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Wenda Wu
Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Králové 500 03, Czech Republic

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Journal article
Published: 31 August 2021 in Journal of Fungi
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Endophytes have the ability to improve plant nutrition alongside their agronomic performance, among which arbuscular mycorrhizal fungi provide the most benefits to their host. Previously, we reported for the first time that an arbuscular mycorrhizal-like fungus Piriformospora indica had the ability to colonize roots of trifoliate orange (Poncirus trifoliata) and conferred positive effects on nutrient acquisition. Present study showed the changes in fatty acids and sugars to unravel the physiological and symbiotic association of trifoliate orange with P. indica and an arbuscular mycorrhizal fungus, Funneliformis mosseae singly or in combination. All the endophytic fungi collectively increased fructose, glucose, and sucrose content in leaves and roots, along with a relatively higher increase with P. indica inoculation than with F. mosseae alone or dual inoculation. Treatment with P. indica increased the concentration of part unsaturated fatty acids such as C18:3N6, C20:2, C20:3N6, C20:4N6, C20:3N3, C20:5N3, C22:1N9, and C24:1. Additionally, P. indica induced the increase in the concentration of part saturated fatty acids such as C6:0, C8:0, C13:0, C14:0, and C24:0. F. mosseae hardly changed the content of fatty acids, except for increase in C14:0 and C20:5N3. Double inoculation only reduced the C21:0, C10:0, C12:0, C18:3N3, and C18:1 content and increased the C20:5N3 content. These endophytic fungi up-regulated the root PtFAD2, PtFAD6, PtΔ9, and PtΔ15 gene expression level, coupled with a higher expression of PtFAD2 and PtΔ9 by P. indica than by F. mosseae. It was concluded that P. indica exhibited a stronger response, for sugars and fatty acids, than F. mosseae on trifoliate orange. Such results also reveal the Pi (an in vitro culturable fungus) as a bio-stimulator applying to citriculture.

ACS Style

Lu-Lu Meng; Rui-Cheng Liu; Liu Yang; Ying-Ning Zou; Anoop Kumar Srivastava; Kamil Kuča; Abeer Hashem; Elsayed Fathi Abd_Allah; Bhoopander Giri; Qiang-Sheng Wu. The Change in Fatty Acids and Sugars Reveals the Association between Trifoliate Orange and Endophytic Fungi. Journal of Fungi 2021, 7, 716 .

AMA Style

Lu-Lu Meng, Rui-Cheng Liu, Liu Yang, Ying-Ning Zou, Anoop Kumar Srivastava, Kamil Kuča, Abeer Hashem, Elsayed Fathi Abd_Allah, Bhoopander Giri, Qiang-Sheng Wu. The Change in Fatty Acids and Sugars Reveals the Association between Trifoliate Orange and Endophytic Fungi. Journal of Fungi. 2021; 7 (9):716.

Chicago/Turabian Style

Lu-Lu Meng; Rui-Cheng Liu; Liu Yang; Ying-Ning Zou; Anoop Kumar Srivastava; Kamil Kuča; Abeer Hashem; Elsayed Fathi Abd_Allah; Bhoopander Giri; Qiang-Sheng Wu. 2021. "The Change in Fatty Acids and Sugars Reveals the Association between Trifoliate Orange and Endophytic Fungi." Journal of Fungi 7, no. 9: 716.

Journal article
Published: 27 August 2021 in Polymers
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The impact of polymer-based slow-release urea formulations on soil microbial N dynamics in potatoes has been sparingly deciphered. The present study investigated the effect of a biodegradable nano-polymer urea formulation on soil enzymatic activities and microflora involved in the N cycling of potato (Solanum tuberosum L.). The nano-chitosan-urea composite (NCUC) treatment significantly increased the soil dehydrogenase activity, organic carbon content and available potassium compared to the conventional urea (CU) treatment. The soil ammonical nitrogen (NH4+-N) and nitrate nitrogen (NO3-N) contents and urease activity were significantly decreased in the NCUC-amended soil. The slow urea hydrolysis rate led to low concentrations of NH4+-N and NO3-N in the tested potato soil. Furthermore, these results corroborate the low count of ammonia oxidizer and nitrate reducer populations. Quantitative PCR (q-PCR) studies revealed that the relative abundance of eubacterial (AOB) and archaeal ammonia-oxidizing (AOA) populations was reduced in the NCUC-treated soil compared to CU. The abundance of AOA was particularly lower than AOB, probably due to the more neutral and alkaline conditions of the tested soil. Our results suggest that the biodegradable polymer urea composite had a significant effect on the microbiota associated with soil N dynamics. Therefore, the developed NCUC could be used as a slow N-release fertilizer for enhanced growth and crop yields of potato.

ACS Style

Rohini Kondal; Anu Kalia; Ondrej Krejcar; Kamil Kuca; Sat Pal Sharma; Karanvir Luthra; Gurmeet Singh Dheri; Yogesh Vikal; Monica Sachdeva Taggar; Kamel A. Abd-Elsalam; Carmen L. Gomes. Chitosan-Urea Nanocomposite for Improved Fertilizer Applications: The Effect on the Soil Enzymatic Activities and Microflora Dynamics in N Cycle of Potatoes (Solanum tuberosum L.). Polymers 2021, 13, 2887 .

AMA Style

Rohini Kondal, Anu Kalia, Ondrej Krejcar, Kamil Kuca, Sat Pal Sharma, Karanvir Luthra, Gurmeet Singh Dheri, Yogesh Vikal, Monica Sachdeva Taggar, Kamel A. Abd-Elsalam, Carmen L. Gomes. Chitosan-Urea Nanocomposite for Improved Fertilizer Applications: The Effect on the Soil Enzymatic Activities and Microflora Dynamics in N Cycle of Potatoes (Solanum tuberosum L.). Polymers. 2021; 13 (17):2887.

