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Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
Tatjana Ruskovska; Irena Budić-Leto; Karla Corral-Jara; Vladimir Ajdžanović; Anna Arola-Arnal; Francisca Bravo; Georgia-Eirini Deligiannidou; Jaroslav Havlik; Milkica Janeva; Elena Kistanova; Christos Kontogiorgis; Irena Krga; Marika Massaro; Marko Miler; Verica Milosevic; Christine Morand; Egeria Scoditti; Manuel Suárez; David Vauzour; Dragan Milenkovic. Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies. Nutrients 2021, 13, 2326 .
AMA StyleTatjana Ruskovska, Irena Budić-Leto, Karla Corral-Jara, Vladimir Ajdžanović, Anna Arola-Arnal, Francisca Bravo, Georgia-Eirini Deligiannidou, Jaroslav Havlik, Milkica Janeva, Elena Kistanova, Christos Kontogiorgis, Irena Krga, Marika Massaro, Marko Miler, Verica Milosevic, Christine Morand, Egeria Scoditti, Manuel Suárez, David Vauzour, Dragan Milenkovic. Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies. Nutrients. 2021; 13 (7):2326.
Chicago/Turabian StyleTatjana Ruskovska; Irena Budić-Leto; Karla Corral-Jara; Vladimir Ajdžanović; Anna Arola-Arnal; Francisca Bravo; Georgia-Eirini Deligiannidou; Jaroslav Havlik; Milkica Janeva; Elena Kistanova; Christos Kontogiorgis; Irena Krga; Marika Massaro; Marko Miler; Verica Milosevic; Christine Morand; Egeria Scoditti; Manuel Suárez; David Vauzour; Dragan Milenkovic. 2021. "Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies." Nutrients 13, no. 7: 2326.
Recent case reports suggested that concomitant use of sodium-glucose co-transporter 2 (SGLT2) inhibitors with statins could lead to increased statin toxicity. We aimed to provide a comprehensive overview of the available pharmacological and clinical evidence on this potential drug-drug interaction (DDI). We searched MEDLINE PubMed until November 2020 for (i) pharmacokinetic studies on SGLT2 inhibitors, statins, and their potential interaction, and (ii) case reports and clinical studies assessing the safety of concomitant use of SGLT2 inhibitors and statins. We also searched regulatory documents submitted to the United States Food and Drug Administration for unpublished data on this potential DDI. SGLT2 inhibitors are increasingly used for type 2 diabetes, chronic heart failure, and chronic kidney disease, and concomitant use with statins is common given the comorbidity of indications. While pharmacokinetic studies in healthy subjects showed no clinically relevant changes in statin levels during SGLT2 inhibitor co-administration, the published case reports and pharmacologic reasoning support the possibility of an interaction. Underlying mechanisms could be pharmacokinetic or pharmacodynamic, and canagliflozin appears to be the SGLT2 inhibitor with the highest interaction potential. Further research including ‘real-world’ pharmacoepidemiologic studies is needed to better understand the clinical significance of this DDI.
Panagiotis-Nikolaos Lalagkas; Georgios Poulentzas; Christos Kontogiorgis; Antonios Douros. Potential drug-drug interaction between sodium-glucose co-transporter 2 inhibitors and statins: pharmacological and clinical evidence. Expert Opinion on Drug Metabolism & Toxicology 2021, 17, 697 -705.
AMA StylePanagiotis-Nikolaos Lalagkas, Georgios Poulentzas, Christos Kontogiorgis, Antonios Douros. Potential drug-drug interaction between sodium-glucose co-transporter 2 inhibitors and statins: pharmacological and clinical evidence. Expert Opinion on Drug Metabolism & Toxicology. 2021; 17 (6):697-705.
Chicago/Turabian StylePanagiotis-Nikolaos Lalagkas; Georgios Poulentzas; Christos Kontogiorgis; Antonios Douros. 2021. "Potential drug-drug interaction between sodium-glucose co-transporter 2 inhibitors and statins: pharmacological and clinical evidence." Expert Opinion on Drug Metabolism & Toxicology 17, no. 6: 697-705.
