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The use of phytosterols (or plant sterols) for the control of plasma cholesterol concentrations has recently gained traction because their efficacy is acknowledged by scientific authorities and leading guidelines. Phytosterols, marketed as supplements or functional foods, are formally classified as food in the European Union, are freely available for purchase, and are frequently used without any health professional advice; therefore, they are often self-prescribed, either inappropriately or in situations in which no significant advantage can be obtained. For this reason, a panel of experts with diverse medical and scientific backgrounds was convened by NFI—Nutrition Foundation of Italy—to critically evaluate and summarize the literature available on the topic, with the goal of providing medical doctors and all health professionals useful information to actively govern the use of phytosterols in the context of plasma cholesterol control. Some practical indications to help professionals identify subjects who will most likely benefit from the use of these products, optimizing the therapeutic outcomes, are also provided. The panel concluded that the use of phytosterols as supplements or functional foods to control Low Density Lipoprotein (LDL) cholesterol levels should be preceded by the assessment of some relevant individual characteristics: cardiovascular risk, lipid profile, correct understanding of how to use these products, and willingness to pay for the treatment.
Andrea Poli; Franca Marangoni; Alberto Corsini; Enzo Manzato; Walter Marrocco; Daniela Martini; Gerardo Medea; Francesco Visioli. Phytosterols, Cholesterol Control, and Cardiovascular Disease. Nutrients 2021, 13, 2810 .
AMA StyleAndrea Poli, Franca Marangoni, Alberto Corsini, Enzo Manzato, Walter Marrocco, Daniela Martini, Gerardo Medea, Francesco Visioli. Phytosterols, Cholesterol Control, and Cardiovascular Disease. Nutrients. 2021; 13 (8):2810.
Chicago/Turabian StyleAndrea Poli; Franca Marangoni; Alberto Corsini; Enzo Manzato; Walter Marrocco; Daniela Martini; Gerardo Medea; Francesco Visioli. 2021. "Phytosterols, Cholesterol Control, and Cardiovascular Disease." Nutrients 13, no. 8: 2810.
Francesco Visioli; Manuel Franco; Miguel Ángel Martínez-González. Front of package labels and olive oil: a call for caution. European Journal of Clinical Nutrition 2021, 1 -3.
AMA StyleFrancesco Visioli, Manuel Franco, Miguel Ángel Martínez-González. Front of package labels and olive oil: a call for caution. European Journal of Clinical Nutrition. 2021; ():1-3.
Chicago/Turabian StyleFrancesco Visioli; Manuel Franco; Miguel Ángel Martínez-González. 2021. "Front of package labels and olive oil: a call for caution." European Journal of Clinical Nutrition , no. : 1-3.
Diet is an important contributor to human health and public health bodies are issuing guidelines aimed at favouring healthy food choices. The aim of our paper is to discuss the aspects underlying the concept of nutrient profiles, that is, defining levels of energy, some macronutrients, or salt which should not be exceeded in individual foods, according to the available evidence, to help in understanding to what extent such approach may actually be useful for improving nutrition and quality of life of European consumers. We list several pitfalls and oversimplifications of the current approaches to nutrient profiling and of the dichotomic classification of foods into “healthy” and “unhealthy” products. In view of the current “Facilitating healthier food choices – establishing nutrient profiles” EU initiative, we believe that further debate among all stakeholders is warranted and must consider all the limitations outlined in this paper.
Francesco Visioli; Franca Marangoni; Andrea Poli; Andrea Ghiselli; Daniela Martini. Nutrition and health or nutrients and health? International Journal of Food Sciences and Nutrition 2021, 1 -8.
AMA StyleFrancesco Visioli, Franca Marangoni, Andrea Poli, Andrea Ghiselli, Daniela Martini. Nutrition and health or nutrients and health? International Journal of Food Sciences and Nutrition. 2021; ():1-8.
Chicago/Turabian StyleFrancesco Visioli; Franca Marangoni; Andrea Poli; Andrea Ghiselli; Daniela Martini. 2021. "Nutrition and health or nutrients and health?" International Journal of Food Sciences and Nutrition , no. : 1-8.
