This page has only limited features, please log in for full access.

Dr. Agnieszka Szopa
Jagiellonian University Medical College, Faculty of Pharmacy

Basic Info


Research Keywords & Expertise

0 Botany
0 phytochemical analysis
0 lignans
0 Phenolic acids and flavonols
0 Plant biotechnology

Fingerprints

Phenolic acids and flavonols
in vitro cultures

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Review
Published: 02 August 2021 in Journal of Ethnopharmacology
Reads 0
Downloads 0

‘Akebia stem’ (Akebiae caulis) is one of the newest raw materials officially introduced into therapeutic practice from traditional Chinese medicine. A monograph on this material appeared for the first time in 2018 in Supplement 9.6 to the 9th edition of the European Pharmacopoeia. In the latest 10th edition of the European Pharmacopoeia, the monograph remained unchanged. The ‘Akebia stem’ monograph allows the use, as a raw material, of Akebia quinata (Houtt.) Decne., A. trifoliata (Thunb.) Koidz, or a mixture of the two species. The aim of this work is a detailed review of the scientific literature on the genus Akebia (family Lardizabalaceae), with particular emphasis on A. quinata and A. trifoliata, providing information on the botanical, ecological, and chemical characteristics of these species. Professional research on their biological activity has been reviewed. The attention is given to phytochemistry and cosmetology. The traditional use of Akebia species and their potential use in medicine and cosmetology are assessed. In addition, individual papers describing biotechnology research on in vitro cultures of the two Akebia species are presented. The presented botanical, ecological, phytochemical and biotechnological characterization is based on a thorough review of published scientific research. It is a compilation and evaluation of data on the chemical composition and biological activities of these Akebia species. This critical review of phytochemical studies demonstrates that triterpenoid saponins are dominant secondary metabolites from these species. A comparative analysis of phytochemical studies on A. quinata and A. trifoliata stems, roots, fruits, and seeds showed differences in metabolites based on the plant parts and species. The triterpenoid saponins mutongsaponin C and saponin Pj1 have been found only in A. trifoliata, whereas the phenolic glycoside 2-(3,4-dihydroxyphenyl)-ethyl-O-β-D-glucopyranoside has been found only in A. quinata. Biological activity studies of A. quinata stem, leaf and/or fruit extracts have confirmed diuretic, hepatoregenerative, neuroprotective, analgesic, anti-inflammatory, and anti-obesity effects and an influence on ethanol metabolism. Different action profiles have been demonstrated for A. trifoliata stem, leaf and/or fruit extracts, different profiles of action. Studies have proven the antibacterial and anticancer (liver and stomach) effects of these species. This review presents potential phytopharmacological applications of both species and detailed data on their broad applications in cosmetology. Attention is also drawn to information on the safety of using Akebia. Finally, an overview of biotechnology research on both species is presented. This review provides comprehensive knowledge about the ethnopharmacological use of Akebia species. Moreover, new findings on the differences in the chemical composition and biological activity profiles are underlined.

ACS Style

Daria Maciąg; Ewa Dobrowolska; Marta Sharafan; Halina Ekiert; Michał Tomczyk; Agnieszka Szopa. Akebia quinata and Akebia trifoliata - a review of phytochemical composition, ethnopharmacological approaches and biological studies. Journal of Ethnopharmacology 2021, 280, 114486 .

AMA Style

Daria Maciąg, Ewa Dobrowolska, Marta Sharafan, Halina Ekiert, Michał Tomczyk, Agnieszka Szopa. Akebia quinata and Akebia trifoliata - a review of phytochemical composition, ethnopharmacological approaches and biological studies. Journal of Ethnopharmacology. 2021; 280 ():114486.

Chicago/Turabian Style

Daria Maciąg; Ewa Dobrowolska; Marta Sharafan; Halina Ekiert; Michał Tomczyk; Agnieszka Szopa. 2021. "Akebia quinata and Akebia trifoliata - a review of phytochemical composition, ethnopharmacological approaches and biological studies." Journal of Ethnopharmacology 280, no. : 114486.

Journal article
Published: 31 July 2021 in Molecules
Reads 0
Downloads 0

The study demonstrated the effects of precursor feeding on the production of glucosinolates (GSLs), flavonoids, polyphenols, saccharides, and photosynthetic pigments in Nasturtium officinale microshoot cultures grown in Plantform bioreactors. It also evaluated the antioxidant and antimicrobial activities of extracts. L-phenylalanine (Phe) and L-tryptophan (Trp) as precursors were tested at 0.05, 0.1, 0.5, 1.0, and 3.0 mM. They were added at the beginning (day 0) or on day 10 of the culture. Microshoots were harvested after 20 days. Microshoots treated with 3.0 mM Phe (day 0) had the highest total GSL content (269.20 mg/100 g DW). The qualitative and quantitative profiles of the GSLs (UHPLC-DAD-MS/MS) were influenced by precursor feeding. Phe at 3.0 mM stimulated the best production of 4-methoxyglucobrassicin (149.99 mg/100 g DW) and gluconasturtiin (36.17 mg/100 g DW). Total flavonoids increased to a maximum of 1364.38 mg/100 g DW with 3.0 mM Phe (day 0), and polyphenols to a maximum of 1062.76 mg/100 g DW with 3.0 mM Trp (day 0). The precursors also increased the amounts of p-coumaric and ferulic acids, and rutoside, and generally increased the production of active photosynthetic pigments. Antioxidant potential increased the most with 0.1 mM Phe (day 0) (CUPRAC, FRAP), and with 0.5 mM Trp (day 10) (DPPH). The extracts of microshoots treated with 3.0 mM Phe (day 0) showed the most promising bacteriostatic activity against microaerobic Gram-positive acne strains (MIC 250–500 µg/mL, 20–21 mm inhibition zones). No extract was cytotoxic to normal human fibroblasts over the tested concentration range (up to 250 μg/mL).

ACS Style

Marta Klimek-Szczykutowicz; Michał Dziurka; Ivica Blažević; Azra Đulović; Małgorzata Miazga-Karska; Katarzyna Klimek; Halina Ekiert; Agnieszka Szopa. Precursor-Boosted Production of Metabolites in Nasturtium officinale Microshoots Grown in Plantform Bioreactors, and Antioxidant and Antimicrobial Activities of Biomass Extracts. Molecules 2021, 26, 4660 .

