This page has only limited features, please log in for full access.

Prof. Ki Chang NAM
Dongguk University College of Medicine

Basic Info


Research Keywords & Expertise

0 Pulmonary Function Testing (PFT)
0 Drug delivery system
0 Nebulization
0 drug and gene delivery
0 Pulmonary drug delivery

Fingerprints

Nebulization

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 10 June 2021 in BioMedical Engineering OnLine
Reads 0
Downloads 0

Background Nebulizers are medical devices that deliver aerosolized medication directly to lungs to treat a variety of respiratory diseases. However, breathing patterns, respiration rates, airway diameters, and amounts of drugs delivered by nebulizers may be respiratory disease dependent. Method In this study, we developed a respiratory simulator consisting of an airway model, an artificial lung, a flow sensor, and an aerosol collecting filter. Various breathing patterns were generated using a linear actuator and an air cylinder. We tested six home nebulizers (jet (2), static (2), and vibrating mesh nebulizers (2)). Nebulizers were evaluated under two conditions, that is, for the duration of nebulization and at a constant output 1.3 mL using four breathing patterns, namely, the breathing pattern specified in ISO 27427:2013, normal adult, asthmatic, and COPD. Results One of the vibrating mesh nebulizers had the highest dose delivery efficiency. The drug delivery efficiencies of nebulizers were found to depend on breathing patterns. Conclusion We suggest a quantitative drug delivery efficiency evaluation method and calculation parameters that include considerations of constant outputs and residual volumes. The study shows output rates and breathing patterns should be considered when the drug delivery efficiencies of nebulizers are evaluated.

ACS Style

Hyun Mok Park; Kyung Hwa Chang; Sang-Hyub Moon; Bong Joo Park; Sun Kook Yoo; Ki Chang Nam. In vitro delivery efficiencies of nebulizers for different breathing patterns. BioMedical Engineering OnLine 2021, 20, 1 -14.

AMA Style

Hyun Mok Park, Kyung Hwa Chang, Sang-Hyub Moon, Bong Joo Park, Sun Kook Yoo, Ki Chang Nam. In vitro delivery efficiencies of nebulizers for different breathing patterns. BioMedical Engineering OnLine. 2021; 20 (1):1-14.

Chicago/Turabian Style

Hyun Mok Park; Kyung Hwa Chang; Sang-Hyub Moon; Bong Joo Park; Sun Kook Yoo; Ki Chang Nam. 2021. "In vitro delivery efficiencies of nebulizers for different breathing patterns." BioMedical Engineering OnLine 20, no. 1: 1-14.

Journal article
Published: 04 May 2021 in Health Policy
Reads 0
Downloads 0

Medical devices may revolutionize healthcare delivery but can lead to serious adverse events for treated patients and users. While reporting of adverse events related to medical devices is an essential starting point for post-market surveillance, underreporting of medical device adverse events is a global problem. Korea introduced a voluntary medical device adverse event reporting system in 2010, called the Medical Device Safety Information Monitoring Center, which has led to an increase in adverse event reports. For 10 years, the Medical Device Safety Information Monitoring Center has analyzed medical device adverse events systematically and has provided active feedback to the manufacturers and education on safe use. Recently, the Medical Device Safety Information Monitoring Center contributed to harmonization of international medical device vigilance through the sharing of adverse events. This experience of Korea might contribute to improvements in medical device vigilance, which is a critical prerequisite for improving medical device policies and regulations.

ACS Style

Soo Jeong Choi; Ki Chang Nam; Sooin Choi; Jin Kuk Kim; You Kyoung Lee; Bum Sun Kwon. The establishment of the Korean medical device safety information monitoring center: Reviewing ten years of experience. Health Policy 2021, 125, 941 -946.

AMA Style

Soo Jeong Choi, Ki Chang Nam, Sooin Choi, Jin Kuk Kim, You Kyoung Lee, Bum Sun Kwon. The establishment of the Korean medical device safety information monitoring center: Reviewing ten years of experience. Health Policy. 2021; 125 (7):941-946.