The Mediterranean diet (MD) has been sponsored worldwide as a healthy and sustainable diet. Our aim was to update and compare MD adherence and food choices across several Southern European countries: Spain (SP), Portugal (PT), Italy (IT), Greece (GR), and Cyprus (CY) (MED, Mediterranean), and Bulgaria (BG) and the Republic of North Macedonia (NMK) (non-MED, non-Mediterranean). Participants (N = 3145, ≥18 y) completed a survey (MeDiWeB) with sociodemographic, anthropometric, and food questions (14-item Mediterranean Diet Adherence Screener, 14-MEDAS). The MED and non-MED populations showed moderate (7.08 ± 1.96) and weak (5.58 ± 1.82) MD adherence, respectively, with significant yet small differences across countries (SP > PT > GR > IT > CY > BG > NMK, p-value < 0.001). The MED participants scored higher than the non-MED ones for most of the Mediterranean-typical foods, with the greatest differences found for olive oil (OO) and white meat preference. In most countries, ≥70% of the participants reported quantities of red meat, butter, sweet drinks, and desserts below the recommended cutoff points, whereas <50% achieved the targets for plant-based foods, OO, fish, and wine. Being a woman and increasing age were associated with superior adherence (p-value < 0.001), but differences were rather small. Our results suggest that the campaigns carried out to support and reinforce the MD and to promote plant-based foods have limited success across Southern Europe, and that more hard-hitting strategies are needed.
Stefano Quarta; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Rui Jorge; Vanda Andrade; Elena Philippou; Constantinos Zisimou; Viktorija Maksimova; Katarina Smilkov; Darinka Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Deligiannidou; Christos Kontogiorgis; Julio Sánchez-Meca; Paula Pinto; María-Teresa García-Conesa. Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations? Nutrients 2021, 13, 1432 .
AMA StyleStefano Quarta, Marika Massaro, Mihail Chervenkov, Teodora Ivanova, Dessislava Dimitrova, Rui Jorge, Vanda Andrade, Elena Philippou, Constantinos Zisimou, Viktorija Maksimova, Katarina Smilkov, Darinka Ackova, Lence Miloseva, Tatjana Ruskovska, Georgia Deligiannidou, Christos Kontogiorgis, Julio Sánchez-Meca, Paula Pinto, María-Teresa García-Conesa. Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations? Nutrients. 2021; 13 (5):1432.
Chicago/Turabian StyleStefano Quarta; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Rui Jorge; Vanda Andrade; Elena Philippou; Constantinos Zisimou; Viktorija Maksimova; Katarina Smilkov; Darinka Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Deligiannidou; Christos Kontogiorgis; Julio Sánchez-Meca; Paula Pinto; María-Teresa García-Conesa. 2021. "Persistent Moderate-to-Weak Mediterranean Diet Adherence and Low Scoring for Plant-Based Foods across Several Southern European Countries: Are We Overlooking the Mediterranean Diet Recommendations?" Nutrients 13, no. 5: 1432.
Rheumatoid arthritis (RA) is an autoimmune disorder affecting a vast variety of the population. The onset of RA as well as the development of systematic immunization is affected by both genetic and environmental risk factors. This review aims to point out the role of natural products in the management of RA, focusing on the reports of basic research (in vitro and animal studies) emphasizing the antioxidant and anti-inflammatory properties considered in the field of RA. A systematic screening of the relevant literature was carried out on PubMed, Google Scholar, and Scopus with the following criteria: publication date, 2015–2020; language, English; study design, in vitro or animal models; and the investigation of one or several natural products in the context of RA, including, when available, the molecular mechanisms implicated. A total of 211 papers were initially obtained and screened. In vitro and animal studies referring to 20 natural products and 15 pure compounds were ultimately included in this review. The outcomes of this work provide an overview of the methods employed in basic research over the past five years, with emphasis on the limitations presented, while demonstrating the potential benefits of utilizing natural products in the management of RA as supported by in vitro and animal studies.
