This page has only limited features, please log in for full access.
The evolution of the class of antibacterial quinolones includes the introduction in therapy of highly successful compounds. Although many representatives were withdrawn due to severe adverse reactions, a few representatives have proven their therapeutical value over time. The classification of antibacterial quinolones into generations is a valuable tool for physicians, pharmacists, and researchers. In addition, the transition from one generation to another has brought new representatives with improved properties. In the last two decades, several representatives of antibacterial quinolones received approval for therapy. This review sets out to chronologically outline the group of approved antibacterial quinolones since 2000. Special attention is given to eight representatives: besifloxacin, delafoxacin, finafloxacin, lascufloxacin, nadifloxacin and levonadifloxacin, nemonoxacin, and zabofloxacin. These compounds have been characterized regarding physicochemical properties, formulations, antibacterial activity spectrum and advantageous structural characteristics related to antibacterial efficiency. At present these new compounds (with the exception of nadifloxacin) are reported differently, most often in the fourth generation and less frequently in a new generation (the fifth). Although these new compounds’ mechanism does not contain essential new elements, the question of shaping a new generation (the fifth) arises, based on higher potency and broad spectrum of activity, including resistant bacterial strains. The functional groups that ensured the biological activity, good pharmacokinetic properties and a safety profile were highlighted. In addition, these new representatives have a low risk of determining bacterial resistance. Several positive aspects are added to the fourth fluoroquinolones generation, characteristics that can be the basis of the fifth generation. Antibacterial quinolones class continues to acquire new compounds with antibacterial potential, among other effects. Numerous derivatives, hybrids or conjugates are currently in various stages of research.
Aura Rusu; Ioana-Andreea Lungu; Octavia-Laura Moldovan; Corneliu Tanase; Gabriel Hancu. Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation. Pharmaceutics 2021, 13, 1289 .
AMA StyleAura Rusu, Ioana-Andreea Lungu, Octavia-Laura Moldovan, Corneliu Tanase, Gabriel Hancu. Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation. Pharmaceutics. 2021; 13 (8):1289.
Chicago/Turabian StyleAura Rusu; Ioana-Andreea Lungu; Octavia-Laura Moldovan; Corneliu Tanase; Gabriel Hancu. 2021. "Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation." Pharmaceutics 13, no. 8: 1289.
One of the most widely used flavour enhancers in the food industry is monosodium glutamate (MSG). MSG consumption has been on an upward trend, worrying in terms of potential toxic effects. This review is focused on the long-term toxicity of MSG and the experimental evidence that supports it. The article's primary purpose was to survey recently published data regarding the consumption of MSG within safe limits. The administered doses in animal models are very varied and have given rise to controversy. Also, the paper comprises pathways to lower MSG toxicity and highlight other underexploited biological effects, as anti-cancer potential. The administration of MSG, combined with various compounds, has been shown benefit against toxic effects. Several recent studies have identified a possible mechanism that recommends MSG and some derivatives as potential anti-cancer agents. New anti-cancer compounds based on the glutamic acid structure must be studied and further exploited. International regulations require harmonization of safe doses of MSG based on current scientific studies. Replacing MSG with other umami flavour enhancers may be a safer alternative for human health in the future. The biological consequences of MSG consumption or therapeutical administration have not been fully deciphered yet.
Octavia-Laura Moldovan; Aura Rusu; Corneliu Tanase; Camil-Eugen Vari. Glutamate - A multifaceted molecule: Endogenous neurotransmitter, controversial food additive, design compound for anti-cancer drugs. A critical appraisal. Food and Chemical Toxicology 2021, 153, 112290 .
AMA StyleOctavia-Laura Moldovan, Aura Rusu, Corneliu Tanase, Camil-Eugen Vari. Glutamate - A multifaceted molecule: Endogenous neurotransmitter, controversial food additive, design compound for anti-cancer drugs. A critical appraisal. Food and Chemical Toxicology. 2021; 153 ():112290.
Chicago/Turabian StyleOctavia-Laura Moldovan; Aura Rusu; Corneliu Tanase; Camil-Eugen Vari. 2021. "Glutamate - A multifaceted molecule: Endogenous neurotransmitter, controversial food additive, design compound for anti-cancer drugs. A critical appraisal." Food and Chemical Toxicology 153, no. : 112290.
The bark of various tree species is a byproduct of the forestry industry that is not used at its full potential, considering the wide range of phytochemicals that are contained in these vegetal matrices and the health benefits that these compounds could provide for society. Our goal was to assess and compare the phytochemical composition of some hydroalcoholic spruce (Picea abies) bark extracts attained by ultrasound assisted extraction (UAE) and microwave-assisted extraction (MAE) and their antioxidant and antibacterial effects. The levels of total phenolics and tannins in the bark extracts were determined using methods based on the Folin–Ciocâlteu reagent, while specific phenolic and volatile compounds were identified and quantified using an UPLC-PDA method and a GC-FID method, respectively. After the chemical composition assessment, the antioxidant capacity (AC) was evaluated by measuring the scavenging ability against two free radicals (DPPH and ABTS). The minimum inhibitory concentration (MIC) was determined to assess the antibacterial activity of the extracts. The results indicated that the extracts produced by UAE had higher contents of polyphenols and tannins and also a higher content of the main phenolic compounds identified, catechin and epicatechin, compared to the MAE extracts. In contrast the highest content of volatile terpenoids (mainly α- and β-pinene) was found in the MAE extracts. All of the tested extracts exhibited relatively high antioxidant activities (especially the UAE extracts) and low MICs against Gram-positive bacteria but were mildly efficient against Gram-negative bacteria. These findings show that the spruce bark might be an important source of bioactive compounds that can be easily extracted from these industrial secondary products. Various uses of this vegetal material may emerge, due to its antioxidant and antibacterial effects.