Chicago/Turabian Style

Rohini Kondal; Anu Kalia; Ondrej Krejcar; Kamil Kuca; Sat Pal Sharma; Karanvir Luthra; Gurmeet Singh Dheri; Yogesh Vikal; Monica Sachdeva Taggar; Kamel A. Abd-Elsalam; Carmen L. Gomes. 2021. "Chitosan-Urea Nanocomposite for Improved Fertilizer Applications: The Effect on the Soil Enzymatic Activities and Microflora Dynamics in N Cycle of Potatoes (Solanum tuberosum L.)." Polymers 13, no. 17: 2887.

Review article
Published: 24 August 2021 in Pharmacology & Therapeutics
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The underlying mechanism of tumor immune evasion is a highly concerning subject for researchers. Increasing evidences reveal that the over-activated signal transducer and activator of transcription 3 (STAT3) is a crucial molecular hub in malignant tumors. STAT3 controls autophagy molecules that impair CTL-mediated tumor cell lysis, inhibiting natural killer cells and inducing apoptosis in T lymphocytes to create an immunosuppressive environment. STAT3 signaling regulates the expression of immune factors and recruits immunosuppressive cells to establish a tolerant tumor microenvironment (TME). STAT3 signaling regulates the expression of immune factors and recruits immunosuppressive cells to create an immunosuppressive environment. All this aid tumor cells in escaping from immune surveillance. In this review, we outlined the STAT3-mediated mechanisms involved in tumor immune evasion and their potential regulatory functions in the TME. We discussed the impact of STAT3 signaling on PD-L1, HIF-1α, exosome, lncRNA, and autophagy in the promotion of tumor immune evasion and highlighted the recent research on STAT3 signaling and tumor immune evasion that may assist in developing effective STAT3-targeted drugs for advancing immunotherapy.

ACS Style

Luying Zhang; Kamil Kuca; Li You; Yingying Zhao; Kamil Musilek; Eugenie Nepovimova; Qinghua Wu; Wenda Wu; Vojtech Adam. Signal transducer and activator of transcription 3 signaling in tumor immune evasion. Pharmacology & Therapeutics 2021, 107969 .

AMA Style

Luying Zhang, Kamil Kuca, Li You, Yingying Zhao, Kamil Musilek, Eugenie Nepovimova, Qinghua Wu, Wenda Wu, Vojtech Adam. Signal transducer and activator of transcription 3 signaling in tumor immune evasion. Pharmacology & Therapeutics. 2021; ():107969.

Chicago/Turabian Style

Luying Zhang; Kamil Kuca; Li You; Yingying Zhao; Kamil Musilek; Eugenie Nepovimova; Qinghua Wu; Wenda Wu; Vojtech Adam. 2021. "Signal transducer and activator of transcription 3 signaling in tumor immune evasion." Pharmacology & Therapeutics , no. : 107969.

Review
Published: 18 August 2021 in International Journal of Molecular Sciences
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At present, Alzheimer’s disease (AD) and related dementias cannot be cured. Therefore, scientists all over the world are trying to find a new approach to prolong an active life of patients with initial dementia. Both pharmacological and non-pharmacological pathways are investigated to improve the key symptom of the disease, memory loss. In this respect, influencing the neuromodulator acetylcholine via muscarinic receptors, such as cevimeline, might be one of the therapeutic alternatives. The purpose of this study is to explore the potential of cevimeline on the cognitive functions of AD patients. The methodology is based on a systematic literature review of available studies found in Web of Science, PubMed, Springer, and Scopus on the research topic. The findings indicate that cevimeline has shown an improvement in experimentally induced cognitive deficits in animal models. Furthermore, it has demonstrated to positively influence tau pathology and reduce the levels of amyloid-β (Aβ) peptide in the cerebral spinal fluid of Alzheimer’s patients. Although this drug has not been approved by the FDA for its use among AD patients and there is a lack of clinical studies confirming and extending this finding, cevimeline might represent a breakthrough in the treatment of AD.

ACS Style

Patrik Oleksak; Michal Novotny; Jiri Patocka; Eugenie Nepovimova; Jakub Hort; Jan Pavlik; Blanka Klimova; Martin Valis; Kamil Kuca. Neuropharmacology of Cevimeline and Muscarinic Drugs—Focus on Cognition and Neurodegeneration. International Journal of Molecular Sciences 2021, 22, 8908 .

AMA Style

Patrik Oleksak, Michal Novotny, Jiri Patocka, Eugenie Nepovimova, Jakub Hort, Jan Pavlik, Blanka Klimova, Martin Valis, Kamil Kuca. Neuropharmacology of Cevimeline and Muscarinic Drugs—Focus on Cognition and Neurodegeneration. International Journal of Molecular Sciences. 2021; 22 (16):8908.

Chicago/Turabian Style

Patrik Oleksak; Michal Novotny; Jiri Patocka; Eugenie Nepovimova; Jakub Hort; Jan Pavlik; Blanka Klimova; Martin Valis; Kamil Kuca. 2021. "Neuropharmacology of Cevimeline and Muscarinic Drugs—Focus on Cognition and Neurodegeneration." International Journal of Molecular Sciences 22, no. 16: 8908.