Georgia-Eirini Deligiannidou; Vasiliki Gougoula; Eugenia Bezirtzoglou; Christos Kontogiorgis; Theodoros Constantinides. The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research. Antioxidants 2021, 10, 599 .
AMA StyleGeorgia-Eirini Deligiannidou, Vasiliki Gougoula, Eugenia Bezirtzoglou, Christos Kontogiorgis, Theodoros Constantinides. The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research. Antioxidants. 2021; 10 (4):599.
Chicago/Turabian StyleGeorgia-Eirini Deligiannidou; Vasiliki Gougoula; Eugenia Bezirtzoglou; Christos Kontogiorgis; Theodoros Constantinides. 2021. "The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research." Antioxidants 10, no. 4: 599.
The Mediterranean diet (MD) and other lifestyle characteristics have been associated with well-being, a broad multiparameter concept that includes individual’s subjective assessment of their own well-being (SWB). Some studies have suggested that diet influences SWB, thus, this work aimed to add novel information on the association of MD and SWB in a sample of Portuguese adults. Data on sociodemographic, economic, lifestyle, diet, and SWB were collected through a self-filled online questionnaire. MD adherence was assessed by the Mediterranean Diet Adherence Screener (MEDAS) score ]. Results showed a moderate adherence to the MD in 490 Portuguese adults (mean MEDAS of 7.4 ± 2.1). A higher MD adherence was found to be significantly positively associated with women, employed individuals, a higher number of meals per day, and those with frequent contact with nature (p-value < 0.0025, using Bonferroni adjustment). As a novelty, this study divided the participants into low SWB, medium SWB, and medium to high SWB profiles (3.9 ± 1.0; 6.2 ± 1.0; 8.2 ± 1.3, respectively; p-value < 0.05), which reported significantly increasing MEDAS scores (6.5 ± 2.1; 7.3 ± 2.1; 7.8 ± 1.9; respectively, p-value < 0.05).
Vanda Andrade; Rui Jorge; María-Teresa García-Conesa; Elena Philippou; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults. Nutrients 2020, 12, 3837 .
AMA StyleVanda Andrade, Rui Jorge, María-Teresa García-Conesa, Elena Philippou, Marika Massaro, Mihail Chervenkov, Teodora Ivanova, Viktorija Maksimova, Katarina Smilkov, Darinka Gjorgieva Ackova, Lence Miloseva, Tatjana Ruskovska, Georgia Eirini Deligiannidou, Christos A. Kontogiorgis, Paula Pinto. Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults. Nutrients. 2020; 12 (12):3837.
Chicago/Turabian StyleVanda Andrade; Rui Jorge; María-Teresa García-Conesa; Elena Philippou; Marika Massaro; Mihail Chervenkov; Teodora Ivanova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. 2020. "Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults." Nutrients 12, no. 12: 3837.
This study provides comprehensive validation of the 14-item Mediterranean Diet Adherence Screener (14-MEDAS) in an adult population from Greece (GR), Portugal (PT), Italy (IT), Spain (SP), Cyprus (CY), Republic of North Macedonia (NMK), and Bulgaria (BG). A moderate association between the 14-MEDAS and the reference food diary was estimated for the entire population (Pearson r = 0.573, p-value < 0.001; Intraclass Correlation Coefficient (ICC) = 0.692, p-value < 0.001) with the strongest correlation found in GR, followed by PT, IT, SP, and CY. These results were supported by kappa statistics in GR, PT, IT, and SP with ≥50% of food items exhibiting a fair or better agreement. Bland–Altman analyses showed an overestimation of the 14-MEDAS score in the whole population (0.79 ± 1.81, 95%Confidence Interval (CI) 0.61, 0.96), but this value was variable across countries, with GR, NMK, and BG exhibiting the lowest bias. Taking all analyses together, the validation achieved slightly better results in the Mediterranean countries but a definitive validation ranking order was not evident. Considering growing evidence of the shift from Mediterranean Diet (MD) adherence and of the importance of culture in making food choices it is crucial that we further improve validation protocols with specific applications to compare MD adherence across countries.
