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Zhiyuan Zhang
School of Mechanical Engineering, Yanshan University, Qinhuangdao City 066004, China

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Journal article
Published: 06 August 2019 in Metals
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Aiming at the forming efficiency and roundness of the longitudinal submerged arc welded (LSAW) pipes in JCO (J-shape to C-shape to O-shape) forming process, this paper proposes a four-point air bending process. Compared with the traditional three-point air bending process, The new process can provide a more uniform bending moment, does not need to crimp the edges of steel sheet, shorten the residual straight segment length, and lengthen the forming length in single pass. The mechanical model is established to analyze the static equilibrium conditions and elastic–plastic deformation. The process is simulated by using the software package ABAQUS, to find the maximum punch spacing, and further determine the formulation principles of other process parameters. In addition, a contour detection method for the LSAW pipes in forming process is proposed based on machine vision (planar-array CCD camera produced by Gray Point Corporation, Vancouver, Canada). This method can not only quickly detect the contour of each pass, but also splice the detected contours together to obtain the overall contour with the given splicing algorithm. According to the measured contour, the bending angle, radius, and roundness can be calculated, to correct the punch reduction in the next pass and improve the forming accuracy of the pipes. Finally, an experimental system is designed to verify the proposed four-point bending JCO forming process and contour detection method. The result shows that the error between the contour detection method and CMM (coordinate measuring machine) is less than 0.5% for the overall contour, the two experimental pipes require 13 and 15 passes respectively, the roundness of pipes are less than 1.1%, which is much better than that of traditional three-point bending JCO forming process.

ACS Style

Zhiyuan Zhang; Haoran Wang; Gaochao Yu; Jun Zhao; Wang; Yu; Zhao. Research on Four-Point Air Bending Process and Contour Detection Method for JCO Forming Process of LSAW Pipes. Metals 2019, 9, 859 .

AMA Style

Zhiyuan Zhang, Haoran Wang, Gaochao Yu, Jun Zhao, Wang, Yu, Zhao. Research on Four-Point Air Bending Process and Contour Detection Method for JCO Forming Process of LSAW Pipes. Metals. 2019; 9 (8):859.

Chicago/Turabian Style

Zhiyuan Zhang; Haoran Wang; Gaochao Yu; Jun Zhao; Wang; Yu; Zhao. 2019. "Research on Four-Point Air Bending Process and Contour Detection Method for JCO Forming Process of LSAW Pipes." Metals 9, no. 8: 859.

Journal article
Published: 07 April 2018 in Thin-Walled Structures
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In the over-bend straightening process of longitudinally submerged arc welding (LSAW) pipes, the cross section tends to be distorted due to the axial curvature variation in the reverse elastic-plastic bending. Based on the minimum work principle, a analytical model of the cross-sectional distortion of the curved pipe with initial curvature in the reverse axial elastoplastic bending is established, and the prediction error is not more than 10% compared with the experimental value of the maximum distortion coefficient. Especially for smaller deformations and thinner pipes, the prediction accuracy is higher. Compared to ovality, the maximum distortion coefficient with a smaller error can be used as an effective prediction parameter. In addition, the application of this prediction model is analyzed by an example of a straightness-offgrade LSAW pipe. The results show that the maximum value and position of cross section with most serious distortion can be determined once the initial curvature of a curved pipe is measured, which can be compared with the standard to adjust the shape of the straightening tools and process parameters.

ACS Style

Chunge Wang; Zhiyuan Zhang; Ruixue Zhai; Gaochao Yu; Jun Zhao. Cross-sectional distortion of LSAW pipes in over-bend straightening process. Thin-Walled Structures 2018, 129, 85 -93.

AMA Style

Chunge Wang, Zhiyuan Zhang, Ruixue Zhai, Gaochao Yu, Jun Zhao. Cross-sectional distortion of LSAW pipes in over-bend straightening process. Thin-Walled Structures. 2018; 129 ():85-93.

