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Hui-Ju Lin
Eye Center, China Medical University Hospital, Taichung 404, Taiwan

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Journal article
Published: 16 July 2021 in Current Issues in Molecular Biology
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Resveratrol is a key component of red wine and other grape products. Recent studies have characterized resveratrol as a polyphenol, and shown its beneficial effects on cancer, metabolism, and infection. This study aimed to obtain insights into the biological effects of resveratrol on myopia. To this end, we examined its anti-inflammatory influence on human retinal pigment epithelium cells and in a monocular form deprivation (MFD)-induced animal model of myopia. In MFD-induced myopia, resveratrol increased collagen I level and reduced the expression levels of matrix metalloproteinase (MMP)2, transforming growth factor (TGF)-β, and nuclear factor (NF)-κB expression levels. It also suppressed the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. Resveratrol exhibited no significant cytotoxicity in ARPE-19 cells. Downregulation of inflammatory cytokine production, and inhibition of AKT, c-Raf, Stat3, and NFκB phosphorylation were observed in ARPE-19 cells that were treated with resveratrol. In conclusion, the findings suggest that resveratrol inhibits inflammatory effects by blocking the relevant signaling pathways, to ameliorate myopia development. This may make it a natural candidate for drug development for myopia.

ACS Style

Yu-An Hsu; Chih-Sheng Chen; Yao-Chien Wang; En-Shyh Lin; Ching-Yao Chang; Jamie Chen; Ming-Yen Wu; Hui-Ju Lin; Lei Wan. Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model. Current Issues in Molecular Biology 2021, 43, 716 -727.

AMA Style

Yu-An Hsu, Chih-Sheng Chen, Yao-Chien Wang, En-Shyh Lin, Ching-Yao Chang, Jamie Chen, Ming-Yen Wu, Hui-Ju Lin, Lei Wan. Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model. Current Issues in Molecular Biology. 2021; 43 (2):716-727.

Chicago/Turabian Style

Yu-An Hsu; Chih-Sheng Chen; Yao-Chien Wang; En-Shyh Lin; Ching-Yao Chang; Jamie Chen; Ming-Yen Wu; Hui-Ju Lin; Lei Wan. 2021. "Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model." Current Issues in Molecular Biology 43, no. 2: 716-727.

Journal article
Published: 03 July 2021 in Mediators of Inflammation
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Myopia is a highly prevalent refractive disorder. We investigated the effect of diacerein on monocular form deprivation (MFD) in hamsters as a possible therapeutic intervention. Diacerein is an anthraquinone derivative drug whose active metabolite is rhein. Diacerein or atropine was applied to the MFD hamsters, and their refractive error and axial length were measured after 21 days. The refractive error (control: − 0.91 ± 0.023 , atropine: − 0.3 ± 0.08 , and diacerein: − 0.27 ± 0.07 D ) and axial length (control: 0.401 ± 0.017 , atropine: 0.326 ± 0.017 , and diacerein: 0.334 ± 0.016 mm ) showed statistically significant differences between control, atropine-treated, and diacerein-treated MFD eyes. Furthermore, we determined the level of transforming growth factor-beta- (TGF-) β1, matrix metalloproteinase- (MMP-) 2, type I collagen, interleukin- (IL-) 6, IL-8, and monocyte chemoattractant protein- (MCP-) 1 in the retina. Atropine and diacerein suppressed levels of the myopia-related TGF-β1 and MMP-2 while increasing type I collagen expression. They also inhibited the interleukin IL-6, IL-8, and MCP-1 levels. Diacerein reduced the IL-6, IL-8, and MCP-1 expression in ARPE-19 cells. Furthermore, diacerein inhibited inflammation by attenuating the phosphorylation of protein kinase B (AKT) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway. This suggests that diacerein has a therapeutic effect on myopia and is a potential treatment option.

ACS Style

Peng-Tai Tien; Chia-Hung Lin; Chih-Sheng Chen; Ching-Yao Chang; Hsiangyu Ku; Dekang Gan; Yi-Yu Tsai; Jamie Jiin-Yi Chen; Hui-Ju Lin; Lei Wan. Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell. Mediators of Inflammation 2021, 2021, 1 -11.

AMA Style

Peng-Tai Tien, Chia-Hung Lin, Chih-Sheng Chen, Ching-Yao Chang, Hsiangyu Ku, Dekang Gan, Yi-Yu Tsai, Jamie Jiin-Yi Chen, Hui-Ju Lin, Lei Wan. Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell. Mediators of Inflammation. 2021; 2021 ():1-11.

