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Sean A. Lynch
QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia

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Brief report
Published: 16 August 2021 in Viruses
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The COVID-19 pandemic has highlighted the importance of understanding the immune response to seasonal human coronavirus (HCoV) infections such as HCoV-NL63, how existing neutralising antibodies to HCoV may modulate responses to SARS-CoV-2 infection, and the utility of seasonal HCoV as human challenge models. Therefore, in this study we quantified HCoV-NL63 neutralising antibody titres in a healthy adult population using plasma from 100 blood donors in Australia. A microneutralisation assay was performed with plasma diluted from 1:10 to 1:160 and tested with the HCoV-NL63 Amsterdam-1 strain. Neutralising antibodies were detected in 71% of the plasma samples, with a median geometric mean titre of 14. This titre was similar to those reported in convalescent sera taken from individuals 3–7 months following asymptomatic SARS-CoV-2 infection, and 2–3 years post-infection from symptomatic SARS-CoV-1 patients. HCoV-NL63 neutralising antibody titres decreased with increasing age (R2 = 0.042, p = 0.038), but did not differ by sex. Overall, this study demonstrates that neutralising antibody to HCoV-NL63 is detectable in approximately 71% of the healthy adult population of Australia. Similar titres did not impede the use of another seasonal human coronavirus (HCoV-229E) in a human challenge model, thus, HCoV-NL63 may be useful as a human challenge model for more pathogenic coronaviruses.

ACS Style

Sean A. Lynch; Kanta Subbarao; Siddhartha Mahanty; Bridget E. Barber; Eileen V. Roulis; Lia van der Hoek; James S. McCarthy; Kirsten M. Spann. Prevalence of Neutralising Antibodies to HCoV-NL63 in Healthy Adults in Australia. Viruses 2021, 13, 1618 .

AMA Style

Sean A. Lynch, Kanta Subbarao, Siddhartha Mahanty, Bridget E. Barber, Eileen V. Roulis, Lia van der Hoek, James S. McCarthy, Kirsten M. Spann. Prevalence of Neutralising Antibodies to HCoV-NL63 in Healthy Adults in Australia. Viruses. 2021; 13 (8):1618.

Chicago/Turabian Style

Sean A. Lynch; Kanta Subbarao; Siddhartha Mahanty; Bridget E. Barber; Eileen V. Roulis; Lia van der Hoek; James S. McCarthy; Kirsten M. Spann. 2021. "Prevalence of Neutralising Antibodies to HCoV-NL63 in Healthy Adults in Australia." Viruses 13, no. 8: 1618.