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This retrospective cohort study compared the rates of virologically-confirmed SARS-CoV-2 infections, symptomatic or lethal COVID-19 among the residents of the Italian province of Pescara who received one or two doses of COVID-19 vaccines, versus the unvaccinated. The official data of the National Health System were used, and a total of 69,539 vaccinated adults were compared with 175,687 unvaccinated. Among the subjects who received at least one vaccine dose, 85 infections (0.12%), 18 severe and 3 lethal COVID-19 cases were recorded after an average follow-up of 38 days. Among the unvaccinated, the numbers were 6948 (4.00%), 933 (0.53%) and 241 (0.14%), respectively. The serious adverse event reports—yet unconfirmed—were 24 out of 102,394 administered doses. In a Cox model, adjusting for age, gender, and selected comorbidities, the effectiveness of either BNT162b2, ChAdOx1 nCoV-19 or mRNA-1273 vaccines was higher than 95% in preventing infections (mostly due to B.1.1.7 variant), symptomatic or lethal COVID-19. No differences were observed across genders, and among the 691 subjects who received the second dose of vaccine later than the recommended date. Although preliminary, these findings support current immunization policies and may help reducing vaccine hesitancy.
Maria Flacco; Graziella Soldato; Cecilia Acuti Martellucci; Roberto Carota; Rossano Di Luzio; Antonio Caponetti; Lamberto Manzoli. Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province. Vaccines 2021, 9, 628 .
AMA StyleMaria Flacco, Graziella Soldato, Cecilia Acuti Martellucci, Roberto Carota, Rossano Di Luzio, Antonio Caponetti, Lamberto Manzoli. Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province. Vaccines. 2021; 9 (6):628.
Chicago/Turabian StyleMaria Flacco; Graziella Soldato; Cecilia Acuti Martellucci; Roberto Carota; Rossano Di Luzio; Antonio Caponetti; Lamberto Manzoli. 2021. "Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province." Vaccines 9, no. 6: 628.
Cecilia Acuti Martellucci; Margherita Morettini; Maria Elena Flacco; Lamberto Manzoli; Matthew Palmer; Giusi Giacomini; Francesca Pasqualini. Delivering cervical cancer screening during the COVID-19 emergency. BMJ Sexual & Reproductive Health 2021, 1 .
AMA StyleCecilia Acuti Martellucci, Margherita Morettini, Maria Elena Flacco, Lamberto Manzoli, Matthew Palmer, Giusi Giacomini, Francesca Pasqualini. Delivering cervical cancer screening during the COVID-19 emergency. BMJ Sexual & Reproductive Health. 2021; ():1.
Chicago/Turabian StyleCecilia Acuti Martellucci; Margherita Morettini; Maria Elena Flacco; Lamberto Manzoli; Matthew Palmer; Giusi Giacomini; Francesca Pasqualini. 2021. "Delivering cervical cancer screening during the COVID-19 emergency." BMJ Sexual & Reproductive Health , no. : 1.
The aim of the present study was to evaluate the contamination levels of some classes of persistent organic pollutants in free-range hen eggs and to estimate the related human dietary exposure in a site of national interest, characterized by a serious state of environmental pollution in the Bussi sul Tirino area in central Italy. For these purposes, 17 samples of free-range hen eggs collected in home-producing farms located in the site of national interest territory were analyzed for 17 polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), 12 dioxin-like polychlorinated biphenyls (dl-PCBs), and 6 non–dioxin-like PCBs (ndl-PCBs). Dietary exposure was assessed assuming a standard consumption of eggs per week. The concentration of ∑PCDD/Fs plus dl-PCBs ranged from 0.463 to 8.028 pg toxic equivalent g−1 fat, whereas the mean contamination level of the ∑ndl-PCBs ranged from 0.234 to 7.741 ng toxic equivalent g−1 fat. PCDD/Fs and PCBs contamination levels were lower than maximum values established by the Commission Regulation (European Union) 1259/2011, except for one sample. The estimated weekly intake, calculated to evaluate the contribution in terms of the monitored pollutants of the locally produced eggs to the diet, was lower than the tolerable weekly intake established by the European Food Safety Authority. HIGHLIGHTS
Federica Castellani; Lamberto Manzoli; Cecilia Acuti Martellucci; Maria Elena Flacco; Maria Luisa Astolfi; Leila Fabiani; Riccardo Mastrantonio; Pasquale Avino; Carmela Protano; Matteo Vitali. Levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls in Free-Range Hen Eggs in Central Italy and Estimated Human Dietary Exposure. Journal of Food Protection 2021, 84, 1455 -1462.