María-Teresa García-Conesa; Elena Philippou; Christos Pafilas; Marika Massaro; Stefano Quarta; Vanda Andrade; Rui Jorge; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region. Nutrients 2020, 12, 2960 .
AMA StyleMaría-Teresa García-Conesa, Elena Philippou, Christos Pafilas, Marika Massaro, Stefano Quarta, Vanda Andrade, Rui Jorge, Mihail Chervenkov, Teodora Ivanova, Dessislava Dimitrova, Viktorija Maksimova, Katarina Smilkov, Darinka Gjorgieva Ackova, Lence Miloseva, Tatjana Ruskovska, Georgia Eirini Deligiannidou, Christos A. Kontogiorgis, Paula Pinto. Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region. Nutrients. 2020; 12 (10):2960.
Chicago/Turabian StyleMaría-Teresa García-Conesa; Elena Philippou; Christos Pafilas; Marika Massaro; Stefano Quarta; Vanda Andrade; Rui Jorge; Mihail Chervenkov; Teodora Ivanova; Dessislava Dimitrova; Viktorija Maksimova; Katarina Smilkov; Darinka Gjorgieva Ackova; Lence Miloseva; Tatjana Ruskovska; Georgia Eirini Deligiannidou; Christos A. Kontogiorgis; Paula Pinto. 2020. "Exploring the Validity of the 14-Item Mediterranean Diet Adherence Screener (MEDAS): A Cross-National Study in Seven European Countries around the Mediterranean Region." Nutrients 12, no. 10: 2960.
Air contamination in the hospital setting can be a reason for the spread of nosocomial infection among susceptible patients. The aim of this study was to identify bacterial species, and their load and drug resistance, in the air of a tertiary hospital. Air samples were collected on a monthly basis for 12 consecutive months in four different departments of the hospital (Intensive Care Unit (ICU), Internal Medicine Ward (IMW), Surgical Ward (SW), and Neonatal Unit (NU)). In total, 101 samples were collected, out of which 158 Gram-positive (GP) and 44 Gram-negative (GN) strains were isolated. The majority of GP isolates were Staphylococcus spp. (n = 100). The highest total microbial load was reported in the IMW (p = 0.005), while the highest Staphylococcus load was observed in the ICU (p = 0.018). GP bacterial load was higher in autumn, while GN load was higher in spring. Regarding drug resistance, four multi-drug-resistant (MDR) strains and one extensively drug-resistant (XDR) strain were isolated in the ICU, two MDR strains and one XDR strain in the SW, one MDR strain in the IMW and one MDR strain in the NU samples. Air in hospital settings is contaminated with various microbes; some of them are MDR, consisting a potential cause of hospital-acquired infection.
Athanasios Tselebonis; Evangelia Nena; Maria Panopoulou; Christos Kontogiorgis; Eugenia Bezirtzoglou; Theodoros Constantinidis. Air Contamination in Different Departments of a Tertiary Hospital. Assessment of Microbial Load and of Antimicrobial Susceptibility. Biomedicines 2020, 8, 1 .
AMA StyleAthanasios Tselebonis, Evangelia Nena, Maria Panopoulou, Christos Kontogiorgis, Eugenia Bezirtzoglou, Theodoros Constantinidis. Air Contamination in Different Departments of a Tertiary Hospital. Assessment of Microbial Load and of Antimicrobial Susceptibility. Biomedicines. 2020; 8 (6):1.
Chicago/Turabian StyleAthanasios Tselebonis; Evangelia Nena; Maria Panopoulou; Christos Kontogiorgis; Eugenia Bezirtzoglou; Theodoros Constantinidis. 2020. "Air Contamination in Different Departments of a Tertiary Hospital. Assessment of Microbial Load and of Antimicrobial Susceptibility." Biomedicines 8, no. 6: 1.