The lockdown due to the coronavirus pandemic may have exacerbated mental health problems. To what degree mental health may be affected by social isolation is still poorly known. We collected prospective data on students’ mental health in two instances: (i) in October and December 2019, and (ii) 6 months later, in April 2020 amidst the COVID-19 lockdown in Italy and in mid-May/June 2020, after the lifting of lockdown. A total of 358 Italian students aged 18-30 completed socio-demographic questionnaires and the Beck Depression Inventory – 2 (BDI-2), the Beck Anxiety Inventory (BAI), the Obsessive-Compulsive Inventory – Revised (OCI-R), the Eating Habits Questionnaire (EHQ), and the Eating Disorder Inventory-3 (EDI-3). We applied multiple regression models to evince any changes in the aforementioned questionnaire scores during and after lockdown with respect to the scores before lockdown. Students reported on average worse depressive symptoms during lockdown than 6 months before isolation (median increase in the BDI-2 score +2; IQR = -3, 6; β = 0.09 ± 0.03, p = 0.005), with students without any established diagnosis of psychopathology being affected the most. The regression models predict that 86.2% (IQR = 67.9, 91.4%) of students would not experience a clinically significant worsening of symptoms, while approximately 6% of our target population could develop more severe depressive symptoms. This study supports the view that depressive symptomatology may be aggravated during lockdown, but also highlights that after the lifting of lockdown any changes quickly vanished, as the BDI-2 scores were not different from the ones reported before lockdown.
Nicola Meda; Susanna Pardini; Irene Slongo; Luca Bodini; Mauro Agostino Zordan; Paolo Rigobello; Francesco Visioli; Caterina Novara. Students’ mental health problems before, during, and after COVID-19 lockdown in Italy. Journal of Psychiatric Research 2020, 134, 69 -77.
AMA StyleNicola Meda, Susanna Pardini, Irene Slongo, Luca Bodini, Mauro Agostino Zordan, Paolo Rigobello, Francesco Visioli, Caterina Novara. Students’ mental health problems before, during, and after COVID-19 lockdown in Italy. Journal of Psychiatric Research. 2020; 134 ():69-77.
Chicago/Turabian StyleNicola Meda; Susanna Pardini; Irene Slongo; Luca Bodini; Mauro Agostino Zordan; Paolo Rigobello; Francesco Visioli; Caterina Novara. 2020. "Students’ mental health problems before, during, and after COVID-19 lockdown in Italy." Journal of Psychiatric Research 134, no. : 69-77.
One of the most controversial areas of nutrition research relates to fats, particularly essential fatty acids, in the context of cardiovascular disease risk. A critical feature of dietary fatty acids is that they incorporate into the plasma membrane, modifying fluidity and key physiological functions. Importantly, they can reshape the bioavailability of eicosanoids and other lipid mediators, which direct cellular responses to external stimuli, such as inflammation and chronic stress conditions. This paper provides an overview of the most recent evidence, as well as historical controversies, linking fat consumption with human health and disease. We underscore current pitfalls in the area of fatty acid research and critically frame fatty acid intake in the larger context of diet and behavior. We conclude that fundamental research on fatty acids and lipids is appropriate in certain areas, but the rigor and reproducibility are lacking in others. The pros and cons are highlighted throughout the review, seeking to guide future research on the important area of nutrition, fat intake, and cardiovascular disease risk.
Francesco Visioli; Andrea Poli. Fatty Acids and Cardiovascular Risk. Evidence, Lack of Evidence, and Diligence. Nutrients 2020, 12, 3782 .
AMA StyleFrancesco Visioli, Andrea Poli. Fatty Acids and Cardiovascular Risk. Evidence, Lack of Evidence, and Diligence. Nutrients. 2020; 12 (12):3782.
Chicago/Turabian StyleFrancesco Visioli; Andrea Poli. 2020. "Fatty Acids and Cardiovascular Risk. Evidence, Lack of Evidence, and Diligence." Nutrients 12, no. 12: 3782.
Mitochondrial energetic deficit is one of the hallmarks of neurodegenerative disorders, e.g. Alzheimer´s disease (AD). Adherence to a Mediterranean diet is associated with lower incidence of cognitive decline and AD and extra virgin olive oil's (poly)phenols such as oleuropein and hydroxytyrosol (HT) are being actively studied in this respect. In this study, we assessed the effects of HT on mitochondrial energetic dysfunction in the 7PA2 cells cellular model, i.e. one of the best cellular models of Aβ toxicity with a well-characterized mitochondrial dysfunction typically observed in AD. We report an increase of new mitochondria at 8 h post HT-treatment, which was followed by higher mitochondrial fusion. Further, ATP concentrations were significantly increased after 24 h of treatment with HT as compared with controls. Our data suggest that HT may revert the energetic deficit of a cellular model of AD by potentiating mitochondrial activity. Because HT is being proposed as dietary supplement or component of functional foods, future studies in appropriate animal models and - eventually - humans are warranted to further investigate its potential neuroprotective actions in AD.
