This page has only limited features, please log in for full access.

Unclaimed
Orietta Monticelli
Dipartimento di Chimica e Chimica Industriale, Università di Genova, Via Dodecaneso, 31, Genova 16146, Italy

Basic Info

Basic Info is private.

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 27 August 2021 in Reactive and Functional Polymers
Reads 0
Downloads 0

The work was focused on the synthesis and characterization of a polymer designed with suitable features to be applied in the development of graphite nanoplates (GNP)-based nanopapers, prepared by using a solution blending approach, followed by filtration, drying and pressing treatments. Indeed, the polymer was tailored to possess: i) pyrenic functionalities, potentially capable of interacting with the graphite surface; ii) a star shape to promote the formation of a physical networking among the GNP layers; iii) arms made of a semicrystalline biopolymer, namely polycaprolactone (PCL), to obtain a mechanically robust and sustainable system. The polymer structure, synthesized by applying a three-step procedure, was validated by IR and 1H NMR measurements. The presence of the pyrenic end groups turned out to decrease the crystallinity of the polymer, compared to the starting PCL with hydroxylic and carboxylic functionalities, while significantly increasing its thermal stability at high temperature. The star shape structure of the synthesized PCL, together with its pyrene functionality, allowed introducing into the nanopapers structure a greater amount of polymer than that which can be inserted by using a high-molecular weight linear PCL. Moreover, GNP was found to promote significantly the pyrenic-PCL crystallization, acting as a nucleating agent. The strong interaction between the functionalized PCL and GNP delivered nanopapers exhibiting remarkable thermomechanical stability, up to well above the PCL melting temperature, coupled with noticeable heat spreading performance. Indeed, the developed nanopapers, being also based on a biopolymer, represent novel promising high performance and sustainable materials.

ACS Style

Giacomo Damonte; Alberto Vallin; Daniele Battegazzore; Alberto Fina; Orietta Monticelli. Synthesis and characterization of a novel star polycaprolactone to be applied in the development of graphite nanoplates-based nanopapers. Reactive and Functional Polymers 2021, 105019 .

AMA Style

Giacomo Damonte, Alberto Vallin, Daniele Battegazzore, Alberto Fina, Orietta Monticelli. Synthesis and characterization of a novel star polycaprolactone to be applied in the development of graphite nanoplates-based nanopapers. Reactive and Functional Polymers. 2021; ():105019.

Chicago/Turabian Style

Giacomo Damonte; Alberto Vallin; Daniele Battegazzore; Alberto Fina; Orietta Monticelli. 2021. "Synthesis and characterization of a novel star polycaprolactone to be applied in the development of graphite nanoplates-based nanopapers." Reactive and Functional Polymers , no. : 105019.

Journal article
Published: 21 August 2021 in Applied Surface Science
Reads 0
Downloads 0

In this work, novel catalytic microflow reactors prepared by 3D printing and based on polylactic acid (PLA), a compostable biopolymer of relevant industrial interest, were developed. To maintain the properties of the polymer bulk, the metal catalyst, namely palladium (Pd), was deposited in the form of nanoclusters on the surface of the inner walls of the microreactor. A functionalization reaction, i.e. aminolysis, was carried out to activate the channel surface to the metal precursor. The catalyst deposition approach, carried out in water, allowed obtaining a homogeneous distribution of Pd clusters with average dimensions of ca. 20 nm. Hydrogenation reactions performed in a batch system, using reactor sections, superficially decorated with Pd nanoclusters, demonstrated the excellent activity of the system and the absence of the catalyst leaching. In order to prove the effectiveness of the catalytic system under flow conditions, the elimination of the propargyloxy protecting group from Proc-4-methoxybenzylamine was performed using the activated microflow reactor. The higher catalytic activity, observed under flow conditions compared to a batch system, demonstrated the effectiveness of this configuration. Finally, the developed catalytic microreactor was shown to maintain the same degradation behavior as the neat material and to be easily recyclable.

ACS Style

Alessandro Blangiardo; Giacomo Lagomarsino; Andrea Basso; Paolo Canepa; Ornella Cavalleri; Sergio Rossi; Orietta Monticelli. Preparation, application and recycling of a catalytic microflow reactor based on polylactic acid. Applied Surface Science 2021, 569, 151019 .

AMA Style

Alessandro Blangiardo, Giacomo Lagomarsino, Andrea Basso, Paolo Canepa, Ornella Cavalleri, Sergio Rossi, Orietta Monticelli. Preparation, application and recycling of a catalytic microflow reactor based on polylactic acid. Applied Surface Science. 2021; 569 ():151019.

Chicago/Turabian Style

Alessandro Blangiardo; Giacomo Lagomarsino; Andrea Basso; Paolo Canepa; Ornella Cavalleri; Sergio Rossi; Orietta Monticelli. 2021. "Preparation, application and recycling of a catalytic microflow reactor based on polylactic acid." Applied Surface Science 569, no. : 151019.

Journal article
Published: 18 August 2021 in Polymers
Reads 0
Downloads 0

Poly(glycolic acid) (PGA) holds unique properties, including high gas barrier properties, high tensile strength, high resistance to common organic solvents, high heat distortion temperature, high stiffness, as well as fast biodegradability and compostability. Nevertheless, this polymer has not been exploited at a large scale due to its relatively high production cost. As such, the combination of PGA with other bioplastics on one hand could reduce the material final cost and on the other disclose new properties while maintaining its “green” features. With this in mind, in this work, PGA was combined with two of the most widely applied bioplastics, namely poly(l-lactide) (PLLA) and poycaprolactone (PCL), using the melt blending technique, which is an easily scalable method. FE-SEM measurements demonstrated the formation of PGA domains whose dimensions depended on the polymer matrix and which turned out to decrease by diminishing the PGA content in the mixture. Although there was scarce compatibility between the blend components, interestingly, PGA was found to affect both the thermal properties and the degradation behavior of the polymer matrices. In particular, concerning the latter property, the presence of PGA in the blends turned out to accelerate the hydrolysis process, particularly in the case of the PLLA-based systems.

