This page has only limited features, please log in for full access.

Prof. Dr. Jon Irazusta
Department of Physiology, University of the Basque Country

Basic Info


Research Keywords & Expertise

0 Health
0 quality of life
0 physical activity
0 frailty
0 Phsyical fitness

Fingerprints

physical activity
Health
frailty
quality of life

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 01 June 2021 in European Journal of Operational Research
Reads 0
Downloads 0

In this work, a heuristic as operational tool to estimate the lactate threshold and to facilitate its integration into the training process of recreational runners is proposed. To do so, we formalize the principles for the lactate threshold estimation from empirical data and an iterative methodology that enables experience based learning. This strategy arises as a robust and adaptive approach to solve data analysis problems. We compare the results of the heuristic with the most commonly used protocol by making a first quantitative error analysis to show its reliability. Additionally, we provide a computational algorithm so that this quantitative analysis can be easily performed in other lactate threshold protocols. With this work, we have shown that a heuristic (%60 of endurance running speed reserve), serves for the same purpose of the most commonly used protocol in recreational runners, but improving its operational limitations of accessibility and consistent use.

ACS Style

Urtats Etxegarai; Eva Portillo; Jon Irazusta; Lucien Koefoed; Nikola Kasabov. A heuristic approach for lactate threshold estimation for training decision-making: An accessible and easy to use solution for recreational runners. European Journal of Operational Research 2021, 291, 427 -437.

AMA Style

Urtats Etxegarai, Eva Portillo, Jon Irazusta, Lucien Koefoed, Nikola Kasabov. A heuristic approach for lactate threshold estimation for training decision-making: An accessible and easy to use solution for recreational runners. European Journal of Operational Research. 2021; 291 (2):427-437.

Chicago/Turabian Style

Urtats Etxegarai; Eva Portillo; Jon Irazusta; Lucien Koefoed; Nikola Kasabov. 2021. "A heuristic approach for lactate threshold estimation for training decision-making: An accessible and easy to use solution for recreational runners." European Journal of Operational Research 291, no. 2: 427-437.

Journal article
Published: 27 April 2021 in Scientific Reports
Reads 0
Downloads 0

Serum alpha-klotho (s-klotho) protein has been linked with lifespan, and low concentrations of s-klotho have been associated with worse physical and cognitive outcomes. Although its significance in aging remains unclear, s-klotho has been proposed as a molecular biomarker of frailty and dependence. This study is a secondary analysis of data from a clinical trial performed in a population of 103 older individuals living in 10 nursing homes in Gipuzkoa (Spain). We aimed to elucidate associations between s-klotho (as measured by enzyme-linked immunosorbent assay) and body composition, physical fitness, and cognition, as well as frailty and dependence (determined using validated tests and scales). In addition, we investigated the association of s-klotho concentration with falls in the six months following the initial assessment. Low s-klotho levels were associated with a lower score in the psychological component of the Tilburg Frailty Indicator, a worse score in the Coding Wechsler Adult Intelligence Scale, and a greater dependence in activities of daily living. Moreover, participants with lower s-klotho concentrations suffered more falls during the 6 months after the assessment. Future translational research should aim to validate klotho’s putative role as a biomarker that could identify the risk of aging-related adverse events in clinical practice.

ACS Style

Begoña Sanz; Haritz Arrieta; Chloe Rezola-Pardo; Ainhoa Fernández-Atutxa; Jon Garin-Balerdi; Nagore Arizaga; Ana Rodriguez-Larrad; Jon Irazusta. Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents. Scientific Reports 2021, 11, 1 -10.

AMA Style

Begoña Sanz, Haritz Arrieta, Chloe Rezola-Pardo, Ainhoa Fernández-Atutxa, Jon Garin-Balerdi, Nagore Arizaga, Ana Rodriguez-Larrad, Jon Irazusta. Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents. Scientific Reports. 2021; 11 (1):1-10.

Chicago/Turabian Style

Begoña Sanz; Haritz Arrieta; Chloe Rezola-Pardo; Ainhoa Fernández-Atutxa; Jon Garin-Balerdi; Nagore Arizaga; Ana Rodriguez-Larrad; Jon Irazusta. 2021. "Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents." Scientific Reports 11, no. 1: 1-10.

Journal article
Published: 03 April 2021 in Geriatric Nursing
Reads 0
Downloads 0

Exercise interventions improve physical fitness, cognitive and affective function, and quality of life among nursing home residents. However, little is known regarding the consequences of cessation of activity, or detraining. We analyzed physical fitness, physical activity level, cognitive function, quality of life, and loneliness during a 6-month observational follow-up after a 6-month randomized controlled trial in which nursing home residents performed either routine activities (control group) or group-based exercise (intervention group). The intervention group showed an important decline in most physical fitness and cognitive function parameters after a 6-month detraining period. These results highlight the importance of recreation as part of residents’ care needs, and exercise should therefore be implemented continuously.

ACS Style

Ana Rodriguez-Larrad; Haritz Arrieta; Chloe Rezola-Pardo; Izaro Esain; Pablo Mendia-Oria; Jon Irazusta. Loss of benefits after cessation of exercise interventions in nursing home residents: randomized controlled trial follow-up. Geriatric Nursing 2021, 42, 621 -627.

AMA Style

Ana Rodriguez-Larrad, Haritz Arrieta, Chloe Rezola-Pardo, Izaro Esain, Pablo Mendia-Oria, Jon Irazusta. Loss of benefits after cessation of exercise interventions in nursing home residents: randomized controlled trial follow-up. Geriatric Nursing. 2021; 42 (3):621-627.

Chicago/Turabian Style

Ana Rodriguez-Larrad; Haritz Arrieta; Chloe Rezola-Pardo; Izaro Esain; Pablo Mendia-Oria; Jon Irazusta. 2021. "Loss of benefits after cessation of exercise interventions in nursing home residents: randomized controlled trial follow-up." Geriatric Nursing 42, no. 3: 621-627.

Journal article
Published: 22 March 2021 in International Journal of Molecular Sciences
Reads 0
Downloads 0

Sperm fertility ability may be modulated by different molecular systems, such as the renin-angiotensin system (RAS). Although renin is one of its most relevant peptides, the presence and role of the (pro)renin receptor (PRR) is completely unknown. We have proved for the first time the existence of PRR and its transcript in human sperm by western blot and RT-PCR. Immunofluorescence studies showed that this receptor is mainly located in the apical region over the acrosome and in the postacrosomal region of the sperm head and along the sperm tail. In addition, this prospective cohort study also proves that semen samples with higher percentages of PRR-positive spermatozoa are associated with poor sperm motility, worse blastocyst development and no-viable blastocysts. Our results provide insight into how PRR play a negative role in sperm physiology that it may condition human embryo quality and development. An in-depth understanding of the role of PRR in sperm fertility can help elucidate its role in male infertility, as well as establish biomarkers for the diagnosis or selection of sperm to use during assisted reproductive techniques.