Francesco Visioli; María Rodríguez-Pérez; Óscar Gómez-Torres; Cristina Pintado-Losa; Emma Burgos-Ramos. Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease. Nutritional Neuroscience 2020, 1 -11.
AMA StyleFrancesco Visioli, María Rodríguez-Pérez, Óscar Gómez-Torres, Cristina Pintado-Losa, Emma Burgos-Ramos. Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease. Nutritional Neuroscience. 2020; ():1-11.
Chicago/Turabian StyleFrancesco Visioli; María Rodríguez-Pérez; Óscar Gómez-Torres; Cristina Pintado-Losa; Emma Burgos-Ramos. 2020. "Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer’s disease." Nutritional Neuroscience , no. : 1-11.
In support of the J curve that describes the association between wine consumption and all-cause mortality, researchers and the lay press often advocate the health benefits of (poly)phenol consumption via red wine intake and cite the vast amount of in vitro literature that would corroborate the hypothesis. Other researchers dismiss such evidence and call for total abstention. In this review, we take a skeptical, Pythagorean stance and we critically try to move the debate forward by pointing the readers to the many pitfalls of red wine (poly)phenol research, which we arbitrarily treat as if they were pharmacological agents. We conclude that, after 30 years of dedicated research and despite the considerable expenditure, we still lack solid, “pharmacological”, human evidence to confirm wine (poly)phenols’ biological actions. Future research will eventually clarify their activities and will back the current recommendations of responsibly drinking moderate amounts of wine with meals.
Francesco Visioli; Stefan-Alexandru Panaite; Joao Tomé-Carneiro. Wine’s Phenolic Compounds and Health: A Pythagorean View. Molecules 2020, 25, 4105 .
AMA StyleFrancesco Visioli, Stefan-Alexandru Panaite, Joao Tomé-Carneiro. Wine’s Phenolic Compounds and Health: A Pythagorean View. Molecules. 2020; 25 (18):4105.
Chicago/Turabian StyleFrancesco Visioli; Stefan-Alexandru Panaite; Joao Tomé-Carneiro. 2020. "Wine’s Phenolic Compounds and Health: A Pythagorean View." Molecules 25, no. 18: 4105.
Consumption of omega-3 fatty acids, including the precursor α-linolenic acid (ALA) is often sub-optimal and not in line with international guidelines. Supplementation is debatable, but some individuals, e.g., pre-diabetic, low-grade inflammation, cardiometabolic yet otherwise healthy subjects, might benefit from supra-physiological omega-3 intake, particularly to lessen inflammation. We explored the feasibility of a large clinical trial by performing a pilot study to evaluate adherence, palatability, and self-reported side effects of ALA administration in a group of volunteers. We enrolled 12 individuals with borderline dyslipidemia or overweight, treated with dietary advice according to international guidelines and who had insufficient intakes of essential fatty acids. Subjects were followed for nutritional counselling and were matched with appropriate controls. Patients were administered 6 g/day of ALA, for two months. We report the absence of side effects. such as fishy aftertaste and gastrointestinal distress, in addition to a slight decrease of C-reactive protein concentrations (Identifier: ISRCTN13118704).
Marcella Cavina; Maurizio Battino; Antonio V. Gaddi; Maria Teresa Savo; Francesco Visioli. Supplementation with alpha-linolenic acid and inflammation: a feasibility trial. International Journal of Food Sciences and Nutrition 2020, 72, 386 -390.
AMA StyleMarcella Cavina, Maurizio Battino, Antonio V. Gaddi, Maria Teresa Savo, Francesco Visioli. Supplementation with alpha-linolenic acid and inflammation: a feasibility trial. International Journal of Food Sciences and Nutrition. 2020; 72 (3):386-390.
Chicago/Turabian StyleMarcella Cavina; Maurizio Battino; Antonio V. Gaddi; Maria Teresa Savo; Francesco Visioli. 2020. "Supplementation with alpha-linolenic acid and inflammation: a feasibility trial." International Journal of Food Sciences and Nutrition 72, no. 3: 386-390.
Grape seed polyphenol extract-derived (poly)phenols are minimally, if any, transported by exosomes.