AMA Style

Marta Klimek-Szczykutowicz, Michał Dziurka, Ivica Blažević, Azra Đulović, Małgorzata Miazga-Karska, Katarzyna Klimek, Halina Ekiert, Agnieszka Szopa. Precursor-Boosted Production of Metabolites in Nasturtium officinale Microshoots Grown in Plantform Bioreactors, and Antioxidant and Antimicrobial Activities of Biomass Extracts. Molecules. 2021; 26 (15):4660.

Chicago/Turabian Style

Marta Klimek-Szczykutowicz; Michał Dziurka; Ivica Blažević; Azra Đulović; Małgorzata Miazga-Karska; Katarzyna Klimek; Halina Ekiert; Agnieszka Szopa. 2021. "Precursor-Boosted Production of Metabolites in Nasturtium officinale Microshoots Grown in Plantform Bioreactors, and Antioxidant and Antimicrobial Activities of Biomass Extracts." Molecules 26, no. 15: 4660.

Journal article
Published: 29 July 2021 in Journal of Fungi
Reads 0
Downloads 0

Button mushrooms have a very short shelf life after harvesting and are sensitive to mechanical damage and browning. This can be a severe problem in enlarging the market and the long-distance exportation of this product. In this respect, edible coatings could be an alternative treatment to extend the shelf life of button mushrooms, maintaining their quality during long-term storage. The aim of this study was to investigate the impact of gum, agar, sodium alginate, egg white protein, and lecithin on the postharvest weight loss, color, browning, respiration rate, ethylene production, and storage life of button mushrooms. The results showed that the above-mentioned edible coatings are a promising way to extend the life and maintain the quality of button mushrooms. Significant differences (p< 0.05) were observed between the control and edible coating-treated samples in all parameters. Sodium alginate and gum were more effective in preventing weight loss, coloring, and browning than other edible coatings. On the other hand, the respiration rate and ethylene production were more suppressed by the agar and lecithin coatings compared to the others. In conclusion, it can be recommended that the above-mentioned edible coatings could be used as novel coatings in commercial treatments for maintaining the quality of button mushrooms during a long-term storage period.

ACS Style

Seyda Cavusoglu; Yusuf Uzun; Nurettin Yilmaz; Sezai Ercisli; Erkan Eren; Halina Ekiert; Hosam Elansary; Agnieszka Szopa. Maintaining the Quality and Storage Life of Button Mushrooms (Agaricus bisporus) with Gum, Agar, Sodium Alginate, Egg White Protein, and Lecithin Coating. Journal of Fungi 2021, 7, 614 .

AMA Style

Seyda Cavusoglu, Yusuf Uzun, Nurettin Yilmaz, Sezai Ercisli, Erkan Eren, Halina Ekiert, Hosam Elansary, Agnieszka Szopa. Maintaining the Quality and Storage Life of Button Mushrooms (Agaricus bisporus) with Gum, Agar, Sodium Alginate, Egg White Protein, and Lecithin Coating. Journal of Fungi. 2021; 7 (8):614.

Chicago/Turabian Style

Seyda Cavusoglu; Yusuf Uzun; Nurettin Yilmaz; Sezai Ercisli; Erkan Eren; Halina Ekiert; Hosam Elansary; Agnieszka Szopa. 2021. "Maintaining the Quality and Storage Life of Button Mushrooms (Agaricus bisporus) with Gum, Agar, Sodium Alginate, Egg White Protein, and Lecithin Coating." Journal of Fungi 7, no. 8: 614.

Reference work
Published: 28 July 2021 in Plant Antioxidants and Health
Reads 0
Downloads 0

The search for a new natural source of antioxidants has been, for more than a decade, one of the most dynamically developing directions of scientific research conducted by various research centers around the world. Numerous species of medicinal plants that are a rich source of natural antioxidants have not been fully explored yet. Cultures of such plant species in vitro can also be a potential rich source of antioxidants. The largest group of plant-based antioxidants is compounds with the structure of polyphenols. They are metabolites frequently found in numerous medicinal plants. The aim of this chapter is to present the most interesting results of our biotechnological research that have proven the very high biosynthetic potential of cells of medicinal plants grown in vitro, obtained in the production of selected subgroups of polyphenols – phenolic acids, flavonoids specific to the genus Scutellaria, phenylpropanoid glycosides, catechins, and the dibenzocyclooctadiene lignans (Schisandra-type lignans). As part of the presented research, the conditions for cultivating cultures in vitro were optimized (testing of basal media, quality and quantity of PGRs, feeding with biosynthetic precursors, elicitation, light conditions, and different types of in vitro cultures). The optimization was conducted for in vitro cultures of Aronia spp., Cistus × incanus, Hypericum perforatum (cvs. Elixir, Helos, and Topas), Scutellaria spp., Verbena officinalis, and Schisandra spp. The results of this optimization work are of an application value. Selected types of in vitro cultures of the plant species tested by us are a very rich source of various subgroups of polyphenols, including depsides, selected Scutellaria specific flavonoids (incl. baicalin and wogonoside), selected phenylpropanoid glycosides (incl. verbascoside and isoverbascoside), selected catechins (incl. catechin and epicatechin gallate), and selected Schisandra-type lignans (incl. gomisin A and schisantherin B). The obtained amounts of these compounds are very often, from a few to a several times, higher than in the extracts of plant material from plants growing in vivo (in open air) analyzed for comparison. Extracts from the biomass grown in vitro of some plant species analyzed for antioxidant potential have high antioxidant activity as determined by various methods (DPPH, FRAP, CUPRAC, QUENCHER-CUPRAC, Fe2+ chelating activity, and reducing power assay).

ACS Style

Halina Ekiert; Paweł Kubica; Inga Kwiecień; Karolina Jafernik; Marta Klimek-Szczykutowicz; Agnieszka Szopa. Cultures of Medicinal Plants In Vitro as a Potential Rich Source of Antioxidants. Plant Antioxidants and Health 2021, 1 -44.

AMA Style

Halina Ekiert, Paweł Kubica, Inga Kwiecień, Karolina Jafernik, Marta Klimek-Szczykutowicz, Agnieszka Szopa. Cultures of Medicinal Plants In Vitro as a Potential Rich Source of Antioxidants. Plant Antioxidants and Health. 2021; ():1-44.