ACS Style

Marta Gianzo; Itziar Urizar-Arenaza; Iraia Muñoa-Hoyos; Zaloa Larreategui; Nicolás Garrido; Jon Irazusta; Nerea Subirán. (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability. International Journal of Molecular Sciences 2021, 22, 3215 .

AMA Style

Marta Gianzo, Itziar Urizar-Arenaza, Iraia Muñoa-Hoyos, Zaloa Larreategui, Nicolás Garrido, Jon Irazusta, Nerea Subirán. (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability. International Journal of Molecular Sciences. 2021; 22 (6):3215.

Chicago/Turabian Style

Marta Gianzo; Itziar Urizar-Arenaza; Iraia Muñoa-Hoyos; Zaloa Larreategui; Nicolás Garrido; Jon Irazusta; Nerea Subirán. 2021. "(Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability." International Journal of Molecular Sciences 22, no. 6: 3215.

Journal article
Published: 06 January 2021 in International Journal of Environmental Research and Public Health
Reads 0
Downloads 0

During the COVID-19 pandemic, entire populations were instructed to live in home-confinement to prevent the expansion of the disease. Spain was one of the countries with the strictest conditions, as outdoor physical activity was banned for nearly two months. This study aimed to analyse the changes in physical activity and sedentary behaviours in Spanish university students before and during the confinement by COVID-19 with special focus on gender. We also analysed enjoyment, the tools used and motivation and impediments for doing physical activity. An online questionnaire, which included the International Physical Activity Questionnaire Short Form and certain “ad hoc” questions, was designed. Students were recruited by distributing an invitation through the administrative channels of 16 universities and a total of 13,754 valid surveys were collected. Overall, university students reduced moderate (−29.5%) and vigorous (−18.3%) physical activity during the confinement and increased sedentary time (+52.7%). However, they spent more time on high intensity interval training (HIIT) (+18.2%) and mind-body activities (e.g., yoga) (+80.0%). Adaptation to the confinement, in terms of physical activity, was handled better by women than by men. These results will help design strategies for each gender to promote physical activity and reduce sedentary behaviour during confinement periods.

ACS Style

Ana Rodríguez-Larrad; Asier Mañas; Idoia Labayen; Marcela González-Gross; Ander Espin; Susana Aznar; José Antonio Serrano-Sánchez; Francisco J. Vera-Garcia; Domingo González-Lamuño; Ignacio Ara; Luis Carrasco-Páez; José Castro-Piñero; Mari Carmen Gómez-Cabrera; Sara Márquez; Josep A. Tur; Narcis Gusi; Pedro J. Benito; Diego Moliner-Urdiales; Jonatan R. Ruiz; Francisco B. Ortega; David Jiménez-Pavón; José Antonio Casajús; Jon Irazusta. Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender. International Journal of Environmental Research and Public Health 2021, 18, 369 .

AMA Style

Ana Rodríguez-Larrad, Asier Mañas, Idoia Labayen, Marcela González-Gross, Ander Espin, Susana Aznar, José Antonio Serrano-Sánchez, Francisco J. Vera-Garcia, Domingo González-Lamuño, Ignacio Ara, Luis Carrasco-Páez, José Castro-Piñero, Mari Carmen Gómez-Cabrera, Sara Márquez, Josep A. Tur, Narcis Gusi, Pedro J. Benito, Diego Moliner-Urdiales, Jonatan R. Ruiz, Francisco B. Ortega, David Jiménez-Pavón, José Antonio Casajús, Jon Irazusta. Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender. International Journal of Environmental Research and Public Health. 2021; 18 (2):369.

Chicago/Turabian Style

Ana Rodríguez-Larrad; Asier Mañas; Idoia Labayen; Marcela González-Gross; Ander Espin; Susana Aznar; José Antonio Serrano-Sánchez; Francisco J. Vera-Garcia; Domingo González-Lamuño; Ignacio Ara; Luis Carrasco-Páez; José Castro-Piñero; Mari Carmen Gómez-Cabrera; Sara Márquez; Josep A. Tur; Narcis Gusi; Pedro J. Benito; Diego Moliner-Urdiales; Jonatan R. Ruiz; Francisco B. Ortega; David Jiménez-Pavón; José Antonio Casajús; Jon Irazusta. 2021. "Impact of COVID-19 Confinement on Physical Activity and Sedentary Behaviour in Spanish University Students: Role of Gender." International Journal of Environmental Research and Public Health 18, no. 2: 369.

Journal article
Published: 11 December 2020 in Archives of Physical Medicine and Rehabilitation
Reads 0
Downloads 0

Objective To determine how overground robotic (OR) training added to ongoing rehabilitation affects gait speed, lower extremity function, functional mobility, and fatigue in individuals with multiple sclerosis (MS) and moderate to severe gait impairments. Design Randomized controlled trial. Setting Outpatient setting at the Multiple Sclerosis Association of Bizkaia, an association serving MS patients in Bizkaia, Spain. Participants Individuals with MS (N=36) participated in this interventional study. Inclusion criteria were age of 18 years or older, Expanded Disability Status Scale score between 4.5 and 7, and the need for assistive devices for walking outdoors. Interventions The control group (CG) engaged in an ongoing rehabilitation program consisting of weekly 1-hour individualized sessions. The intervention group (OR group) also participated in this program in addition to a twice-weekly individualized and progressive OR gait training intervention for 3 months, aiming to reach a maximum of 40 minutes by the end of the 3-month period. Main Outcome Measures Primary outcome was the 10-meter walking test (10MWT). Secondary variables included the Short Physical Performance Battery, the timed Up and Go (TUG) test, and the Modified Fatigue Impact Scale. Results The OR group maintained 10MWT performance and significantly improved on the TUG test (P=.049, medium effect size) without increasing fatigue perception. The CG demonstrated a decline on the 10MWT (P=.044, small effect size) and reduced fatigue (P=.024, medium effect size). No time per group interaction was observed for any variable. Conclusion The evaluated intervention could preserve gait speed and significantly improve functional mobility without increasing perceived fatigue in participants. Thus, OR exoskeletons could be considered a tool to deliver intensive practice of good-quality gait training in individuals with MS and moderate to severe gait impairments. Further studies are necessary to confirm these preliminary results.