Chicago/Turabian Style

Soo Jeong Choi; Ki Chang Nam; Sooin Choi; Jin Kuk Kim; You Kyoung Lee; Bum Sun Kwon. 2021. "The establishment of the Korean medical device safety information monitoring center: Reviewing ten years of experience." Health Policy 125, no. 7: 941-946.

Journal article
Published: 16 April 2021 in Applied Sciences
Reads 0
Downloads 0

Computed tomography (CT) quality control (QC) is regularly performed with standard phantoms, to bar faulty equipment from medical use. Its accuracy may be improved by replacing qualitative methods based on good visual distinction with pixel value-based quantitative methods. We hypothesized that statistical texture analysis (TA) that covers the entire phantom image would be a more appropriate tool. Therefore, our study devised a novel QC method based on the TA for contrast resolution (CR) and spatial resolution (SR) and proposed new, quantitative CT QC criteria. TA of CR and SR images on an American Association of Physicists in Medicine (AAPM) CT Performance Phantom were performed with nine CT scanner models. Six texture descriptors derived from first-order statistics of grayscale image histograms were analyzed. Principal component analysis was used to reveal descriptors with high utility. For CR evaluation, contrast and softness were the most accurate descriptors. For SR evaluation, contrast, softness, and skewness were the most useful descriptors. We propose the following ranges: contrast for CR, 29.5 ± 15%, for SR, 29 ± 10%; softness for CR, <0.015, for SR, −1.85. Our novel TA method may improve the assessment of CR and SR of AAPM phantom images.

ACS Style

Ki Lee; Ki Nam; Ji Jang; Ho Kim. Feasibility of the Quantitative Assessment Method for CT Quality Control in Phantom Image Evaluation. Applied Sciences 2021, 11, 3570 .

AMA Style

Ki Lee, Ki Nam, Ji Jang, Ho Kim. Feasibility of the Quantitative Assessment Method for CT Quality Control in Phantom Image Evaluation. Applied Sciences. 2021; 11 (8):3570.

Chicago/Turabian Style

Ki Lee; Ki Nam; Ji Jang; Ho Kim. 2021. "Feasibility of the Quantitative Assessment Method for CT Quality Control in Phantom Image Evaluation." Applied Sciences 11, no. 8: 3570.

Journal article
Published: 01 February 2021 in Applied Sciences
Reads 0
Downloads 0

The functional components of vibrating mesh nebulizers are a piezoelectric ceramic with a mesh mounted on one side, a reservoir, and a driving circuit. The piezoelectric material vibrates at a specific intrinsic frequency, and when the mechanical resonance frequency of the piezoelectric ceramic and the frequency of the applied electrical signal match, the vibration amplitude of the ceramic is greatest. In the present study, nebulizing performances were tested with respect to driving voltage amplitude after automatic resonance frequency tuning (ARFT) and/or impedance matching (IM) for salbutamol and glycerol solutions. A 1% mismatch of resonance frequency reduced the output rate by 11.0~30.1% and increased particle size by 1.6~7.7% and power consumption increased by 6.6~13.6%. Driving at 30 Vpp after ARFT and IM increased output rate by 45% and decreased power consumption by 31% compared with operation at nominal resonance frequency without IM at 50 Vpp. Nebulization of viscous solutions was also enhanced by applying ARFT with IM. The study shows the application of ARFT with IM improves vibrating mesh nebulizer performance and reduces power consumption.

ACS Style

Sang-Hyub Moon; Kyung Hwa Chang; Hyun Mok Park; Bong Joo Park; Sun Kook Yoo; Ki Chang Nam. Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers. Applied Sciences 2021, 11, 1296 .

AMA Style

Sang-Hyub Moon, Kyung Hwa Chang, Hyun Mok Park, Bong Joo Park, Sun Kook Yoo, Ki Chang Nam. Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers. Applied Sciences. 2021; 11 (3):1296.

Chicago/Turabian Style

Sang-Hyub Moon; Kyung Hwa Chang; Hyun Mok Park; Bong Joo Park; Sun Kook Yoo; Ki Chang Nam. 2021. "Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers." Applied Sciences 11, no. 3: 1296.