Anna Arola-Arnal; Mª Del Carmen López De Las Hazas; Lisard Iglesias-Carres; Diana C. Mantilla-Escalante; Manuel Suárez; Rebeca Busto; Francesco Visioli; Cinta Bladé; Alberto Dávalos. Exosomes transport trace amounts of (poly)phenols. Food & Function 2020, 11, 1 .
AMA StyleAnna Arola-Arnal, Mª Del Carmen López De Las Hazas, Lisard Iglesias-Carres, Diana C. Mantilla-Escalante, Manuel Suárez, Rebeca Busto, Francesco Visioli, Cinta Bladé, Alberto Dávalos. Exosomes transport trace amounts of (poly)phenols. Food & Function. 2020; 11 (9):1.
Chicago/Turabian StyleAnna Arola-Arnal; Mª Del Carmen López De Las Hazas; Lisard Iglesias-Carres; Diana C. Mantilla-Escalante; Manuel Suárez; Rebeca Busto; Francesco Visioli; Cinta Bladé; Alberto Dávalos. 2020. "Exosomes transport trace amounts of (poly)phenols." Food & Function 11, no. 9: 1.
Confinement due to the COVID-19 pandemic can influence dietary profiles, especially those of adolescents, who are highly susceptible to acquiring bad eating habits. Adolescents’ poor dietary habits increase their subsequent risk of degenerative diseases such as obesity, diabetes, cardiovascular pathologies, etc. Our aim was to study nutritional modifications during COVID-19 confinement in adolescents aged 10 to 19 years, compare them with their usual diet and dietary guidelines, and identify variables that may have influenced changes. Data were collected by an anonymous online questionnaire on food intake among 820 adolescents from Spain, Italy, Brazil, Colombia, and Chile. The results show that COVID-19 confinement did influence their dietary habits. In particular, we recorded modified consumption of fried food, sweet food, legumes, vegetables, and fruits. Moreover, gender, family members at home, watching TV during mealtime, country of residence, and maternal education were diversely correlated with adequate nutrition during COVID-19 confinement. Understanding the adolescents’ nutrition behavior during COVID-19 lockdown will help public health authorities reshape future policies on their nutritional recommendations, in preparation for future pandemics.
María Belén Ruiz-Roso; Patricia De Carvalho Padilha; Diana C. Mantilla-Escalante; Natalia Ulloa; Paola Brun; Diofanor Acevedo-Correa; Wilza Arantes Ferreira Peres; Miquel Martorell; Mariana Tschoepke Aires; Letícia De Oliveira Cardoso; Fernanda Carrasco-Marín; Katherine Paternina-Sierra; Jhon E. Rodriguez-Meza; Piedad M. Montero; Giulia Bernabè; Anthony Pauletto; Xhoajda Taci; Francesco Visioli; Alberto Dávalos. Covid-19 Confinement and Changes of Adolescent’s Dietary Trends in Italy, Spain, Chile, Colombia and Brazil. Nutrients 2020, 12, 1807 .
AMA StyleMaría Belén Ruiz-Roso, Patricia De Carvalho Padilha, Diana C. Mantilla-Escalante, Natalia Ulloa, Paola Brun, Diofanor Acevedo-Correa, Wilza Arantes Ferreira Peres, Miquel Martorell, Mariana Tschoepke Aires, Letícia De Oliveira Cardoso, Fernanda Carrasco-Marín, Katherine Paternina-Sierra, Jhon E. Rodriguez-Meza, Piedad M. Montero, Giulia Bernabè, Anthony Pauletto, Xhoajda Taci, Francesco Visioli, Alberto Dávalos. Covid-19 Confinement and Changes of Adolescent’s Dietary Trends in Italy, Spain, Chile, Colombia and Brazil. Nutrients. 2020; 12 (6):1807.
Chicago/Turabian StyleMaría Belén Ruiz-Roso; Patricia De Carvalho Padilha; Diana C. Mantilla-Escalante; Natalia Ulloa; Paola Brun; Diofanor Acevedo-Correa; Wilza Arantes Ferreira Peres; Miquel Martorell; Mariana Tschoepke Aires; Letícia De Oliveira Cardoso; Fernanda Carrasco-Marín; Katherine Paternina-Sierra; Jhon E. Rodriguez-Meza; Piedad M. Montero; Giulia Bernabè; Anthony Pauletto; Xhoajda Taci; Francesco Visioli; Alberto Dávalos. 2020. "Covid-19 Confinement and Changes of Adolescent’s Dietary Trends in Italy, Spain, Chile, Colombia and Brazil." Nutrients 12, no. 6: 1807.