ACS Style

Rakel Berriozabalgoitia; Iraia Bidaurrazaga-Letona; Erika Otxoa; Miriam Urquiza; Jon Irazusta; Ana Rodriguez-Larrad. Overground Robotic Program Preserves Gait in Individuals With Multiple Sclerosis and Moderate to Severe Impairments: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation 2020, 102, 932 -939.

AMA Style

Rakel Berriozabalgoitia, Iraia Bidaurrazaga-Letona, Erika Otxoa, Miriam Urquiza, Jon Irazusta, Ana Rodriguez-Larrad. Overground Robotic Program Preserves Gait in Individuals With Multiple Sclerosis and Moderate to Severe Impairments: A Randomized Controlled Trial. Archives of Physical Medicine and Rehabilitation. 2020; 102 (5):932-939.

Chicago/Turabian Style

Rakel Berriozabalgoitia; Iraia Bidaurrazaga-Letona; Erika Otxoa; Miriam Urquiza; Jon Irazusta; Ana Rodriguez-Larrad. 2020. "Overground Robotic Program Preserves Gait in Individuals With Multiple Sclerosis and Moderate to Severe Impairments: A Randomized Controlled Trial." Archives of Physical Medicine and Rehabilitation 102, no. 5: 932-939.

Journal article
Published: 16 October 2020 in BMC Geriatrics
Reads 0
Downloads 0

Background Older patients often experience a decline in physical function and cognitive status after hospitalization. Although interventions involving physical exercise are effective in improving functional performance, participation in physical exercise interventions among older individuals is low. We aimed to identify factors that contribute to exercise refusal among post-hospitalized older patients. Methods A cross-sectional study of recruitment data from a randomized controlled trial was conducted involving 495 hospitalized people ≥70 years old. Sociodemographic and clinical data were obtained from the Basque Public Health System database. We determined physical function with the Short Physical Performance Battery (SPPB), nutritional status with the Mini-Nutritional Assessment, frailty according to the Fried phenotype criteria, and cognitive function with the Short Portable Mental Status Questionnaire (SPMSQ). Student’s t, Mann-Whitney U, or chi-squared tests were applied for bivariate analysis. Parameters significantly associated with participation were introduced in a logistic multivariate regression model. Results Among the analyzed patients, 88.8% declined participation in the physical exercise program. Multivariate regression revealed that older age (OR: 1.13; 95% CI: 1.07–1.19), poor nutritional status (OR: 0.81; 95% CI: 0.69–0.95), and reduced home accessibility (OR: 0.27; 95% CI: 0.08–0.94) were predictors of participation refusal. Moreover, patients who declined participation had worse performance on the SPPB (P < 0.05) and its tests of balance, leg strength, and walking speed (P < 0.05). No differences were found between groups in other variables. Conclusions This study confirms low participation of older adults in a post-hospitalization physical exercise program. Non-participation was associated with increased age, poor nutritional status, and reduced home accessibility. Our findings support the need for intervention design that accounts for these factors to increase older patient participation in beneficial exercise programs. Trial registration Australian New Zealand Clinical Trials Registry, ACTRN12619000093189, (date: January 22, 2019, retrospectively registered).

ACS Style

Miriam Urquiza; Iñaki Echeverria; Ariadna Besga; María Amasene; Idoia Labayen; Ana Rodriguez-Larrad; Julia Barroso; Mikel Aldamiz; Jon Irazusta. Determinants of participation in a post-hospitalization physical exercise program for older adults. BMC Geriatrics 2020, 20, 1 -9.

AMA Style

Miriam Urquiza, Iñaki Echeverria, Ariadna Besga, María Amasene, Idoia Labayen, Ana Rodriguez-Larrad, Julia Barroso, Mikel Aldamiz, Jon Irazusta. Determinants of participation in a post-hospitalization physical exercise program for older adults. BMC Geriatrics. 2020; 20 (1):1-9.

Chicago/Turabian Style

Miriam Urquiza; Iñaki Echeverria; Ariadna Besga; María Amasene; Idoia Labayen; Ana Rodriguez-Larrad; Julia Barroso; Mikel Aldamiz; Jon Irazusta. 2020. "Determinants of participation in a post-hospitalization physical exercise program for older adults." BMC Geriatrics 20, no. 1: 1-9.

Original paper
Published: 05 October 2020 in European Journal of Clinical Investigation
Reads 0
Downloads 0

Background People with frailty and/or sarcopenia have an increased risk of negative health outcomes. However, their diagnosis is often difficult. Considering the potential value of myostatin and follistatin as biomarkers of these conditions, we aimed to compare the association between both myokines and frailty and/or sarcopenia in post‐hospitalised older people. In addition, the capability of myostatin and follistatin for identifying frailty and sarcopenia was compared with physical tests. Materials And Methods Participants in this cross‐sectional study consisted of 84 post‐hospitalised patients immediately after discharge. Participants met the following inclusion criteria: aged ≥70 years, score of ≥20 on the Mini‐Mental State Examination, and able to stand up and walk independently for at least 4 metres. Serum myostatin and follistatin concentrations were measured by enzyme‐linked immunosorbent assay. Body measures and results from 4 physical tests (hand grip, chair stand, 8‐foot timed Up‐and‐Go (8TUG) and gait speed (GS)) were also recorded. Frailty was evaluated by the Fried index, and sarcopenia by the criteria of the European Working Group on Sarcopenia in Older People. Results Myostatin concentration was lower and follistatin concentration higher in people with frailty or sarcopenia. Receiver operating characteristic curves indicated that GS and 8TUG tests had the greatest capability for identifying frailty. Myostatin was the only variable capable of identifying sarcopenia. Conclusion Myostatin may be a useful biomarker for sarcopenia in post‐hospitalised older adults. However, it has a lower capability for identifying frailty than physical tests. Further studies using larger samples and these myokines together with other biomarkers are warranted.

ACS Style

Iñaki Echeverria; Ariadna Besga; Begoña Sanz; María Amasene; Gotzone Hervás; Julia Barroso; Ana Rodriguez‐Larrad; Jon Irazusta. Identification of frailty and sarcopenia in hospitalised older people. European Journal of Clinical Investigation 2020, 51, e13420 .

AMA Style

Iñaki Echeverria, Ariadna Besga, Begoña Sanz, María Amasene, Gotzone Hervás, Julia Barroso, Ana Rodriguez‐Larrad, Jon Irazusta. Identification of frailty and sarcopenia in hospitalised older people. European Journal of Clinical Investigation. 2020; 51 (4):e13420.