Journal article
Published: 31 July 2020 in Pharmaceutics
Reads 0
Downloads 0

Recent reports on mesh nebulizers suggest the possibility of stable nebulization of various therapeutic protein drugs. In this study, the in vitro performance and drug stability of jet and mesh nebulizers were examined for dornase alfa and compared with respect to their lung delivery efficiency in BALB/c mice. We compared four nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U150), and a vibrating mesh nebulizer (NE-SM1). The enzymatic activity of dornase alfa was assessed using a kinetic fluorometric DNase activity assay. Both jet nebulizers had large residual volumes between 24% and 27%, while the volume of the NE-SM1 nebulizer was less than 2%. Evaluation of dornase alfa aerosols produced by the four nebulizers showed no overall loss of enzymatic activity or protein content and no increase in aggregation or degradation. The amount of dornase alfa delivered to the lungs was highest for the PARI BOY SX-red jet nebulizer. This result confirmed that aerosol droplet size is an important factor in determining the efficiency of dornase alfa delivery to the lungs. Further clinical studies and analysis are required before any conclusions can be drawn regarding the clinical safety and efficacy of these nebulizers.

ACS Style

Kyung Hwa Chang; Sang-Hyub Moon; Sun Kook Yoo; Bong Joo Park; Ki Chang Nam. Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers. Pharmaceutics 2020, 12, 721 .

AMA Style

Kyung Hwa Chang, Sang-Hyub Moon, Sun Kook Yoo, Bong Joo Park, Ki Chang Nam. Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers. Pharmaceutics. 2020; 12 (8):721.

Chicago/Turabian Style

Kyung Hwa Chang; Sang-Hyub Moon; Sun Kook Yoo; Bong Joo Park; Ki Chang Nam. 2020. "Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers." Pharmaceutics 12, no. 8: 721.

Journal article
Published: 01 March 2020 in Cancers
Reads 0
Downloads 0

Various theragnostic agents have been devised and developed as cancer treatments; however, existing agents are often limited by their specific functions and complexities. Here, we report multifunctional magnetite (Fe3O4) nanoparticles functionalized with chlorin e6 (Ce6) and folic acid (FA) using a simple fabrication process to be used as theragnostic agents in photodynamic therapy (PDT). The effectiveness of cellular uptake of Fe3O4-Ce6-FA nanoparticles (FCF NPs) and its visualization as well as the photodynamic anticancer activities were evaluated. The mechanism of cancer cell death by the FCF NPs was also verified with qualitative and quantitative methods. Results indicate that FCF NPs have good penetration efficacy, resulting in excellent in vitro fluorescence and magnetic resonance imaging in cancer cells. FCF NPs exhibited promising anticancer activity in an irradiation time- and FCF NPs-dose-dependent manner in various cancer cell lines, leading to apoptotic cell death via morphological changes in cell membrane, nuclear, and DNA damage, and via overexpression of apoptosis-related genes, such as ZFP36L1, CYR61, GADD45G, caspases-2, -3, -9, 10, and -14. This study suggests that FCF NPs may be safely used in cancer therapy via PDT and could be a versatile therapeutic tool and biocompatible theragnostic agent, which may be used in diagnostic imaging.

ACS Style

Ki Chang Nam; Yong Soo Han; Jong-Min Lee; Si Chan Kim; Guangsup Cho; Bong Joo Park. Photo-Functionalized Magnetic Nanoparticles as a Nanocarrier of Photodynamic Anticancer Agent for Biomedical Theragnostics. Cancers 2020, 12, 571 .

AMA Style

Ki Chang Nam, Yong Soo Han, Jong-Min Lee, Si Chan Kim, Guangsup Cho, Bong Joo Park. Photo-Functionalized Magnetic Nanoparticles as a Nanocarrier of Photodynamic Anticancer Agent for Biomedical Theragnostics. Cancers. 2020; 12 (3):571.