ACS Style

Luca Magazzini; Sara Grilli; Seif Eddine Fenni; Alessandro Donetti; Dario Cavallo; Orietta Monticelli. The Blending of Poly(glycolic acid) with Polycaprolactone and Poly(l-lactide): Promising Combinations. Polymers 2021, 13, 2780 .

AMA Style

Luca Magazzini, Sara Grilli, Seif Eddine Fenni, Alessandro Donetti, Dario Cavallo, Orietta Monticelli. The Blending of Poly(glycolic acid) with Polycaprolactone and Poly(l-lactide): Promising Combinations. Polymers. 2021; 13 (16):2780.

Chicago/Turabian Style

Luca Magazzini; Sara Grilli; Seif Eddine Fenni; Alessandro Donetti; Dario Cavallo; Orietta Monticelli. 2021. "The Blending of Poly(glycolic acid) with Polycaprolactone and Poly(l-lactide): Promising Combinations." Polymers 13, no. 16: 2780.

Journal article
Published: 10 July 2021 in Carbohydrate Polymers
Reads 0
Downloads 0

In this work, novel composite microparticles based on chitosan (CHI) and graphite nanoplatelets (GNP) were developed as 3D scaffolds for neuronal cells. The aim is to improve the scaffold strength while maintaining its ability to sustain cell adhesion and differentiation. An air-assisted jetting technique followed by physical crosslinking is employed to obtain CHI/GNP microparticles. Optical and Field Emission Scanning Electron Microscopy micrographs showed a uniform distribution of GNP within the CHI porous matrix. The presence of GNP turned out to improve the strength of the microparticles while conferring good electrical conductivity and ameliorating their stability in aqueous environment. The morphological and immunocytochemical characterization, combined with a preliminary electrophysiological analysis, evidenced the effectiveness of the developed composite microparticles as a scaffold for neuron growth. These scaffolds could be employed for the development of advanced 3D neuronal in vitro models for networks dynamics analysis and drug screening.

ACS Style

Pietro Arnaldi; Donatella Di Lisa; Lorenza Maddalena; Federico Carosio; Alberto Fina; Laura Pastorino; Orietta Monticelli. A facile approach for the development of high mechanical strength 3D neuronal network scaffold based on chitosan and graphite nanoplatelets. Carbohydrate Polymers 2021, 271, 118420 .

AMA Style

Pietro Arnaldi, Donatella Di Lisa, Lorenza Maddalena, Federico Carosio, Alberto Fina, Laura Pastorino, Orietta Monticelli. A facile approach for the development of high mechanical strength 3D neuronal network scaffold based on chitosan and graphite nanoplatelets. Carbohydrate Polymers. 2021; 271 ():118420.

Chicago/Turabian Style

Pietro Arnaldi; Donatella Di Lisa; Lorenza Maddalena; Federico Carosio; Alberto Fina; Laura Pastorino; Orietta Monticelli. 2021. "A facile approach for the development of high mechanical strength 3D neuronal network scaffold based on chitosan and graphite nanoplatelets." Carbohydrate Polymers 271, no. : 118420.

Short communication
Published: 05 July 2021 in Electrochemistry Communications
Reads 0
Downloads 0

The main aim of this study was to test the biopolymer polycaprolactone (PCL) as an electrode modifier for the electrochemical detection of dopamine (DA). PCL was chosen following a search for polymers with the appropriate geometry and functional groups for dopamine detection. The chemical structure and the average molecular weight of the synthesized PCL were determined by 1H NMR, while DSC measurements showed a decrease in the crystallinity of a star-shaped polymer compared to a linear polymer. Atomic force microscopy and wettability tests performed on PCL-coated ITO electrodes demonstrated the influence of polymer architecture and functional groups on hydrophilicity and film morphology. Electrochemical studies revealed that electrodes coated with star polymers ending with carboxyl groups show good activity and selectivity, thus demonstrating the effectiveness and applicability of the developed sensors for the electrochemical detection of DA.

ACS Style

Eva Raccosta Leone; Lucia Simona Ferraraccio; Giacomo Damonte; Paola Lova; Paolo Bertoncello; Orietta Monticelli. On the development of electrochemical sensors coated with polycaprolactone. Electrochemistry Communications 2021, 129, 107089 .

AMA Style

Eva Raccosta Leone, Lucia Simona Ferraraccio, Giacomo Damonte, Paola Lova, Paolo Bertoncello, Orietta Monticelli. On the development of electrochemical sensors coated with polycaprolactone. Electrochemistry Communications. 2021; 129 ():107089.

Chicago/Turabian Style

Eva Raccosta Leone; Lucia Simona Ferraraccio; Giacomo Damonte; Paola Lova; Paolo Bertoncello; Orietta Monticelli. 2021. "On the development of electrochemical sensors coated with polycaprolactone." Electrochemistry Communications 129, no. : 107089.