Chicago/Turabian Style

Halina Ekiert; Paweł Kubica; Inga Kwiecień; Karolina Jafernik; Marta Klimek-Szczykutowicz; Agnieszka Szopa. 2021. "Cultures of Medicinal Plants In Vitro as a Potential Rich Source of Antioxidants." Plant Antioxidants and Health , no. : 1-44.

Journal article
Published: 19 July 2021 in Sustainability
Reads 0
Downloads 0

The Rosa is one of the most diverse genera in the plant kingdom and, in particular, its fruits have been used for multiple purposes in different parts of the world for centuries. Within the genus, Rosa canina and Rosa dumalis are, economically, the most important species and dominate Rosa fruit production. In this study, some important fruit and shrub traits of ten Rosa canina and ten Rosa dumalis ecotypes collected from rural areas of Kars province, located in the east Anatolia region of Turkey were investigated. We found significant differences among ecotypes in most of the morphological and biochemical traits. The ecotypes were found between 1446–2210 m altitude. Fruit weight and fruit flesh ratio ranged from 2.95 g to 4.72 g and 62.55% to 74.42%, respectively. SSC (Soluble Solid Content), Vitamin C, total phenolic, total flavonoid, total carotenoid, and total anthocyanin content of the ecotypes ranged from 16.9–22.7%, 430–690 mg per 100 g FW (fresh weight), 390–532 mg gallic acid equivalent per 100 g FW, 0.88–2.04 mg per g FW, 6.83–15.17 mg per g FW and 3.62–7.81 mg cyanidin-3-glucoside equivalent per kg, respectively. Antioxidant activity was determined to be between 19.7–34.7 mg ascorbic acid equivalent per g fresh weight. Rosa ecotypes contained chlorogenic acid and rutin the most as phenolic compound. Our results indicated great diversity within both R. canina and R. dumalis fruits.

ACS Style

Mehmet Bozhuyuk; Sezai Ercisli; Neva Karatas; Halina Ekiert; Hosam Elansary; Agnieszka Szopa. Morphological and Biochemical Diversity in Fruits of Unsprayed Rosa canina and Rosa dumalis Ecotypes Found in Different Agroecological Conditions. Sustainability 2021, 13, 8060 .

AMA Style

Mehmet Bozhuyuk, Sezai Ercisli, Neva Karatas, Halina Ekiert, Hosam Elansary, Agnieszka Szopa. Morphological and Biochemical Diversity in Fruits of Unsprayed Rosa canina and Rosa dumalis Ecotypes Found in Different Agroecological Conditions. Sustainability. 2021; 13 (14):8060.

Chicago/Turabian Style

Mehmet Bozhuyuk; Sezai Ercisli; Neva Karatas; Halina Ekiert; Hosam Elansary; Agnieszka Szopa. 2021. "Morphological and Biochemical Diversity in Fruits of Unsprayed Rosa canina and Rosa dumalis Ecotypes Found in Different Agroecological Conditions." Sustainability 13, no. 14: 8060.

Journal article
Published: 30 June 2021 in International Journal of Molecular Sciences
Reads 0
Downloads 0

Fetal alcohol spectrum disorders (FASDs) are one of the most common consequences of ethanol exposure during pregnancy. In adulthood, these disorders can be manifested by learning and memory deficits and depressive-like behavior. Ethanol-induced oxidative stress may be one of the factors that induces FASD development. The mammalian target of the Rapamycin (mTOR) signaling pathway that acts via two distinct multiprotein complexes, mTORC1 and mTORC2, can affect oxidative stress. We investigated whether mTOR-dependent or mTOR-independent mechanisms are engaged in this phenomenon. Thus, Rapamycin—a selective inhibitor of mTORC1, Torin-2—a non-selective mTORC1/mTORC2 inhibitor, and FK-506—a drug that impacts oxidative stress in an mTOR-independent manner were used. Behavioral tests were performed in adult (PND60-65) rats using a passive avoidance (PA) task (aversive learning and memory) and forced swimming test (FST) (depressive-like behaviors). In addition, the biochemical parameters of oxidative stress, such as lipid peroxidation (LPO), as well as apurinic/apyrimidinic (AP)-sites were determined in the hippocampus and prefrontal cortex in adult (PND65) rats. The rat FASD model was induced by intragastric ethanol (5 g/kg/day) administration at postnatal day (PND)4–9 (an equivalent to the third trimester of human pregnancy). All substances (3 mg/kg) were given 30 min before ethanol. Our results show that neonatal ethanol exposure leads to deficits in context-dependent fear learning and depressive-like behavior in adult rats that were associated with increased oxidative stress parameters in the hippocampus and prefrontal cortex. Because these effects were completely reversed by Rapamycin, an mTORC1 inhibitor, this outcome suggests its usefulness as a preventive therapy in disorders connected with prenatal ethanol exposure.

ACS Style

Malgorzata Lopatynska-Mazurek; Lukasz Komsta; Ewa Gibula-Tarlowska; Jolanta Kotlinska. Aversive Learning Deficits and Depressive-Like Behaviors Are Accompanied by an Increase in Oxidative Stress in a Rat Model of Fetal Alcohol Spectrum Disorders: The Protective Effect of Rapamycin. International Journal of Molecular Sciences 2021, 22, 7083 .

AMA Style

Malgorzata Lopatynska-Mazurek, Lukasz Komsta, Ewa Gibula-Tarlowska, Jolanta Kotlinska. Aversive Learning Deficits and Depressive-Like Behaviors Are Accompanied by an Increase in Oxidative Stress in a Rat Model of Fetal Alcohol Spectrum Disorders: The Protective Effect of Rapamycin. International Journal of Molecular Sciences. 2021; 22 (13):7083.

Chicago/Turabian Style

Malgorzata Lopatynska-Mazurek; Lukasz Komsta; Ewa Gibula-Tarlowska; Jolanta Kotlinska. 2021. "Aversive Learning Deficits and Depressive-Like Behaviors Are Accompanied by an Increase in Oxidative Stress in a Rat Model of Fetal Alcohol Spectrum Disorders: The Protective Effect of Rapamycin." International Journal of Molecular Sciences 22, no. 13: 7083.