Background: Aromatic plants are quite popular for daily use worldwide. However, little is known about the appropriate preparation of beverages in “house conditions” in order to preserve their beneficial characteristics after processing. Taraxacum officinale Weber ex Wigg contains a variety of compounds, with well-documented effects against oxidative stress. This study aims to investigate the optimum preparation conditions of a Taraxacum beverage in the household setting, with respect to its antioxidant characteristics. Methods: Dried, commercial T. officinale was used to prepare beverages boiling for 1, 3 or 5 min. The beverages were extracted using organic solvents of increasing polarity, and the solid residues of each extraction were examined by in vitro analysis on: the evaluation of total phenolic content (Folin Ciocalteau), the evaluation of antioxidant activity (DPPH and ABTS radicals scavenging), the evaluation of the ability of the tested extracts to compete with DMSO for OH radicals, the ability to inhibit lipid peroxidation of linoleic acid and soybean lipoxygenase inhibition assay. Results: All preparations had an overall good antioxidant profile. Regarding the chosen solvents, mid polarity solvents were more likely to give better results in all tests conducted, which can be indicative of the compounds extracted in each fraction. Samples prepared under 3 min boiling presented significant interaction with DPPH and strong lipoxygenase and lipid peroxidation inhibition. Conclusion: As previously observed in the literature, food processing can greatly affect its biochemical characteristics. In the case of Taraxacum, boiling for 3 min resulted in the best overall profile of the beverage with respect to its antioxidant properties. However, due to a variety of components present in each plant, further investigation and stratification, along with in vivo experiments are needed.
Christos Kontogiorgis; Georgia Eirini Deligiannidou; Vasiliki Karamani; Dimitra Hadjipavlou-Litina; Diamanto Lazari; Athanasios Papadopoulos. Antioxidant Profile of Home Prepared Taraxacum Officinale Weber Ex Wigg Beverage. Current Nutraceuticals 2020, 1, 64 -72.
AMA StyleChristos Kontogiorgis, Georgia Eirini Deligiannidou, Vasiliki Karamani, Dimitra Hadjipavlou-Litina, Diamanto Lazari, Athanasios Papadopoulos. Antioxidant Profile of Home Prepared Taraxacum Officinale Weber Ex Wigg Beverage. Current Nutraceuticals. 2020; 1 (1):64-72.
Chicago/Turabian StyleChristos Kontogiorgis; Georgia Eirini Deligiannidou; Vasiliki Karamani; Dimitra Hadjipavlou-Litina; Diamanto Lazari; Athanasios Papadopoulos. 2020. "Antioxidant Profile of Home Prepared Taraxacum Officinale Weber Ex Wigg Beverage." Current Nutraceuticals 1, no. 1: 64-72.
The natural process of aging gradually causes changes in living organisms, leading to the deterioration of organs, tissues, and cells. In the case of osteoarthritis (OA), the degradation of cartilage is a result of both mechanical stress and biochemical factors. Natural products have already been evaluated for their potential role in the prevention and treatment of OA, providing a safe and effective adjunctive therapeutic approach. This review aimed to assess the therapeutic potential of natural products and their derivatives in osteoarthritis via a systematic search of literature after 2008, including in vitro, in vivo, ex vivo, and animal models, along with clinical trials and meta-analysis. Overall, 170 papers were obtained and screened. Here, we presented findings referring to the preventative and therapeutic potential of 17 natural products and 14 naturally occurring compounds, underlining, when available, the mechanisms implicated. The nature of OA calls to initially focus on the management of symptoms, and, in that context, several naturally occurring compounds have been utilized. Underlying a global need for more sustainable natural sources for treatment, the evidence supporting their chondroprotective potential is still building up. However, arriving at that kind of solution requires more clinical research, targeting the implications of long-term treatment, adverse effects, and epigenetic implications.