Chicago/Turabian Style

Iñaki Echeverria; Ariadna Besga; Begoña Sanz; María Amasene; Gotzone Hervás; Julia Barroso; Ana Rodriguez‐Larrad; Jon Irazusta. 2020. "Identification of frailty and sarcopenia in hospitalised older people." European Journal of Clinical Investigation 51, no. 4: e13420.

Journal article
Published: 18 September 2020 in Nutrients
Reads 0
Downloads 0

Nutritional status is relevant to functional recovery in patients after an acute process requiring rehabilitation. Nevertheless, little is known about the impact of malnutrition on geriatric rehabilitation. This study aimed to determine the association between nutritional status at admission and the evolution of functional and physical outcomes, as well as the capability of nutritional status to identify fallers among patients admitted to geriatric rehabilitation for different reasons. This was a retrospective cohort study of 375 patients. Data collected included age, gender, diagnosis at admission, comorbidities, cognitive and nutritional status, functional and physical measurements, length of stay, mortality and falls. Orthogeriatric patients with worse nutritional status according to the Mini Nutritional Assessment-Short Form (MNA-SF) had a significantly lower Barthel Index at admission and discharge with worse functional gain and poorer outcomes in the Short Physical Performance Battery (SPPB). However, in hospital-deconditioned patients, the MNA-SF score was not significantly associated with functional and physical recovery. Poor nutritional status at admission increased the risk of experiencing at least one fall during rehabilitation in orthogeriatric patients. However, hospital-deconditioned patients who fell had better SPPB scores than those who did not fall. Our results demonstrate the importance of nutritional status in the clinical evolution of orthogeriatric patients throughout the rehabilitation process.

ACS Style

Miriam Urquiza; Naiara Fernandez; Ismene Arrinda; Irati Sierra; Jon Irazusta; Ana Rodriguez Larrad. Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study. Nutrients 2020, 12, 2855 .

AMA Style

Miriam Urquiza, Naiara Fernandez, Ismene Arrinda, Irati Sierra, Jon Irazusta, Ana Rodriguez Larrad. Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study. Nutrients. 2020; 12 (9):2855.

Chicago/Turabian Style

Miriam Urquiza; Naiara Fernandez; Ismene Arrinda; Irati Sierra; Jon Irazusta; Ana Rodriguez Larrad. 2020. "Nutritional Status Is Associated with Function, Physical Performance and Falls in Older Adults Admitted to Geriatric Rehabilitation: A Retrospective Cohort Study." Nutrients 12, no. 9: 2855.

Journal article
Published: 18 July 2020 in Experimental Gerontology
Reads 0
Downloads 0

Physical exercise protects against age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) may mediate some of the cognitive benefits of physical exercise, but the effect of physical exercise on serum BDNF is unclear. Indeed, differential findings have been reported depending on the characteristics of the participants and the intensity, duration, and type of exercise. The aim of this study was to determine whether three different physical exercise interventions alter serum BDNF levels in older adults living in long-term nursing homes (LTNHs) and whether changes in physical, cognitive, and dual-task performance are related to changes in serum BDNF. LTNH study participants (n = 126) were randomly assigned to multicomponent or dual-task training or a walking program and serum BDNF levels were analyzed by ELISA. We also assessed physical, cognitive, and dual-task parameters. Neither the multicomponent, dual-task, nor walking exercise programs caused changes in serum BDNF concentration in older adults living in LTNHs. Changes in BDNF during the interventions were not significantly associated with modifications in physical, cognitive or dual-task performance parameters. Our results provide new evidence clarifying the relationship between physical and cognitive exercise and BDNF.

ACS Style

Chloe Rezola-Pardo; Gotzone Hervás; Haritz Arrieta; Alejandra Hernández-De Diego; Fatima Ruiz-Litago; Susana Maria Gil; Ana Rodriguez-Larrad; Jon Irazusta. Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes. Experimental Gerontology 2020, 139, 111024 .

AMA Style

Chloe Rezola-Pardo, Gotzone Hervás, Haritz Arrieta, Alejandra Hernández-De Diego, Fatima Ruiz-Litago, Susana Maria Gil, Ana Rodriguez-Larrad, Jon Irazusta. Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes. Experimental Gerontology. 2020; 139 ():111024.

Chicago/Turabian Style

Chloe Rezola-Pardo; Gotzone Hervás; Haritz Arrieta; Alejandra Hernández-De Diego; Fatima Ruiz-Litago; Susana Maria Gil; Ana Rodriguez-Larrad; Jon Irazusta. 2020. "Physical exercise interventions have no effect on serum BDNF concentration in older adults living in long-term nursing homes." Experimental Gerontology 139, no. : 111024.

Journal article
Published: 23 June 2020 in International Journal of Environmental Research and Public Health
Reads 0
Downloads 0

Residential greenness may positively impact diverse human health indicators through the reduction of air pollution, the improvement of psychological health, and the promotion of physical activity. Previous studies indicate a weak but positive association with pregnancy outcomes. Our aim was to test the multiple pathways from residential greenness to pregnancy outcomes model, using residential NO2 concentrations, psychological health, and moderate-to-vigorous physical activity (MVPA) during the first trimester of pregnancy, in a sample of 440 pregnant women residing in Donostia, Spain. Three metrics of residential greenness were calculated around each participant’s home address: normalized difference vegetation index (NDVI) within 300 m, and green space (>5000 m2) availability within 300 and 500 m. Residential NO2 concentrations, psychological health, and MVPA were explored as mediators of the associations between these metrics and the following pregnancy outcomes: birth weight (BW), low birth weight (LBW), prematurity, small for gestational age (SGA), and large for gestational age (LGA). Educational attainment, parity, and body mass index (BMI) were treated as covariates. Counterfactual mediation analyses showed very low to null statistical support for an association between any of the greenspace metrics and pregnancy outcomes in the full sample. Green space availability (300 m) was associated with lower BW and showed a marginal protective effect against LGA.

ACS Style

Asier Anabitarte; Mikel Subiza-Pérez; Jesús Ibarluzea; Kepa Azkona; Gonzalo García-Baquero; Carme Miralles-Guasch; Jon Irazusta; Kristina W. Whitworth; Guillem Vich; Aitana Lertxundi. Testing the Multiple Pathways of Residential Greenness to Pregnancy Outcomes Model in a Sample of Pregnant Women in the Metropolitan Area of Donostia-San Sebastián. International Journal of Environmental Research and Public Health 2020, 17, 4520 .

