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Dr. Anna_Antsiferova Antsiferova
National Research Center “Kurchatov Institute”, Akademika Kurchatova pl. 1, 123182, Moscow, Russian Federation

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Research Keywords & Expertise

0 Biomedicine
0 Characterization
0 Electron Microscopy
0 Elemental Analysis
0 Medicine

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nanoparticle
mammals
Biokinetics
Neutron Activation Analysis
Cognitive functions
Electron Microscopy
Medicine

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Short Biography

Anna Antsiferova graduated from the Department of Physics of Lomonosov Moscow State University in 2011. She has recieved her PhD degree in Physics and Math at the National Research Center ‘Kurchatov Institute’ in 2016. She is the Head of the Laboratory of Nanosafety of the National Research Center ‘Kurchatov Institute’, Deputy Dean of the Institute of Nano-, Bio-, Informational, Cognitive and Sociohumanitarian Technologies at Moscow Institute of Physics and Technology and an Assocciate Professor there. Interests: nanosafety, EHS, condensed matter physics, medicine, tourism, painting, foreign languages.

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Journal article
Published: 03 February 2021 in Toxics
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The influence of daily prolonged administration of silver nanoparticles on the cognitive functions of a model mammal was studied. The accumulation of silver in the whole brain and the hippocampus, cerebellum, cortex and residual brain tissue of the mouse was investigated by highly precise and representative neutron activation analysis, and histological studies were conducted. Here, we show that long-term memory impairments were caused by the accumulation of silver nanoparticles in the brain and its subregions, such as the hippocampus, cerebellum and cortex, in a step-like manner by disturbance of hippocampal cell integrity. Three different approaches allowed us to observe this phenomenon and discover the reasons it occurred.

ACS Style

Anna Antsiferova; Marina Kopaeva; Vyacheslav Kochkin; Pavel Kashkarov; Mikhail Kovalchuk. Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain. Toxics 2021, 9, 30 .

AMA Style

Anna Antsiferova, Marina Kopaeva, Vyacheslav Kochkin, Pavel Kashkarov, Mikhail Kovalchuk. Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain. Toxics. 2021; 9 (2):30.

Chicago/Turabian Style

Anna Antsiferova; Marina Kopaeva; Vyacheslav Kochkin; Pavel Kashkarov; Mikhail Kovalchuk. 2021. "Disturbance in Mammalian Cognition Caused by Accumulation of Silver in Brain." Toxics 9, no. 2: 30.

Originalpaper
Published: 01 March 2020 in Nanotechnologies in Russia
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The toxic effects of multiwalled carbon nanotubes (MWCNTs) in mammals are important to assess due to MWCNTs are a widespread environmental pollutant. MWCNTs were tested for the effect on the behavioral functions of laboratory mice in the open field, rotarod, and elevated plus maze tests. Two possible routes of MWCNT entry into the body were examined: intrapharyngeal aspiration and intravenous administration, in order to model the most common ways of MWCNT entry, through the lungs and by assimilation from the blood through blood–tissue barriers. The potential toxin was administered once intrapharyngeally at 20 μg per mouse or intravenously at 0.2 μg per mouse. Acute and delayed effects were evaluated 24 h and 30 days after administration. Latent emotional tension and weaker exploratory reactions were observed 24 h after intrapharyngeal MWCNT aspiration. Signs of stress were still detectable 30 days after exposure. In contrast, an increase in locomotor and exploratory activities was observed 24 h after intravenous MWCNT administration. The result was explained by an inhibitory MWCNT effect on the lower respiratory tract and a potential lack of MWCNT accumulation in organs because MWCNTs were relatively large in size and could not penetrate through blood–tissue barriers.

ACS Style

A. A. Antsiferova; G. A. Timerbulatova; G. F. Gabidinova; D. O. Nikitin; A. M. Dimiev; Sh. F. Galyaltdinov; A. V. Vershinin; P. K. Kashkarov; L. M. Fatkhutdinova. The Influence of Multiwalled Carbon Nanotubes on the Behavior of Mammals after Single Intrapharyngeal or Intravenous Exposure. Nanotechnologies in Russia 2020, 15, 241 -247.