Journal article
Published: 05 August 2021 in Horticulturae
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The role of arbuscular mycorrhizal fungi in sweet oranges is well known, but the function of their secondary metabolite, especially the easily extractable glomalin-related soil protein (EE-GRSP), an active fraction of glomalin, is still unclear. The proposed study aimed to analyze the field response of foliar application of exogenous EE-GRSP on tree mycorrhizal development and fruit quality of two sweet orange (Citrus sinensis L. Osbeck) varieties viz., Lane Late Navel (LLN) and Rohde Red Valencia (RRV). Application of EE-GRSP significantly increased the root mycorrhizal colonization and soil mycorrhizal hyphal length in both the sweet orange varieties. The external quality of fruits (fruit weight, polar diameter, and equatorial diameter) also improved in response to foliar application of EE-GRSP in both sweet orange varieties. However, EE-GRSP treatment showed no change in fruit soluble solid content, while it increased the Vc content, solids-acid ratio, fructose, glucose, and sucrose content of sarcocarp in the two sweet oranges varieties. The LLN variety treated with EE-GRSP recorded significantly higher N, P, K, Fe, and Si content of sarcocarp as a mark of nutritional quality, while the RRV variety treated with EE-GRSP displayed a higher concentration of nutrients like Cu, Fe, Si, and Zn in the sarcocarp as compared with the corresponding non-treated control. To the best of our knowledge, this is the first report regarding the improvement in fruit quality of late-ripening sweet oranges (especially LLN) in response to foliar application of EE-GRSP as another potential biostimulant.

ACS Style

Lu-Lu Meng; Sheng-Min Liang; Anoop Srivastava; Yan Li; Chun-Yan Liu; Ying-Ning Zou; Kamil Kuča; Abeer Hashem; Elsayed Fathi Abd_Allah; Qiang-Sheng Wu. Easily Extractable Glomalin-Related Soil Protein as Foliar Spray Improves Nutritional Qualities of Late Ripening Sweet Oranges. Horticulturae 2021, 7, 228 .

AMA Style

Lu-Lu Meng, Sheng-Min Liang, Anoop Srivastava, Yan Li, Chun-Yan Liu, Ying-Ning Zou, Kamil Kuča, Abeer Hashem, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu. Easily Extractable Glomalin-Related Soil Protein as Foliar Spray Improves Nutritional Qualities of Late Ripening Sweet Oranges. Horticulturae. 2021; 7 (8):228.

Chicago/Turabian Style

Lu-Lu Meng; Sheng-Min Liang; Anoop Srivastava; Yan Li; Chun-Yan Liu; Ying-Ning Zou; Kamil Kuča; Abeer Hashem; Elsayed Fathi Abd_Allah; Qiang-Sheng Wu. 2021. "Easily Extractable Glomalin-Related Soil Protein as Foliar Spray Improves Nutritional Qualities of Late Ripening Sweet Oranges." Horticulturae 7, no. 8: 228.

Journal article
Published: 23 July 2021 in Food and Chemical Toxicology
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Aflatoxin B1 is a mycotoxin that widely exists in feed and has a great impact on human and animal health. This study aimed to examine whether Bacillus amyloliquefaciens B10 protected against aflatoxin B1-induced cecal inflammation in mice. It was found that Bacillus amyloliquefaciens B10 could significantly improve the effects of AFB1 on body weight and intestinal inflammation of mice and enhance the expression of tight-junction protein. Compared with the CON group, the combination of AFB1 and B10 significantly increased the abundance of Actinobacteria and Bacilli in a collaborative manner, and significantly reduced the abundance of Ruminococcae, Lactobacillaceae and Clostridia. Meanwhile, the results showed that the abundance of Bacterides and Bacterdia in AFB1 + B10 group was significantly lower than that of AFB1 group, and the Firmicutes increased significantly. Bacillus amyloliquefaciens B10 can be used as a feed additive and alleviate cecal inflammation induced by AFB1 in mice by regulating intestinal flora.

ACS Style

Jia Chen; Zhiming Lv; Ziyang Cheng; Tiancheng Wang; Peng Li; Aibo Wu; Eugenie Nepovimova; Miao Long; Wenda Wu; Kamil Kuca. Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora. Food and Chemical Toxicology 2021, 156, 112438 .

AMA Style

Jia Chen, Zhiming Lv, Ziyang Cheng, Tiancheng Wang, Peng Li, Aibo Wu, Eugenie Nepovimova, Miao Long, Wenda Wu, Kamil Kuca. Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora. Food and Chemical Toxicology. 2021; 156 ():112438.

Chicago/Turabian Style

Jia Chen; Zhiming Lv; Ziyang Cheng; Tiancheng Wang; Peng Li; Aibo Wu; Eugenie Nepovimova; Miao Long; Wenda Wu; Kamil Kuca. 2021. "Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora." Food and Chemical Toxicology 156, no. : 112438.

Journal article
Published: 22 July 2021 in Toxins
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Deoxynivalenol (DON), also known as vomitoxin, is a mycotoxin that can cause antifeeding and vomiting in animals. However, the mechanism of DON inducing anorexia is complicated. Studies have shown that intestinal hormones play a significant part in the anorexia caused by DON. We adopted the “modeling of acute antifeeding in mice” as the basic experimental model, and used two methods of gavage and intraperitoneal injection to explore the effect of intestinal hormones on the antifeedant response induced by DON in mice. We found that 1 and 2.5 mg/kg·bw of DON can acutely induce anorexia and increase the plasma intestinal hormones CCK, PYY, GIP, and GLP-1 in mice within 3 h. Direct injection of exogenous intestinal hormones CCK, PYY, GIP, and GLP-1 can trigger anorexia behavior in mice. Furthermore, the PYY receptor antagonist JNJ-31020028, GLP-1 receptor antagonist Exendin(9-39), CCK receptor antagonist Proglumide, GIP receptor antagonist GIP(3-30)NH2 attenuated both intestinal hormone and DON-induced anorectic responses. These results indicate that intestinal hormones play a critical role in the anorexia response induced by DON.

ACS Style

Jianming Yue; Dawei Guo; Xiuge Gao; Jiacai Wang; Eugenie Nepovimova; Wenda Wu; Kamil Kuca. Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice. Toxins 2021, 13, 512 .

AMA Style

Jianming Yue, Dawei Guo, Xiuge Gao, Jiacai Wang, Eugenie Nepovimova, Wenda Wu, Kamil Kuca. Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice. Toxins. 2021; 13 (8):512.

