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Circulating immune cell numbers and phenotypes are impacted by high-intensity acute bouts of exercise and infection history with the latent herpesviruses cytomegalovirus (CMV). In particular, CMV infection history impairs the exercise-induced mobilization of cytotoxic innate lymphoid cells 1 (ILC1) cells, also known as NK cells, in the blood. However, it remains unknown whether exercise and CMV infection modulate the mobilization of traditionally tissue-resident non-cytotoxic ILCs into the peripheral blood compartment. To address this question, 22 healthy individuals with or without CMV (20–35 years—45% CMVpos) completed 30 min of cycling at 70% VO2 max, and detailed phenotypic analysis of circulating ILCs was performed at rest and immediately post-exercise. We show for the first time that a bout of high-intensity exercise is associated with an influx of ILCs that are traditionally regarded as tissue-resident. In addition, this is the first study to highlight that latent CMV infection blunts the exercise-response of total ILCs and progenitor ILCs (ILCPs). These promising data suggest that acute exercise facilitates the circulation of certain ILC subsets, further advocating for the improvements in health seen with exercise by enhancing cellular mobilization and immunosurveillance, while also highlighting the indirect deleterious effects of CMV infection in healthy adults.
Eunhan Cho; Bailey Theall; James Stampley; Joshua Granger; Neil Johannsen; Brian Irving; Guillaume Spielmann. Cytomegalovirus Infection Impairs the Mobilization of Tissue-Resident Innate Lymphoid Cells into the Peripheral Blood Compartment in Response to Acute Exercise. Viruses 2021, 13, 1535 .
AMA StyleEunhan Cho, Bailey Theall, James Stampley, Joshua Granger, Neil Johannsen, Brian Irving, Guillaume Spielmann. Cytomegalovirus Infection Impairs the Mobilization of Tissue-Resident Innate Lymphoid Cells into the Peripheral Blood Compartment in Response to Acute Exercise. Viruses. 2021; 13 (8):1535.
Chicago/Turabian StyleEunhan Cho; Bailey Theall; James Stampley; Joshua Granger; Neil Johannsen; Brian Irving; Guillaume Spielmann. 2021. "Cytomegalovirus Infection Impairs the Mobilization of Tissue-Resident Innate Lymphoid Cells into the Peripheral Blood Compartment in Response to Acute Exercise." Viruses 13, no. 8: 1535.
Eunhan Cho; Bailey Theall; James Stampley; Brett Davis; Heather Quiriarte; Frank Greenway; Neil Johannsen; Guillaume Spielmann; Brian A. Irving. Light Physical Activity Is Associated With Reduced Signs Of Immune Aging In Healthy Older Adults. Medicine & Science in Sports & Exercise 2020, 52, 127 -128.
AMA StyleEunhan Cho, Bailey Theall, James Stampley, Brett Davis, Heather Quiriarte, Frank Greenway, Neil Johannsen, Guillaume Spielmann, Brian A. Irving. Light Physical Activity Is Associated With Reduced Signs Of Immune Aging In Healthy Older Adults. Medicine & Science in Sports & Exercise. 2020; 52 (7S):127-128.
Chicago/Turabian StyleEunhan Cho; Bailey Theall; James Stampley; Brett Davis; Heather Quiriarte; Frank Greenway; Neil Johannsen; Guillaume Spielmann; Brian A. Irving. 2020. "Light Physical Activity Is Associated With Reduced Signs Of Immune Aging In Healthy Older Adults." Medicine & Science in Sports & Exercise 52, no. 7S: 127-128.
Eunhan Cho; Nathan Lemoine; Bailey Theall; Amy Turner; Jack Marucci; Shelly Mullenix; Derek Calvert; Michael MacLellan; Nikita Kuznetsov; Brian A. Irving; Neil M. Johannsen; Guillaume Spielmann. Identification Of Blood Biomarkers Of Mild Traumatic Brain Injury In Collegiate Football Players. Medicine & Science in Sports & Exercise 2019, 51, 740 -740.
AMA StyleEunhan Cho, Nathan Lemoine, Bailey Theall, Amy Turner, Jack Marucci, Shelly Mullenix, Derek Calvert, Michael MacLellan, Nikita Kuznetsov, Brian A. Irving, Neil M. Johannsen, Guillaume Spielmann. Identification Of Blood Biomarkers Of Mild Traumatic Brain Injury In Collegiate Football Players. Medicine & Science in Sports & Exercise. 2019; 51 (6S):740-740.
Chicago/Turabian StyleEunhan Cho; Nathan Lemoine; Bailey Theall; Amy Turner; Jack Marucci; Shelly Mullenix; Derek Calvert; Michael MacLellan; Nikita Kuznetsov; Brian A. Irving; Neil M. Johannsen; Guillaume Spielmann. 2019. "Identification Of Blood Biomarkers Of Mild Traumatic Brain Injury In Collegiate Football Players." Medicine & Science in Sports & Exercise 51, no. 6S: 740-740.