Pasquale Ortasi; Francesco Visioli; Michela Dimilta. The effect of ALFALIFE™ for the prevention of coronary heart disease in high-risk patients. http://isrctn.com/ 2020, 1 .
AMA StylePasquale Ortasi, Francesco Visioli, Michela Dimilta. The effect of ALFALIFE™ for the prevention of coronary heart disease in high-risk patients. http://isrctn.com/. 2020; ():1.
Chicago/Turabian StylePasquale Ortasi; Francesco Visioli; Michela Dimilta. 2020. "The effect of ALFALIFE™ for the prevention of coronary heart disease in high-risk patients." http://isrctn.com/ , no. : 1.
Maurizio Cipolla; Lina Giuseppina Gentile; Antonio V. Gaddi; Francesco Visioli. The effect of ALFALIFE™ in reducing low-grade inflammation. http://isrctn.com/ 2020, 1 .
AMA StyleMaurizio Cipolla, Lina Giuseppina Gentile, Antonio V. Gaddi, Francesco Visioli. The effect of ALFALIFE™ in reducing low-grade inflammation. http://isrctn.com/. 2020; ():1.
Chicago/Turabian StyleMaurizio Cipolla; Lina Giuseppina Gentile; Antonio V. Gaddi; Francesco Visioli. 2020. "The effect of ALFALIFE™ in reducing low-grade inflammation." http://isrctn.com/ , no. : 1.
An increasing number of studies suggests that the oral and the intestinal microbiota may indirectly or directly influence cardiovascular risk. In this regard, the microbiota could act by modifying compounds naturally present in food, both in a potentially atherogenic sense and in a protective sense; on the other hand, specific bacterial strains whose growth could also be facilitated by compounds of alimentary origin, i.e. prebiotics could instead play direct effects on atherogenesis. In other words, the microbiota-food relationship is a bi-directional one in which the latter modifies the former that, in return, produces metabolites with healthful or noxious effects. In this scoping review, we examine some of the microbiota-cardiovascular risk interactions that, in light of the available evidence, can be considered to already enjoy convincing scientific solidity. Notably, we focus on the oral and intestinal microbiota, where research is most active, and we propose some future cardio-preventive opportunities: one would be to develop and test compounds that can inhibit the formation of microbiota-derived noxious molecules. After the development of appropriate, reliable, and inexpensive screening tools for metabotypes, personalized diets can be implemented and pertinent supplements could be prescribed. The other therapeutic and preventive route that could be traveled is that of microbiota modification, via the use of appropriate pro- and prebiotics.
Federico Scarmozzino; Andrea Poli; Francesco Visioli. Microbiota and cardiovascular disease risk: A scoping review. Pharmacological Research 2020, 159, 104952 .
AMA StyleFederico Scarmozzino, Andrea Poli, Francesco Visioli. Microbiota and cardiovascular disease risk: A scoping review. Pharmacological Research. 2020; 159 ():104952.
Chicago/Turabian StyleFederico Scarmozzino; Andrea Poli; Francesco Visioli. 2020. "Microbiota and cardiovascular disease risk: A scoping review." Pharmacological Research 159, no. : 104952.
Research on milk fat globule membrane (MFGM) is gaining traction. The interest is two-fold; on the one hand, it is a unique trilayer structure with specific secretory function. On the other hand, it is the basis for ingredients with the presence of phospho- and sphingolipids and glycoproteins, which are being used as food ingredients with valuable functionality, in particular, for use as a supplement in infant nutrition. This last application is at the center of this Review, which aims to contribute to understanding MFGM’s function in the proper development of immunity, cognition, and intestinal trophism, in addition to other potential effects such as prevention of diseases including cardiovascular disease, impaired bone turnover and inflammation, skin conditions, and infections as well as age-associated cognitive decline and muscle loss. The phospholipid composition of MFGM from bovine milk is quite like human milk and, although there are some differences due to dairy processing, these do not result in a chemical change. The MFGM ingredients, as used to improve the formulation in different clinical studies, have indeed increased the presence of phospholipids, sphingolipids, glycolipids, and glycoproteins with the resulting benefits of different outcomes (especially immune and cognitive outcomes) with no reported adverse effects. Nevertheless, the precise mechanism(s) of action of MFGM remain to be elucidated and further basic investigation is warranted.