AMA Style

Asier Anabitarte, Mikel Subiza-Pérez, Jesús Ibarluzea, Kepa Azkona, Gonzalo García-Baquero, Carme Miralles-Guasch, Jon Irazusta, Kristina W. Whitworth, Guillem Vich, Aitana Lertxundi. Testing the Multiple Pathways of Residential Greenness to Pregnancy Outcomes Model in a Sample of Pregnant Women in the Metropolitan Area of Donostia-San Sebastián. International Journal of Environmental Research and Public Health. 2020; 17 (12):4520.

Chicago/Turabian Style

Asier Anabitarte; Mikel Subiza-Pérez; Jesús Ibarluzea; Kepa Azkona; Gonzalo García-Baquero; Carme Miralles-Guasch; Jon Irazusta; Kristina W. Whitworth; Guillem Vich; Aitana Lertxundi. 2020. "Testing the Multiple Pathways of Residential Greenness to Pregnancy Outcomes Model in a Sample of Pregnant Women in the Metropolitan Area of Donostia-San Sebastián." International Journal of Environmental Research and Public Health 17, no. 12: 4520.

Study protocol article
Published: 09 June 2020 in Frontiers in Medicine
Reads 0
Downloads 0

Maintaining the ability to walk is one of the significant challenges in people with multiple sclerosis (MS) for keeping a good quality of life as the disease and the aging process progresses. Overground robotic (OR) wearable exoskeletons are promising tools for gait rehabilitation, but currently there is no evidence of their clinical effects on patients with MS. The present study aims to determine the effects of an OR intervention in people with MS and moderate to severe walking disabilities and ascertain if benefits are maintained over a follow-up period of 3 months. This randomized controlled trial will include 36 participants with MS. Inclusion criteria are: older than 18 years, definitive diagnosis of MS, 4.5–7 points on the EDSS (Expanded Disability Status Scale), and needing one or two canes or crutches for walking outdoors. Subjects in the control group will receive conventional physiotherapy sessions at ADEMBI (Asociación de Esclerosis Múltiple de Bizkaia) provided to control spasticity, maintain articular range and exercise balance. Subjects in the intervention group will receive the same physiotherapy but also participate in a progressive OR gait training program assisted by the EksoTM exoskeleton. The program consists of twice a week individually supervised sessions in two setting modalities: PreGait and ProStepPlus. The training parameters (duration, speed, cadence, length of steps) will be set during the first session and the progression and intensity of the intervention will be adapted to the tolerance of each participant. The primary outcome of this study is gait speed. Secondary outcomes will include physical and cognitive performance tests, clinical, fatigue and quality of life assessments, and changes in the plasma levels of inflammatory cytokines. The present trial is the first analyzing the effectiveness of an OR intervention for gait training in patients with MS. It will help clarify the applicability of robotic technologies to clinical practice, extending the functionality and quality of life of people with MS to face a successful aging process. (ACTRN12619000014156; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376548).

ACS Style

Rakel Berriozabalgoitia; Begoña Sanz; Ana Belén Fraile-Bermúdez; Erika Otxoa; Izaskun Yeregui; Iraia Bidaurrazaga-Letona; Iratxe Duñabeitia; Alfredo Antigüedad; Maria Domercq; Jon Irazusta; Ana Rodriguez-Larrad. An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial. Frontiers in Medicine 2020, 7, 1 .

AMA Style

Rakel Berriozabalgoitia, Begoña Sanz, Ana Belén Fraile-Bermúdez, Erika Otxoa, Izaskun Yeregui, Iraia Bidaurrazaga-Letona, Iratxe Duñabeitia, Alfredo Antigüedad, Maria Domercq, Jon Irazusta, Ana Rodriguez-Larrad. An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial. Frontiers in Medicine. 2020; 7 ():1.

Chicago/Turabian Style

Rakel Berriozabalgoitia; Begoña Sanz; Ana Belén Fraile-Bermúdez; Erika Otxoa; Izaskun Yeregui; Iraia Bidaurrazaga-Letona; Iratxe Duñabeitia; Alfredo Antigüedad; Maria Domercq; Jon Irazusta; Ana Rodriguez-Larrad. 2020. "An Overground Robotic Gait Training Program for People With Multiple Sclerosis: A Protocol for a Randomized Clinical Trial." Frontiers in Medicine 7, no. : 1.

Original article
Published: 20 May 2020 in Supportive Care in Cancer
Reads 0
Downloads 0

Decreased health-related quality of life (HRQoL) is common in patients with cancer. We investigated the effects of dietary intervention and baseline nutritional status on worsening of HRQoL in older patients during chemotherapy. In this randomized control trial assessing the effect on mortality of dietary advice to increase dietary intake during chemotherapy, this post hoc analysis included 155 patients with cancer at risk of malnutrition. The effects of dietary intervention, baseline Mini Nutritional Assessment item scores, weight loss, and protein and energy intake before treatment on the worsening of HRQoL (physical functioning, fatigue) and secondary outcomes (Timed Up and Go test, one-leg stance time, depressive symptoms, basic (ADL), or instrumental (IADL) activities of daily living) were analyzed by multinomial regressions. Dietary intervention increased total energy and protein intake but had no effect on any examined outcomes. Worsening of fatigue and ADL was predicted by very low protein intake (< 0.8 g kg−1 day−1) before chemotherapy (OR 3.02, 95% CI 1.22–7.46, p = 0.018 and OR 5.21, 95% CI 1.18–22.73, p = 0.029 respectively). Increase in depressive symptomatology was predicted by 5.0–9.9% weight loss before chemotherapy (OR 2.68, 95% CI 1.10–6.80, p = 0.038). Nutritional intervention to prevent HRQoL decline during chemotherapy should focus on patients with very low protein intake along with those with weight loss.

ACS Style

Sophie C. Regueme; Iñaki Echeverria; Nicolas Monéger; Jessica Durrieu; Maïté Becerro-Hallard; Sophie Duc; Aurelie LaFargue; Cécile Mertens; Hamid Laksir; Joël Ceccaldi; Sandrine Lavau-Denes; Thierry Dantoine; Jon Irazusta; Isabelle Bourdel-Marchasson. Protein intake, weight loss, dietary intervention, and worsening of quality of life in older patients during chemotherapy for cancer. Supportive Care in Cancer 2020, 29, 687 -696.

AMA Style

Sophie C. Regueme, Iñaki Echeverria, Nicolas Monéger, Jessica Durrieu, Maïté Becerro-Hallard, Sophie Duc, Aurelie LaFargue, Cécile Mertens, Hamid Laksir, Joël Ceccaldi, Sandrine Lavau-Denes, Thierry Dantoine, Jon Irazusta, Isabelle Bourdel-Marchasson. Protein intake, weight loss, dietary intervention, and worsening of quality of life in older patients during chemotherapy for cancer. Supportive Care in Cancer. 2020; 29 (2):687-696.