Journal article
Published: 24 May 2021 in Nanomaterials
Reads 0
Downloads 0

The aim of this work was to develop an effective approach to improve the graphite dispersion and, consequently, the electrical conductivity of nanocomposites based on polycaprolactone (PCL) and graphite nanoplates (GNP). With this aim, a polymeric additive was designed to be compatible with the polymer matrix and capable of interacting with the graphite layers. Indeed, the compound consists of a low molecular mass PCL ending with a pyrene group (Pyr-PCL). The exploitation of such a molecule is expected to promote from one side specific interactions of the pyrene terminal group with the surface of graphite layers and from the other to guarantee the compatibility with PCL, having a chain with the same nature as the matrix. The features of the nanocomposites prepared by directly blending PCL with GNP were compared with those of the same systems also containing the additive. Moreover, a neat mixture, based on PCL and PCL-Pyr, was prepared and characterized. The specific interactions between the ad hoc synthesized compound and graphite were verified by UV measurements, while SEM characterization demonstrated a finer dispersion of GNP in the samples containing Pyr-PCL. GNP nucleating effect, proved by the increase in the crystallization temperature, was observed in all the samples containing the nanofiller. Moreover, a significant improvement of the electrical conductivity was found in the systems based on the pyrenyl terminated PCL. This peculiar and interesting phenomenon was related to the optimized nanofiller dispersion and to the ameliorated compatibility with the polymer matrix.

ACS Style

Giacomo Damonte; Alberto Vallin; Alberto Fina; Orietta Monticelli. On the Development of an Effective Method to Produce Conductive PCL Film. Nanomaterials 2021, 11, 1385 .

AMA Style

Giacomo Damonte, Alberto Vallin, Alberto Fina, Orietta Monticelli. On the Development of an Effective Method to Produce Conductive PCL Film. Nanomaterials. 2021; 11 (6):1385.

Chicago/Turabian Style

Giacomo Damonte; Alberto Vallin; Alberto Fina; Orietta Monticelli. 2021. "On the Development of an Effective Method to Produce Conductive PCL Film." Nanomaterials 11, no. 6: 1385.

Research article
Published: 08 October 2020 in ACS Omega
Reads 0
Downloads 0

Melt blending of homopolymers is an effective way to achieve an attractive combination of polymer properties. Dynamic vulcanization of fatty-acid-based polyester polyol with glycerol and poly(l-lactic acid) (PLLA) in the presence of hexamethylene diisocyanate (HDI) was performed with the aim of toughening PLLA. The dynamic vulcanization in an internal mixer led to the formation of a PLLA/PU biobased blend. Melt torque, Fourier transform infrared (FTIR), and gel fraction analysis demonstrated the successful formation of cross-linked polyurethane (PU) inside the PLLA matrix. Scanning electron microscopy (SEM) analysis showed that the PLLA/PU blends exhibit a sea-island morphology. Gel fraction analysis revealed that a rubbery phase was formed inside the PLLA matrix, which was insoluble in chloroform. FTIR analysis of the insoluble part shows the appearance of an absorption band centered at 1758 cm-1, related to the crystalline carbonyl vibration of the PLLA component, thus suggesting the partial involvement of PLLA chains in the cross-linking reaction. The overall content of the PU phase in the blends significantly affected the mechanical properties, thermal stability, and crystallization behavior of the materials. The overall crystallization rate of PLLA was noticeably decreased by the incorporation of PU. At the same time, polarized light optical microscopy (PLOM) analysis revealed that the presence of the PU rubbery phase inside the PLLA matrix promoted PLLA nucleation. With the formation of the PU network, the impact strength showed a remarkable increase while Young's modulus correspondingly decreased. The blends showed slightly reduced thermal stability compared to the neat PLLA.

ACS Style

Seif Eddine Fenni; Francesca Bertella; Orietta Monticelli; Alejandro J. Müller; Nacerddine Hadadoui; Dario Cavallo. Renewable and Tough Poly(l-lactic acid)/Polyurethane Blends Prepared by Dynamic Vulcanization. ACS Omega 2020, 5, 26421 -26430.

AMA Style

Seif Eddine Fenni, Francesca Bertella, Orietta Monticelli, Alejandro J. Müller, Nacerddine Hadadoui, Dario Cavallo. Renewable and Tough Poly(l-lactic acid)/Polyurethane Blends Prepared by Dynamic Vulcanization. ACS Omega. 2020; 5 (41):26421-26430.

Chicago/Turabian Style

Seif Eddine Fenni; Francesca Bertella; Orietta Monticelli; Alejandro J. Müller; Nacerddine Hadadoui; Dario Cavallo. 2020. "Renewable and Tough Poly(l-lactic acid)/Polyurethane Blends Prepared by Dynamic Vulcanization." ACS Omega 5, no. 41: 26421-26430.

Journal article
Published: 31 July 2020 in Colloids and Surfaces B: Biointerfaces
Reads 0
Downloads 0

This manuscript reports the development of functional 3D scaffolds based on chitosan (CHI) and graphite oxide nanoplatelets (GO) for neuronal network growth. To this aim, CHI microparticles, produced by alkaline gelation method, were coated with GO exploiting a simple template-assisted assembly based on the electrostatic attraction in an aqueous medium. The optimal deposition conditions were evaluated by optical microscopy and studied by quartz crystal microbalance. FE-SEM observations highlight the formation of a core-shell structure where the porous chitosan core is completely wrapped by a uniform GO layer. This outer shell protects the inner chitosan from enzymatic degradation thus potentially extending the scaffold viability for in vivo applications. The presence of hydrophilic oxygen-containing functionalities on the outermost layer of GO and its inner conductive graphitic core maintained the bioactivity of the scaffold and promoted neuronal cell adhesion and growth. The proposed approach to modify the surface of CHI microparticles makes it possible for the design of 3D scaffolds for advanced neuronal tissue engineering applications.