Chicago/Turabian Style

Peng-Tai Tien; Chia-Hung Lin; Chih-Sheng Chen; Ching-Yao Chang; Hsiangyu Ku; Dekang Gan; Yi-Yu Tsai; Jamie Jiin-Yi Chen; Hui-Ju Lin; Lei Wan. 2021. "Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell." Mediators of Inflammation 2021, no. : 1-11.

Journal article
Published: 07 December 2020 in International Journal of Environmental Research and Public Health
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Although studies have suggested environmental factors to be triggers of headache, the contribution of long-term air pollution exposure to recurrent headaches is poorly understood. Hence, we executed this nationwide cohort study to investigate associations between levels of ambient air pollutants and risks of recurrent headaches in children in Taiwan from 2000 to 2012. We used data from the Taiwan National Health Insurance Research Database and linked them to the Taiwan Air Quality Monitoring Database. Overall, 218,008 children aged < 18 were identified from 1 January 2000, and then followed until they were diagnosed by a physician for ≥3 times with recurrent headaches or until 31 December 2012. We categorized the annual average concentration of each air pollutant (fine particulate matter, total hydrocarbon, methane, sulfur dioxide, and nitrogen dioxide) into quartiles (Q1–Q4). We measured the incidence rate, hazard ratios (HRs), and the corresponding 95% confidence intervals for recurrent headaches. stratified by the quartiles. A total of 28,037 children (12.9%) were identified with recurrent headaches. The incidence rate and adjusted HR for recurrent headaches increased with higher-level exposure of air pollutants, except sulfur dioxide. We herein demonstrate that long-term ambient air pollutant exposure might be a risk factor for childhood recurrent headaches.

ACS Style

Syuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study. International Journal of Environmental Research and Public Health 2020, 17, 9140 .

AMA Style

Syuan-Yu Hong, Lei Wan, Hui-Ju Lin, Cheng-Li Lin, Chang-Ching Wei. Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study. International Journal of Environmental Research and Public Health. 2020; 17 (23):9140.

Chicago/Turabian Style

Syuan-Yu Hong; Lei Wan; Hui-Ju Lin; Cheng-Li Lin; Chang-Ching Wei. 2020. "Long-Term Ambient Air Pollutant Exposure and Risk of Recurrent Headache in Children: A 12-Year Cohort Study." International Journal of Environmental Research and Public Health 17, no. 23: 9140.

Published erratum
Published: 01 March 2019 in EBioMedicine
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ACS Style

Chang-Ching Wei; Yung-Jen Kung; Chih Sheng Chen; Ching-Yao Chang; Chao-Jen Lin; Peng-Tai Tien; Hsing-Yi Chang; Hsuan-Ju Chen; Yong-San Huang; Hui-Ju Lin; Lei Wan. Corrigendum to “Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression” [EBioMedicine 28 (2018) 274–286]. EBioMedicine 2019, 41, 717 -718.

AMA Style

Chang-Ching Wei, Yung-Jen Kung, Chih Sheng Chen, Ching-Yao Chang, Chao-Jen Lin, Peng-Tai Tien, Hsing-Yi Chang, Hsuan-Ju Chen, Yong-San Huang, Hui-Ju Lin, Lei Wan. Corrigendum to “Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression” [EBioMedicine 28 (2018) 274–286]. EBioMedicine. 2019; 41 ():717-718.

Chicago/Turabian Style

Chang-Ching Wei; Yung-Jen Kung; Chih Sheng Chen; Ching-Yao Chang; Chao-Jen Lin; Peng-Tai Tien; Hsing-Yi Chang; Hsuan-Ju Chen; Yong-San Huang; Hui-Ju Lin; Lei Wan. 2019. "Corrigendum to “Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression” [EBioMedicine 28 (2018) 274–286]." EBioMedicine 41, no. : 717-718.

Journal article
Published: 01 February 2018 in EBioMedicine
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Myopia is a highly prevalent eye disease. There is limited information suggesting a relationship between myopia and inflammation. We found children with allergic conjunctivitis (AC) had the highest adjusted odds ratio (1.75, 95% confidence interval [CI], 1.72–1.77) for myopia among the four allergic diseases. A cohort study was conducted and confirmed that children with AC had a higher incidence and subsequent risk of myopia (hazard ratio 2.35, 95%CI 2.29–2.40) compared to those without AC. Lower refractive error and longer axial length were observed in an AC animal model. Myopia progression was enhanced by tumor necrosis factor (TNF)-α or interleukin (IL)-6 administration, two cytokines secreted by mast cell degranulation. The TNF-α or IL-6 weakened the tight junction formed by corneal epithelial (CEP) cells and inflammatory cytokines across the layer of CEP cells, which increased the levels of TNF-α, IL-6, and IL-8 secreted by retinal pigment epithelial cells. The expression levels of TNF-α, IL-6, IL-8, monocyte chemoattractant protein-1, and nuclear factor kappa B were up-regulated in eyes with AC, whereas IL-10 and the inhibitor of kappa B were down-regulated. In conclusion, the experimental findings in mice corroborate the epidemiological data showing that allergic inflammation influences the development of myopia.

