCA), uterine arteries pulsatility index (PI) and the cerebroplacental ratio in predicting an adverse outcome when applied to singleton pregnancies at term. Prospective study carried out in a dedicated research ultrasound clinic. Attended clinicians were blinded to Doppler findings. Inclusion criteria were consecutive singleton pregnancies between 36+0 and 37+6 weeks of gestation. The primary outcome was a composite score of adverse perinatal outcome. Logistic regression and ROC curve analyses were used to analyze the data. In all, 600 consecutive singleton pregnancies from 36 weeks of gestation were included in the study. Mean MCA PI (1.1 ± 0.2 vs 1.5 ± 0.4, P < 0.001) and cerebroplacental ratio (1.4 ± 0.4 vs 1.9 ± 0.6, P < 0.001) were lower, whereas uterine arteries PI (0.8 ±0.2 vs 0.7 ±0.3, P = 0.001) was higher in pregnancies experiencing than in those not experiencing composite adverse outcome. Conversely, there was no difference in either UA PI (P = 0.399) or estimated fetal weight centile (P = 0.712) between the two groups, but AC centile was lower in fetuses experiencing composite adverse outcome (45.4 vs 53.2, P = 0.040). At logistic regression analysis, MCA PI (odds ratio [OR] 0.1, 95% CI 0.01-.2, P = 0.001), uterine arteries PI (OR 1.4, 95% CI 1.2-1.6, P = 0.001), abdominal circumference centile (OR 1.12, 95% CI 1.1-1.4, P = 0.001) and gestational age at birth (OR 1.6, 95% CI 1.2-2.1, P = 0.004) were independently associated with composite adverse outcome. Despite this, the diagnostic accuracy of Doppler in predicting adverse pregnancy outcome at term was poor. MCA PI and cerebroplacental ratio are associated with adverse perinatal outcome at term. However, their predictive accuracy for perinatal compromise is poor, and thus their use as standalone screening test for adverse perinatal outcome in singleton pregnancies at term is not supported.

ACS Style

Francesco D'antonio; Giuseppe Rizzo; Sarah Gustapane; Danilo Buca; Maria Elena Flacco; Cecilia Martellucci; Lamberto Manzoli; Alexander Makatsariya; Luigi Nappi; Giorgio Pagani; Marco Liberati. Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study. Acta Obstetricia et Gynecologica Scandinavica 2019, 99, 42 -47.

AMA Style

Francesco D'antonio, Giuseppe Rizzo, Sarah Gustapane, Danilo Buca, Maria Elena Flacco, Cecilia Martellucci, Lamberto Manzoli, Alexander Makatsariya, Luigi Nappi, Giorgio Pagani, Marco Liberati. Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study. Acta Obstetricia et Gynecologica Scandinavica. 2019; 99 (1):42-47.

Chicago/Turabian Style

Francesco D'antonio; Giuseppe Rizzo; Sarah Gustapane; Danilo Buca; Maria Elena Flacco; Cecilia Martellucci; Lamberto Manzoli; Alexander Makatsariya; Luigi Nappi; Giorgio Pagani; Marco Liberati. 2019. "Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study." Acta Obstetricia et Gynecologica Scandinavica 99, no. 1: 42-47.