Chicago/Turabian Style

Sophie C. Regueme; Iñaki Echeverria; Nicolas Monéger; Jessica Durrieu; Maïté Becerro-Hallard; Sophie Duc; Aurelie LaFargue; Cécile Mertens; Hamid Laksir; Joël Ceccaldi; Sandrine Lavau-Denes; Thierry Dantoine; Jon Irazusta; Isabelle Bourdel-Marchasson. 2020. "Protein intake, weight loss, dietary intervention, and worsening of quality of life in older patients during chemotherapy for cancer." Supportive Care in Cancer 29, no. 2: 687-696.

Journal article
Published: 01 March 2020 in Reproduction
Reads 0
Downloads 0

Rennin-angiotensin system (RAS) has been involved in sperm function, even so, little is known about the implication of one of the RAS axis formed by Ang-(1–7) (angiotensin-(1–7)) and MAS receptor. Hence, in the present work, we focused on elucidating the function of the MAS receptor in human spermatozoa. We analyzed the expression and localization of MAS receptor in human spermatozoa and we observed if its activation is able to modulate the sperm motility of normal motility and/or asthenozoospermic patients, as well as, the acrosome reaction of the spermatozoa. MAS receptor is present in human mature spermatozoa, not only at the mRNA level but also at protein level. MAS is localized at the acrosome region, as well as, in the tail of spermatozoa. The sperm incubation with MAS agonist Ang-(1–7) activates at dose-dependent manner the PI3K/AKT pathway (P < 0.01 vs control) and improves the motility of asthenozoospermic patients (P < 0.01 vs control), which is blocked by the specific antagonist (A779) (P < 0.01), but it do not modulate the acrosome reaction. These findings suggest that the ACE2/Ang-(1–7)/Mas axis may be a useful biochemical tool for the treatment of male infertility related to sperm mobility.

ACS Style

Asier Valdivia; Lorea Cortés; Maider Beitia; Lide Totorikaguena; Naiara Agirregoitia; Beatriz Corcostegui; Luis Casis; Roberto Matorras; Jon Irazusta; Ekaitz Agirregoitia. Role of Angiotensin-(1–7) via MAS receptor in human sperm motility and acrosome reaction. Reproduction 2020, 159, 241 -249.

AMA Style

Asier Valdivia, Lorea Cortés, Maider Beitia, Lide Totorikaguena, Naiara Agirregoitia, Beatriz Corcostegui, Luis Casis, Roberto Matorras, Jon Irazusta, Ekaitz Agirregoitia. Role of Angiotensin-(1–7) via MAS receptor in human sperm motility and acrosome reaction. Reproduction. 2020; 159 (3):241-249.

Chicago/Turabian Style

Asier Valdivia; Lorea Cortés; Maider Beitia; Lide Totorikaguena; Naiara Agirregoitia; Beatriz Corcostegui; Luis Casis; Roberto Matorras; Jon Irazusta; Ekaitz Agirregoitia. 2020. "Role of Angiotensin-(1–7) via MAS receptor in human sperm motility and acrosome reaction." Reproduction 159, no. 3: 241-249.

Journal article
Published: 20 January 2020 in International Journal of Environmental Research and Public Health
Reads 0
Downloads 0

Multicomponent physical exercise is effective in curbing the effect of hospitalization in older adults. However, it is not well established which characteristics of the exercise interventions would optimize intervention sustainability and efficacy. This study compared the effects of two group-based multicomponent exercise interventions of different lengths in older adults after hospitalization. Fifty-five participants were randomly assigned to a short-term group-based branch (SGB, n = 27) or to a long-term group-based branch (LGB, n = 28). The SGB participated in a six-week multicomponent group-based exercise-training program followed by 18 weeks of home-based exercise. The LGB completed 12 weeks of each phase. Physical function, physical activity, quality of life, anthropometrics, and nutritional status were assessed at baseline, after 12 weeks, and after 24 weeks of intervention. Both groups improved physical function and nutritional status and increased physical activity after 12 weeks of intervention (paired student’s t-test, p < 0.01), and maintained the positive effects during the following 12 weeks. No group-by-time interaction was observed in any of the studied variables using mixed-model ANOVA. Based on these findings, we determined that 6 weeks of a group-based exercise intervention caused similar functional and nutritional benefits to a longer group-based intervention of 12 weeks when both are continued at home until 24 weeks.

ACS Style

Iñaki Echeverria; Maria Amasene; Miriam Urquiza; Idoia Labayen; Pilar Anaut; Ana Rodriguez-Larrad; Jon Irazusta; Ariadna Besga. Multicomponent Physical Exercise in Older Adults after Hospitalization: A Randomized Controlled Trial Comparing Short- vs. Long-Term Group-Based Interventions. International Journal of Environmental Research and Public Health 2020, 17, 666 .

AMA Style

Iñaki Echeverria, Maria Amasene, Miriam Urquiza, Idoia Labayen, Pilar Anaut, Ana Rodriguez-Larrad, Jon Irazusta, Ariadna Besga. Multicomponent Physical Exercise in Older Adults after Hospitalization: A Randomized Controlled Trial Comparing Short- vs. Long-Term Group-Based Interventions. International Journal of Environmental Research and Public Health. 2020; 17 (2):666.

Chicago/Turabian Style

Iñaki Echeverria; Maria Amasene; Miriam Urquiza; Idoia Labayen; Pilar Anaut; Ana Rodriguez-Larrad; Jon Irazusta; Ariadna Besga. 2020. "Multicomponent Physical Exercise in Older Adults after Hospitalization: A Randomized Controlled Trial Comparing Short- vs. Long-Term Group-Based Interventions." International Journal of Environmental Research and Public Health 17, no. 2: 666.