ACS Style

Pietro Arnaldi; Federico Carosio; Donatella Di Lisa; Lorenzo Muzzi; Orietta Monticelli; Laura Pastorino. Assembly of chitosan-graphite oxide nanoplatelets core shell microparticles for advanced 3D scaffolds supporting neuronal networks growth. Colloids and Surfaces B: Biointerfaces 2020, 196, 111295 .

AMA Style

Pietro Arnaldi, Federico Carosio, Donatella Di Lisa, Lorenzo Muzzi, Orietta Monticelli, Laura Pastorino. Assembly of chitosan-graphite oxide nanoplatelets core shell microparticles for advanced 3D scaffolds supporting neuronal networks growth. Colloids and Surfaces B: Biointerfaces. 2020; 196 ():111295.

Chicago/Turabian Style

Pietro Arnaldi; Federico Carosio; Donatella Di Lisa; Lorenzo Muzzi; Orietta Monticelli; Laura Pastorino. 2020. "Assembly of chitosan-graphite oxide nanoplatelets core shell microparticles for advanced 3D scaffolds supporting neuronal networks growth." Colloids and Surfaces B: Biointerfaces 196, no. : 111295.

Journal article
Published: 06 July 2020 in International Journal of Biological Macromolecules
Reads 0
Downloads 0

The work investigated the possibility to develop an easy scalable treatment capable of modifying only the surface of chitosan-based materials, limiting the degradation of the bulk and the burst release of a drug, without compromising the properties of the polymeric matrix. To this aim, microparticles of CHI were superficially coated with poly-(styrene-co-maleic anhydride) (PSMA), taking advantage of the potential reactivity of chitosan amino groups and maleic functionalities of PSMA. The specific reactions/interactions occurring between the two polymers were studied by IR measurements, while FE-SEM analysis evidenced the modification of the morphology of the particles contacted with PSMA. Contact angle measurements demonstrated the change of wettability in the modified systems and TGA analysis allowed to estimate the amount of the deposited PSMA. The above treatment turned out to improve the particle stability both in an acidic environment and in an enzymatic system. The release properties of the treated and of the untreated particles, over a period of 10 h, were tested using, as model drug, the protein Bovine Serum Albumin (BSA). Finally, the cytocompatibility of the developed composite microparticles was assessed on MCF-7 human breast cancer cells, which measurements demonstrated the non-toxicity of the treatment.

ACS Style

Pietro Arnaldi; Laura Pastorino; Orietta Monticelli. On an effective approach to improve the properties and the drug release of chitosan-based microparticles. International Journal of Biological Macromolecules 2020, 163, 393 -401.

AMA Style

Pietro Arnaldi, Laura Pastorino, Orietta Monticelli. On an effective approach to improve the properties and the drug release of chitosan-based microparticles. International Journal of Biological Macromolecules. 2020; 163 ():393-401.

Chicago/Turabian Style

Pietro Arnaldi; Laura Pastorino; Orietta Monticelli. 2020. "On an effective approach to improve the properties and the drug release of chitosan-based microparticles." International Journal of Biological Macromolecules 163, no. : 393-401.

Journal article
Published: 25 April 2020 in Applied Surface Science
Reads 0
Downloads 0

In this work, the Layer-by-Layer assembly of multilayered coatings comprising graphite oxide (GO) in combination with either chitosan or branched polyethylenimine was employed to modify the surface functional properties of polylactic acid (PLA) films. The aim is to extend the applicability of this biopolymer, which is of great industrial interest. Surface analyses by contact angle measurements and electron microscopy demonstrated the formation of a uniform GO layer, which enhanced the surface hydrophilicity. A 10 bi-layer coated film showed oxygen permeability reduced by 70% in both dry and humid conditions, compared to the neat PLA film. The use of a water soluble reducing agent allowed for the effective room temperature reduction of the GO deposited within the film, as evidenced by IR and contact angle measurements. GO reduction resulted in a significantly decreased surface resistivity and remarkable antistatic properties, suggesting possible applications in the field of antistatic packaging.

ACS Style

Kun Li; Alberto Fina; Daniele Marrè; Federico Carosio; Orietta Monticelli. Graphite oxide nanocoatings as a sustaibale route to extend the applicability of biopolymer-based film. Applied Surface Science 2020, 522, 146471 .

AMA Style

Kun Li, Alberto Fina, Daniele Marrè, Federico Carosio, Orietta Monticelli. Graphite oxide nanocoatings as a sustaibale route to extend the applicability of biopolymer-based film. Applied Surface Science. 2020; 522 ():146471.

Chicago/Turabian Style

Kun Li; Alberto Fina; Daniele Marrè; Federico Carosio; Orietta Monticelli. 2020. "Graphite oxide nanocoatings as a sustaibale route to extend the applicability of biopolymer-based film." Applied Surface Science 522, no. : 146471.