Chicago/Turabian Style

Jianming Yue; Dawei Guo; Xiuge Gao; Jiacai Wang; Eugenie Nepovimova; Wenda Wu; Kamil Kuca. 2021. "Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Mice." Toxins 13, no. 8: 512.

Editorial
Published: 19 July 2021 in Food and Chemical Toxicology
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The special issue "Mycotoxins in Food: New Determination Methods, Toxic Mechanisms, and Control Strategies" in Food and Chemical Toxicology contains 28 articles on current hot topics in mycotoxins, including deoxynivalenol, T-2 toxin, and fumonisins. Intestinal toxicity, immune toxicity, and oxidative stress are especially concerned by researchers in this special issue; moreover, mycotoxin detoxification and exposure and assessments in humans are reported in this context. All the new results in this special issue will help to further understand the toxic mechanisms of mycotoxins and cast new light for the control of mycotoxin contamination.

ACS Style

Ying Deng; Qinghua Wu; Wenda Wu; Kamil Kuca. New Determination Methods, Toxic Mechanisms, and Control Strategies (Preface to the special issue of Food and Chemical Toxicology on the Outcomes of Mycotoxins in Food). Food and Chemical Toxicology 2021, 155, 112436 .

AMA Style

Ying Deng, Qinghua Wu, Wenda Wu, Kamil Kuca. New Determination Methods, Toxic Mechanisms, and Control Strategies (Preface to the special issue of Food and Chemical Toxicology on the Outcomes of Mycotoxins in Food). Food and Chemical Toxicology. 2021; 155 ():112436.

Chicago/Turabian Style

Ying Deng; Qinghua Wu; Wenda Wu; Kamil Kuca. 2021. "New Determination Methods, Toxic Mechanisms, and Control Strategies (Preface to the special issue of Food and Chemical Toxicology on the Outcomes of Mycotoxins in Food)." Food and Chemical Toxicology 155, no. : 112436.

Review
Published: 12 July 2021 in International Journal of Molecular Sciences
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Rapid developments in the field of plant genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems necessitate more detailed consideration of the delivery of the CRISPR system into plants. Successful and safe editing of plant genomes is partly based on efficient delivery of the CRISPR system. Along with the use of plasmids and viral vectors as cargo material for genome editing, non-viral vectors have also been considered for delivery purposes. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, and protein- and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have a decreased immune response, an advantage over viral vectors, and offer additional flexibility in their design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. This review is dedicated to describing the delivery methods of CRISPR system into plants with emphasis on the use of non-viral vectors.

ACS Style

Mousa Alghuthaymi; Aftab Ahmad; Zulqurnain Khan; Sultan Khan; Farah Ahmed; Sajid Faiz; Eugenie Nepovimova; Kamil Kuča; Kamel Abd-Elsalam. Exosome/Liposome-like Nanoparticles: New Carriers for CRISPR Genome Editing in Plants. International Journal of Molecular Sciences 2021, 22, 7456 .

AMA Style

Mousa Alghuthaymi, Aftab Ahmad, Zulqurnain Khan, Sultan Khan, Farah Ahmed, Sajid Faiz, Eugenie Nepovimova, Kamil Kuča, Kamel Abd-Elsalam. Exosome/Liposome-like Nanoparticles: New Carriers for CRISPR Genome Editing in Plants. International Journal of Molecular Sciences. 2021; 22 (14):7456.

Chicago/Turabian Style

Mousa Alghuthaymi; Aftab Ahmad; Zulqurnain Khan; Sultan Khan; Farah Ahmed; Sajid Faiz; Eugenie Nepovimova; Kamil Kuča; Kamel Abd-Elsalam. 2021. "Exosome/Liposome-like Nanoparticles: New Carriers for CRISPR Genome Editing in Plants." International Journal of Molecular Sciences 22, no. 14: 7456.

Review article
Published: 08 July 2021 in Food and Chemical Toxicology
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The molecular target of mycotoxins is not fully understood. Extensive data derived from cell and animal experimental studies demonstrate that long non-coding RNAs (lncRNAs) play crucial roles in mycotoxin-induced toxicities. Mycotoxins stimulate the upregulation/downregulation of lncRNA expression, which further promote apoptosis, is related to the mTOR/FoxO signaling pathway, and contributes to tumor cell growth, death, and liver and chondrocyte damage. Moreover, lncRNA can establish interactions with NF-κB and cause immune evasion. These preliminary data suggest that lncRNAs are involved in potential upstream regulatory events and further regulate downstream apoptosis, oxidative stress, and anti-apoptotic events that affect cell death and survival. Therefore, we hypothesize that lncRNAs are potential targets of mycotoxins. Investigation of the expression of the potential target lncRNAs by mycotoxin-mediated stimulation, and exploration of the upstream and downstream relationship between lncRNA and the key proteins involved in mycotoxin toxicity, should be performed. This Hypothesis provides clues for further understanding of the molecular mechanisms of mycotoxins.

ACS Style

Li You; Xu Wang; Wenda Wu; Vesna Jaćević; Eugenie Nepovimova; Qinghua Wu; Kamil Kuca. Hypothesis: Long non-coding RNA is a potential target of mycotoxins. Food and Chemical Toxicology 2021, 155, 112397 .

AMA Style

Li You, Xu Wang, Wenda Wu, Vesna Jaćević, Eugenie Nepovimova, Qinghua Wu, Kamil Kuca. Hypothesis: Long non-coding RNA is a potential target of mycotoxins. Food and Chemical Toxicology. 2021; 155 ():112397.

Chicago/Turabian Style

Li You; Xu Wang; Wenda Wu; Vesna Jaćević; Eugenie Nepovimova; Qinghua Wu; Kamil Kuca. 2021. "Hypothesis: Long non-coding RNA is a potential target of mycotoxins." Food and Chemical Toxicology 155, no. : 112397.