AMA StyleFederica Castellani, Lamberto Manzoli, Cecilia Acuti Martellucci, Maria Elena Flacco, Maria Luisa Astolfi, Leila Fabiani, Riccardo Mastrantonio, Pasquale Avino, Carmela Protano, Matteo Vitali. Levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls in Free-Range Hen Eggs in Central Italy and Estimated Human Dietary Exposure. Journal of Food Protection. 2021; 84 (8):1455-1462.
Chicago/Turabian StyleFederica Castellani; Lamberto Manzoli; Cecilia Acuti Martellucci; Maria Elena Flacco; Maria Luisa Astolfi; Leila Fabiani; Riccardo Mastrantonio; Pasquale Avino; Carmela Protano; Matteo Vitali. 2021. "Levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls in Free-Range Hen Eggs in Central Italy and Estimated Human Dietary Exposure." Journal of Food Protection 84, no. 8: 1455-1462.
Objective To assess the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities identified at subsequent screening. Design Retrospective cohort study using administrative health data. Setting General population of Ferrara Province, Italy. Population Female residents born in 1986–1993 and participating in the organized cervical screening programme in 2011–2018, who were eligible for HPV vaccination in catch‐up cohorts. Methods Logistic regression to evaluate the potential association between abnormal cervical cytology and one, two, three or at least one dose of HPV vaccine. Main outcome measures Cervical abnormalities, as predicted by low‐grade or high‐grade cytology, by number of vaccine doses, stratified by age. Results The sample consisted of 7785 women (mean age 27.5 years, SD 2.3). Overall, 391 (5.0%) were vaccinated with ≥1 dose and 893 (11.5%) had abnormal cytology. Women receiving at least one vaccine dose were significantly less likely to have an abnormal cytology (adjusted odds ratio 0.52; 95% confidence interval 0.34–0.79). Similar results were observed for women receiving a single dose, for both bivalent and quadrivalent vaccines, and applying buffer periods (excluding cytological outcomes within 1 month, 6 months and 1 year of the first dose). Conclusions In the context of an organised cervical screening programme in Italy, catch‐up HPV vaccination almost halved the risk of cytological abnormalities. Tweetable abstract Among Ferrara women, vaccination against human papillomavirus halved the risk of screening cervical abnormalities.
C Acuti Martellucci; Shuhei Nomura; D Yoneoka; P Ueda; Jml Brotherton; K Canfell; M Palmer; L Manzoli; P Giorgi Rossi; A De Togni; C Palmonari; A Califano; E Saito; M Hashizume; K Shibuya. Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study. BJOG: An International Journal of Obstetrics & Gynaecology 2020, 128, 532 -539.
AMA StyleC Acuti Martellucci, Shuhei Nomura, D Yoneoka, P Ueda, Jml Brotherton, K Canfell, M Palmer, L Manzoli, P Giorgi Rossi, A De Togni, C Palmonari, A Califano, E Saito, M Hashizume, K Shibuya. Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 2020; 128 (3):532-539.
Chicago/Turabian StyleC Acuti Martellucci; Shuhei Nomura; D Yoneoka; P Ueda; Jml Brotherton; K Canfell; M Palmer; L Manzoli; P Giorgi Rossi; A De Togni; C Palmonari; A Califano; E Saito; M Hashizume; K Shibuya. 2020. "Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study." BJOG: An International Journal of Obstetrics & Gynaecology 128, no. 3: 532-539.
This retrospective case-control study was aimed at identifying potential independent predictors of severe/lethal COVID-19, including the treatment with Angiotensin-Converting Enzyme inhibitors (ACEi) and/or Angiotensin II Receptor Blockers (ARBs). All adults with SARS-CoV-2 infection in two Italian provinces were followed for a median of 24 days. ARBs and/or ACEi treatments, and hypertension, diabetes, cancer, COPD, renal and major cardiovascular diseases (CVD) were extracted from clinical charts and electronic health records, up to two years before infection. The sample consisted of 1603 subjects (mean age 58.0y; 47.3% males): 454 (28.3%) had severe symptoms, 192 (12.0%) very severe or lethal disease (154 deaths; mean age 79.3 years; 70.8% hypertensive, 42.2% with CVD). The youngest deceased person aged 44 years. Among hypertensive subjects (n = 543), the proportion of those treated with ARBs or ACEi were 88.4%, 78.7% and 80.6% among patients with mild, severe and very severe/lethal disease, respectively. At multivariate analysis, no association was observed between therapy and disease severity (Adjusted OR for very severe/lethal COVID-19: 0.87; 95% CI: 0.50–1.49). Significant predictors of severe disease were older age (with AORs largely increasing after 70 years of age), male gender (AOR: 1.76; 1.40–2.23), diabetes (AOR: 1.52; 1.05–2.18), CVD (AOR: 1.88; 1.32–2.70) and COPD (AOR: 1.88; 1.11–3.20). Only gender, age and diabetes also predicted very severe/lethal disease. No association was found between COVID-19 severity and treatment with ARBs and/or ACEi, supporting the recommendation to continue medication for all patients unless otherwise advised by their physicians.