Journal article
Published: 14 April 2020 in International Journal of Biological Macromolecules
Reads 0
Downloads 0

The process of Ca2+ mediated gelation of alginate and the fabrication of nanoengineered polyelectrolyte capsules were combined for the preparation of alginate microbeads characterized by the presence of well-defined drug loaded microvoids in their volume. The obtained engineered alginate microbeads are described in terms of their morphology, loading efficiency and release characteristics. It was found that the generation of microvoids in the volume of alginate microbeads could be a promising approach for the creation of microstructured and biocompatible hydrogels, prospectively having highly tunable properties in terms of loading and releasing characteristics. In particular, it was found that the developed system was able to limit drug leakage during the gelation process and to control the initial burst release of small hydrophilic drug molecules, such as doxorubicin hydrochloride. Finally, the cytocompatibility of the developed microhydrogels was assessed on MCF-7 human breast cancer cells as well as their ability to sustain the release of the model drug during time.

ACS Style

Stefania Boi; Nadia Rouatbi; Elena Dellacasa; Donatella Di Lisa; Paolo Bianchini; Orietta Monticelli; Laura Pastorino. Alginate microbeads with internal microvoids for the sustained release of drugs. International Journal of Biological Macromolecules 2020, 156, 454 -461.

AMA Style

Stefania Boi, Nadia Rouatbi, Elena Dellacasa, Donatella Di Lisa, Paolo Bianchini, Orietta Monticelli, Laura Pastorino. Alginate microbeads with internal microvoids for the sustained release of drugs. International Journal of Biological Macromolecules. 2020; 156 ():454-461.

Chicago/Turabian Style

Stefania Boi; Nadia Rouatbi; Elena Dellacasa; Donatella Di Lisa; Paolo Bianchini; Orietta Monticelli; Laura Pastorino. 2020. "Alginate microbeads with internal microvoids for the sustained release of drugs." International Journal of Biological Macromolecules 156, no. : 454-461.

Preprint
Published: 30 October 2019
Reads 0
Downloads 0

The control of nanostructuration of graphene and graphene related materials (GRM) into self-assembled structures is strictly related to the nanoflakes chemical functionalization, which may be obtained via covalent grafting of non-covalent interactions, mostly exploiting {\pi}-stacking. As the non-covalent functionalization does not affect the sp2 carbon structure, this is often exploited to preserve the thermal and electrical properties of the GRM and it is a well-known route to tailor the interaction between GRM and organic media. In this work, non-covalent functionalization of graphite nanoplatelets (GnP) was carried out with ad-hoc synthesized pyrene-terminated oligomers of polylactic acid (PLA), aiming at the modification of GnP nanopapers thermal properties. PLA was selected based on the possibility to self-assemble in crystalline domains via stereocomplexation of complementary poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA) enantiomers. Pyrene-initiated PLLA and PDLA were indeed demonstrated to anchor to the GnP surface. Calorimetric and X-ray diffraction investigations highlighted the enantiomeric PLAs adsorbed on the surface of the nanoplatelets self-organize to produce highly crystalline stereocomplex domains. Most importantly, PLLA/PDLA stereocomplexation delivered a significantly higher efficiency in nanopapers heat transfer, in particular through the thickness of the nanopaper. This is explained by a thermal bridging effect of crystalline domains between overlapped GnP, promoting heat transfer across the nanoparticles contacts. This work demonstrates the possibility to enhance the physical properties of contacts within a percolating network of GRM via the self-assembly of macromolecules and opens a new way for the engineering of GRM-based nanostructures.

ACS Style

Matteo Eleuteri; Mar Bernal; Marco Milanesio; Orietta Monticelli; Alberto Fina. Stereocomplexation of Poly(Lactic Acid)s on Graphite Nanoplatelets: from Functionalized Nanoparticles to Self-Assembled Nanostructures. 2019, 1 .

AMA Style

Matteo Eleuteri, Mar Bernal, Marco Milanesio, Orietta Monticelli, Alberto Fina. Stereocomplexation of Poly(Lactic Acid)s on Graphite Nanoplatelets: from Functionalized Nanoparticles to Self-Assembled Nanostructures. . 2019; ():1.

Chicago/Turabian Style

Matteo Eleuteri; Mar Bernal; Marco Milanesio; Orietta Monticelli; Alberto Fina. 2019. "Stereocomplexation of Poly(Lactic Acid)s on Graphite Nanoplatelets: from Functionalized Nanoparticles to Self-Assembled Nanostructures." , no. : 1.

Preprint
Published: 30 October 2019
Reads 0
Downloads 0

In this work, the preparation of nanocomposites based on poly(L-lactide) PLLA and graphite nanoplatelets (GNP) was assessed, by applying, for the first time, the reactive extrusion (REX) polymerization approach, which is considered a low environmental impact method to prepare polymer systems and which allows an easy scalability. In particular, ad hoc synthesized molecules, constituted by a pyrene end group and a poly (D-lactide) (PDLA) chain (Pyr-D), capable of interacting with the surface of GNP layers as well as forming stereoblocks during the ring opening polymerization (ROP) of L-lactide, were used. The nanocomposites were synthesized by adding to L-lactide the GNP/initiator system, prepared by dispersing the graphite in the acetone/Pyr-D solution, which was dried after the sonication process. DSC and X-ray diffraction measurements evidenced the stereocomplexation of the systems synthesized by using the pyrene-based initiators, whose extent turned out to depend on the PDLA chain length. All the prepared nanocomposites - including those synthesized starting from a classical initiator, that is 1-dodecanol - retained similar electrical conductivity, whereas the thermal conductivity was found to increase in the stereocomplexed samples. Preferential localization of stereocomplexed PLA close to the interface with GNP was demonstrated by Scanning Probe Microscopy (SPM) techniques, supporting for an important role of local crystallinity in the thermal conductivity of the nanocomposites.