Javier Fontecha; Lauren Brink; Steven Wu; Yves Pouliot; Francesco Visioli; Rafael Jiménez-Flores. Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being. Nutrients 2020, 12, 1 .
AMA StyleJavier Fontecha, Lauren Brink, Steven Wu, Yves Pouliot, Francesco Visioli, Rafael Jiménez-Flores. Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being. Nutrients. 2020; 12 (6):1.
Chicago/Turabian StyleJavier Fontecha; Lauren Brink; Steven Wu; Yves Pouliot; Francesco Visioli; Rafael Jiménez-Flores. 2020. "Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being." Nutrients 12, no. 6: 1.
The Covid-19 pandemic led to lockdowns in several parts of the world and, hence, changed some daily habits, including social interactions, the ability to perform sports, and—possibly—diet. The Italian government established and promulgated lockdown policies on 9 March 2020. We aim at assessing the effects of Covid-19-induced confinement policies on self-reported food consumption of self-selected Italians by means of a questionnaire that was created and diffused by the Internet. Nearly half, i.e., 49.6% of responders did not substantially modify their diet during the lockdown; however, 46.1% of them reported that they were eating more during confinement, and 19.5% gained weight. In particular, we report an increase in “comfort food” consumption, notably chocolate, ice-cream, and desserts (42.5%) and salty snacks (23.5%). In addition, 42.7% percent of this cohort attributed this increase to higher anxiety levels. Related to this, 36.8% of responders reported a decrease in alcohol consumption, even though 10.1% of them reported an increase. Interestingly, 21.2% of responders increased their consumption of fresh fruit and vegetables. Only 33.5% of those who declared decreased consumption attributed this change of diet to lower availability and ease of purchasing such items. Equally interesting, over half of responders, i.e., 56.2%, admitted that fruit and vegetables did not appeal to them while in lockdown. Purchases of ready-made meals were reduced by nearly 50%. Future large-scale similar studies should be undertaken worldwide and will help public health authorities shape their reactions to future, unavoidable pandemics.
Federico Scarmozzino; Francesco Visioli. Covid-19 and the Subsequent Lockdown Modified Dietary Habits of Almost Half the Population in an Italian Sample. Foods 2020, 9, 675 .
AMA StyleFederico Scarmozzino, Francesco Visioli. Covid-19 and the Subsequent Lockdown Modified Dietary Habits of Almost Half the Population in an Italian Sample. Foods. 2020; 9 (5):675.
Chicago/Turabian StyleFederico Scarmozzino; Francesco Visioli. 2020. "Covid-19 and the Subsequent Lockdown Modified Dietary Habits of Almost Half the Population in an Italian Sample." Foods 9, no. 5: 675.
The lockdown due to coronavirus pandemic may exacerbate depressive symptoms, experts argue. Here we report that students, a high-risk category for mental disorders, report on average worse depressive symptoms than six months before isolation. The prospective data reported herein should alert clinician of a possible aggravation as well as new-onsets of depressive symptoms in students.
Nicola Meda; Susanna Pardini; Irene Slongo; Luca Bodini; Paolo Rigobello; Francesco Visioli; Caterina Novara. COVID-19 and depressive symptoms in students before and during lockdown. 2020, 1 .
AMA StyleNicola Meda, Susanna Pardini, Irene Slongo, Luca Bodini, Paolo Rigobello, Francesco Visioli, Caterina Novara. COVID-19 and depressive symptoms in students before and during lockdown. . 2020; ():1.
Chicago/Turabian StyleNicola Meda; Susanna Pardini; Irene Slongo; Luca Bodini; Paolo Rigobello; Francesco Visioli; Caterina Novara. 2020. "COVID-19 and depressive symptoms in students before and during lockdown." , no. : 1.
Cognitive decline is one of the hallmarks of aging and can vary from mild cognitive impairment to dementia to Alzheimer's disease. In addition to some lifestyle interventions, there is room for the use of nutraceuticals/functional foods as pharma-nutritional tools to lessen the burden of cognitive decline before it worsens. We previously reported the promising molecular actions of milk fat globule membranes and krill oil concentrates in a rat model of aging. In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with concentrates of polar lipids from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements, calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in ω3 long-chain polyunsaturated fatty acids, on cognitive decline.