Review
Published: 24 June 2021 in Cancer Cell International
Reads 0
Downloads 0

The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Monica Butnariu; Lia Sanda Rotariu; Oksana Sytar; Simona Sestito; Simona Rapposelli; Muhammad Akram; Mehwish Iqbal; Akash Krishna; Nanjangud Venkatesh Anil Kumar; Susana S. Braga; Susana M. Cardoso; Karolina Jafernik; Halina Ekiert; Natália Cruz-Martins; Agnieszka Szopa; Marcelo Villagran; Lorena Mardones; Miquel Martorell; Anca Oana Docea; Daniela Calina. Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment. Cancer Cell International 2021, 21, 1 -21.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna, Nanjangud Venkatesh Anil Kumar, Susana S. Braga, Susana M. Cardoso, Karolina Jafernik, Halina Ekiert, Natália Cruz-Martins, Agnieszka Szopa, Marcelo Villagran, Lorena Mardones, Miquel Martorell, Anca Oana Docea, Daniela Calina. Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment. Cancer Cell International. 2021; 21 (1):1-21.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Monica Butnariu; Lia Sanda Rotariu; Oksana Sytar; Simona Sestito; Simona Rapposelli; Muhammad Akram; Mehwish Iqbal; Akash Krishna; Nanjangud Venkatesh Anil Kumar; Susana S. Braga; Susana M. Cardoso; Karolina Jafernik; Halina Ekiert; Natália Cruz-Martins; Agnieszka Szopa; Marcelo Villagran; Lorena Mardones; Miquel Martorell; Anca Oana Docea; Daniela Calina. 2021. "Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment." Cancer Cell International 21, no. 1: 1-21.

Review
Published: 25 April 2021 in Molecules
Reads 0
Downloads 0

Artemisia abrotanum L. (southern wormwood) is a plant species with an important position in the history of European and Asian medicine. It is a species famous as a medicinal plant in Central Asia, Asia Minor, and in South-East and Central Europe. The raw materials obtained from this species are Abrotani herba and Abrotani folium. In the traditional European medicine, they have been used successfully most of all in liver and biliary tract diseases, in parasitic diseases in children and as antipyretic medication. In the official European medicine, this plant species is recommended by the French Pharmacopoeia for use in homeopathy. In many European countries, it is used traditionally in allopathy. The latest studies on the biological activity of extracts from the aboveground parts of the plant and/or the leaves, and/or the essential oil have provided evidence of other possible applications related to their antibacterial, antifungal, antioxidant, anticancer, and antiallergic properties. The latest studies have also focused on the repellent activity of the essential oil of this species and the possibility to use it in the prevention of diseases in which insects are the vectors. The main substances obtained from the plant that are responsible for this activity are: the essential oil, coumarins, phenolic acids, and flavonoids. Some of the latest investigations emphasize the large differences in the composition of the essential oil, determined by the geographical (climatic) origin of the plant. A. abrotanum is recommended by the European Cosmetic Ingredients Database (CosIng) as a source of valuable cosmetic ingredients. Additionally, the leaves of this species possess a well-established position in the food industry. This plant species is also the object of biotechnological studies.

ACS Style

Halina Ekiert; Ewa Knut; Joanna Świątkowska; Paweł Klin; Agnieszka Rzepiela; Michał Tomczyk; Agnieszka Szopa. Artemisia abrotanum L. (Southern Wormwood)—History, Current Knowledge on the Chemistry, Biological Activity, Traditional Use and Possible New Pharmaceutical and Cosmetological Applications. Molecules 2021, 26, 2503 .

AMA Style

Halina Ekiert, Ewa Knut, Joanna Świątkowska, Paweł Klin, Agnieszka Rzepiela, Michał Tomczyk, Agnieszka Szopa. Artemisia abrotanum L. (Southern Wormwood)—History, Current Knowledge on the Chemistry, Biological Activity, Traditional Use and Possible New Pharmaceutical and Cosmetological Applications. Molecules. 2021; 26 (9):2503.

Chicago/Turabian Style

Halina Ekiert; Ewa Knut; Joanna Świątkowska; Paweł Klin; Agnieszka Rzepiela; Michał Tomczyk; Agnieszka Szopa. 2021. "Artemisia abrotanum L. (Southern Wormwood)—History, Current Knowledge on the Chemistry, Biological Activity, Traditional Use and Possible New Pharmaceutical and Cosmetological Applications." Molecules 26, no. 9: 2503.

Review
Published: 13 April 2021 in Frontiers in Pharmacology
Reads 0
Downloads 0

Artemisia dracunculus L. (tarragon), Asteraceae, is a species that has long been used in traditional Asian medicine, mainly in Iran, Pakistan, Azerbaijan and India. It is known as a spice species in Asia, Europe and the Americas. The raw materials obtained from this species are herb and leaf. The presence of essential oil with a highly variable composition, as well as flavonoids, phenolic acids, coumarins and alkamides, determines the medicinal and/or spice properties of the plant. In traditional Asian medicine, this species is used, for example, in the treatment of digestive system diseases, as an analgesic, hypnotic, antiepileptic, anti-inflammatory and antipyretic agent, and as an effective remedy in the treatment of helminthiasis. Nowadays, A. dracunculus is the subject of professional phytochemical and pharmacological researches. Pharmacological studies have confirmed its anti-inflammatory and analgesic effects known from traditional uses; they have also proved very important new findings regarding its biological activity, such as antioxidant, immunomodulating and anti-tumour activities, as well as hepatoprotective and hypoglycaemic effects. A. dracunculus has long-held an established position in the food industry as a spice. And its use is growing in the cosmetics industry. Moreover, it is the subject of biotechnological research focused mainly on the development of micro-propagation protocols.

ACS Style

Halina Ekiert; Joanna Świątkowska; Ewa Knut; Paweł Klin; Agnieszka Rzepiela; Michał Tomczyk; Agnieszka Szopa. Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology. Frontiers in Pharmacology 2021, 12, 1 .

AMA Style

Halina Ekiert, Joanna Świątkowska, Ewa Knut, Paweł Klin, Agnieszka Rzepiela, Michał Tomczyk, Agnieszka Szopa. Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology. Frontiers in Pharmacology. 2021; 12 ():1.

Chicago/Turabian Style

Halina Ekiert; Joanna Świątkowska; Ewa Knut; Paweł Klin; Agnieszka Rzepiela; Michał Tomczyk; Agnieszka Szopa. 2021. "Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology." Frontiers in Pharmacology 12, no. : 1.