Review
Published: 22 June 2021 in Journal of Fungi
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The global recognition for the potential of nanoproducts and processes in human biomedicine has given impetus for the development of novel strategies for rapid, reliable, and proficient diagnosis, prevention, and control of animal diseases. Nanomaterials exhibit significant antifungal and antimycotoxin activities against mycosis and mycotoxicosis disorders in animals, as evidenced through reports published over the recent decade and more. These nanoantifungals can be potentially utilized for the development of a variety of products of pharmaceutical and biomedical significance including the nano-scale vaccines, adjuvants, anticancer and gene therapy systems, farm disinfectants, animal husbandry, and nutritional products. This review will provide details on the therapeutic and preventative aspects of nanoantifungals against diverse fungal and mycotoxin-related diseases in animals. The predominant mechanisms of action of these nanoantifungals and their potential as antifungal and cytotoxicity-causing agents will also be illustrated. Also, the other theragnostic applications of nanoantifungals in veterinary medicine will be identified.

ACS Style

Mousa Alghuthaymi; Atef Hassan; Anu Kalia; Rasha Sayed El Ahl; Ahmed El Hamaky; Patrik Oleksak; Kamil Kuca; Kamel Abd-Elsalam. Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects. Journal of Fungi 2021, 7, 494 .

AMA Style

Mousa Alghuthaymi, Atef Hassan, Anu Kalia, Rasha Sayed El Ahl, Ahmed El Hamaky, Patrik Oleksak, Kamil Kuca, Kamel Abd-Elsalam. Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects. Journal of Fungi. 2021; 7 (7):494.

Chicago/Turabian Style

Mousa Alghuthaymi; Atef Hassan; Anu Kalia; Rasha Sayed El Ahl; Ahmed El Hamaky; Patrik Oleksak; Kamil Kuca; Kamel Abd-Elsalam. 2021. "Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects." Journal of Fungi 7, no. 7: 494.

Research article
Published: 18 June 2021 in Waves in Random and Complex Media
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Our skin reacts to various stimuli that we receive. Since all parts of the human body are controlled by the brain, a relationship should exist among brain and skin activities. This study evaluates the relation among skin and brain activities. As such, we benefited from the information-based analysis. We collected GSR and EEG signals of eight participants in various olfactory stimulations. Accordingly, we ran Shannon entropy-based analysis to evaluate the correlation between the information contents of these two signals. The results showed that the alterations in the complexity of stimulus and the information of GSR and EEG signals are strongly correlated. We also verified the results of the analysis of Shannon entropy of signals by calculating their Hurst exponent to quantify their memory. According to the results, the alterations of the memory of EEG and GSR signals are similar to the alterations of the information of these signals.

ACS Style

Shafiul Omam; Mohammad Hossein Babini; Sue Sim; Rui Tee; Visvamba Nathan; Soheil Gohari; Colin Burvill; Kamil Kuca; Ondrej Krejcar; Hamidreza Namazi. Decoding of the coupling between brain and skin activities in olfactory stimulation by analysis of EEG and GSR signals. Waves in Random and Complex Media 2021, 1 -15.

AMA Style

Shafiul Omam, Mohammad Hossein Babini, Sue Sim, Rui Tee, Visvamba Nathan, Soheil Gohari, Colin Burvill, Kamil Kuca, Ondrej Krejcar, Hamidreza Namazi. Decoding of the coupling between brain and skin activities in olfactory stimulation by analysis of EEG and GSR signals. Waves in Random and Complex Media. 2021; ():1-15.

Chicago/Turabian Style

Shafiul Omam; Mohammad Hossein Babini; Sue Sim; Rui Tee; Visvamba Nathan; Soheil Gohari; Colin Burvill; Kamil Kuca; Ondrej Krejcar; Hamidreza Namazi. 2021. "Decoding of the coupling between brain and skin activities in olfactory stimulation by analysis of EEG and GSR signals." Waves in Random and Complex Media , no. : 1-15.

Journal article
Published: 13 June 2021 in Toxins
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A host’s immune system can be invaded by mycotoxin deoxynivalenol (DON) poisoning and porcine circovirus type 2 (PCV2) infections, which affect the host’s natural immune function. Pro-inflammatory cytokines, IL-1β and IL-6, are important regulators in the process of natural immune response, which participate in inflammatory response and enhance immune-mediated tissue damage. Preliminary studies have shown that DON promotes PCV2 infection by activating the MAPK signaling pathway. Here, we explored whether the mRNA expression of IL-1β and IL-6, induced by the combination of DON and PCV2, would depend on the MAPK signaling pathway. Specific pharmacological antagonists U0126, SP600125 and SB203580, were used to inhibit the activities of ERK, JNK and p38 in the MAPK signaling pathway, respectively. Then, the mRNA expression of IL-1β and IL-6 in PK-15 cells was detected to explore the effect of the MAPK signaling pathway on IL-1β and IL-6 mRNA induced by DON and PCV2. The results showed that PK-15 cells treated with DON or PCV2 induced the mRNA expression of IL-1β and IL-6 in a time- and dose-dependent manner. The combination of DON and PCV2 has an additive effect on inducing the mRNA expression of IL-1β and IL-6. Additionally, both DON and PCV2 could induce the mRNA expression of IL-1β and IL-6 via the ERK and the p38 MAPK signal pathways, while PCV2 could induce it via the JNK signal pathway. Taken together, our results suggest that MAPKs play a contributory role in IL-1β and IL-6 mRNA expression when induced by both DON and PCV2.

ACS Style

Chao Gu; Xiuge Gao; Dawei Guo; Jiacai Wang; Qinghua Wu; Eugenie Nepovimova; Wenda Wu; Kamil Kuca. Combined Effect of Deoxynivalenol (DON) and Porcine Circovirus Type 2 (Pcv2) on Inflammatory Cytokine mRNA Expression. Toxins 2021, 13, 422 .