AMA Style

A. A. Antsiferova, G. A. Timerbulatova, G. F. Gabidinova, D. O. Nikitin, A. M. Dimiev, Sh. F. Galyaltdinov, A. V. Vershinin, P. K. Kashkarov, L. M. Fatkhutdinova. The Influence of Multiwalled Carbon Nanotubes on the Behavior of Mammals after Single Intrapharyngeal or Intravenous Exposure. Nanotechnologies in Russia. 2020; 15 (2):241-247.

Chicago/Turabian Style

A. A. Antsiferova; G. A. Timerbulatova; G. F. Gabidinova; D. O. Nikitin; A. M. Dimiev; Sh. F. Galyaltdinov; A. V. Vershinin; P. K. Kashkarov; L. M. Fatkhutdinova. 2020. "The Influence of Multiwalled Carbon Nanotubes on the Behavior of Mammals after Single Intrapharyngeal or Intravenous Exposure." Nanotechnologies in Russia 15, no. 2: 241-247.

Originalpaper
Published: 01 March 2020 in Nanotechnologies in Russia
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A technique was designed to assess the human health risk associated with exposure to radioactive radon. As a focus, a dose–effect relationship model was developed on the basis of international and first-hand experience. The model suggests a multiplicative dependence on the probability of spontaneous lung cancer and takes account of the fact that radiation effects on the lungs are exerted by the radon decay daughter products entering the lungs in a nanodispersed form. The effects of radon are already present in the statistics of spontaneous lung cancer, and the risk of death from spontaneous and radiation-induced lung cancer depends strongly on the smoking status. A test calculation of the radon-associated risk was performed for a region of the Russian Federation and showed that radon may substantially contribute to mortality from lung cancer in areas with relatively high radon concentrations in the ambient air. Exposure to radon at an annual average radon concentration comparable with the standard level for new buildings under construction (200 Bq/m3) increases the risk of death from lung cancer by 20%. The method is suitable for assessing the health risk associated with exposure to radon for miners and the general population.

ACS Style

V. F. Demin; I. V. Nikonov; A. A. Antsiferova. Human Health Risk Assessment for Exposure to Radioactive Radon with Due Regard for Its Nanodispersed Decay Products. Nanotechnologies in Russia 2020, 15, 248 -253.

AMA Style

V. F. Demin, I. V. Nikonov, A. A. Antsiferova. Human Health Risk Assessment for Exposure to Radioactive Radon with Due Regard for Its Nanodispersed Decay Products. Nanotechnologies in Russia. 2020; 15 (2):248-253.

Chicago/Turabian Style

V. F. Demin; I. V. Nikonov; A. A. Antsiferova. 2020. "Human Health Risk Assessment for Exposure to Radioactive Radon with Due Regard for Its Nanodispersed Decay Products." Nanotechnologies in Russia 15, no. 2: 248-253.

Originalpaper
Published: 01 November 2019 in Crystallography Reports
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The results of studying an ancient terracotta sculpture found in the Kerch bay are presented. An attempt is made to reconstruct the initial terracotta color and determine the palette composition of ancient painters using a complex of analytical methods: optical and scanning electron microscopy, energy-dispersive X-ray microanalysis, X-ray diffraction, and IR spectroscopy. A study of the terracotta made it possible to reveal a polychromatic character of the decor and determine the composition of the pigments. Iron/manganese compounds were used as a dark brown pigment for coloring the hair, beard, and moustache of the ceramic sculpture. Red ochre and gypsum were applied for coloring lips. Sandarac was used as an adhesive layer for depositing inorganic pigments, as well as a protective layer. The portrait terracotta is suggested to play a role of a ship decoration element.

ACS Style

M. V. Kovalchuk; N. A. Makarov; E. B. Yatsishina; A. A. Antsiferova; P. V. Dorovatovskii; E. A. Greshnikov; P. K. Kashkarov; S. N. Malakhov; S. V. Olkhovskii; N. N. Presniakova; Roman Svetogorov. Investigation of the Pigments of the Ancient Portrait Terracotta Found in the Kerch Bay. Crystallography Reports 2019, 64, 1003 -1010.