Journal article
Published: 17 December 2019 in The Gerontologist
Reads 0
Downloads 0

Background and Objectives There is evidence that exercise interventions counteract the functional and cognitive decline experienced by long-term nursing home (LTNH) residents. To determine the most effective exercise intervention, we compared the effects of a multicomponent exercise intervention and a walking intervention on physical and cognitive performance, habitual physical activity, affective function, and quality of life among older adults living in LTNHs. Research Design and Methods This 3-month single-blind randomized controlled trial (NCT03996083) involved 81 participants at 9 LTNHs randomly assigned to a multicomponent (MG) or a walking (WG) group. The MG participated in a twice-a-week individualized and progressive program composed of strength and balance exercises for 3 months. The WG was also individualized and participants walked up to 20 min per day. The primary outcome was the score on the short physical performance battery (SPPB). Secondary outcomes included other physical performance tests, habitual physical activity, cognitive performance, affective function, and quality of life. Results Compared with the WG, the MG group showed greater improvements in physical performance, including the SPPB (p < .05). No significant differences were observed in cognitive performance or habitual physical activity. Both groups showed improvements in anxiety and quality of life (p < .05). Discussion and Implications Although both interventions were effective in maintaining or improving affective function, the MG conferred greater improvements in physical function. Therefore, multicomponent interventions would be preferable over walking-only interventions. Otherwise, individualized and progressive walking interventions should be implemented to face the rapid decline in functionality encountered in LTNHs.

ACS Style

Chloe Rezola-Pardo; Ana Rodriguez-Larrad; Julen Gomez-Diaz; Garbiñe Lozano Real; Itxaso Mugica-Errazquin; Maria Jesus Patiño; Iraia Bidaurrazaga-Letona; Jon Irazusta; Susana María Gil. Comparison Between Multicomponent Exercise and Walking Interventions in Long-Term Nursing Homes: A Randomized Controlled Trial. The Gerontologist 2019, 60, 1364 -1373.

AMA Style

Chloe Rezola-Pardo, Ana Rodriguez-Larrad, Julen Gomez-Diaz, Garbiñe Lozano Real, Itxaso Mugica-Errazquin, Maria Jesus Patiño, Iraia Bidaurrazaga-Letona, Jon Irazusta, Susana María Gil. Comparison Between Multicomponent Exercise and Walking Interventions in Long-Term Nursing Homes: A Randomized Controlled Trial. The Gerontologist. 2019; 60 (7):1364-1373.

Chicago/Turabian Style

Chloe Rezola-Pardo; Ana Rodriguez-Larrad; Julen Gomez-Diaz; Garbiñe Lozano Real; Itxaso Mugica-Errazquin; Maria Jesus Patiño; Iraia Bidaurrazaga-Letona; Jon Irazusta; Susana María Gil. 2019. "Comparison Between Multicomponent Exercise and Walking Interventions in Long-Term Nursing Homes: A Randomized Controlled Trial." The Gerontologist 60, no. 7: 1364-1373.

Journal article
Published: 27 November 2019 in Journal of Strength and Conditioning Research
Reads 0
Downloads 0

Duñabeitia, I, Arrieta, H, Rodriguez-Larrad, A, Gil, J, Esain, I, Gil, SM, Irazusta, J, and Bidaurrazaga-Letona, I. Effects of massage and cold water immersion after an exhaustive run on running economy and biomechanics: A randomized controlled trial. J Strength Cond Res XX(X): 000–000, 2019—This study compares the effects of 2 common recovery interventions performed shortly after an exhausting interval running session on running economy (RE) and biomechanics. Forty-eight well-trained male runners performed an exhaustive interval running protocol and an incremental treadmill test 24 hours later at 3 speeds: 12, 14, and 16 km·h−1. Subjects randomly received either massage, cold water immersion (CWI), or passive rest (control). Runners repeated the treadmill test 48 hours after the first test. A two-way mixed analysis of variance was performed comparing groups and testing times. The massage group had significantly better recovery than the control group at 14 km·h−1 in RE (p < 0.05; η2 = 0.176) and greater stride height and angle changes at 16 km·h−1 (p < 0.05; η2 = 0.166 and p < 0.05; η2 = 0.208, respectively). No differences were observed between the CWI and control groups. The massage group had greater stride height and angle changes at 16 km·h−1 than the CWI group (p < 0.05; η2 = 0.139 and p < 0.05; η2 = 0.168, respectively). Moreover, differences in magnitude suggested moderate effects on RE (η2 = 0.076) and swing time (η2 = 0.110). These results suggest that massage intervention promotes faster recovery of RE and running biomechanics than CWI or passive rest.

ACS Style

Iratxe Duñabeitia; Haritz Arrieta; Ana Rodriguez-Larrad; Javier Gil; Izaro Esain; Susana M. Gil; Jon Irazusta; Iraia Bidaurrazaga-Letona. Effects of Massage and Cold Water Immersion After an Exhaustive Run on Running Economy and Biomechanics. Journal of Strength and Conditioning Research 2019, Publish Ah, 1 .

AMA Style

Iratxe Duñabeitia, Haritz Arrieta, Ana Rodriguez-Larrad, Javier Gil, Izaro Esain, Susana M. Gil, Jon Irazusta, Iraia Bidaurrazaga-Letona. Effects of Massage and Cold Water Immersion After an Exhaustive Run on Running Economy and Biomechanics. Journal of Strength and Conditioning Research. 2019; Publish Ah ():1.

Chicago/Turabian Style

Iratxe Duñabeitia; Haritz Arrieta; Ana Rodriguez-Larrad; Javier Gil; Izaro Esain; Susana M. Gil; Jon Irazusta; Iraia Bidaurrazaga-Letona. 2019. "Effects of Massage and Cold Water Immersion After an Exhaustive Run on Running Economy and Biomechanics." Journal of Strength and Conditioning Research Publish Ah, no. : 1.

Randomized controlled trial
Published: 05 November 2019 in Maturitas
Reads 0
Downloads 0

To determine the effects of a multicomponent physical exercise program on cognitive and affective functioning among nursing home residents and to clarify whether there are any changes in serum levels of brain-derived neurotrophic factor (BDNF) among participants. This was a single-blind randomized controlled trial in ten nursing homes in Gipuzkoa, Spain. The study included 112 men and women. Participants in the control group engaged in routine activities while those in the intervention group participated in a six-month individualized, progressive, multicomponent physical exercise program focused on strength, balance, and walking. Cognitive and affective functions were assessed at baseline and at six months. Serum BDNF levels were assessed via ELISA. After six months, a group by time interaction in favor of the intervention group was observed on the Montreal Cognitive Assessment (MOCA), symbol search and De Jong-Gierveld Loneliness Scale (P < 0.05). The control group scored more poorly on the MOCA, WAIS-IV (coding and symbol search), verbal fluency, and semantic fluency tests after six months (P < 0.05) than they did at baseline. The intervention group showed poorer results on the coding test (P < 0.05). Loneliness perception was reduced in the intervention group (P < 0.05). No changes in serum BDNF were observed (group x time and within groups, P > 0.05). A six-month individualized, progressive, multicomponent physical exercise intervention is effective at maintaining cognitive function and decreasing perceptions of loneliness among nursing home residents. Blood levels of BDNF were not affected by the intervention.