Georgia-Eirini Deligiannidou; Rafail-Efraim Papadopoulos; Christos Kontogiorgis; Anastasia Detsi; Eugenia Bezirtzoglou; Theodoros Constantinides. Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview. Antioxidants 2020, 9, 348 .
AMA StyleGeorgia-Eirini Deligiannidou, Rafail-Efraim Papadopoulos, Christos Kontogiorgis, Anastasia Detsi, Eugenia Bezirtzoglou, Theodoros Constantinides. Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview. Antioxidants. 2020; 9 (4):348.
Chicago/Turabian StyleGeorgia-Eirini Deligiannidou; Rafail-Efraim Papadopoulos; Christos Kontogiorgis; Anastasia Detsi; Eugenia Bezirtzoglou; Theodoros Constantinides. 2020. "Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview." Antioxidants 9, no. 4: 348.
Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.
Daniela Martini; Laura Chiavaroli; Antonio González-Sarrías; Letizia Bresciani; Susana A. Palma-Duran; Margherita Dall’Asta; Georgia-Eirini Deligiannidou; Marika Massaro; Egeria Scoditti; Emilie Combet; Viktorija Maksimova; Mireia Urpi-Sarda; Christos A. Kontogiorgis; Cristina Andrés-Lacueva; Eileen R. Gibney; Daniele Del Rio; Christine Morand; Mar Garcia-Aloy; Ana Rodriguez-Mateos; Pedro Mena. Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability. Nutrients 2019, 11, 1805 .
AMA StyleDaniela Martini, Laura Chiavaroli, Antonio González-Sarrías, Letizia Bresciani, Susana A. Palma-Duran, Margherita Dall’Asta, Georgia-Eirini Deligiannidou, Marika Massaro, Egeria Scoditti, Emilie Combet, Viktorija Maksimova, Mireia Urpi-Sarda, Christos A. Kontogiorgis, Cristina Andrés-Lacueva, Eileen R. Gibney, Daniele Del Rio, Christine Morand, Mar Garcia-Aloy, Ana Rodriguez-Mateos, Pedro Mena. Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability. Nutrients. 2019; 11 (8):1805.
Chicago/Turabian StyleDaniela Martini; Laura Chiavaroli; Antonio González-Sarrías; Letizia Bresciani; Susana A. Palma-Duran; Margherita Dall’Asta; Georgia-Eirini Deligiannidou; Marika Massaro; Egeria Scoditti; Emilie Combet; Viktorija Maksimova; Mireia Urpi-Sarda; Christos A. Kontogiorgis; Cristina Andrés-Lacueva; Eileen R. Gibney; Daniele Del Rio; Christine Morand; Mar Garcia-Aloy; Ana Rodriguez-Mateos; Pedro Mena. 2019. "Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability." Nutrients 11, no. 8: 1805.
Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.
María-Teresa García-Conesa; Karen Chambers; Emilie Combet; Paula Pinto; Mar Garcia-Aloy; Cristina Andrés-Lacueva; Sonia De Pascual-Teresa; Pedro Mena; Aleksandra Konic Ristic; Wendy J. Hollands; Paul A. Kroon; Ana Rodríguez-Mateos; Geoffrey Istas; Christos A. Kontogiorgis; Dilip K. Rai; Eileen R. Gibney; Christine Morand; Juan Carlos Espín; Antonio González-Sarrías. Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses. International Journal of Molecular Sciences 2018, 19, 694 .
AMA StyleMaría-Teresa García-Conesa, Karen Chambers, Emilie Combet, Paula Pinto, Mar Garcia-Aloy, Cristina Andrés-Lacueva, Sonia De Pascual-Teresa, Pedro Mena, Aleksandra Konic Ristic, Wendy J. Hollands, Paul A. Kroon, Ana Rodríguez-Mateos, Geoffrey Istas, Christos A. Kontogiorgis, Dilip K. Rai, Eileen R. Gibney, Christine Morand, Juan Carlos Espín, Antonio González-Sarrías. Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses. International Journal of Molecular Sciences. 2018; 19 (3):694.