ACS Style

Alberto Fina; Samuele Colonna; Lorenza Maddalena; Mauro Tortello; Orietta Monticelli. A facile and low environmental impact approach to prepare thermally conductive nanocomposites based on polylactide and graphite nanoplatelets. 2019, 1 .

AMA Style

Alberto Fina, Samuele Colonna, Lorenza Maddalena, Mauro Tortello, Orietta Monticelli. A facile and low environmental impact approach to prepare thermally conductive nanocomposites based on polylactide and graphite nanoplatelets. . 2019; ():1.

Chicago/Turabian Style

Alberto Fina; Samuele Colonna; Lorenza Maddalena; Mauro Tortello; Orietta Monticelli. 2019. "A facile and low environmental impact approach to prepare thermally conductive nanocomposites based on polylactide and graphite nanoplatelets." , no. : 1.

Communication
Published: 09 August 2019 in Nanomaterials
Reads 0
Downloads 0

This work considers the development of an easy and scalable approach to change the features of poly(l-lactide) (PLLA) films, which is based on the application of a surface treatment with an amino-functionalized polyhedral oligomeric silsesquioxane (POSS). Indeed, the developed approach is based on the potential reactivity of POSS amino group towards the polymer functionalities to produce an aminolysis reaction, which should promote the direct grafting of the silsesquioxane molecules on the polymer surface. Neat and treated films were studied by infrared spectroscopy and X-ray photoelectron spectroscopy, which proved the effectiveness of POSS grafting. Moreover, scanning electron microscopy measurements demonstrated the homogeneous distribution of Si on the film surface treated with the silsesquioxane. The influence of the film treatment on the surface wettability was evidenced by contact angle measurements. These findings demonstrated a relevant enhancement of the surface hydrophobicity, which increase turned out to depend on the conditions applied, as it increased by increasing the reaction temperature and the contact time. Finally, in order to evaluate the stability of neat and of the treated PLLA films the surface morphology of the samples treated with pH 7.4 buffer at 50 °C was studied.

ACS Style

Kun Li; Samuele Colonna; Alberto Fina; Orietta Monticelli; Li; Fina. Polyhedral Oligomeric Silsesquioxane (POSS) Surface Grafting: A Novel Method to Enhance Polylactide Hydrolysis Resistance. Nanomaterials 2019, 9, 1144 .

AMA Style

Kun Li, Samuele Colonna, Alberto Fina, Orietta Monticelli, Li, Fina. Polyhedral Oligomeric Silsesquioxane (POSS) Surface Grafting: A Novel Method to Enhance Polylactide Hydrolysis Resistance. Nanomaterials. 2019; 9 (8):1144.

Chicago/Turabian Style

Kun Li; Samuele Colonna; Alberto Fina; Orietta Monticelli; Li; Fina. 2019. "Polyhedral Oligomeric Silsesquioxane (POSS) Surface Grafting: A Novel Method to Enhance Polylactide Hydrolysis Resistance." Nanomaterials 9, no. 8: 1144.

Short communication
Published: 03 May 2019 in Materials Letters
Reads 0
Downloads 0

In this work, an innovative approach to covalently anchor cyclodextrins (CDs) on the surface of submicrometric particles, prepared from an equimolar mixture of poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), was developed. The idea of the applied method lays in the potential reactivity of amino CDs towards the polymer functionalities to produce an aminolysis reaction, which should lead to the direct grafting of cyclodextrin molecules on the polymer surface. A preliminary investigation demonstrated the significant capacity of the modified particles to adsorb a model pollutant (alizarin red) and a hydrophobic drug (ketoprofen).

ACS Style

Stefania Boi; Laura Pastorino; Orietta Monticelli. Multi applicable stereocomplex PLA particles decorated with cyclodextrins. Materials Letters 2019, 250, 135 -138.

AMA Style

Stefania Boi, Laura Pastorino, Orietta Monticelli. Multi applicable stereocomplex PLA particles decorated with cyclodextrins. Materials Letters. 2019; 250 ():135-138.

Chicago/Turabian Style

Stefania Boi; Laura Pastorino; Orietta Monticelli. 2019. "Multi applicable stereocomplex PLA particles decorated with cyclodextrins." Materials Letters 250, no. : 135-138.

Journal article
Published: 01 April 2019 in Colloids and Surfaces B: Biointerfaces
Reads 0
Downloads 0

In this work, the preparation of a novel enzyme carrier based on a polymer multicomponent system was assessed. Indeed, the design of the above system considered several issues that are the need of applying a biodegradable polymer carrier, characterized by a nanometric dimension, thus suitable to diffuse into the dense mucus structure, with functionalities capable of interacting/reacting with enzymes but resistant to enzymatic degradation. The particles were prepared from solutions containing equimolar amount of high-molecular-weight poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA) and by applying the nanoprecipitation method. Dynamic Light Scattering (DLS) measurements allowed to establish the optimal preparation conditions to obtain polymer particles characterized by diameters lower than 1 μm, which dimensions were confirmed by Field Emission Scanning Electron Microscope (FE-SEM) analysis. In order to produce surface functionalization, necessary for anchoring enzymes, the stereocomplexed particles, whose structuration was confirmed by Differential Scanning Calorimetry (DSC) measurements, underwent an amminolysis reaction by using a diamine as reactant. The treated particles were characterized by means of FE-SEM, Fourier-Transform Infrared Spectroscopy (FTIR), DLS and zeta potential measurements and their characteristics were compared with those of the neat PLLA/PDLA particles. The degree of functionalization turned out to depend on the applied conditions, it increasing by enhancing the reaction time. The activity of enzymes, i.e. papain and alginate lyase, anchored to the particles, was evaluated by Quartz Crystal Microbalance (QCM) and UV measurements. Moreover, with the aim at exploiting the material for an inhalation administration, a method to encapsulate the enzyme-particles systems was assessed. Conversely to free enzymes, the the developed systems were found to be capable of diminishing the viscosity of two hydrogels, ad hoc prepared and based on the main constituents of the real mucus.