Journal article
Published: 27 February 2021 in Plants
Reads 0
Downloads 0

Comparative estimations of the antioxidant activity of methanolic extracts from biomasses of different types of in vitro cultures of Cistus × incanus, Verbena officinalis, Scutellaria lateriflora, and S. baicalensis and also from plant raw materials were performed. The antioxidant measurements were based on the modern assays—cupric ion reducing antioxidant capacity (CUPRAC) and quick, easy, new, cheap, and reproducible CUPRAC (QUENCHER-CUPRAC). The total extractable antioxidants (CUPRAC assay) ranged from 10.4 to 49.7 mmol (100 g)−1 of dry weight (DW) expressed as Trolox equivalent antioxidant capacity (TEAC), and the global antioxidant response (QUENCHER-CUPRAC assay) ranged from 16.0 to 79.1 mmol (100 g)−1 DW for in vitro cultures, whereas for plant raw materials the total extractable antioxidants ranged from 20.9 to 69.5 mmol (100 g)−1 DW, and the global antioxidant response ranged from 67.2 to 97.8 mmol (100 g)−1 DW. Finally, the in vitro cultures could be regarded as an antioxidant-rich alternative resource for the pharmaceutical, health food and cosmetics industries.

ACS Style

Michał Dziurka; Paweł Kubica; Inga Kwiecień; Jolanta Biesaga-Kościelniak; Halina Ekiert; Shaimaa Abdelmohsen; Fatemah Al-Harbi; Diaa El-Ansary; Hosam Elansary; Agnieszka Szopa. In Vitro Cultures of Some Medicinal Plant Species (Cistus × incanus, Verbena officinalis, Scutellaria lateriflora, and Scutellaria baicalensis) as a Rich Potential Source of Antioxidants—Evaluation by CUPRAC and QUENCHER-CUPRAC Assays. Plants 2021, 10, 454 .

AMA Style

Michał Dziurka, Paweł Kubica, Inga Kwiecień, Jolanta Biesaga-Kościelniak, Halina Ekiert, Shaimaa Abdelmohsen, Fatemah Al-Harbi, Diaa El-Ansary, Hosam Elansary, Agnieszka Szopa. In Vitro Cultures of Some Medicinal Plant Species (Cistus × incanus, Verbena officinalis, Scutellaria lateriflora, and Scutellaria baicalensis) as a Rich Potential Source of Antioxidants—Evaluation by CUPRAC and QUENCHER-CUPRAC Assays. Plants. 2021; 10 (3):454.

Chicago/Turabian Style

Michał Dziurka; Paweł Kubica; Inga Kwiecień; Jolanta Biesaga-Kościelniak; Halina Ekiert; Shaimaa Abdelmohsen; Fatemah Al-Harbi; Diaa El-Ansary; Hosam Elansary; Agnieszka Szopa. 2021. "In Vitro Cultures of Some Medicinal Plant Species (Cistus × incanus, Verbena officinalis, Scutellaria lateriflora, and Scutellaria baicalensis) as a Rich Potential Source of Antioxidants—Evaluation by CUPRAC and QUENCHER-CUPRAC Assays." Plants 10, no. 3: 454.

Reviews
Published: 22 January 2021 in Planta Medica
Reads 0
Downloads 0

Artemisia annua (annual mugwort) is a species that has long been used in traditional Asian medicine, mainly Chinese and Hindu. The species is widespread and known as a medicinal plant not only in Asia but also in Europe, in both Americas, and Australia. The species has become a subject of particular interest due to the 2015 Nobel Prize awarded for detecting the sesquiterpene lactone artemisinin in it and proving its antimalarial activities. The raw materials obtained from this species are Artemisiae annuae folium and Artemisiae annuae herba. The leaves are a raw material in the Chinese Pharmacopoeia and Vietnamese Pharmacopoeia. Both raw materials are in the International Pharmacopoeia published by the WHO. The main components of these raw materials are mainly specific sesquiterpene lactones, essential oil, flavonoids, coumarins, and phenolic acids. In traditional Asian medicine, the species is used, for example, in the treatment of jaundice and bacterial dysentery, as an antipyretic agent in malaria and tuberculosis, in the treatment of wounds and haemorrhoids, and in viral, bacterial, and autoimmune diseases. Professional pharmacological studies conducted today have confirmed its known traditional applications and explain previously unknown mechanisms of its biological action and have also found evidence of new directions of biological activity, including, among others, anti-inflammatory, analgesic, antioxidant, antitumour, and nephroprotective activities. The species is of growing importance in the cosmetics industry.

ACS Style

Halina Ekiert; Joanna Świątkowska; Paweł Klin; Agnieszka Rzepiela; Agnieszka Szopa. Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications. Planta Medica 2021, 1 .

AMA Style

Halina Ekiert, Joanna Świątkowska, Paweł Klin, Agnieszka Rzepiela, Agnieszka Szopa. Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications. Planta Medica. 2021; ():1.

Chicago/Turabian Style

Halina Ekiert; Joanna Świątkowska; Paweł Klin; Agnieszka Rzepiela; Agnieszka Szopa. 2021. "Artemisia annua – Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications." Planta Medica , no. : 1.

Editorial
Published: 07 December 2020 in Molecules
Reads 0
Downloads 0

Natural products and their biological activities are currently a subject of great interest in the pharmaceutical, health food, and cosmetics industries, and numbers of scientific studies in this field are increasing rapidly

ACS Style

Halina Maria Ekiert; Agnieszka Szopa. Biological Activities of Natural Products. Molecules 2020, 25, 5769 .

AMA Style

Halina Maria Ekiert, Agnieszka Szopa. Biological Activities of Natural Products. Molecules. 2020; 25 (23):5769.

Chicago/Turabian Style

Halina Maria Ekiert; Agnieszka Szopa. 2020. "Biological Activities of Natural Products." Molecules 25, no. 23: 5769.

Book chapter
Published: 04 December 2020 in Reference Series in Phytochemistry
Reads 0
Downloads 0

Chinese magnolia vine (Schisandra chinensis) is a well-known traditional Chinese medicinal plant species, which is very important in modern phytotherapy. The key role is assigned to specific compounds – dibenzocyclooctadiene lignans. This chapter describes the use of S. chinensis in vitro cultures as a tool to increase their production under controlled conditions as a promising biotechnological alternative to their extraction from ex vitro plant material or by chemical synthesis. Moreover, the chosen phenolic compounds (phenolic acids and flavonoids) were taken into consideration, too. The whole process of biotechnological research was applied to studying S. chinensis and its cultivar – S. chinensis cv. Sadova No. 1. The studies involved initiation of in vitro cultures, optimization of the basal composition of the culture media, duration of the growth cycles, type of cultures, culture lighting conditions, elicitors, and bioreactor design. In all the steps of biotechnological process, efficient production of specific lignans and phenolic compounds was achieved. The research proved that plant in vitro cultures of both Schisandras can be an efficient tool used to increase the production of the desired secondary metabolites.