ACS Style

Haritz Arrieta; Chloe Rezola Pardo; Maider Kortajarena; Gotzone Hervás; Javier Gil; José J. Yanguas; Miren Iturburu; Susana M. Gil; Jon Irazusta; Ana Rodriguez-Larrad. The impact of physical exercise on cognitive and affective functions and serum levels of brain-derived neurotrophic factor in nursing home residents: A randomized controlled trial. Maturitas 2019, 131, 72 -77.

AMA Style

Haritz Arrieta, Chloe Rezola Pardo, Maider Kortajarena, Gotzone Hervás, Javier Gil, José J. Yanguas, Miren Iturburu, Susana M. Gil, Jon Irazusta, Ana Rodriguez-Larrad. The impact of physical exercise on cognitive and affective functions and serum levels of brain-derived neurotrophic factor in nursing home residents: A randomized controlled trial. Maturitas. 2019; 131 ():72-77.

Chicago/Turabian Style

Haritz Arrieta; Chloe Rezola Pardo; Maider Kortajarena; Gotzone Hervás; Javier Gil; José J. Yanguas; Miren Iturburu; Susana M. Gil; Jon Irazusta; Ana Rodriguez-Larrad. 2019. "The impact of physical exercise on cognitive and affective functions and serum levels of brain-derived neurotrophic factor in nursing home residents: A randomized controlled trial." Maturitas 131, no. : 72-77.

Journal article
Published: 09 October 2019 in Age And Ageing
Reads 0
Downloads 0

Background the potential benefits of dual-task interventions on older adults living in long-term nursing homes (LTNHs) from a multidimensional perspective are unknown. We sought to determine whether the addition of simultaneous cognitive training to a multicomponent exercise program offers further benefits to dual-task, physical and cognitive performance, psycho-affective status, quality of life and frailty in LTNH residents. Design: a single-blind randomized controlled trial. Setting nine LTNHs in Gipuzkoa, Spain. Subjects 85 men and women (ACTRN12618000536268). Methods participants were randomly assigned to a multicomponent or dual-task training group. The multicomponent group performed two sessions per week of individualized and progressive strength and balance exercises for 3 months. The dual-task group performed simultaneous cognitive tasks to the same tasks as in the multicomponent group. Gait speed under single- and dual-task conditions, physical and cognitive performance, psycho-affective status, quality of life and frailty were measured at baseline and after 3 months of intervention. Results both groups showed clinically significant improvements on gait performance under single- and dual-task conditions and on the short physical performance battery (P < 0.05). Both interventions were effective in maintaining cognitive function (P > 0.05). Only the multicomponent group significantly improved quality of life, and reduced anxiety and Fried frailty score (P < 0.05). No group-by-time interactions were found except for the chair-stand test in favour of the multicomponent group (P < 0.05). Conclusions the addition of simultaneous cognitive training does not seem to offer significantly greater benefits to the evaluated multicomponent exercise program in older adults living in LTNHs.

ACS Style

Chloe Rezola Pardo; Haritz Arrieta; Susana María Gil; Idoia Zarrazquin; José Javier Yanguas; Maria Antonia López; Jon Irazusta; Ana Rodriguez-Larrad. Comparison between multicomponent and simultaneous dual-task exercise interventions in long-term nursing home residents: the Ageing-ONDUAL-TASK randomized controlled study. Age And Ageing 2019, 48, 817 -823.

AMA Style

Chloe Rezola Pardo, Haritz Arrieta, Susana María Gil, Idoia Zarrazquin, José Javier Yanguas, Maria Antonia López, Jon Irazusta, Ana Rodriguez-Larrad. Comparison between multicomponent and simultaneous dual-task exercise interventions in long-term nursing home residents: the Ageing-ONDUAL-TASK randomized controlled study. Age And Ageing. 2019; 48 (6):817-823.

Chicago/Turabian Style

Chloe Rezola Pardo; Haritz Arrieta; Susana María Gil; Idoia Zarrazquin; José Javier Yanguas; Maria Antonia López; Jon Irazusta; Ana Rodriguez-Larrad. 2019. "Comparison between multicomponent and simultaneous dual-task exercise interventions in long-term nursing home residents: the Ageing-ONDUAL-TASK randomized controlled study." Age And Ageing 48, no. 6: 817-823.

Randomized controlled trial
Published: 01 October 2019 in Nutrients
Reads 0
Downloads 0

Age-related strength and muscle mass loss is further increased after acute periods of inactivity. To avoid this, resistance training has been proposed as an effective countermeasure, but the additional effect of a protein supplement is not so clear. The aim of this study was to examine the effect of a whey protein supplement enriched with leucine after resistance training on muscle mass and strength gains in a post-hospitalized elderly population. A total of 28 participants were included and allocated to either protein supplementation or placebo supplementation following resistance training for 12 weeks (2 days/week). Physical function (lower and upper body strength, aerobic capacity and the Short Physical Performance Battery (SPPB) test), mini nutritional assessment (MNA) and body composition (Dual X-ray Absorptiometry) were assessed at baseline and after 12 weeks of resistance training. Both groups showed improvements in physical function after the intervention (p < 0.01), but there were no further effects for the protein group (p > 0.05). Muscle mass did not improve after resistance training in either group (p > 0.05). In conclusion, 12 weeks of resistance training are enough to improve physical function in a post-hospitalized elderly population with no further benefits for the protein-supplemented group.

ACS Style

Maria Amasene; Ariadna Besga; Iñaki Echeverria; Miriam Urquiza; Jonatan R. Ruiz; Ana Rodriguez-Larrad; Mikel Aldamiz; Pilar Anaut; Jon Irazusta; Idoia Labayen. Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial. Nutrients 2019, 11, 2337 .

AMA Style

Maria Amasene, Ariadna Besga, Iñaki Echeverria, Miriam Urquiza, Jonatan R. Ruiz, Ana Rodriguez-Larrad, Mikel Aldamiz, Pilar Anaut, Jon Irazusta, Idoia Labayen. Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial. Nutrients. 2019; 11 (10):2337.

Chicago/Turabian Style

Maria Amasene; Ariadna Besga; Iñaki Echeverria; Miriam Urquiza; Jonatan R. Ruiz; Ana Rodriguez-Larrad; Mikel Aldamiz; Pilar Anaut; Jon Irazusta; Idoia Labayen. 2019. "Effects of Leucine-Enriched Whey Protein Supplementation on Physical Function in Post-Hospitalized Older Adults Participating in 12-Weeks of Resistance Training Program: A Randomized Controlled Trial." Nutrients 11, no. 10: 2337.