AMA Style

Chao Gu, Xiuge Gao, Dawei Guo, Jiacai Wang, Qinghua Wu, Eugenie Nepovimova, Wenda Wu, Kamil Kuca. Combined Effect of Deoxynivalenol (DON) and Porcine Circovirus Type 2 (Pcv2) on Inflammatory Cytokine mRNA Expression. Toxins. 2021; 13 (6):422.

Chicago/Turabian Style

Chao Gu; Xiuge Gao; Dawei Guo; Jiacai Wang; Qinghua Wu; Eugenie Nepovimova; Wenda Wu; Kamil Kuca. 2021. "Combined Effect of Deoxynivalenol (DON) and Porcine Circovirus Type 2 (Pcv2) on Inflammatory Cytokine mRNA Expression." Toxins 13, no. 6: 422.

Review
Published: 06 June 2021 in Molecules
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The ingestion of contaminated water and food is known to cause food illness. Moreover, on assessing the patients suffering from foodborne disease has revealed the role of microbes in such diseases. Concerning which different methods have been developed for protecting food from microbes, the treatment of food with chemicals has been reported to exhibit an unwanted organoleptic effect while also affecting the nutritional value of food. Owing to these challenges, the demand for natural food preservatives has substantially increased. Therefore, the interest of researchers and food industries has shifted towards fruit polyphenols as potent inhibitors of foodborne bacteria. Recently, numerous fruit polyphenols have been acclaimed for their ability to avert toxin production and biofilm formation. Furthermore, various studies have recommended using fruit polyphenols solely or in combination with chemical disinfectants and food preservatives. Currently, different nanoparticles have been synthesized using fruit polyphenols to curb the growth of pathogenic microbes. Hence, this review intends to summarize the current knowledge about fruit polyphenols as antibacterial agents against foodborne pathogens. Additionally, the application of different fruit extracts in synthesizing functionalized nanoparticles has also been discussed.

ACS Style

Harsh Kumar; Kanchan Bhardwaj; Natália Cruz-Martins; Eugenie Nepovimova; Patrik Oleksak; Daljeet Dhanjal; Sonali Bhardwaj; Reena Singh; Chirag Chopra; Rachna Verma; Prem Chauhan; Dinesh Kumar; Kamil Kuča. Applications of Fruit Polyphenols and Their Functionalized Nanoparticles Against Foodborne Bacteria: A Mini Review. Molecules 2021, 26, 3447 .

AMA Style

Harsh Kumar, Kanchan Bhardwaj, Natália Cruz-Martins, Eugenie Nepovimova, Patrik Oleksak, Daljeet Dhanjal, Sonali Bhardwaj, Reena Singh, Chirag Chopra, Rachna Verma, Prem Chauhan, Dinesh Kumar, Kamil Kuča. Applications of Fruit Polyphenols and Their Functionalized Nanoparticles Against Foodborne Bacteria: A Mini Review. Molecules. 2021; 26 (11):3447.

Chicago/Turabian Style

Harsh Kumar; Kanchan Bhardwaj; Natália Cruz-Martins; Eugenie Nepovimova; Patrik Oleksak; Daljeet Dhanjal; Sonali Bhardwaj; Reena Singh; Chirag Chopra; Rachna Verma; Prem Chauhan; Dinesh Kumar; Kamil Kuča. 2021. "Applications of Fruit Polyphenols and Their Functionalized Nanoparticles Against Foodborne Bacteria: A Mini Review." Molecules 26, no. 11: 3447.

Review
Published: 28 May 2021 in Journal of Fungi
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Currently, the food and agricultural sectors are concerned about environmental problems caused by raw material waste, and they are looking for strategies to reduce the growing amount of waste disposal. Now, approaches are being explored that could increment and provide value-added products from agricultural waste to contribute to the circular economy and environmental protection. Edible mushrooms have been globally appreciated for their medicinal properties and nutritional value, but during the mushroom production process nearly one-fifth of the mushroom gets wasted. Therefore, improper disposal of mushrooms and untreated residues can cause fungal disease. The residues of edible mushrooms, being rich in sterols, vitamin D2, amino acids, and polysaccharides, among others, makes it underutilized waste. Most of the published literature has primarily focused on the isolation of bioactive components of these edible mushrooms; however, utilization of waste or edible mushrooms themselves, for the production of value-added products, has remained an overlooked area. Waste of edible mushrooms also represents a disposal problem, but they are a rich source of important compounds, owing to their nutritional and functional properties. Researchers have started exploiting edible mushroom by-products/waste for value-added goods with applications in diverse fields. Bioactive compounds obtained from edible mushrooms are being used in media production and skincare formulations. Furthermore, diverse applications from edible mushrooms are also being explored, including the synthesis of biosorbent, biochar, edible films/coating, probiotics, nanoparticles and cosmetic products. The primary intent of this review is to summarize the information related to edible mushrooms and their valorization in developing value-added products with industrial applications.

ACS Style

Harsh Kumar; Kanchan Bhardwaj; Ruchi Sharma; Eugenie Nepovimova; Natália Cruz-Martins; Daljeet Dhanjal; Reena Singh; Chirag Chopra; Rachna Verma; Kamel Abd-Elsalam; Ashwani Tapwal; Kamil Musilek; Dinesh Kumar; Kamil Kuča. Potential Usage of Edible Mushrooms and Their Residues to Retrieve Valuable Supplies for Industrial Applications. Journal of Fungi 2021, 7, 427 .

AMA Style

Harsh Kumar, Kanchan Bhardwaj, Ruchi Sharma, Eugenie Nepovimova, Natália Cruz-Martins, Daljeet Dhanjal, Reena Singh, Chirag Chopra, Rachna Verma, Kamel Abd-Elsalam, Ashwani Tapwal, Kamil Musilek, Dinesh Kumar, Kamil Kuča. Potential Usage of Edible Mushrooms and Their Residues to Retrieve Valuable Supplies for Industrial Applications. Journal of Fungi. 2021; 7 (6):427.