Francesca Bravi; Maria Elena Flacco; Tiziano Carradori; Carlo Alberto Volta; Giuseppe Cosenza; Aldo De Togni; Cecilia Acuti Martellucci; Giustino Parruti; Lorenzo Mantovani; Lamberto Manzoli. Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens. PLOS ONE 2020, 15, e0235248 .
AMA StyleFrancesca Bravi, Maria Elena Flacco, Tiziano Carradori, Carlo Alberto Volta, Giuseppe Cosenza, Aldo De Togni, Cecilia Acuti Martellucci, Giustino Parruti, Lorenzo Mantovani, Lamberto Manzoli. Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens. PLOS ONE. 2020; 15 (6):e0235248.
Chicago/Turabian StyleFrancesca Bravi; Maria Elena Flacco; Tiziano Carradori; Carlo Alberto Volta; Giuseppe Cosenza; Aldo De Togni; Cecilia Acuti Martellucci; Giustino Parruti; Lorenzo Mantovani; Lamberto Manzoli. 2020. "Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens." PLOS ONE 15, no. 6: e0235248.
By the end of May 2020, SARS-CoV-2 pandemic caused more than 350,000 deaths worldwide. In the first months, there have been uncertainties on almost any area: infection transmission route, virus origin and persistence in the environment, diagnostic tests, therapeutic approach, high-risk subjects, lethality, and containment policies. We provide an updated summary of the current knowledge on the pandemic, discussing the available evidence on the effectiveness of the adopted mitigation strategies.
Cecilia Acuti Martellucci; Maria Elena Flacco; Rosaria Cappadona; Francesca Bravi; Lorenzo Mantovani; Lamberto Manzoli. SARS-CoV-2 pandemic: An overview. Advances in Biological Regulation 2020, 77, 100736 -100736.
AMA StyleCecilia Acuti Martellucci, Maria Elena Flacco, Rosaria Cappadona, Francesca Bravi, Lorenzo Mantovani, Lamberto Manzoli. SARS-CoV-2 pandemic: An overview. Advances in Biological Regulation. 2020; 77 ():100736-100736.
Chicago/Turabian StyleCecilia Acuti Martellucci; Maria Elena Flacco; Rosaria Cappadona; Francesca Bravi; Lorenzo Mantovani; Lamberto Manzoli. 2020. "SARS-CoV-2 pandemic: An overview." Advances in Biological Regulation 77, no. : 100736-100736.
Objective To assess the effectiveness of the current cervical cancer screening tools in Western Kazakhstan. Methods Smears taken through (i) conventional cytology using azur-eosin staining and (ii) liquid-based cytology (LBC) ‘Cell Scan’ in the general female population and in women first diagnosed with cervical cancer were collected throughout the region. ROC-analysis with curve construction and weighted Cohen's κ calculation were applied. A total of 494 cytological pairs were collected, including 94 sets with histology findings. Results The conventional (azur-eosin staining) technique contained 0.2% non-informative material and LBC ‘Cell Scan’ had 5.9%. Area under the curve was 0.95 for the conventional technique and 0.92 for ‘Cell Scan’ ( p > 0.05). The conventional smears showed κ 0.62, sensitivity 90.4% at specificity 90.0% for CIN2+, while LBC ‘Cell Scan’ smears showed κ 0.47, sensitivity 83.3% at specificity 92.5%. Conclusions In this analysis it was not possible to prove that the LBC ‘Cell Scan’ technique was superior to its predecessor, azur-eosin staining. These findings highlight the need to modify the current screening programme according to updated international scientific evidence on effective screening design, such as the use of HPV DNA testing with Pap smear triage in women aged 30 or older. Further research, and a Health Technology Assessment, are necessary if we wish to establish a national standardized screening programme using the available technology appropriately.