Alba García-Serrano; Joao Tomé-Carneiro; M. Carmen Crespo; M. Visitación Calvo; Inmaculada Pereda-Pérez; Shishir Baliyan; Emma Burgos-Ramos; Olimpio Montero; Alberto Dávalos; César Venero; Francesco Visioli; Javier Fontecha. Concentrates of buttermilk and krill oil improve cognition in aged rats. Prostaglandins, Leukotrienes and Essential Fatty Acids 2020, 155, 102077 .
AMA StyleAlba García-Serrano, Joao Tomé-Carneiro, M. Carmen Crespo, M. Visitación Calvo, Inmaculada Pereda-Pérez, Shishir Baliyan, Emma Burgos-Ramos, Olimpio Montero, Alberto Dávalos, César Venero, Francesco Visioli, Javier Fontecha. Concentrates of buttermilk and krill oil improve cognition in aged rats. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2020; 155 ():102077.
Chicago/Turabian StyleAlba García-Serrano; Joao Tomé-Carneiro; M. Carmen Crespo; M. Visitación Calvo; Inmaculada Pereda-Pérez; Shishir Baliyan; Emma Burgos-Ramos; Olimpio Montero; Alberto Dávalos; César Venero; Francesco Visioli; Javier Fontecha. 2020. "Concentrates of buttermilk and krill oil improve cognition in aged rats." Prostaglandins, Leukotrienes and Essential Fatty Acids 155, no. : 102077.
The Mediterranean diet is considered as the foremost dietary regimen and its adoption is associated with the prevention of degenerative diseases and an extended longevity. The preeminent features of the Mediterranean diet have been agreed upon and the consumption of olive oil stands out as the most peculiar one. Indeed, the use of olive oil as the nearly exclusive dietary fat is what mostly characterizes the Mediterranean area. Plenty of epidemiological studies have correlated that the consumption of olive oil was associated with better overall health. Indeed, extra virgin olive oil contains (poly)phenolic compounds that are being actively investigated for their purported biological and pharma-nutritional properties. On 18 and 19 May 2018, several experts convened in Jaen (Spain) to discuss the most recent research on the benefits of olive oil and its components. We reported a summary of that meeting (reviewing several topics related to olive oil, not limited to health) and concluded that substantial evidence is accruing to support the widespread opinion that extra virgin olive oil should, indeed, be the fat of choice when it comes to human health and sustainable agronomy.
José J. Gaforio; Francesco Visioli; Catalina Alarcón-De-La-Lastra; Olga Castañer; Miguel Delgado-Rodríguez; Monserrat Fitó; Antonio F. Hernández; Jesús R. Huertas; Miguel A. Martínez-González; Javier A. Menendez; Jesús De La Osada; Angeliki Papadaki; Tesifón Parrón; Jorge E. Pereira; María A. Rosillo; Cristina Sánchez-Quesada; Lukas Schwingshackl; Estefanía Toledo; Aristidis M. Tsatsakis. Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018. Nutrients 2019, 11, 2039 .
AMA StyleJosé J. Gaforio, Francesco Visioli, Catalina Alarcón-De-La-Lastra, Olga Castañer, Miguel Delgado-Rodríguez, Monserrat Fitó, Antonio F. Hernández, Jesús R. Huertas, Miguel A. Martínez-González, Javier A. Menendez, Jesús De La Osada, Angeliki Papadaki, Tesifón Parrón, Jorge E. Pereira, María A. Rosillo, Cristina Sánchez-Quesada, Lukas Schwingshackl, Estefanía Toledo, Aristidis M. Tsatsakis. Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018. Nutrients. 2019; 11 (9):2039.
Chicago/Turabian StyleJosé J. Gaforio; Francesco Visioli; Catalina Alarcón-De-La-Lastra; Olga Castañer; Miguel Delgado-Rodríguez; Monserrat Fitó; Antonio F. Hernández; Jesús R. Huertas; Miguel A. Martínez-González; Javier A. Menendez; Jesús De La Osada; Angeliki Papadaki; Tesifón Parrón; Jorge E. Pereira; María A. Rosillo; Cristina Sánchez-Quesada; Lukas Schwingshackl; Estefanía Toledo; Aristidis M. Tsatsakis. 2019. "Virgin Olive Oil and Health: Summary of the III International Conference on Virgin Olive Oil and Health Consensus Report, JAEN (Spain) 2018." Nutrients 11, no. 9: 2039.
