Prof. Hiroaki Kume

1) Kume H, Hojo M, Hashimoto N. Eosinophil Inflammation and Hyperresponsiveness in the Airways as Phenotypes of COPD, and Usefulness of Inhaled Glucocorticosteroids. Front Pharmacol 2019 Jul 25;10:765. doi: 10.3389/fphar.2019.00765. eCollection 2019. 2) Kume H, Nishiyama O, Isoya1 T, Higashimoto Y, Tohda Y, Noda Y Involvement of Allosteric Effect and KCa Channel in Crosstalk between 2-Adrenergic and Muscarinic M2 Receptors in airway Smooth Muscle Int J Mol Sci 2018 Jul 9; 19(7). pii: E1999. 4) Kume H, Fukunaga K, Oguma T. Research and development of bronchodilators for asthma and COPD with a focus on G protein/KCa channel linkage and β2-adrenergic intrinsic efficacy. Pharmacol Ther 2015; 156:75-89.. 41) Kume H, Takagi K. Inhibition of b-adrenergic desensitization by KCa channels in human trachealis. Am J Respir Crit Care Med 1999; 159: 452-60. 47) Kume H, Hall IP, Washabau RJ, Takagi K, Kotlikoff MI. b-Adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J Clin Invest 1994; 93: 371-9. 48) Kume H, Graziano MP, Kotlikoff MI. Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins. Proc Natl Acad Sci U S A 1992; 89: 11051-5. 51) Kume H, Takai A, Tokuno H, Tomita T. Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation. Nature 1989; 341: 152-4.