Saule Balmagambetova; Giovanni Gabutti; Arip Koyshybaev; Cecilia Acuti Martellucci; Olzhas Urazayev; Kanshaiym Sakiyeva; Karlygash Bekova. Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining. Journal of Medical Screening 2019, 27, 90 -95.
AMA StyleSaule Balmagambetova, Giovanni Gabutti, Arip Koyshybaev, Cecilia Acuti Martellucci, Olzhas Urazayev, Kanshaiym Sakiyeva, Karlygash Bekova. Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining. Journal of Medical Screening. 2019; 27 (2):90-95.
Chicago/Turabian StyleSaule Balmagambetova; Giovanni Gabutti; Arip Koyshybaev; Cecilia Acuti Martellucci; Olzhas Urazayev; Kanshaiym Sakiyeva; Karlygash Bekova. 2019. "Cervical screening in Western Kazakhstan: Liquid-based cytology ‘Cell Scan’ versus azur-eosin staining." Journal of Medical Screening 27, no. 2: 90-95.
To explore the strength of association and the diagnostic accuracy of umbilical (UA), middle cerebral (MCA), uterine arteries pulsatility index (PI) and the cerebroplacental ratio in predicting an adverse outcome when applied to singleton pregnancies at term. Prospective study carried out in a dedicated research ultrasound clinic. Attended clinicians were blinded to Doppler findings. Inclusion criteria were consecutive singleton pregnancies between 36+0 and 37+6 weeks of gestation. The primary outcome was a composite score of adverse perinatal outcome. Logistic regression and ROC curve analyses were used to analyze the data. In all, 600 consecutive singleton pregnancies from 36 weeks of gestation were included in the study. Mean MCA PI (1.1 ± 0.2 vs 1.5 ± 0.4, P < 0.001) and cerebroplacental ratio (1.4 ± 0.4 vs 1.9 ± 0.6, P < 0.001) were lower, whereas uterine arteries PI (0.8 ±0.2 vs 0.7 ±0.3, P = 0.001) was higher in pregnancies experiencing than in those not experiencing composite adverse outcome. Conversely, there was no difference in either UA PI (P = 0.399) or estimated fetal weight centile (P = 0.712) between the two groups, but AC centile was lower in fetuses experiencing composite adverse outcome (45.4 vs 53.2, P = 0.040). At logistic regression analysis, MCA PI (odds ratio [OR] 0.1, 95% CI 0.01-.2, P = 0.001), uterine arteries PI (OR 1.4, 95% CI 1.2-1.6, P = 0.001), abdominal circumference centile (OR 1.12, 95% CI 1.1-1.4, P = 0.001) and gestational age at birth (OR 1.6, 95% CI 1.2-2.1, P = 0.004) were independently associated with composite adverse outcome. Despite this, the diagnostic accuracy of Doppler in predicting adverse pregnancy outcome at term was poor. MCA PI and cerebroplacental ratio are associated with adverse perinatal outcome at term. However, their predictive accuracy for perinatal compromise is poor, and thus their use as standalone screening test for adverse perinatal outcome in singleton pregnancies at term is not supported.
Francesco D'antonio; Giuseppe Rizzo; Sarah Gustapane; Danilo Buca; Maria Elena Flacco; Cecilia Martellucci; Lamberto Manzoli; Alexander Makatsariya; Luigi Nappi; Giorgio Pagani; Marco Liberati. Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study. Acta Obstetricia et Gynecologica Scandinavica 2019, 99, 42 -47.
AMA StyleFrancesco D'antonio, Giuseppe Rizzo, Sarah Gustapane, Danilo Buca, Maria Elena Flacco, Cecilia Martellucci, Lamberto Manzoli, Alexander Makatsariya, Luigi Nappi, Giorgio Pagani, Marco Liberati. Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study. Acta Obstetricia et Gynecologica Scandinavica. 2019; 99 (1):42-47.
Chicago/Turabian StyleFrancesco D'antonio; Giuseppe Rizzo; Sarah Gustapane; Danilo Buca; Maria Elena Flacco; Cecilia Martellucci; Lamberto Manzoli; Alexander Makatsariya; Luigi Nappi; Giorgio Pagani; Marco Liberati. 2019. "Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study." Acta Obstetricia et Gynecologica Scandinavica 99, no. 1: 42-47.