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Mr. Po Wei Sung
China Medical University, Taichung City, Taiwan

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Research Keywords & Expertise

0 Amino Acids and Peptides
0 corona virus covid-19
0 Viral and bacterial infections
0 Medicine biochemistry
0 Immunology and virology

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Short Biography

Currently studying as a medical student at China medical university in Taichung, Taiwan.

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Journal article
Published: 04 July 2021 in Viruses
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Amino acids have been implicated with virus infection and replication. Here, we demonstrate the effects of two basic amino acids, arginine and lysine, and their ester derivatives on infection of two enveloped viruses, SARS-CoV-2, and influenza A virus. We found that lysine and its ester derivative can efficiently block infection of both viruses in vitro. Furthermore, the arginine ester derivative caused a significant boost in virus infection. Studies on their mechanism of action revealed that the compounds potentially disturb virus uncoating rather than virus attachment and endosomal acidification. Our findings suggest that lysine supplementation and the reduction of arginine-rich food intake can be considered as prophylactic and therapeutic regimens against these viruses while also providing a paradigm for the development of broad-spectrum antivirals.

ACS Style

Ivonne Melano; Li-Lan Kuo; Yan-Chung Lo; Po-Wei Sung; Ni Tien; Wen-Chi Su. Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection. Viruses 2021, 13, 1301 .

AMA Style

Ivonne Melano, Li-Lan Kuo, Yan-Chung Lo, Po-Wei Sung, Ni Tien, Wen-Chi Su. Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection. Viruses. 2021; 13 (7):1301.

Chicago/Turabian Style

Ivonne Melano; Li-Lan Kuo; Yan-Chung Lo; Po-Wei Sung; Ni Tien; Wen-Chi Su. 2021. "Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection." Viruses 13, no. 7: 1301.