Chicago/Turabian Style

Harsh Kumar; Kanchan Bhardwaj; Ruchi Sharma; Eugenie Nepovimova; Natália Cruz-Martins; Daljeet Dhanjal; Reena Singh; Chirag Chopra; Rachna Verma; Kamel Abd-Elsalam; Ashwani Tapwal; Kamil Musilek; Dinesh Kumar; Kamil Kuča. 2021. "Potential Usage of Edible Mushrooms and Their Residues to Retrieve Valuable Supplies for Industrial Applications." Journal of Fungi 7, no. 6: 427.

Review
Published: 28 May 2021 in Plants
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Drug resistance among microbial pathogens and oxidative stress caused by reactive oxygen species are two of the most challenging global issues. Firstly, drug-resistant pathogens cause several fatalities every year. Secondly aging and a variety of diseases, such as cardiovascular disease and cancer, are associated with free radical generated oxidative stress. The treatments currently available are limited, ineffective, or less efficient, so there is an immediate need to tackle these issues by looking for new therapies to resolve resistance and neutralize the harmful effects of free radicals. In the 21st century, the best way to save humans from them could be by using plants as well as their bioactive constituents. In this specific context, Jasminum is a major plant genus that is used in the Ayurvedic system of medicine to treat a variety of ailments. The information in this review was gathered from a variety of sources, including books, websites, and databases such as Science Direct, PubMed, and Google Scholar. In this review, a total of 14 species of Jasminum have been found to be efficient and effective against a wide variety of microbial pathogens. In addition, 14 species were found to be active free radical scavengers. The review is also focused on the disorders related to oxidative stress, and it was concluded that Jasminum grandiflorum and J. sambac normalized various parameters that were elevated by free radical generation. Alkaloids, flavonoids (rutoside), terpenes, phenols, and iridoid glucosides are among the main phytoconstituents found in various Jasminum species. Furthermore, this review also provides insight into the mechanistic basis of drug resistance, the generation of free radicals, and the role of Jasminum plants in combating resistance and neutralizing free radicals.

ACS Style

Acharya Balkrishna; Akansha Rohela; Abhishek Kumar; Ashwani Kumar; Vedpriya Arya; Pallavi Thakur; Patrik Oleksak; Ondrej Krejcar; Rachna Verma; Dinesh Kumar; Kamil Kuca. Mechanistic Insight into Antimicrobial and Antioxidant Potential of Jasminum Species: A Herbal Approach for Disease Management. Plants 2021, 10, 1089 .

AMA Style

Acharya Balkrishna, Akansha Rohela, Abhishek Kumar, Ashwani Kumar, Vedpriya Arya, Pallavi Thakur, Patrik Oleksak, Ondrej Krejcar, Rachna Verma, Dinesh Kumar, Kamil Kuca. Mechanistic Insight into Antimicrobial and Antioxidant Potential of Jasminum Species: A Herbal Approach for Disease Management. Plants. 2021; 10 (6):1089.

Chicago/Turabian Style

Acharya Balkrishna; Akansha Rohela; Abhishek Kumar; Ashwani Kumar; Vedpriya Arya; Pallavi Thakur; Patrik Oleksak; Ondrej Krejcar; Rachna Verma; Dinesh Kumar; Kamil Kuca. 2021. "Mechanistic Insight into Antimicrobial and Antioxidant Potential of Jasminum Species: A Herbal Approach for Disease Management." Plants 10, no. 6: 1089.

Journal article
Published: 27 May 2021 in Biology
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To develop a benign nanomaterial from biogenic sources, we have attempted to formulate and fabricate silver nanoparticles synthesized from the culture filtrate of an endophytic fungus Penicillium oxalicum strain LA-1 (PoAgNPs). The synthesized PoAgNPs were exclusively characterized through UV–vis absorption spectroscopy, Fourier Transform Infra-Red spectroscopy (FT-IR), X-ray powder diffraction (XRD), and Transmission Electron Microscopy (TEM) with energy dispersive X-ray spectroscopy (EDX). The synthesized nanoparticles showed strong absorbance around 430 nm with surface plasmon resonance (SPR) and exhibited a face-centered cubic crystalline nature in XRD analysis. Proteins presented in the culture filtrate acted as reducing, capping, and stabilization agents to form PoAgNPs. TEM analysis revealed the generation of polydispersed spherical PoAgNPs with an average size of 52.26 nm. The PoAgNPs showed excellent antibacterial activity against bacterial pathogens. The PoAgNPs induced a dose-dependent cytotoxic activity against human adenocarcinoma breast cancer cell lines (MDA-MB-231), and apoptotic morphological changes were observed by dual staining. Additionally, PoAgNPs demonstrated better larvicidal activity against the larvae of Culex quinquefasciatus. Moreover, the hemolytic test indicated that the as-synthesized PoAgNPs are a safe and biocompatible nanomaterial with versatile bio-applications.

ACS Style

Prabu Seetharaman; Rajkuberan Chandrasekaran; Rajiv Periakaruppan; Sathishkumar Gnanasekar; Sivaramakrishnan Sivaperumal; Kamel Abd-Elsalam; Martin Valis; Kamil Kuca. Functional Attributes of Myco-Synthesized Silver Nanoparticles from Endophytic Fungi: A New Implication in Biomedical Applications. Biology 2021, 10, 473 .

AMA Style

Prabu Seetharaman, Rajkuberan Chandrasekaran, Rajiv Periakaruppan, Sathishkumar Gnanasekar, Sivaramakrishnan Sivaperumal, Kamel Abd-Elsalam, Martin Valis, Kamil Kuca. Functional Attributes of Myco-Synthesized Silver Nanoparticles from Endophytic Fungi: A New Implication in Biomedical Applications. Biology. 2021; 10 (6):473.