Chicago/Turabian Style

Chunge Wang; Zhiyuan Zhang; Ruixue Zhai; Gaochao Yu; Jun Zhao. 2018. "Cross-sectional distortion of LSAW pipes in over-bend straightening process." Thin-Walled Structures 129, no. : 85-93.

Article
Published: 16 October 2013 in Clinical Implant Dentistry and Related Research
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Background The repair of segmental mandibular defects remains challenging in the clinic. Previous studies have shown that cryopreserved bone‐derived osteoblasts (CBOs) have good proliferation and osteogenicity. However, whether these cells can be used in the repair of segmental mandibular defects is largely unknown. Purpose In this study, we applied CBOs combined with beta‐tricalcium phosphate (β‐TCP) to repair a segmental mandibular defect in canines and thus established the feasibility of using this type of tissue‐bank cell for the repair of large bone defects in the future. Material and Methods Sixteen segmental mandibular defects in 16 animals were made on the right side. Sequential radiographs, computer tomography, polychrome fluorescent labeling, immunohistochemical staining, and histological analysis were used to evaluate the effects of tissue‐engineered bone for segmental mandibular defects. Results Our results demonstrated that CBOs combined with β‐TCP promoted bone mineralization and deposition at the early stage, and bony union was achieved in the CBO and fresh bone‐derived osteoblast (FBO) groups. However, nonunion and minimal callus were present in the β‐TCP group. Furthermore, there was a large amount of newly formed bone in the CBO and FBO groups and in the autogenous bone group. Additionally, osteocalcin immunohistochemistry showed intensive osteocalcin immunoreactivity in the bone matrix of the CBO and FBO groups. Conclusions These data indicate that CBOs implanted in a scaffold can promote new bone formation, and this tissue‐engineered bone can repair critically sized segmental mandibular defects in canines. The use of CBOs combined with β‐TCP may be an effective approach for the reconstruction of segmental mandibular defects in the clinic.

ACS Style

Shaoyi Wang; Jun Zhao; Wenjie Zhang; Dongxia Ye; Xiaochen Zhang; Duohong Zou; Xiuli Zhang; Xiaojuan Sun; Shuyang Sun; Weijie Zhang; Chi Yang; Xinquan Jiang; Zhiyuan Zhang. Comprehensive Evaluation of Cryopreserved Bone-Derived Osteoblasts for the Repair of Segmental Mandibular Defects in Canines. Clinical Implant Dentistry and Related Research 2013, 17, 798 -810.

AMA Style

Shaoyi Wang, Jun Zhao, Wenjie Zhang, Dongxia Ye, Xiaochen Zhang, Duohong Zou, Xiuli Zhang, Xiaojuan Sun, Shuyang Sun, Weijie Zhang, Chi Yang, Xinquan Jiang, Zhiyuan Zhang. Comprehensive Evaluation of Cryopreserved Bone-Derived Osteoblasts for the Repair of Segmental Mandibular Defects in Canines. Clinical Implant Dentistry and Related Research. 2013; 17 (4):798-810.

Chicago/Turabian Style

Shaoyi Wang; Jun Zhao; Wenjie Zhang; Dongxia Ye; Xiaochen Zhang; Duohong Zou; Xiuli Zhang; Xiaojuan Sun; Shuyang Sun; Weijie Zhang; Chi Yang; Xinquan Jiang; Zhiyuan Zhang. 2013. "Comprehensive Evaluation of Cryopreserved Bone-Derived Osteoblasts for the Repair of Segmental Mandibular Defects in Canines." Clinical Implant Dentistry and Related Research 17, no. 4: 798-810.