AMA Style

M. V. Kovalchuk, N. A. Makarov, E. B. Yatsishina, A. A. Antsiferova, P. V. Dorovatovskii, E. A. Greshnikov, P. K. Kashkarov, S. N. Malakhov, S. V. Olkhovskii, N. N. Presniakova, Roman Svetogorov. Investigation of the Pigments of the Ancient Portrait Terracotta Found in the Kerch Bay. Crystallography Reports. 2019; 64 (6):1003-1010.

Chicago/Turabian Style

M. V. Kovalchuk; N. A. Makarov; E. B. Yatsishina; A. A. Antsiferova; P. V. Dorovatovskii; E. A. Greshnikov; P. K. Kashkarov; S. N. Malakhov; S. V. Olkhovskii; N. N. Presniakova; Roman Svetogorov. 2019. "Investigation of the Pigments of the Ancient Portrait Terracotta Found in the Kerch Bay." Crystallography Reports 64, no. 6: 1003-1010.

Preprint
Published: 20 November 2018
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The influence of the daily prolonged administration of silver nanoparticles on cognitive functions of model mammals was studied. The accumulation of silver in whole brain, hippocampus, cerebellum, cortex and residual part of mice brain was investigated by highly precise and representative Neutron Activation Analysis and the histological studies were conducted in the present research. Some of the main results of the comprehensive study are the description of the biokinetics of silver in the hippocampus, cerebellum and cortex, the finding of the jump increase of silver in the hippocampus and cerebellum after the period of administration of 120 days. Accumulation of silver in the mice brain and hippocampus itself as well as the integrity violation of the CA2 subregion caused long-term contextual memory impairment at 180 days of silver nanoparticle exposure. However, destruction of CA2 had started 60 days before the visible changes in behavior appeared. Complex of the three types of the approach let us find the cognitive impairment and understand the reasons of it.

ACS Style

Anna Antsiferova; Marina Kopaeva; Vyacheslav Kochkin; Pavel Kashkarov; Mikhail Kovalchuk. Comprehensive study on influence of low dose chronic consumption of silver nanoparticles on cognitive functions and identification of the effect reasons. 2018, 1 .

AMA Style

Anna Antsiferova, Marina Kopaeva, Vyacheslav Kochkin, Pavel Kashkarov, Mikhail Kovalchuk. Comprehensive study on influence of low dose chronic consumption of silver nanoparticles on cognitive functions and identification of the effect reasons. . 2018; ():1.

Chicago/Turabian Style

Anna Antsiferova; Marina Kopaeva; Vyacheslav Kochkin; Pavel Kashkarov; Mikhail Kovalchuk. 2018. "Comprehensive study on influence of low dose chronic consumption of silver nanoparticles on cognitive functions and identification of the effect reasons." , no. : 1.

Journal article
Published: 01 July 2018 in Nanotechnologies in Russia
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The concentration of carbon nanopipes (CNPs) can be detected and quantitatively measured in various matrices, including biological ones, using the methodology of formation of a gamma-emitting radioactive isotope marker in a CNP. The methodology has been tested in a 10-day experiment on the sprouting of wheat seeds on an artificial substrate damped by a water suspension of radioactively marked Taunit-M multiwall CNPs (MCNP) (Russia). Changes in the activities of samples of developing plant organs—root system, coleoptile and root base, and stem with leaves—makes it possible to define the quantitative concentration of MCNPs passing from a substrate with a known concentration of the given nanomaterial into a plant. The results show promising outlooks for applying this methodology for quantitative measurements of CNP mass/concentration in various media and biological objects.

ACS Style

A. A. Antsiferova; Yu. P. Buzulukov; A. A. Gusev; V. F. Demin; P. K. Kashkarov; E. S. Kormazeva. Assimilation of Multiwall Carbon Nanopipes to Developing Plants. Nanotechnologies in Russia 2018, 13, 448 -451.

AMA Style

A. A. Antsiferova, Yu. P. Buzulukov, A. A. Gusev, V. F. Demin, P. K. Kashkarov, E. S. Kormazeva. Assimilation of Multiwall Carbon Nanopipes to Developing Plants. Nanotechnologies in Russia. 2018; 13 (7-8):448-451.

