Prof. Boris B. Dzantiev

The researches of Prof. Dzantiev are directed at studying quantitative regularities of antigen–antibody interactions and the development of new immunochemical techniques for the detection of biologically active compounds. The relations between the properties of immunoreagents and kinetic and equilibrium parameters of the antigen–antibody reaction are studied theoretically and experimentally. Structural changes of protein antigens in the course of their interaction with antibodies are characterized, including antibody-assisted refolding and modulation of catalytic activities of enzymes. The substances significant for medicine, agriculture, biotechnology and environmental monitoring are used as model antigens. This enables us to determine common regularities and specific features of the immunochemical interactions. New assay formats and label systems are proposed that ensure the growth of sensitivity and rapidity of testing. The efficacy of the novel methods for practical purposes is characterized; technologies for scaled production of immunoanalytical test systems are developed jointly with manufacturers. The laboratory of Prof. Dzantiev realizes the full cycle of the development of immunoanalytical techniques, beginning with obtaining antibodies and finalizing with the creation of manufacturing technologies.