ACS Style

Agnieszka Szopa; Adam Kokotkiewicz; Marta Klimek-Szczykutowicz; Maria Luczkiewicz; Halina Maria Ekiert. Different Types of In Vitro Cultures of Schisandra chinensis and Its Cultivar (S. chinensis cv. Sadova): A Rich Potential Source of Specific Lignans and Phenolic Compounds. Reference Series in Phytochemistry 2020, 309 -336.

AMA Style

Agnieszka Szopa, Adam Kokotkiewicz, Marta Klimek-Szczykutowicz, Maria Luczkiewicz, Halina Maria Ekiert. Different Types of In Vitro Cultures of Schisandra chinensis and Its Cultivar (S. chinensis cv. Sadova): A Rich Potential Source of Specific Lignans and Phenolic Compounds. Reference Series in Phytochemistry. 2020; ():309-336.

Chicago/Turabian Style

Agnieszka Szopa; Adam Kokotkiewicz; Marta Klimek-Szczykutowicz; Maria Luczkiewicz; Halina Maria Ekiert. 2020. "Different Types of In Vitro Cultures of Schisandra chinensis and Its Cultivar (S. chinensis cv. Sadova): A Rich Potential Source of Specific Lignans and Phenolic Compounds." Reference Series in Phytochemistry , no. : 309-336.

Journal article
Published: 28 November 2020 in Molecules
Reads 0
Downloads 0

Callus, suspension and bioreactor cultures of Verbena officinalis were established, and optimized for biomass growth and production of phenylpropanoid glycosides, phenolic acids, flavonoids and iridoids. All types of cultures were maintained on/in the Murashige and Skoog (MS) media with 1 mg/L BAP and 1 mg/L NAA. The inoculum sizes were optimized in callus and suspension cultures. Moreover, the growth of the culture in two different types of bioreactors—a balloon bioreactor (BB) and a stirred-tank bioreactor (STB) was tested. In methanolic extracts from biomass of all types of in vitro cultures the presence of the same metabolites—verbascoside, isoverbascoside, and six phenolic acids: protocatechuic, chlorogenic, vanillic, caffeic, ferulic and rosmarinic acids was confirmed and quantified by the HPLC-DAD method. In the extracts from lyophilized culture media, no metabolites were found. The main metabolites in biomass extracts were verbascoside and isoverbascoside. Their maximum amounts in g/100 g DW (dry weight) in the tested types of cultures were as follow: 7.25 and 0.61 (callus), 7.06 and 0.48 (suspension), 7.69 and 0.31 (BB), 9.18 and 0.34 (STB). The amounts of phenolic acids were many times lower, max. total content reached of 26.90, 50.72, 19.88, and 36.78 mg/100 g DW, respectively. The highest content of verbascoside and also a high content of isoverbascoside obtained in STB (stirred-tank bioreactor) were 5.3 and 7.8 times higher than in extracts from overground parts of the parent plant. In the extracts from parent plant two iridoids—verbenalin and hastatoside, were also abundant. All investigated biomass extracts and the extracts from parent plant showed the antiproliferative, antioxidant and antibacterial activities. The strongest activities were documented for the cultures maintained in STB. We propose extracts from in vitro cultured biomass of vervain, especially from STB, as a rich source of bioactive metabolites with antiproliferative, antioxidant and antibacterial properties.

ACS Style

Paweł Kubica; Agnieszka Szopa; Adam Kokotkiewicz; Natalizia Miceli; Maria Fernanda Taviano; Alessandro Maugeri; Santa Cirmi; Alicja Synowiec; Małgorzata Gniewosz; Hosam O. Elansary; Eman A. Mahmoud; Diaa O. El-Ansary; Omaima Nasif; Maria Luczkiewicz; Halina Ekiert. Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts. Molecules 2020, 25, 5609 .

AMA Style

Paweł Kubica, Agnieszka Szopa, Adam Kokotkiewicz, Natalizia Miceli, Maria Fernanda Taviano, Alessandro Maugeri, Santa Cirmi, Alicja Synowiec, Małgorzata Gniewosz, Hosam O. Elansary, Eman A. Mahmoud, Diaa O. El-Ansary, Omaima Nasif, Maria Luczkiewicz, Halina Ekiert. Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts. Molecules. 2020; 25 (23):5609.

Chicago/Turabian Style

Paweł Kubica; Agnieszka Szopa; Adam Kokotkiewicz; Natalizia Miceli; Maria Fernanda Taviano; Alessandro Maugeri; Santa Cirmi; Alicja Synowiec; Małgorzata Gniewosz; Hosam O. Elansary; Eman A. Mahmoud; Diaa O. El-Ansary; Omaima Nasif; Maria Luczkiewicz; Halina Ekiert. 2020. "Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts." Molecules 25, no. 23: 5609.

Review
Published: 13 November 2020 in Natural Product Research
Reads 0
Downloads 0

The article presents the characteristics of bakuchiol – a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of the species Cullen corylifolium (Psoralea corylifolia). Bakuchiol has recently been playing a significant role in cosmetology as a “natural substitute” for retinol, free of side effects. Clinical studies confirm valuable cosmetological properties of bakuchiol, such as anti-ageing, anti-pigmentation and anti-acne effects. Scientific research has also shown valuable pharmacological properties of bakuchiol, such as anti-cancer, hepatoprotective, cardioprotective, hypoglycemic, hypolipemic, and antidepressant. In addition, antioxidant, anti-inflammatory and antimicrobal activities of bakuchiol, valuable from the point of view of both cosmetology and therapy, have also been confirmed. A separate part of the article is devoted to the botanical, chemical and pharmacological characteristics of the species C. corylifolium as the main source for obtaining bakuchiol. Graphical Abstract

ACS Style

Karolina Jafernik; Ekiert Halina; Sezai Ercisli; Agnieszka Szopa. Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik. Natural Product Research 2020, 1 -15.