Chicago/Turabian Style

A. A. Antsiferova; Yu. P. Buzulukov; A. A. Gusev; V. F. Demin; P. K. Kashkarov; E. S. Kormazeva. 2018. "Assimilation of Multiwall Carbon Nanopipes to Developing Plants." Nanotechnologies in Russia 13, no. 7-8: 448-451.

Journal article
Published: 05 April 2018 in Materials
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Silver nanoparticles have been widely used in the lighting and food industries, in medicine, and in pharmaceutics as an antiseptic agent. Recent research demonstrates that, after prolonged oral administration, silver nanoparticles may cross the blood-brain barrier and accumulate in the brain in rather high amounts. In ex vivo experiments, it has also been shown that silver nanoparticles demonstrate neurotoxicity. The objective of this work was to answer the questions whether silver nanoparticles change cognitive and behavioral functions of mammals after prolonged administration if silver nanoparticles have accumulated in the brain. C57Bl/6 male mice were orally exposed to PVP-coated silver nanoparticles daily for 30, 60, 120 and 180 days. Control mice were exposed to distilled water. After that they were tested in the Open Field, Elevated Plus Maze, Light-Dark Box and contextual fear conditioning task. The data have shown that the experimental mice went through three periods of switching in the behavior caused by adaptation to the toxic silver nanoparticles: anxiety, appearance of research instinct and impairment of long-term memory. This provides evidence of the hazardous effect of silver nanoparticles, which appears after long periods of silver nanoparticle oral administration.

ACS Style

Anna Antsiferova; Marina Kopaeva; Pavel Kashkarov. Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals. Materials 2018, 11, 558 .

AMA Style

Anna Antsiferova, Marina Kopaeva, Pavel Kashkarov. Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals. Materials. 2018; 11 (4):558.

Chicago/Turabian Style

Anna Antsiferova; Marina Kopaeva; Pavel Kashkarov. 2018. "Effects of Prolonged Silver Nanoparticle Exposure on the Contextual Cognition and Behavior of Mammals." Materials 11, no. 4: 558.

Journal article
Published: 01 January 2018 in Nanotechnologies in Russia
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A radiotracer technique is developed using titanium dioxide nanoparticles labeled by fast protons with the acquisition of a 48V radioactive isotope, and the biokinetics of these brookite nanoparticles in the organisms of laboratory rats within the one-time intragastrical injection are studied. The main result of this work is the detection of titanium dioxide in the colon even within 5 days after injecting the slurry in an amount of 0.4% from the total exposition dose, which evidences the accumulation of titanium dioxide nanoparticles in the organ. This means that macro- and nano-fractions of titanium dioxide particles can be potentially dangerous for the colon, exerting a toxic and carcinogenic influence on its epithelial cells. Moreover, some traces of titanium dioxide nanoparticles are found to penetrate into the blood and liver. However, 98% of titanium dioxide is eliminated from the organism with feces within 5 days after injection. Neither kidneys nor brain exhibit the presence of titanium dioxide residues. This effect is due to the agglomeration of titanium dioxide nanoparticles, which is already significant and prompt in the solution for injection. At the same time, despite the ability of agglomerates to dissociate in the acidic medium of the stomach, only a few amounts of titanium dioxide pass into a nanometric form, which then penetrates through the colon into blood.

ACS Style

A. A. Antsiferova; E. S. Kormazeva; V. F. Demin; P. K. Kashkarov; M. V. Koval’Chuk. A Study of Titanium Dioxide Nanoparticle Biokinetics via the Radiotracer Technique upon Intragastrical Administration to Laboratory Mammals. Nanotechnologies in Russia 2018, 13, 51 -60.

AMA Style

A. A. Antsiferova, E. S. Kormazeva, V. F. Demin, P. K. Kashkarov, M. V. Koval’Chuk. A Study of Titanium Dioxide Nanoparticle Biokinetics via the Radiotracer Technique upon Intragastrical Administration to Laboratory Mammals. Nanotechnologies in Russia. 2018; 13 (1-2):51-60.