Chicago/Turabian Style

Ki Chang Nam; Yong Soo Han; Jong-Min Lee; Si Chan Kim; Guangsup Cho; Bong Joo Park. 2020. "Photo-Functionalized Magnetic Nanoparticles as a Nanocarrier of Photodynamic Anticancer Agent for Biomedical Theragnostics." Cancers 12, no. 3: 571.

Journal article
Published: 19 April 2019 in Pharmaceutics
Reads 0
Downloads 0

Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by ELISA. The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage.

ACS Style

Kyung Hwa Chang; Sang-Hyub Moon; Jin Young Oh; Young-Soon Yoon; Namyi Gu; Chi-Yeon Lim; Bong Joo Park; Ki Chang Nam. Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice. Pharmaceutics 2019, 11, 192 .

AMA Style

Kyung Hwa Chang, Sang-Hyub Moon, Jin Young Oh, Young-Soon Yoon, Namyi Gu, Chi-Yeon Lim, Bong Joo Park, Ki Chang Nam. Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice. Pharmaceutics. 2019; 11 (4):192.

Chicago/Turabian Style

Kyung Hwa Chang; Sang-Hyub Moon; Jin Young Oh; Young-Soon Yoon; Namyi Gu; Chi-Yeon Lim; Bong Joo Park; Ki Chang Nam. 2019. "Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice." Pharmaceutics 11, no. 4: 192.

Journal article
Published: 01 January 2019 in Journal of Korean Medical Science
Reads 0
Downloads 0

Medical device adverse event reporting is an essential activity for mitigating device-related risks. Reporting of adverse events can be done by anyone like healthcare workers, patients, and others. However, for an individual to determine the reporting, he or she should recognize the current situation as an adverse event. The objective of this report is to share observed individual differences in the perception of a medical device adverse event, which may affect the judgment and the reporting of adverse events. We trained twenty-three participants from twelve Asia-Pacific Economic Cooperation (APEC) member economies about international guidelines for medical device vigilance. We developed and used six virtual cases and six questions. We divided participants into six groups and compared their opinions. We also surveyed the country's opinion to investigate the beginning point of 'patient use'. The phases of 'patient use' are divided into: 1) inspecting, 2) preparing, and 3) applying medical device. As for the question on the beginning point of 'patient use,' 28.6%, 35.7%, and 35.7% of participants provided answers regarding the first, second, and third phases, respectively. In training for applying international guidelines to virtual cases, only one of the six questions reached a consensus between the two groups in all six virtual cases. For the other five questions, different judgments were given in at least two groups. From training courses using virtual cases, we found that there was no consensus on 'patient use' point of view of medical devices. There was a significant difference in applying definitions of adverse events written in guidelines regarding the medical device associated incidents. Our results point out that international harmonization effort is needed not only to harmonize differences in regulations between countries but also to overcome diversity in perspectives existing at the site of medical device use.

ACS Style

Chiho Yoon; Ki Chang Nam; You Kyoung Lee; Youngjoon Kang; Soo Jeong Choi; Hye Mi Shin; Hyejung Jang; Jin Kuk Kim; Bum Sun Kwon; Hiroshi Ishikawa; Eric Woo. Differences in Perspectives of Medical Device Adverse Events: Observational Results in Training Program Using Virtual Cases. Journal of Korean Medical Science 2019, 34, e255 .

AMA Style

Chiho Yoon, Ki Chang Nam, You Kyoung Lee, Youngjoon Kang, Soo Jeong Choi, Hye Mi Shin, Hyejung Jang, Jin Kuk Kim, Bum Sun Kwon, Hiroshi Ishikawa, Eric Woo. Differences in Perspectives of Medical Device Adverse Events: Observational Results in Training Program Using Virtual Cases. Journal of Korean Medical Science. 2019; 34 (39):e255.

Chicago/Turabian Style

Chiho Yoon; Ki Chang Nam; You Kyoung Lee; Youngjoon Kang; Soo Jeong Choi; Hye Mi Shin; Hyejung Jang; Jin Kuk Kim; Bum Sun Kwon; Hiroshi Ishikawa; Eric Woo. 2019. "Differences in Perspectives of Medical Device Adverse Events: Observational Results in Training Program Using Virtual Cases." Journal of Korean Medical Science 34, no. 39: e255.