Journal article
Published: 01 January 2012 in Tissue Engineering Part A
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Calcium phosphate cements (CPCs), which are widely used in bone regeneration, possess good biocompatibility and osteoconductivity and have been demonstrated to be candidate carriers for bone growth factors. However, limited release of growth factors from CPCs and slow degradation of the materials are not desirable for certain clinical applications. Previous studies have shown that calcium-deficient hydroxyapatite (CDHA) from CPCs presents more rapid degradation rate than CPCs. In this study, a hybrid growth factor delivery system was prepared by using bone morphogenetic protein 2 (BMP-2) loaded CDHA porous scaffold with sulfated chitosan (SCS) coating for improved release profile. We tested the BMP-2 release characteristic of CDHA/BMP-2/SCS composite in vitro and its ability to repair rat calvarial bone defects. A higher percentage of BMP-2 was released when sulfated chitosan coating was present compared with CDHA/BMP-2 group. Eight weeks postoperation, the repaired crania were evaluated by microcomputed tomography, sequential fluorescent labeling, histological analysis, and immunohistochemistry. CDHA/BMP-2/SCS group promoted the most extensive new bone formation than CDHA/BMP-2 and CDHA groups. Our observations suggest that sulfated chitosan coating could enhance the release profile of CDHA/BMP-2 composite in vitro and promote new bone formation in vivo. The hybrid CDHA/BMP-2/SCS system is a promising growth factor delivery strategy for bone regeneration.

ACS Style

Jun Zhao; Gang Shen; Changsheng Liu; Shaoyi Wang; Wenjie Zhang; Xiaochen Zhang; Xiuli Zhang; Dongxia Ye; Jie Wei; Zhiyuan Zhang; Xinquan Jiang. Enhanced Healing of Rat Calvarial Defects with Sulfated Chitosan-Coated Calcium-Deficient Hydroxyapatite/Bone Morphogenetic Protein 2 Scaffolds. Tissue Engineering Part A 2012, 18, 185 -197.

AMA Style

Jun Zhao, Gang Shen, Changsheng Liu, Shaoyi Wang, Wenjie Zhang, Xiaochen Zhang, Xiuli Zhang, Dongxia Ye, Jie Wei, Zhiyuan Zhang, Xinquan Jiang. Enhanced Healing of Rat Calvarial Defects with Sulfated Chitosan-Coated Calcium-Deficient Hydroxyapatite/Bone Morphogenetic Protein 2 Scaffolds. Tissue Engineering Part A. 2012; 18 (1-2):185-197.

Chicago/Turabian Style

Jun Zhao; Gang Shen; Changsheng Liu; Shaoyi Wang; Wenjie Zhang; Xiaochen Zhang; Xiuli Zhang; Dongxia Ye; Jie Wei; Zhiyuan Zhang; Xinquan Jiang. 2012. "Enhanced Healing of Rat Calvarial Defects with Sulfated Chitosan-Coated Calcium-Deficient Hydroxyapatite/Bone Morphogenetic Protein 2 Scaffolds." Tissue Engineering Part A 18, no. 1-2: 185-197.

Evaluation study
Published: 31 July 2011 in Biomaterials
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Cryopreserved bone-derived osteoblasts (CBOs) have been considered as a promising cell source for bone regeneration. Previous studies have demonstrated that CBOs had good proliferation and osteogenicity. However, the long-term outcome of CBOs in vivo still remains unknown. In this experiment, we applied CBOs combined with calcium phosphate cement (CPC) to augment maxillary sinus in canine, computer tomography, polychrome labeling, biomechanical tests, fluorescent immunohistochemistry staining and histological analysis were used to analyze the property and mineralization process of the tissue-engineered bone preclinical application. Our results showed that CBOs combined with CPC could promote bone regeneration, dramatically maintain the height, volume and biomechanical property of augmented maxillary sinus. Furthermore, the tissue-engineered bone was more mature than scaffold alone or autogenous bone, and bone formation and remodeling were still apparent 20 months postoperatively. Additionally, 4 months after surgery might be the suitable time point for implants placement in the regenerated bone. These results also indicate that cryopreserved bone may be a potential source of osteoblasts for maxillary sinus augmentation.