Some forms of early ECG repolarization QRS pattern (ERp) with J-point elevation of 0.1 mV in two contiguous inferior and/or lateral leads with or without ST-elevation are potentially associated with a higher arrhythmic risk in adults. We assessed the prevalence of ERp among non-professional adolescent athletes and correlated it with age, sex, ethnicity, and structural and electric cardiac parameters. We retrospectively analyzed 414 ECGs obtained from young athletes referred to our center from 2006 to 2017. We found ERp in 22% of cases. In the ERp group, we found a greater percentage of black athletes, a higher systolic blood pressure, and lower heart rate (HR) compared with the group without ERp. This pattern was less frequent in female athletes. In athletes with ERp, the occurrence of ventricular ectopic beats was less frequent and QRS-duration was shorter. They also exhibited greater (a) ECG-based left ventricular hypertrophy (LVH), (b) left ventricular mass, and (c) relative wall thickness (RWT), suggesting a tendency to concentric geometry. At logistic regression analysis, we found that HR (OR 0.98 [0.96-0.99] P = .013), QRS-duration (OR 0.96 [0.94-0.99], P = .003), LVH (OR 1.09 [1.05-1.12], P < .001), and RWT (OR 1.08 [1.01-1.16] P = .032) were significant predictors of ERp incidence. ERp is quite common in adolescent athletes and correlates with concentric LV remodeling. Specific clinical and ECG-findings related to training such as lower HR, LVH, and QRS-duration are also predictors of ERp. In adolescent non-professional athletes, ERp is a benign finding associated with some structural and electric cardiac modifications induced by training.
Michele Miragoli; Matteo Goldoni; Pierluigi DeMola; Arianna Paterlini; Mauro Li Calzi; Margherita Ilaria Gioia; Francesco Visioli; Stefano Rossi; Giovanna Pelà. Left ventricular geometry correlates with early repolarization pattern in adolescent athletes. Scandinavian Journal of Medicine & Science in Sports 2019, 29, 1727 -1735.
AMA StyleMichele Miragoli, Matteo Goldoni, Pierluigi DeMola, Arianna Paterlini, Mauro Li Calzi, Margherita Ilaria Gioia, Francesco Visioli, Stefano Rossi, Giovanna Pelà. Left ventricular geometry correlates with early repolarization pattern in adolescent athletes. Scandinavian Journal of Medicine & Science in Sports. 2019; 29 (11):1727-1735.
Chicago/Turabian StyleMichele Miragoli; Matteo Goldoni; Pierluigi DeMola; Arianna Paterlini; Mauro Li Calzi; Margherita Ilaria Gioia; Francesco Visioli; Stefano Rossi; Giovanna Pelà. 2019. "Left ventricular geometry correlates with early repolarization pattern in adolescent athletes." Scandinavian Journal of Medicine & Science in Sports 29, no. 11: 1727-1735.
In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma‐nutritional properties that are the subject of active research worldwide. Based on our more than 25 years of experience in this field, we critically focus on what we believe are the most pharmacologically prominent actions of the constituents of olive oil. Most of the effects are due to the phenolic compounds in extra virgin olive oil, such as hydroxytyrosol and oleocanthal (which are often mis‐categorized as in vivo antioxidants) and concern the cardiovascular system. Other potentially beneficial activities are still to be investigated in depth. We conclude that—in the context of a proper diet that includes high‐quality products—the use of high‐quality olive oil contributes to achieving and sustaining overall health. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc
Francesco Visioli; Alberto Davalos; Mª Del Carmen López De Las Hazas; María Del Carmen Crespo; João Tomé-Carneiro. An overview of the pharmacology of olive oil and its active ingredients. Journal of Cerebral Blood Flow & Metabolism 2019, 177, 1316 -1330.
AMA StyleFrancesco Visioli, Alberto Davalos, Mª Del Carmen López De Las Hazas, María Del Carmen Crespo, João Tomé-Carneiro. An overview of the pharmacology of olive oil and its active ingredients. Journal of Cerebral Blood Flow & Metabolism. 2019; 177 (6):1316-1330.
Chicago/Turabian StyleFrancesco Visioli; Alberto Davalos; Mª Del Carmen López De Las Hazas; María Del Carmen Crespo; João Tomé-Carneiro. 2019. "An overview of the pharmacology of olive oil and its active ingredients." Journal of Cerebral Blood Flow & Metabolism 177, no. 6: 1316-1330.