ACS Style

Stefania Boi; Elena Dellacasa; Paolo Bianchini; Paola Petrini; Laura Pastorino; Orietta Monticelli. Encapsulated functionalized stereocomplex PLA particles: An effective system to support mucolytic enzymes. Colloids and Surfaces B: Biointerfaces 2019, 179, 190 -198.

AMA Style

Stefania Boi, Elena Dellacasa, Paolo Bianchini, Paola Petrini, Laura Pastorino, Orietta Monticelli. Encapsulated functionalized stereocomplex PLA particles: An effective system to support mucolytic enzymes. Colloids and Surfaces B: Biointerfaces. 2019; 179 ():190-198.

Chicago/Turabian Style

Stefania Boi; Elena Dellacasa; Paolo Bianchini; Paola Petrini; Laura Pastorino; Orietta Monticelli. 2019. "Encapsulated functionalized stereocomplex PLA particles: An effective system to support mucolytic enzymes." Colloids and Surfaces B: Biointerfaces 179, no. : 190-198.

Original research article
Published: 29 March 2019 in Frontiers in Chemistry
Reads 0
Downloads 0

The control of nanostructuration of graphene and graphene related materials (GRM) into self-assembled structures is strictly related to the nanoflakes chemical functionalization, which may be obtained via covalent grafting of non-covalent interactions, mostly exploiting π-stacking. As the non-covalent functionalization does not affect the sp2 carbon structure, this is often exploited to preserve the thermal and electrical properties of the GRM and it is a well-known route to tailor the interaction between GRM and organic media. In this work, non-covalent functionalization of graphite nanoplatelets (GnP) was carried out with ad-hoc synthesized pyrene-terminated oligomers of polylactic acid (PLA), aiming at the modification of GnP nanopapers thermal properties. PLA was selected based on the possibility to self-assemble in crystalline domains via stereocomplexation of complementary poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA) enantiomers. Pyrene-initiated PLLA and PDLA were indeed demonstrated to anchor to the GnP surface. Calorimetric and X-ray diffraction investigations highlighted the enantiomeric PLAs adsorbed on the surface of the nanoplatelets self-organize to produce highly crystalline stereocomplex domains. Most importantly, PLLA/PDLA stereocomplexation delivered a significantly higher efficiency in nanopapers heat transfer, in particular through the thickness of the nanopaper. This is explained by a thermal bridging effect of crystalline domains between overlapped GnP, promoting heat transfer across the nanoparticles contacts. This work demonstrates the possibility to enhance the physical properties of contacts within a percolating network of GRM via the self-assembly of macromolecules and opens a new way for the engineering of GRM-based nanostructures.

ACS Style

Matteo Eleuteri; Mar Bernal; Marco Milanesio; Orietta Monticelli; Alberto Fina. Stereocomplexation of Poly(Lactic Acid)s on Graphite Nanoplatelets: From Functionalized Nanoparticles to Self-assembled Nanostructures. Frontiers in Chemistry 2019, 7, 176 .

AMA Style

Matteo Eleuteri, Mar Bernal, Marco Milanesio, Orietta Monticelli, Alberto Fina. Stereocomplexation of Poly(Lactic Acid)s on Graphite Nanoplatelets: From Functionalized Nanoparticles to Self-assembled Nanostructures. Frontiers in Chemistry. 2019; 7 ():176.

Chicago/Turabian Style

Matteo Eleuteri; Mar Bernal; Marco Milanesio; Orietta Monticelli; Alberto Fina. 2019. "Stereocomplexation of Poly(Lactic Acid)s on Graphite Nanoplatelets: From Functionalized Nanoparticles to Self-assembled Nanostructures." Frontiers in Chemistry 7, no. : 176.

Research article
Published: 10 September 2018 in ACS Sustainable Chemistry & Engineering
Reads 0
Downloads 0

In this work, the preparation of nanocomposites based on poly(l-lactide) PLLA and graphite nanoplatelets (GNP) was assessed by applying, for the first time, the reactive extrusion (REX) polymerization approach, which is considered a low environmental impact method to prepare polymer systems and which allows an easy scalability. In particular, ad hoc synthesized molecules, constituted by a pyrene end group and a poly(d-lactide) (PDLA) chain (Pyr-d), capable of interacting with the surface of GNP layers as well as forming stereoblocks during the ring-opening polymerization (ROP) of l-lactide, were used. The nanocomposites were synthesized by adding to l-lactide the GNP/initiator system, prepared by dispersing the graphite in the acetone/Pyr-d solution, which was dried after the sonication process. DSC and X-ray diffraction measurements evidenced the stereocomplexation of the systems synthesized by using the pyrene-based initiators, whose extent turned out to depend on the PDLA chain length. All the prepared nanocomposites, including those synthesized starting from a classical initiator, that is, 1-dodecanol, retained similar electrical conductivity, whereas the thermal conductivity was found to increase in the stereocomplexed samples. Preferential localization of stereocomplexed PLA close to the interface with GNP was demonstrated by scanning probe microscopy (SPM) techniques, supporting an important role of local crystallinity in the thermal conductivity of the nanocomposites.