Chicago/Turabian Style

Prabu Seetharaman; Rajkuberan Chandrasekaran; Rajiv Periakaruppan; Sathishkumar Gnanasekar; Sivaramakrishnan Sivaperumal; Kamel Abd-Elsalam; Martin Valis; Kamil Kuca. 2021. "Functional Attributes of Myco-Synthesized Silver Nanoparticles from Endophytic Fungi: A New Implication in Biomedical Applications." Biology 10, no. 6: 473.

Journal article
Published: 27 May 2021 in Military Medical Science Letters
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Jiří Patočka; Zdeňka Navrátilová; Kamil Kuča; Patrik Olekšák; Uday Kumar Killi. CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19? Military Medical Science Letters 2021, 1 .

AMA Style

Jiří Patočka, Zdeňka Navrátilová, Kamil Kuča, Patrik Olekšák, Uday Kumar Killi. CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19? Military Medical Science Letters. 2021; ():1.

Chicago/Turabian Style

Jiří Patočka; Zdeňka Navrátilová; Kamil Kuča; Patrik Olekšák; Uday Kumar Killi. 2021. "CAN BAICALEIN BECOME A NEW DRUG FOR COVID-19?" Military Medical Science Letters , no. : 1.

Review
Published: 18 May 2021 in Molecules
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Conifers have long been recognized for their therapeutic potential in different disorders. Alkaloids, terpenes and polyphenols are the most abundant naturally occurring phytochemicals in these plants. Here, we provide an overview of the phytochemistry and related commercial products obtained from conifers. The pharmacological actions of different phytochemicals present in conifers against bacterial and fungal infections, cancer, diabetes and cardiovascular diseases are also reviewed. Data obtained from experimental and clinical studies performed to date clearly underline that such compounds exert promising antioxidant effects, being able to inhibit cell damage, cancer growth, inflammation and the onset of neurodegenerative diseases. Therefore, an attempt has been made with the intent to highlight the importance of conifer-derived extracts for pharmacological purposes, with the support of relevant in vitro and in vivo experimental data. In short, this review comprehends the information published to date related to conifers’ phytochemicals and illustrates their potential role as drugs.

ACS Style

Kanchan Bhardwaj; Ana Silva; Maria Atanassova; Rohit Sharma; Eugenie Nepovimova; Kamil Musilek; Ruchi Sharma; Mousa Alghuthaymi; Daljeet Dhanjal; Marcello Nicoletti; Bechan Sharma; Navneet Upadhyay; Natália Cruz-Martins; Prerna Bhardwaj; Kamil Kuča. Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential. Molecules 2021, 26, 3005 .

AMA Style

Kanchan Bhardwaj, Ana Silva, Maria Atanassova, Rohit Sharma, Eugenie Nepovimova, Kamil Musilek, Ruchi Sharma, Mousa Alghuthaymi, Daljeet Dhanjal, Marcello Nicoletti, Bechan Sharma, Navneet Upadhyay, Natália Cruz-Martins, Prerna Bhardwaj, Kamil Kuča. Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential. Molecules. 2021; 26 (10):3005.

Chicago/Turabian Style

Kanchan Bhardwaj; Ana Silva; Maria Atanassova; Rohit Sharma; Eugenie Nepovimova; Kamil Musilek; Ruchi Sharma; Mousa Alghuthaymi; Daljeet Dhanjal; Marcello Nicoletti; Bechan Sharma; Navneet Upadhyay; Natália Cruz-Martins; Prerna Bhardwaj; Kamil Kuča. 2021. "Conifers Phytochemicals: A Valuable Forest with Therapeutic Potential." Molecules 26, no. 10: 3005.

Review
Published: 04 May 2021 in Current Medicinal Chemistry
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: There is a new public health crisis threatening the world with the emergence and spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was later named as a novel Coronavirus disease or COVID-19. It was then declared a pandemic by the World Health Organization on March 11, 2020. The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China, in December 2019. As of February 5, 2021, 103 million laboratory-confirmed cases and nearly 2.3 million deaths have been reported globally. The number of death tolls continue to rise, and a large number of countries have been forced to implement social distancing and lockdown. As per literature, Coronavirus is transmitted human to human or human to animal via airborne droplets. Coronavirus enters the human cell through membrane ACE-2 exopeptidase receptor. WHO, ECDC, and ICMR advised to avoid public places and close contact with infected persons and pet animals. To date, there is no evidence of any effective treatment for COVID-19. The main therapies being used to treat the disease are antiviral drugs, chloroquine/hydroxychloroquine, and respiratory therapy. Although several therapies have been proposed, quarantine is the only intervention that appears to be effective in decreasing the contagion rate. We conducted a literature review of publicly available information to summarize knowledge about the pathogen and the current epidemic. In the present literature review, the causative agents of the pandemic, epidemiology, pathogenesis, and diagnosis techniques are discussed. Further, currently used treatment and prevention strategies along with vaccine trials and computational tools are all described in detail.

ACS Style

Rahul Sharma; Dharmendra Khokhar; Bhanushree Gupta; Purnendu Saxena; Kallol Kumar Ghosh; Arvind Kumar Geda; Kamil Kuca. Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A Review on Pathophysiology, Diagnosis and Investigational Therapeutics. Current Medicinal Chemistry 2021, 28, 1 -1.

AMA Style

Rahul Sharma, Dharmendra Khokhar, Bhanushree Gupta, Purnendu Saxena, Kallol Kumar Ghosh, Arvind Kumar Geda, Kamil Kuca. Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A Review on Pathophysiology, Diagnosis and Investigational Therapeutics. Current Medicinal Chemistry. 2021; 28 ():1-1.

Chicago/Turabian Style

Rahul Sharma; Dharmendra Khokhar; Bhanushree Gupta; Purnendu Saxena; Kallol Kumar Ghosh; Arvind Kumar Geda; Kamil Kuca. 2021. "Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A Review on Pathophysiology, Diagnosis and Investigational Therapeutics." Current Medicinal Chemistry 28, no. : 1-1.