Chicago/Turabian Style

A. A. Antsiferova; E. S. Kormazeva; V. F. Demin; P. K. Kashkarov; M. V. Koval’Chuk. 2018. "A Study of Titanium Dioxide Nanoparticle Biokinetics via the Radiotracer Technique upon Intragastrical Administration to Laboratory Mammals." Nanotechnologies in Russia 13, no. 1-2: 51-60.

Conference paper
Published: 01 January 2017 in Materials Today: Proceedings
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ACS Style

A.L. Ivlieva; V.A. Demin; E.N. Petritskaya; A.A. Antsiferova. Preliminary results on the impact of nanoparticles on brain functioning. Materials Today: Proceedings 2017, 4, 6901 -6907.

AMA Style

A.L. Ivlieva, V.A. Demin, E.N. Petritskaya, A.A. Antsiferova. Preliminary results on the impact of nanoparticles on brain functioning. Materials Today: Proceedings. 2017; 4 (7):6901-6907.

Chicago/Turabian Style

A.L. Ivlieva; V.A. Demin; E.N. Petritskaya; A.A. Antsiferova. 2017. "Preliminary results on the impact of nanoparticles on brain functioning." Materials Today: Proceedings 4, no. 7: 6901-6907.

Journal article
Published: 15 November 2016 in Crystallography Reports
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ACS Style

A. A. Antsiferova; Yu. P. Buzulukov; P. K. Kashkarov; M. V. Kovalchuk. Experimental and theoretical study of the transport of silver nanoparticles at their prolonged administration into a mammal organism. Crystallography Reports 2016, 61, 1020 -1026.

AMA Style

A. A. Antsiferova, Yu. P. Buzulukov, P. K. Kashkarov, M. V. Kovalchuk. Experimental and theoretical study of the transport of silver nanoparticles at their prolonged administration into a mammal organism. Crystallography Reports. 2016; 61 (6):1020-1026.

Chicago/Turabian Style

A. A. Antsiferova; Yu. P. Buzulukov; P. K. Kashkarov; M. V. Kovalchuk. 2016. "Experimental and theoretical study of the transport of silver nanoparticles at their prolonged administration into a mammal organism." Crystallography Reports 61, no. 6: 1020-1026.

Journal article
Published: 01 January 2015 in Nanotechnologies in Russia
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The physical foundations and methodological issues of nuclear activation methods (radiotracers and neutron activation analysis) have been discussed in regards to a study of assimilation of a number of inorganic nanoparticles (NPs) by living organisms and their distribution in organs and excretion. The methods of activation of NPs within a colloidal solution or biological samples have been analyzed. Advantages of the radioactive tracer method and neutron activation analysis have been compared. A brief overview of a number of successful works using nuclear methods for studying the interaction of silver, gold, selenium, and zinc and titanium oxide NPs with living organisms has been given. As an example, a description and results of the experiment on long-term (28 days) injection of silver NPs into laboratory mice have been given. The abilities of neutron activation analysis to estimate the mass of residual blood (and the NPs in it) in biological samples and to confirm the penetration of the NPs through the blood-brain barrier in quantitative terms have been demonstrated.

ACS Style

A. A. Antsiferova; Yu. P. Buzulukov; V. A. Demin; V. F. Demin; D. A. Rogatkin; E. N. Petritskaya; L. F. Abaeva; P. K. Kashkarov. Radiotracer methods and neutron activation analysis for the investigation of nanoparticle biokinetics in living organisms. Nanotechnologies in Russia 2015, 10, 100 -108.

AMA Style

A. A. Antsiferova, Yu. P. Buzulukov, V. A. Demin, V. F. Demin, D. A. Rogatkin, E. N. Petritskaya, L. F. Abaeva, P. K. Kashkarov. Radiotracer methods and neutron activation analysis for the investigation of nanoparticle biokinetics in living organisms. Nanotechnologies in Russia. 2015; 10 (1):100-108.

Chicago/Turabian Style

A. A. Antsiferova; Yu. P. Buzulukov; V. A. Demin; V. F. Demin; D. A. Rogatkin; E. N. Petritskaya; L. F. Abaeva; P. K. Kashkarov. 2015. "Radiotracer methods and neutron activation analysis for the investigation of nanoparticle biokinetics in living organisms." Nanotechnologies in Russia 10, no. 1: 100-108.