Chicago/Turabian StyleMaría-Teresa García-Conesa; Karen Chambers; Emilie Combet; Paula Pinto; Mar Garcia-Aloy; Cristina Andrés-Lacueva; Sonia De Pascual-Teresa; Pedro Mena; Aleksandra Konic Ristic; Wendy J. Hollands; Paul A. Kroon; Ana Rodríguez-Mateos; Geoffrey Istas; Christos A. Kontogiorgis; Dilip K. Rai; Eileen R. Gibney; Christine Morand; Juan Carlos Espín; Antonio González-Sarrías. 2018. "Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses." International Journal of Molecular Sciences 19, no. 3: 694.
Christos Kontogiorgis; Ioannis Valikeserlis; Dimitra Hadjipavlou-Litina; Evangelia Nena; Theodoros C. Constantinidis. Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events. A Systematic Pharmacoepidemiological Review. Current Vascular Pharmacology 2016, 14, 502 -513.
AMA StyleChristos Kontogiorgis, Ioannis Valikeserlis, Dimitra Hadjipavlou-Litina, Evangelia Nena, Theodoros C. Constantinidis. Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events. A Systematic Pharmacoepidemiological Review. Current Vascular Pharmacology. 2016; 14 (6):502-513.
Chicago/Turabian StyleChristos Kontogiorgis; Ioannis Valikeserlis; Dimitra Hadjipavlou-Litina; Evangelia Nena; Theodoros C. Constantinidis. 2016. "Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events. A Systematic Pharmacoepidemiological Review." Current Vascular Pharmacology 14, no. 6: 502-513.
From the aerial parts of Thymus sibthorpii Bentham (Lamiaceae), five flavonoids apigenin (1), 7-methoxy-apigenin (2), naringenin (3), eriodictyol (4) and eriodictyol-7-glucoside (5), have been isolated together with caffeic acid methyl ester (6), rosmarinic acid (7) and rosmarinic acid methyl ester (8). The structures of the isolated compounds were established by spectroscopic methods. The extracts and the isolated compounds were tested for their free radical scavenging activity using the following in vitro assays: (i) interaction with the free stable radical of DPPH (1,1-diphenyl-2-picrylhydrazyl), (ii) inhibition of linoleic acid lipid peroxidation induced by the dihydrochloric acid of 2,2-azobis-2-amidinepropane (AAPH) and (iii) the scavenging activity of enzymatically produced superoxide anion. Their inhibitory activity toward soybean lipoxygenase was evaluated in vitro, using linoleic acid as a substrate. The antioxidant results of the extracts are discussed in terms of their constitution in phenolic compounds, which were determined following the Folin–Ciocalteu method.
Christos Kontogiorgis; Maria Ntella; Lina Mpompou; Fotini Karallaki; Papadopoulos Athanasios; Dimitra Hadjipavlou-Litina; Diamanto Lazari. Study of the antioxidant activity of Thymus sibthorpii Bentham (Lamiaceae). Journal of Enzyme Inhibition and Medicinal Chemistry 2016, 31, 154 -159.
AMA StyleChristos Kontogiorgis, Maria Ntella, Lina Mpompou, Fotini Karallaki, Papadopoulos Athanasios, Dimitra Hadjipavlou-Litina, Diamanto Lazari. Study of the antioxidant activity of Thymus sibthorpii Bentham (Lamiaceae). Journal of Enzyme Inhibition and Medicinal Chemistry. 2016; 31 (sup4):154-159.
Chicago/Turabian StyleChristos Kontogiorgis; Maria Ntella; Lina Mpompou; Fotini Karallaki; Papadopoulos Athanasios; Dimitra Hadjipavlou-Litina; Diamanto Lazari. 2016. "Study of the antioxidant activity of Thymus sibthorpii Bentham (Lamiaceae)." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. sup4: 154-159.