ACS Style

Alberto Fina; Samuele Colonna; Lorenza Maddalena; Mauro Tortello; Orietta Monticelli. Facile and Low Environmental Impact Approach to Prepare Thermally Conductive Nanocomposites Based on Polylactide and Graphite Nanoplatelets. ACS Sustainable Chemistry & Engineering 2018, 6, 14340 -14347.

AMA Style

Alberto Fina, Samuele Colonna, Lorenza Maddalena, Mauro Tortello, Orietta Monticelli. Facile and Low Environmental Impact Approach to Prepare Thermally Conductive Nanocomposites Based on Polylactide and Graphite Nanoplatelets. ACS Sustainable Chemistry & Engineering. 2018; 6 (11):14340-14347.

Chicago/Turabian Style

Alberto Fina; Samuele Colonna; Lorenza Maddalena; Mauro Tortello; Orietta Monticelli. 2018. "Facile and Low Environmental Impact Approach to Prepare Thermally Conductive Nanocomposites Based on Polylactide and Graphite Nanoplatelets." ACS Sustainable Chemistry & Engineering 6, no. 11: 14340-14347.

Journal article
Published: 01 June 2018 in Materials Letters
Reads 0
Downloads 0

Considering the increasing interest for protein immobilization on nanoparticles, in this work, we demonstrate the preparation of poly(styrene-co-maleic anhydride) (PSMA) nanoparticles and their capability to conjugate the proteolytic enzyme papain. PSMA nanoparticles were fabricated by combining precipitation and electrospray technique. Different experimental conditions were tested in order to optimize nanoparticle dimensions and production yield and different techniques were used to characterize the produced nanoparticles. Their mean diameter was found to be 176 nm. The successful papain-nanoparticle conjugation was then demonstrated. The residual catalytic activity of the conjugated enzyme was studied and found to be around 79% respect to the free enzyme.

ACS Style

Elena Dellacasa; Mahdi Forouharshad; Ranieri Rolandi; Laura Pastorino; Orietta Monticelli. Poly(styrene- co -maleic anhydride) nanoparticles as protein carriers. Materials Letters 2018, 220, 241 -244.

AMA Style

Elena Dellacasa, Mahdi Forouharshad, Ranieri Rolandi, Laura Pastorino, Orietta Monticelli. Poly(styrene- co -maleic anhydride) nanoparticles as protein carriers. Materials Letters. 2018; 220 ():241-244.

Chicago/Turabian Style

Elena Dellacasa; Mahdi Forouharshad; Ranieri Rolandi; Laura Pastorino; Orietta Monticelli. 2018. "Poly(styrene- co -maleic anhydride) nanoparticles as protein carriers." Materials Letters 220, no. : 241-244.

Journal article
Published: 01 January 2018 in Colloids and Surfaces B: Biointerfaces
Reads 0
Downloads 0

In this work, a novel drug delivery system consisting of poly(ε-caprolactone) (PCL) electrospun fibers containing an ad-hoc-synthesized star polymer made up of a poly(amido-amine) (PAMAM) core and PCL branches (PAMAM-PCL) was developed. The latter system which was synthesized via the ring opening polymerization of ε-caprolactone, starting from a hydroxyl-terminated PAMAM dendrimer and characterized by means of H NMR, IR and DSC, was found to be compatible with both the polymer matrix and a hydrophilic chemotherapeutic drug, doxorubicin (DOXO), the model drug used in this work. The preparation of the dendritic PCL star product with an average arm length of 2000g/mol was characterized using IR and H NMR measurements. The prepared star polymer possessed a higher crystallinity and a lower melting temperature than that of the used linear PCL. Electrospun fibers were prepared starting from solutions containing the neat PCL as well as the PCL/PAMAM-PCL mixture. Electrospinning conditions were optimized in order to obtain defect free fibers, which was proven by the structural FE-SEM study. PAMAM moieties enhanced the hydrophilicity of the fibers, as proved by comparing the water absorption for the PCL/PAMAM-PCL fibers to that neat PCL fibers. The drug-loaded system PCL/PAMAM-PCL was prepared by directly introducing DOXO into the electrospinning solutions. The DOXO-loaded PCL/PAMAM-PCL showed a prolonged release of the drug with respect to the DOXO-loaded PCL fibers and elicited effective controlled toxicity over A431 epidermoid carcinoma, HeLa cervical cancer cells and drug resistant MCF-7 breast cancer cells. On the contrary, the drug-free PCL/PAMAM-PCL scaffold demonstrated no toxic effects on human dermal fibroblasts, suggesting the biocompatibility of the proposed system which can be used in cellular scaffold applications.

ACS Style

Preethi Bala Balakrishnan; Lorenza Gardella; Mahdi Forouharshad; Teresa Pellegrino; Orietta Monticelli. Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity. Colloids and Surfaces B: Biointerfaces 2018, 161, 488 -496.

AMA Style

Preethi Bala Balakrishnan, Lorenza Gardella, Mahdi Forouharshad, Teresa Pellegrino, Orietta Monticelli. Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity. Colloids and Surfaces B: Biointerfaces. 2018; 161 ():488-496.

Chicago/Turabian Style

Preethi Bala Balakrishnan; Lorenza Gardella; Mahdi Forouharshad; Teresa Pellegrino; Orietta Monticelli. 2018. "Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity." Colloids and Surfaces B: Biointerfaces 161, no. : 488-496.