Journal article
Published: 13 September 2018 in Nanomaterials
Reads 0
Downloads 0

Photodynamic therapy (PDT) is a promising alternative to conventional cancer treatment methods. Nonetheless, improvement of in vivo light penetration and cancer cell-targeting efficiency remain major challenges in clinical photodynamic therapy. This study aimed to develop multifunctional magnetic nanoparticles conjugated with a photosensitizer (PS) and cancer-targeting molecules via a simple surface modification process for PDT. To selectively target cancer cells and PDT functionality, core magnetic (Fe3O4) nanoparticles were covalently bound with chlorin e6 (Ce6) as a PS and folic acid (FA). When irradiated with a 660-nm long-wavelength light source, the Fe3O4-Ce6-FA nanoparticles with good biocompatibility exerted marked anticancer effects via apoptosis, as confirmed by analyzing the translocation of the plasma membrane, nuclear fragmentation, activities of caspase-3/7 in prostate (PC-3) and breast (MCF-7) cancer cells. Ce6, used herein as a PS, is thus more useful for PDT because of its ability to produce a high singlet oxygen quantum yield, which is owed to deep penetration by virtue of its long-wavelength absorption band; however, further in vivo studies are required to verify its biological effects for clinical applications.

ACS Style

Kyong-Hoon Choi; Ki Chang Nam; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells. Nanomaterials 2018, 8, 722 .

AMA Style

Kyong-Hoon Choi, Ki Chang Nam, Guangsup Cho, Jin-Seung Jung, Bong Joo Park. Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells. Nanomaterials. 2018; 8 (9):722.

Chicago/Turabian Style

Kyong-Hoon Choi; Ki Chang Nam; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. 2018. "Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells." Nanomaterials 8, no. 9: 722.

Journal article
Published: 11 April 2018 in Applied Sciences
Reads 0
Downloads 0

In the field of drug delivery, a nebulizer is a device used to convert liquid drugs into tiny airborne droplets, such as aerosol or a mist form. These fine droplets are delivered to a patient’s lungs and airways and then spread throughout the body via blood vessels. Therefore, nebulization therapy is a highly-effective method compared with existing drug delivery methods. To enhance the curative influence of a drug, this study suggests the use of a new micro-porous mesh nebulizer consisting of a controllable palladium–nickel (Pd–Ni) membrane filter, piezoelectric element, and a cavity in the micro-pump. In this research, we optimize a biocompatible Pd–Ni membrane filter, such that it generated the smallest aerosol particles of various drugs. The pore size of the filter outlet is 4.2 μm ± 0.15 μm and the thickness of the Pd-Ni membrane filter is approximately 41.5 μm. In addition, the Pd–Ni membrane filter has good biocompatibility with normal cells. The result of a spray test with deionized (DI) water indicated that the size of a standard liquid droplet is 4.53 μm. The device has an electrical requirement, with a low power consumption of 2.5 W, and an optimal operation frequency of 98.5 kHz.

ACS Style

Kyong-Hoon Choi; Sang-Hyub Moon; Su-Kang Park; Guangsup Cho; Ki Chang Nam; Bong Joo Park. Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery. Applied Sciences 2018, 8, 604 .

AMA Style

Kyong-Hoon Choi, Sang-Hyub Moon, Su-Kang Park, Guangsup Cho, Ki Chang Nam, Bong Joo Park. Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery. Applied Sciences. 2018; 8 (4):604.

Chicago/Turabian Style

Kyong-Hoon Choi; Sang-Hyub Moon; Su-Kang Park; Guangsup Cho; Ki Chang Nam; Bong Joo Park. 2018. "Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery." Applied Sciences 8, no. 4: 604.