A series of 3-acylhydrazono-4-hydroxycoumarins were synthesized via condensation of 3-acetyl-4-hydroxycoumarin with appropriate hydrazides. The structures of the newly-synthesized compounds were characterized by spectral and elememental analysis or HRMS measurements. Their antioxidant properties were evaluated by using scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical as well as inhibition of lipid peroxidation. Moreover, their ability to inhibit in vitro soybean lipoxygenase has been investigated. They were found to be capable of rapid inactivation of alkylperoxy radicals.
Antigoni Kotali; Despina A. Nasiopoulou; Constantinos A. Tsoleridis; Philip A. Harris; Christos A. Kontogiorgis; Dimitra J. Hadjipavlou-Litina. Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins. Molecules 2016, 21, 138 .
AMA StyleAntigoni Kotali, Despina A. Nasiopoulou, Constantinos A. Tsoleridis, Philip A. Harris, Christos A. Kontogiorgis, Dimitra J. Hadjipavlou-Litina. Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins. Molecules. 2016; 21 (2):138.
Chicago/Turabian StyleAntigoni Kotali; Despina A. Nasiopoulou; Constantinos A. Tsoleridis; Philip A. Harris; Christos A. Kontogiorgis; Dimitra J. Hadjipavlou-Litina. 2016. "Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins." Molecules 21, no. 2: 138.
Non-prescription over-the-counter (OTC) drugs are widely used by patients to control aches, pain, and fever. One of the most frequently used OTC medications worldwide is paracetamol (acetaminophen). The aim of the present study was to fill the current knowledge gap regarding the beliefs and attitudes of people in Greece associated with the use of paracetamol during the years of financial crisis. The present study employed a sample of individuals visiting community pharmacies in the second largest city of Greece, Thessaloniki. All participants anonymously answered a questionnaire regarding their beliefs and characteristics of paracetamol consumption. Their answers were then statistically analyzed. The generic paracetamol compound was shown to be more well known than the original. A significant percentage of participants, ranging between 9.9% and 33.7%, falsely believed that certain medications [mainly non-steroidal anti-inflammatory drugs (NSAIDs)] contained paracetamol. Participants’ age, level of education, and gender were shown to be predictive of this false belief. Additionally, 11.1% of participants believed that the maximum allowed daily dose of paracetamol was higher than the correct one. Better educated individuals were less likely to consume alcohol in parallel with paracetamol (odd ratio 0.230, 95% confidence interval 0.058–0.916, P = 0.037). Paracetamol is commonly used, both in its original and generic forms. However, a significant number of individuals confuse it with NSAIDs. Age, level of education, and gender are important determinants of the characteristics of paracetamol consumption. It seems that patients prefer to take paracetamol on their own decision during the financial crisis.
Christos Kontogiorgis; Evangelia Nena; Eleftherios Berberoglou; Kyriaki Moschoni; Spyros Polyzois; Athanasios Tselemponis; Theodoros C. Constantinidis. Estimating Consumers’ Knowledge and Attitudes Towards Over-The-Counter Analgesic Medication in Greece in the Years of Financial Crisis: The Case of Paracetamol. Pain and Therapy 2015, 5, 19 -28.
AMA StyleChristos Kontogiorgis, Evangelia Nena, Eleftherios Berberoglou, Kyriaki Moschoni, Spyros Polyzois, Athanasios Tselemponis, Theodoros C. Constantinidis. Estimating Consumers’ Knowledge and Attitudes Towards Over-The-Counter Analgesic Medication in Greece in the Years of Financial Crisis: The Case of Paracetamol. Pain and Therapy. 2015; 5 (1):19-28.
Chicago/Turabian StyleChristos Kontogiorgis; Evangelia Nena; Eleftherios Berberoglou; Kyriaki Moschoni; Spyros Polyzois; Athanasios Tselemponis; Theodoros C. Constantinidis. 2015. "Estimating Consumers’ Knowledge and Attitudes Towards Over-The-Counter Analgesic Medication in Greece in the Years of Financial Crisis: The Case of Paracetamol." Pain and Therapy 5, no. 1: 19-28.