AMA Style

Karolina Jafernik, Ekiert Halina, Sezai Ercisli, Agnieszka Szopa. Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik. Natural Product Research. 2020; ():1-15.

Chicago/Turabian Style

Karolina Jafernik; Ekiert Halina; Sezai Ercisli; Agnieszka Szopa. 2020. "Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik." Natural Product Research , no. : 1-15.

Journal article
Published: 11 November 2020 in Molecules
Reads 0
Downloads 0

The main compounds in both extracts were gluconasturtiin, 4-methoxyglucobrassicin and rutoside, the amounts of which were, respectively, determined as 182.93, 58.86 and 23.24 mg/100 g dry weight (DW) in biomass extracts and 640.94, 23.47 and 7.20 mg/100 g DW in plant herb extracts. The antioxidant potential of all the studied extracts evaluated using CUPRAC (CUPric Reducing Antioxidant Activity), FRAP (Ferric Reducing Ability of Plasma), and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays was comparable. The anti-inflammatory activity of the extracts was tested based on the inhibition of 15-lipoxygenase, cyclooxygenase-1, cyclooxygenase-2 (COX-2), and phospholipase A2. The results demonstrate significantly higher inhibition of COX-2 for in vitro cultured biomass compared with the herb extracts (75.4 and 41.1%, respectively). Moreover, all the studied extracts showed almost similar antibacterial and antifungal potential. Based on these findings, and due to the fact that the growth of in vitro microshoots is independent of environmental conditions and unaffected by environmental pollution, we propose that biomass that can be rapidly grown in RITA® bioreactors can serve as an alternative source of bioactive compounds with valuable biological properties.

ACS Style

Marta Klimek-Szczykutowicz; Michał Dziurka; Ivica Blažević; Azra Đulović; Sebastian Granica; Izabela Korona-Glowniak; Halina Ekiert; Agnieszka Szopa. Phytochemical and Biological Activity Studies on Nasturtium officinale (Watercress) Microshoot Cultures Grown in RITA® Temporary Immersion Systems. Molecules 2020, 25, 5257 .

AMA Style

Marta Klimek-Szczykutowicz, Michał Dziurka, Ivica Blažević, Azra Đulović, Sebastian Granica, Izabela Korona-Glowniak, Halina Ekiert, Agnieszka Szopa. Phytochemical and Biological Activity Studies on Nasturtium officinale (Watercress) Microshoot Cultures Grown in RITA® Temporary Immersion Systems. Molecules. 2020; 25 (22):5257.

Chicago/Turabian Style

Marta Klimek-Szczykutowicz; Michał Dziurka; Ivica Blažević; Azra Đulović; Sebastian Granica; Izabela Korona-Glowniak; Halina Ekiert; Agnieszka Szopa. 2020. "Phytochemical and Biological Activity Studies on Nasturtium officinale (Watercress) Microshoot Cultures Grown in RITA® Temporary Immersion Systems." Molecules 25, no. 22: 5257.

Journal article
Published: 27 October 2020 in Journal of Chromatographic Science
Reads 0
Downloads 0

This paper is a continuation of lipophilicity research on 14 compounds (tryptophan, kynurenine pathway products, auxin pathway products, serotonin pathway products, tryptamine, as well as two synthetic auxin analogs): indole-2-acetic acid sodium salt (IAA), serotonin, 5-hydroxy-L-tryptophan, tryptamine, L-tryptophan, L-kynurenine (KYN), kynurenic acid (KYA), 3-hydroxy-DL-kynurenine, naphtyl-1-acetamide, indole-3-propionic acid (IPA), naphthalene-1-acetic acid (NAA), indole-3-butyric acid (IBA), indole-3-pyruvic acid (IPV), as well as melatonin. They were chromatographed in high performance liquid chromatography gradient conditions on tree stationary phases (C18, CN, DIOL) using three modifiers on each phase (methanol, acetonitrile and acetone). The resulting retention data was correlated with computational lipophilicity indices. Six compounds were proven to be ionized in neutral pH physiological conditions (IAA, KYA, IPA, NAA, IBA and IPV) and they were rechromatographed with acidic mobile phase to enhance the resulting dataset. It can be concluded that the retention times are highly correlated with lipophilicity regardless of used modifier and column and the main differentiating trend can be only connected to presence of naphthalene or indole ring. The principal component analysis, additive linear modeling, as well as multiplicative trilinear parallel factor analysis (PARAFAC) modeling helped to understand the internal structure of the obtained results.

ACS Style

Katarzyna Wicha-Komsta; Robert Skibiński; Tomasz Kocki; Waldemar A Turski; Łukasz Komsta. HPLC Gradient Retention of Tryptophan and its Metabolites on Three Stationary Phases in Context of Lipophilicity Assessment. Journal of Chromatographic Science 2020, 59, 40 -46.

AMA Style

Katarzyna Wicha-Komsta, Robert Skibiński, Tomasz Kocki, Waldemar A Turski, Łukasz Komsta. HPLC Gradient Retention of Tryptophan and its Metabolites on Three Stationary Phases in Context of Lipophilicity Assessment. Journal of Chromatographic Science. 2020; 59 (1):40-46.

Chicago/Turabian Style

Katarzyna Wicha-Komsta; Robert Skibiński; Tomasz Kocki; Waldemar A Turski; Łukasz Komsta. 2020. "HPLC Gradient Retention of Tryptophan and its Metabolites on Three Stationary Phases in Context of Lipophilicity Assessment." Journal of Chromatographic Science 59, no. 1: 40-46.

Review
Published: 25 September 2020 in Molecules
Reads 0
Downloads 0

Artemisia vulgaris L. (common mugwort) is a species with great importance in the history of medicine and was called the “mother of herbs” in the Middle Ages. It is a common herbaceous plant that exhibits high morphological and phytochemical variability depending on the location where it occurs. This species is well known almost all over the world. Its herb—Artemisiae vulgaris herba—is used as a raw material due to the presence of essential oil, flavonoids, and sesquiterpenoids lactones and their associated biological activities. The European Pharmacopoeia has listed this species as a potential homeopathic raw material. Moreover, this species has been used in traditional Chinese, Hindu, and European medicine to regulate the functioning of the gastrointestinal system and treat various gynecological diseases. The general aim of this review was to analyze the progress of phytochemical and pharmacological as well as professional scientific studies focusing on A. vulgaris. Thus far, numerous authors have confirmed the beneficial properties of A. vulgaris herb extracts, including their antioxidant, hepatoprotective, antispasmolytic, antinociceptive, estrogenic, cytotoxic, antibacterial, and antifungal effects. In addition, several works have reviewed the use of this species in the production of cosmetics and its role as a valuable spice in the food industry. Furthermore, biotechnological micropropagation of A. vulgaris has been analyzed.