Research article
Published: 25 March 2018 in Stem Cells International
Reads 0
Downloads 0

Multipotent stem cells have the capacity to generate terminally differentiated cell types of each lineage; thus, they have great therapeutic potential for a wide variety of diseases. The most widely available stem cells are derived from human tissues, and their use for therapeutic application is limited by their high cost and low productivity. Herein, we report that conditioned media of mesenchymal stem cells (MSCs) isolated from deer antlers enhanced tissue regeneration through paracrine action via a combination of secreted growth factors and cytokines. Notably, DaMSC-conditioned media (DaMSC-CM) enhanced hair regeneration by activating the Wnt signaling pathway. In addition, DaMSC-CM had regenerative potential in damaged skin tissue through induction of skin regeneration-related genes. Remarkably, we identified round vesicles derived from DaMSC-CM, with an average diameter of ~120 nm that were associated with hair follicle formation, suggesting that secretory vesicles may act as paracrine mediators for modulation of local cellular responses. In addition, these secretory vesicles could regulate the expression of Wnt-3a, Wnt-10b, and lymphoid enhancer-binding factor-1 (LEF-1), which are related to tissue renewal. Thus, our findings demonstrate that the use of DaMSC-CM as a unique natural model for rapid and complete tissue regeneration has possible application for therapeutic development.

ACS Style

Minkoo Seo; Jin-Chul Kim; Hyung-Ki Kim; Eun Wook Choi; Suyeong Jeong; Ki Chang Nam; Mihue Jang. A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration. Stem Cells International 2018, 2018, 1 -8.

AMA Style

Minkoo Seo, Jin-Chul Kim, Hyung-Ki Kim, Eun Wook Choi, Suyeong Jeong, Ki Chang Nam, Mihue Jang. A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration. Stem Cells International. 2018; 2018 ():1-8.

Chicago/Turabian Style

Minkoo Seo; Jin-Chul Kim; Hyung-Ki Kim; Eun Wook Choi; Suyeong Jeong; Ki Chang Nam; Mihue Jang. 2018. "A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration." Stem Cells International 2018, no. : 1-8.

Journal article
Published: 16 June 2017 in Nanomaterials
Reads 0
Downloads 0

We report a novel zinc oxide (ZnO) nanoparticle with antioxidant properties, prepared by immobilizing the antioxidant 3-(3,4-dihydroxyphenyl)-2-propenoic acid (caffeic acid, CA) on the surfaces of micro-dielectric barrier discharge (DBD) plasma-treated ZnO nanoparticles. The microstructure and physical properties of [email protected] nanoparticles were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), infrared spectroscopy, and steady state spectroscopic methods. The antioxidant activity of [email protected] nanoparticles was evaluated using an ABTS (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation decolorization assay. [email protected] nanoparticles exhibited robust antioxidant activity. Moreover, [email protected] nanoparticles showed strong antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) including resistant bacteria such as methicillin-resistant S. aureus and against Gram-negative bacteria (Escherichia coli). Although Gram-negative bacteria appeared to be more resistant to [email protected] nanoparticles than Gram-positive bacteria, the antibacterial activity of [email protected] nanoparticles was dependent on particle concentration. The antioxidant and antibacterial activity of [email protected] may be useful for various biomedical and nanoindustrial applications.

ACS Style

Kyong-Hoon Choi; Ki Chang Nam; Sang-Yoon Lee; Guangsup Cho; Jin-Seung Jung; Ho-Joong Kim; Bong Joo Park. Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles. Nanomaterials 2017, 7, 148 .

AMA Style

Kyong-Hoon Choi, Ki Chang Nam, Sang-Yoon Lee, Guangsup Cho, Jin-Seung Jung, Ho-Joong Kim, Bong Joo Park. Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles. Nanomaterials. 2017; 7 (6):148.

Chicago/Turabian Style

Kyong-Hoon Choi; Ki Chang Nam; Sang-Yoon Lee; Guangsup Cho; Jin-Seung Jung; Ho-Joong Kim; Bong Joo Park. 2017. "Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles." Nanomaterials 7, no. 6: 148.