ACS Style

Shaoyi Wang; Wenjie Zhang; Jun Zhao; Dongxia Ye; Chao Zhu; Yunhao Yang; Xiuli Zhang; Xiaojuan Sun; Chi Yang; Xinquan Jiang; Zhiyuan Zhang. Long-term outcome of cryopreserved bone-derived osteoblasts for bone regeneration in vivo. Biomaterials 2011, 32, 4546 -4555.

AMA Style

Shaoyi Wang, Wenjie Zhang, Jun Zhao, Dongxia Ye, Chao Zhu, Yunhao Yang, Xiuli Zhang, Xiaojuan Sun, Chi Yang, Xinquan Jiang, Zhiyuan Zhang. Long-term outcome of cryopreserved bone-derived osteoblasts for bone regeneration in vivo. Biomaterials. 2011; 32 (20):4546-4555.

Chicago/Turabian Style

Shaoyi Wang; Wenjie Zhang; Jun Zhao; Dongxia Ye; Chao Zhu; Yunhao Yang; Xiuli Zhang; Xiaojuan Sun; Chi Yang; Xinquan Jiang; Zhiyuan Zhang. 2011. "Long-term outcome of cryopreserved bone-derived osteoblasts for bone regeneration in vivo." Biomaterials 32, no. 20: 4546-4555.

Journal article
Published: 19 July 2011 in STEM CELLS
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The processes of angiogenesis and bone formation are coupled both temporally and spatially during bone repair. Bone marrow‐derived mesenchymal stem cells (BMSCs) have been effectively used to heal critical‐size bone defects. Enhancing their ability to undergo angiogenic and osteogenic differentiation will enhance their potential use in bone regeneration. Hypoxia‐inducible factor‐1α (HIF‐1α) has recently been identified as a major regulator of angiogenic‐osteogenic coupling. In this study, we tested the hypothesis that HIF‐1α gene therapy could be used to promote the repair of critical‐sized bone defects. Using lentivirus‐mediated delivery of wild‐type (HIF) or constitutively active HIF‐1α (cHIF), we found that in cultured BMSCs in vitro, HIF and cHIF significantly enhanced osteogenic and angiogenic mRNA and protein expression when compared with the LacZ group. We found that HIF‐1α‐overexpressing BMSCs dramatically improved the repair of critical‐sized calvarial defects, including increased bone volume, bone mineral density, blood vessel number, and blood vessel area in vivo. These data confirm the essential role of HIF‐1α modified BMSCs in angiogenesis and osteogenesis in vitro and in vivo. STEM CELLS 2011;29:1380–1390

ACS Style

Duohong Zou; Zhiyuan Zhang; Dongxia Ye; Aifa Tang; Lianfu Deng; Wei Han; Jun Zhao; Shuhong Wang; Wenjie Zhang; Chao Zhu; Jian Zhou; Jiacai He; Yuanyin Wang; Feng Xu; Yuanliang Huang; Xinquan Jiang. Repair of Critical-Sized Rat Calvarial Defects Using Genetically Engineered BMSCs Overexpressing HIF-1α. STEM CELLS 2011, 29, 1380 -1390.

AMA Style

Duohong Zou, Zhiyuan Zhang, Dongxia Ye, Aifa Tang, Lianfu Deng, Wei Han, Jun Zhao, Shuhong Wang, Wenjie Zhang, Chao Zhu, Jian Zhou, Jiacai He, Yuanyin Wang, Feng Xu, Yuanliang Huang, Xinquan Jiang. Repair of Critical-Sized Rat Calvarial Defects Using Genetically Engineered BMSCs Overexpressing HIF-1α. STEM CELLS. 2011; 29 (9):1380-1390.

Chicago/Turabian Style

Duohong Zou; Zhiyuan Zhang; Dongxia Ye; Aifa Tang; Lianfu Deng; Wei Han; Jun Zhao; Shuhong Wang; Wenjie Zhang; Chao Zhu; Jian Zhou; Jiacai He; Yuanyin Wang; Feng Xu; Yuanliang Huang; Xinquan Jiang. 2011. "Repair of Critical-Sized Rat Calvarial Defects Using Genetically Engineered BMSCs Overexpressing HIF-1α." STEM CELLS 29, no. 9: 1380-1390.