ACS Style

Halina Ekiert; Joanna Pajor; Paweł Klin; Agnieszka Rzepiela; Halina Ślesak; Agnieszka Szopa. Significance of Artemisia vulgaris L. (Common Mugwort) in the History of Medicine and Its Possible Contemporary Applications Substantiated by Phytochemical and Pharmacological Studies. Molecules 2020, 25, 4415 .

AMA Style

Halina Ekiert, Joanna Pajor, Paweł Klin, Agnieszka Rzepiela, Halina Ślesak, Agnieszka Szopa. Significance of Artemisia vulgaris L. (Common Mugwort) in the History of Medicine and Its Possible Contemporary Applications Substantiated by Phytochemical and Pharmacological Studies. Molecules. 2020; 25 (19):4415.

Chicago/Turabian Style

Halina Ekiert; Joanna Pajor; Paweł Klin; Agnieszka Rzepiela; Halina Ślesak; Agnieszka Szopa. 2020. "Significance of Artemisia vulgaris L. (Common Mugwort) in the History of Medicine and Its Possible Contemporary Applications Substantiated by Phytochemical and Pharmacological Studies." Molecules 25, no. 19: 4415.

Journal article
Published: 19 September 2020 in Molecules
Reads 0
Downloads 0

The aim of this study was to evaluate the ability of multivariate techniques to predict antioxidant and cytotoxic activity of the selected lichens from the chromatographic data. A simple and reproducible HPLC-DAD technique has been used to obtain the chromatographic fingerprint profiles. Reversed phase high performance liquid chromatography (RP-HPLC) linear gradient system with methanol, water and phosphoric acid (V) (pH 2.3) as the mobile phase was used (50 min). Principal Component Analysis (PCA) has been applied to the evaluation of the phytochemical similarity between studied samples, especially between the same species collected in various places of Poland (Cetraria islandica (L.) Ach., CI, Cladina mitis Sandst., CM, Hypogymnia physodes (L.) Nyl., HP). The ability to scavenge free radicals was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods and the total phenolic content was determined by Folin-Ciocalteu (F-C) test. In the case of DPPH % of inhibition was higher for selected species (Pseudevernia furfuracea (L.) Zopf, H. physodes in comparison to the literature data. The FRAP test showed that the H. physodes extract had higher ability to scavenge free radical in comparison to Cladonia furcata (Huds.) Schrader and Evernia prunastri (L.) Ach., whereas P. furfuracea extract showed higher ability than C. islandica. The high content of phenolics in P. furfuracea and H. physodes confirms their high antioxidant activity. The cytotoxic activity of studied extracts was tested by cell culture method using the human HL-60 / MX2 acute CKL-22 (CRL-2257) promyelocytic leukemia tumor cell line. The lowest values of IC50 [µg∙mL−1] were obtained for: H. physodes (HP1)—99.4; C. digitate—122.6; H. physodes (HP)—136.5, C. subulata—142.6; C. mitis—180.2.

ACS Style

Anna Hawrył; Mirosław Hawrył; Agnieszka Hajnos-Stolarz; Jagoda Abramek; Anna Bogucka-Kocka; Łukasz Komsta. HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations. Molecules 2020, 25, 4301 .

AMA Style

Anna Hawrył, Mirosław Hawrył, Agnieszka Hajnos-Stolarz, Jagoda Abramek, Anna Bogucka-Kocka, Łukasz Komsta. HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations. Molecules. 2020; 25 (18):4301.

Chicago/Turabian Style

Anna Hawrył; Mirosław Hawrył; Agnieszka Hajnos-Stolarz; Jagoda Abramek; Anna Bogucka-Kocka; Łukasz Komsta. 2020. "HPLC Fingerprint Analysis with the Antioxidant and Cytotoxic Activities of Selected Lichens Combined with the Chemometric Calculations." Molecules 25, no. 18: 4301.

Review
Published: 16 September 2020 in Planta Medica
Reads 0
Downloads 0

Verbena officinalis (common vervain) is a medicinal plant species widely distributed in the world and commonly used in folk medicine of different countries, including traditional Chinese medicine. Monographs on “Verbenae herba” have been included in the European Pharmacopoeia since 2008, and in the Chinese Pharmacopoeia since 1995. This work presents botanical characteristics of this species. It reviews the current knowledge of its chemical composition, which is a rich source mostly of iridoids, phenylpropanoid glycosides, phenolic acids, flavonoids, terpenoids, and essential oil. A large part of this article summarizes traditional medicinal uses and professional pharmacological in vitro and in vivo studies that prove new important applications, e.g., antioxidant, antimicrobial, anti-inflammatory, neuroprotective anticancer, analgesic, or anticonvulsant of verbena herb extracts and individual metabolites. Moreover, emphasis is put on the use of V. officinalis in the food and cosmetics industries, especially due to its antioxidant, antibacterial, and anti-inflammatory properties, and the presence of essential oil with an attractive fragrance composition. This paper also presents the state of biotechnological studies of this species.

ACS Style

Paweł Kubica; Agnieszka Szopa; Jakub Dominiak; Maria Luczkiewicz; Halina Ekiert. Verbena officinalis (Common Vervain) – A Review on the Investigations of This Medicinally Important Plant Species. Planta Medica 2020, 86, 1241 -1257.

AMA Style

Paweł Kubica, Agnieszka Szopa, Jakub Dominiak, Maria Luczkiewicz, Halina Ekiert. Verbena officinalis (Common Vervain) – A Review on the Investigations of This Medicinally Important Plant Species. Planta Medica. 2020; 86 (17):1241-1257.

Chicago/Turabian Style

Paweł Kubica; Agnieszka Szopa; Jakub Dominiak; Maria Luczkiewicz; Halina Ekiert. 2020. "Verbena officinalis (Common Vervain) – A Review on the Investigations of This Medicinally Important Plant Species." Planta Medica 86, no. 17: 1241-1257.