Journal article
Published: 10 June 2017 in Nanomaterials
Reads 0
Downloads 0

Photodynamic therapy (PDT) has been adopted as a minimally invasive approach for the localized treatment of superficial tumors, representing an improvement in the care of cancer patients. To improve the efficacy of PDT, it is important to first select an optimized nanocarrier and determine the influence of light parameters on the photosensitizing agent. In particular, much more knowledge concerning the importance of fluence and exposure time is required to gain a better understanding of the photodynamic efficacy. In the present study, we synthesized novel folic acid-(FA) and hematoporphyrin (HP)-conjugated multifunctional magnetic nanoparticles (CoFe2O4-HPs-FAs), which were characterized as effective anticancer reagents for PDT, and evaluated the influence of incubation time and light exposure time on the photodynamic anticancer activities of CoFe2O4-HPs-FAs in prostate cancer cells (PC-3 cells). The results indicated that the same fluence at different exposure times resulted in changes in the anticancer activities on PC-3 cells as well as in reactive oxygen species formation. In addition, an increase of the fluence showed an improvement for cell photo-inactivation. Therefore, we have established optimized conditions for new multifunctional magnetic nanoparticles with direct application for improving PDT for cancer patients.

ACS Style

Kyong-Hoon Choi; Ki Chang Nam; Un-Ho Kim; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles. Nanomaterials 2017, 7, 144 .

AMA Style

Kyong-Hoon Choi, Ki Chang Nam, Un-Ho Kim, Guangsup Cho, Jin-Seung Jung, Bong Joo Park. Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles. Nanomaterials. 2017; 7 (6):144.

Chicago/Turabian Style

Kyong-Hoon Choi; Ki Chang Nam; Un-Ho Kim; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. 2017. "Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles." Nanomaterials 7, no. 6: 144.

Journal article
Published: 06 September 2016 in Molecules
Reads 0
Downloads 0

In this study, newly designed biocompatible multifunctional magnetic submicron particles (CoFe2O4-HPs-FAs) of well-defined sizes (60, 133, 245, and 335 nm) were fabricated for application as a photosensitizer delivery agent for photodynamic therapy in cancer cells. To provide selective targeting of cancer cells and destruction of cancer cell functionality, basic cobalt ferrite (CoFe2O4) particles were covalently bonded with a photosensitizer (PS), which comprises hematoporphyrin (HP), and folic acid (FA) molecules. The magnetic properties of the CoFe2O4 particles were finely adjusted by controlling the size of the primary CoFe2O4 nanograins, and secondary superstructured composite particles were formed by aggregation of the nanograins. The prepared CoFe2O4-HP-FA exhibited high water solubility, good MR-imaging capacity, and biocompatibility without any in vitro cytotoxicity. In particular, our CoFe2O4-HP-FA exhibited remarkable photodynamic anticancer efficiency via induction of apoptotic death in PC-3 prostate cancer cells in a particle size- and concentration-dependent manner. This size-dependent effect was determined by the specific surface area of the particles because the number of HP molecules increased with decreasing size and increasing surface area. These results indicate that our CoFe2O4-HP-FA may be applicable for photodynamic therapy (PDT) as a PS delivery material and a therapeutic agent for MR-imaging based PDT owing to their high saturation value for magnetization and superparamagnetism.

ACS Style

Kyong-Hoon Choi; Ki Chang Nam; Leszek Malkinski; Eun Ha Choi; Jin-Seung Jung; Bong Joo Park. Size-Dependent Photodynamic Anticancer Activity of Biocompatible Multifunctional Magnetic Submicron Particles in Prostate Cancer Cells. Molecules 2016, 21, 1187 .

AMA Style

Kyong-Hoon Choi, Ki Chang Nam, Leszek Malkinski, Eun Ha Choi, Jin-Seung Jung, Bong Joo Park. Size-Dependent Photodynamic Anticancer Activity of Biocompatible Multifunctional Magnetic Submicron Particles in Prostate Cancer Cells. Molecules. 2016; 21 (9):1187.

Chicago/Turabian Style

Kyong-Hoon Choi; Ki Chang Nam; Leszek Malkinski; Eun Ha Choi; Jin-Seung Jung; Bong Joo Park. 2016. "Size-Dependent Photodynamic Anticancer Activity of Biocompatible Multifunctional Magnetic Submicron Particles in Prostate Cancer Cells." Molecules 21, no. 9: 1187.