Journal article
Published: 31 May 2009 in Biomaterials
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A tissue-engineered bone has become a viable alternative to autologous bone for bone augmentation in atrophy alveolar ridge. The aim of the present study was to evaluate porous β-tricalcium phosphate (β-TCP) combined with autologous osteoblasts to augment edentulous alveolar ridge in a canine model. Autologous osteoblasts were expanded and combined with β-TCP scaffold to fabricate a tissue-engineered bone. 12 bilateral alveolar ridge augmentation surgeries were carried out in 6 beagle dogs with the following 3 groups: β-TCP/osteoblasts, β-TCP alone and autogenous iliac bone control (n = 4 per group). Sequential fluorescent labeling and radiographs were used to compare new bone formation and mineralization in each group. 24 weeks later, animals were sacrificed and non-decalcified and decalcified sections were evaluated histologically and histomorphometrically. Results indicated that the tissue-engineered bone dramatically enhanced new bone formation and mineralization, increase the new bone area, and maintain the height and thickness of the augmented alveolar ridge when compared with β-TCP alone group. More importantly, the tissue-engineered bone achieved an elevated bone height and thickness comparable to that of autogenous iliac bone graft. This study demonstrated the potential of porous β-TCP as a substrate for autogenous osteoblasts in bone tissue engineering for alveolar ridge augmentation.

ACS Style

Shaoyi Wang; Zhiyuan Zhang; Jun Zhao; Xiuli Zhang; Xiaojuan Sun; Lunguo Xia; Qing Chang; Dongxia Ye; Xinquan Jiang. Vertical alveolar ridge augmentation with β-tricalcium phosphate and autologous osteoblasts in canine mandible. Biomaterials 2009, 30, 2489 -2498.

AMA Style

Shaoyi Wang, Zhiyuan Zhang, Jun Zhao, Xiuli Zhang, Xiaojuan Sun, Lunguo Xia, Qing Chang, Dongxia Ye, Xinquan Jiang. Vertical alveolar ridge augmentation with β-tricalcium phosphate and autologous osteoblasts in canine mandible. Biomaterials. 2009; 30 (13):2489-2498.

Chicago/Turabian Style

Shaoyi Wang; Zhiyuan Zhang; Jun Zhao; Xiuli Zhang; Xiaojuan Sun; Lunguo Xia; Qing Chang; Dongxia Ye; Xinquan Jiang. 2009. "Vertical alveolar ridge augmentation with β-tricalcium phosphate and autologous osteoblasts in canine mandible." Biomaterials 30, no. 13: 2489-2498.

Journal article
Published: 20 April 2009 in Chinese Medical Journal
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ACS Style

Jing-Zhou Hu; Zhi-Yuan Zhang; Jun Zhao; Xiu-Li Zhang; Gen-Tao Liu; Xin-Quan Jiang. An ectopic study of tissue-engineered bone with Nell-1 gene modified rat bone marrow stromal cells in nude mice. Chinese Medical Journal 2009, 122, 1 .

AMA Style

Jing-Zhou Hu, Zhi-Yuan Zhang, Jun Zhao, Xiu-Li Zhang, Gen-Tao Liu, Xin-Quan Jiang. An ectopic study of tissue-engineered bone with Nell-1 gene modified rat bone marrow stromal cells in nude mice. Chinese Medical Journal. 2009; 122 (8):1.

Chicago/Turabian Style

Jing-Zhou Hu; Zhi-Yuan Zhang; Jun Zhao; Xiu-Li Zhang; Gen-Tao Liu; Xin-Quan Jiang. 2009. "An ectopic study of tissue-engineered bone with Nell-1 gene modified rat bone marrow stromal cells in nude mice." Chinese Medical Journal 122, no. 8: 1.