ACS Style

Chang-Ching Wei; Yung-Jen Kung; Chih Sheng Chen; Ching-Yao Chang; Chao-Jen Lin; Peng-Tai Tien; Hsing-Yi Chang; Hsuan-Ju Chen; Yong-San Huang; Hui-Ju Lin; Lei Wan. Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression. EBioMedicine 2018, 28, 274 -286.

AMA Style

Chang-Ching Wei, Yung-Jen Kung, Chih Sheng Chen, Ching-Yao Chang, Chao-Jen Lin, Peng-Tai Tien, Hsing-Yi Chang, Hsuan-Ju Chen, Yong-San Huang, Hui-Ju Lin, Lei Wan. Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression. EBioMedicine. 2018; 28 ():274-286.

Chicago/Turabian Style

Chang-Ching Wei; Yung-Jen Kung; Chih Sheng Chen; Ching-Yao Chang; Chao-Jen Lin; Peng-Tai Tien; Hsing-Yi Chang; Hsuan-Ju Chen; Yong-San Huang; Hui-Ju Lin; Lei Wan. 2018. "Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression." EBioMedicine 28, no. : 274-286.

Journal article
Published: 16 December 2015 in BMC Cancer
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Flavones found in plants display various biological activities, including anti-allergic, anti-viral, anti-inflammatory, anti-oxidation, and anti-tumor effects. In this study, we investigated the anti-tumor effects of flavone, apigenin and luteolin on human breast cancer cells. The anti-cancer activity of flavone, apigenin and luteolin was investigated using the MTS assay. Apoptosis was analyzed by Hoechst 33342 staining, flow cytometry and western blot. Cell migration was determined using the culture inserts and xCELLigence real-time cell analyzer instrument equipped with a CIM-plate 16. Real-time quantitative PCR and western blot were used to determine the signaling pathway elicited by flavone, apigenin and luteolin. Flavone, apigenin and luteolin showed potent inhibitory effects on the proliferation of Hs578T, MDA-MB-231 and MCF-7 breast cancer cells in a concentration and time-dependent manner. The ability of flavone, apigenin and luteolin to inhibit the growth of breast cancer cells through apoptosis was confirmed by Hoechst33342 staining and the induction of sub-G1 phase of the cell cycle. Flavone, apigenin and luteolin induced forkhead box O3 (FOXO3a) expression by inhibiting Phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB)/Akt. This subsequently elevated the expression of FOXO3a target genes, including the Cyclin-dependent kinase inhibitors p21Cip1 (p21) and p27kip1 (p27), which increased the levels of activated poly(ADP) polymerase (PARP) and cytochrome c. Taken together, these data demonstrated that flavone, apigenin and luteolin induced cell cycle arrest and apoptosis in breast cancer cells through inhibiting PI3K/Akt activation and increasing FOXO3a activation, which suggest that flavone, apigenin and luteolin will be the potential leads for the preventing and treating of breast cancer.

ACS Style

Chia-Hung Lin; Ching-Yao Chang; Kuan-Rong Lee; Hui-Ju Lin; Ter-Hsin Chen; Lei Wan. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. BMC Cancer 2015, 15, 958 .

AMA Style

Chia-Hung Lin, Ching-Yao Chang, Kuan-Rong Lee, Hui-Ju Lin, Ter-Hsin Chen, Lei Wan. Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway. BMC Cancer. 2015; 15 (1):958.

Chicago/Turabian Style

Chia-Hung Lin; Ching-Yao Chang; Kuan-Rong Lee; Hui-Ju Lin; Ter-Hsin Chen; Lei Wan. 2015. "Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway." BMC Cancer 15, no. 1: 958.

Journal article
Published: 31 March 2014 in BMC Ophthalmology
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Many efforts have been invested in slowing progression of myopia. Among the methods, atropine administration and orthokeratology (OK) are most widely used. This study analyzed the efficacy of atropine and OK lens in controlling myopia progression and elongation of axial length.

ACS Style

Hui-Ju Lin; Lei Wan; Fuu-Jen Tsai; Yi-Yu Tsai; Liuh-An Chen; Alicia Lishin Tsai; Yu-Chuen Huang. Overnight orthokeratology is comparable with atropine in controlling myopia. BMC Ophthalmology 2014, 14, 40 -40.

AMA Style

Hui-Ju Lin, Lei Wan, Fuu-Jen Tsai, Yi-Yu Tsai, Liuh-An Chen, Alicia Lishin Tsai, Yu-Chuen Huang. Overnight orthokeratology is comparable with atropine in controlling myopia. BMC Ophthalmology. 2014; 14 (1):40-40.

Chicago/Turabian Style

Hui-Ju Lin; Lei Wan; Fuu-Jen Tsai; Yi-Yu Tsai; Liuh-An Chen; Alicia Lishin Tsai; Yu-Chuen Huang. 2014. "Overnight orthokeratology is comparable with atropine in controlling myopia." BMC Ophthalmology 14, no. 1: 40-40.

Journal article
Published: 01 December 2013 in Taiwan Journal of Ophthalmology
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IntroductionThe orthokeratology lens (OK lens) is designed to reshape the cornea and correct refraction error. Owing to the convenience of ceasing the use of glasses during the day, the use of the OK lens is increasing in myopic children. In this study, changes in corneal curvature and astigmatism after wearing the OK lens were analyzed.MethodsThis retrospective cohort study included 65 children (130 eyes) who underwent full and regular examinations. None of the participants had any ocular disease other than myopia and astigmatism. The OK lenses used in this study were four-zone, reverse-geometry lenses. The corneal curvature of each patient was checked annually after the patients discontinued daily wearing of the OK lens for 10 days. Student t test and repeated measures analysis of variance (ANOVA) analyses were performed to compare the results.ResultsThe radius of corneal curvature showed a progressive annual increase with significant differences, both in the steepest and flattest radius of the corneal curvature (p < 0.001 and p = 0.001, respectively). The mean radius of the steepest and flattest corneal curvature increased significantly from baseline to the following years consecutively (all p < 0.001). Nevertheless, astigmatism did not change significantly in any of the tests.ConclusionCorneal curvature changed as the patients grew older. There was a statistically significant increase in the radius of the corneal curvature in the myopic children studied. For correct fit of OK lenses, the radius of the corneal curvature should be regularly checked prior to dispensing a new set of lenses

ACS Style

Chien-Chih Chou; Yu-Chuen Huang; Yi-Yu Tsai; Jane-Ming Lin; Wen-Lu Chen; Hui-Ju Lin. Changes in corneal curvature after wearing the orthokeratology lens. Taiwan Journal of Ophthalmology 2013, 3, 156 -159.

AMA Style

Chien-Chih Chou, Yu-Chuen Huang, Yi-Yu Tsai, Jane-Ming Lin, Wen-Lu Chen, Hui-Ju Lin. Changes in corneal curvature after wearing the orthokeratology lens. Taiwan Journal of Ophthalmology. 2013; 3 (4):156-159.

Chicago/Turabian Style

Chien-Chih Chou; Yu-Chuen Huang; Yi-Yu Tsai; Jane-Ming Lin; Wen-Lu Chen; Hui-Ju Lin. 2013. "Changes in corneal curvature after wearing the orthokeratology lens." Taiwan Journal of Ophthalmology 3, no. 4: 156-159.

Journal article
Published: 30 November 2012 in BMC Medical Genetics
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Graves disease (GD) is an organ-specific autoimmune disease characterized by hyperthyroidism, diffuse goiter, autoantibodies against thyroid-specific antigens, and dermopathy. Studies of GD have demonstrated the importance of the Th2 and Th17 immune responses in mediating disease progression. In the present study, we investigated the role of a Th2 cytokine, thymic stromal lymphopoietin (TSLP), in GD and Th17 differentiation.

ACS Style

Kun-Hsi Tsai; Fuu-Jen Tsai; Hui-Ju Lin; Hung-Jung Lin; Yu-Huei Liu; Wen-Ling Liao; Lei Wan. Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves’ disease and Graves’ ophthalmopathy. BMC Medical Genetics 2012, 13, 116 -116.

AMA Style

Kun-Hsi Tsai, Fuu-Jen Tsai, Hui-Ju Lin, Hung-Jung Lin, Yu-Huei Liu, Wen-Ling Liao, Lei Wan. Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves’ disease and Graves’ ophthalmopathy. BMC Medical Genetics. 2012; 13 (1):116-116.

Chicago/Turabian Style

Kun-Hsi Tsai; Fuu-Jen Tsai; Hui-Ju Lin; Hung-Jung Lin; Yu-Huei Liu; Wen-Ling Liao; Lei Wan. 2012. "Thymic stromal lymphopoietin gene promoter polymorphisms and expression levels in Graves’ disease and Graves’ ophthalmopathy." BMC Medical Genetics 13, no. 1: 116-116.