Adrian Nisca; Ruxandra Ștefănescu; Diana Stegăruș; Anca Mare; Lenard Farczadi; Corneliu Tanase. Phytochemical Profile and Biological Effects of Spruce (Picea abies) Bark Subjected to Ultrasound Assisted and Microwave-Assisted Extractions. Plants 2021, 10, 870 .
AMA StyleAdrian Nisca, Ruxandra Ștefănescu, Diana Stegăruș, Anca Mare, Lenard Farczadi, Corneliu Tanase. Phytochemical Profile and Biological Effects of Spruce (Picea abies) Bark Subjected to Ultrasound Assisted and Microwave-Assisted Extractions. Plants. 2021; 10 (5):870.
Chicago/Turabian StyleAdrian Nisca; Ruxandra Ștefănescu; Diana Stegăruș; Anca Mare; Lenard Farczadi; Corneliu Tanase. 2021. "Phytochemical Profile and Biological Effects of Spruce (Picea abies) Bark Subjected to Ultrasound Assisted and Microwave-Assisted Extractions." Plants 10, no. 5: 870.
The influence of the addition of oak chips and barrel ageing on basic wine parameters and volatile compounds of Chardonnay wines has been studied. Chardonnay wines were obtained by the traditional wine-making process. Oak chips (4 g/L—non-toasted and light toasted) were added at the final stage of the winemaking process for ageing 1, 2 and 3 months, respectively. Also, the control wine was aged in non-toasted barrels for the same period of time. Following Liquid-liquid extraction-gas chromatography-mass spectrometry analysis, alcohols, esters, fatty acids, lactones, and phenolic compounds were identified and quantified. The light toasted wine was clearly separated by phenolic compounds (vanillin, p-vinyl guaiacol and acetovanillone). The floral aroma supplied by 2-phenylethanol was slowly increased by ageing with odor activity values (OAV) higher in aged samples than control wine (1.07). The vanilla scent could be easily perceived in all aged samples, mainly for light toasted chip-treated samples with OAV values between 2.30 and 2.37. After 3 months, the volatile compounds of wine from non-toasted medium (chips and barrels) were almost similar from the volatile profile point of view. This could have economic and vinification management implications since oak barrels are expensive and the wine oak barrel aging is a long process. All wines studied in this research can provide a viable alternative to young varietal wines.
Diana Stegăruș; Anamaria Călugăr; Corneliu Tanase; Adriana Muscă; Oana Botoran; Mihail Manolache; Anca Babeș; Claudiu Bunea; Emese Gál; Andrea Bunea; Teodora Coldea. Influence of Oak Chips and Oak Barrel Ageing on Volatile Profile in Chardonnay Wine of Romania. Applied Sciences 2021, 11, 3691 .
AMA StyleDiana Stegăruș, Anamaria Călugăr, Corneliu Tanase, Adriana Muscă, Oana Botoran, Mihail Manolache, Anca Babeș, Claudiu Bunea, Emese Gál, Andrea Bunea, Teodora Coldea. Influence of Oak Chips and Oak Barrel Ageing on Volatile Profile in Chardonnay Wine of Romania. Applied Sciences. 2021; 11 (8):3691.
Chicago/Turabian StyleDiana Stegăruș; Anamaria Călugăr; Corneliu Tanase; Adriana Muscă; Oana Botoran; Mihail Manolache; Anca Babeș; Claudiu Bunea; Emese Gál; Andrea Bunea; Teodora Coldea. 2021. "Influence of Oak Chips and Oak Barrel Ageing on Volatile Profile in Chardonnay Wine of Romania." Applied Sciences 11, no. 8: 3691.
The bark resulted after the industrial processing of wood represents a byproduct of the forestry industry, used in many suboptimal ways, being considered a natural waste. Currently, it has been highlighted that the bark of different woody plants may be an important source of several bioactive compounds, with various beneficial biological functions. The aim of this study is to evaluate and compare the chemical composition and biological activities of two different pine species (Pinus nigra and Pinus sylvestris) bark extracts. Ultrasound (UAE) and microwave (MAE) assisted extractions were performed in order to obtain the extracts. The total polyphenol (TPC) and total tannin (TTC) contents of the extracts were assessed via the Folin–Ciocâlteu method. The volatile and polyphenolic compounds were identified and quantified via a GC/MS analysis and an UPLC-PDA analysis, respectively. The antioxidant activity (AOA) was evaluated using the DPPH and ABTS assays, while the antibacterial activity was assessed using the minimum inhibitory concentration (MIC) protocol. The results showed that the Pinus sylvestris bark extracts obtained by UAE had a higher TPC, TTC and AOA, while the Pinus nigra bark extracts obtained by MAE had higher volatile compounds content (mainly α-pinene and β-pinene). Moreover, the inhibition of the bacterial growth was more efficient in the case of Pinus sylvestris extracts, Gram-positive bacteria being the most affected, while Gram-negative strains presented a relative resistance to the tested extract concentrations. These results may indicate the potential use of the pine bark extracts as antioxidant or antibacterial agents.
Adrian Nisca; Ruxandra Ștefănescu; Diana Stegăruș; Anca Mare; Lenard Farczadi; Corneliu Tanase. Comparative Study Regarding the Chemical Composition and Biological Activity of Pine (Pinus nigra and P. sylvestris) Bark Extracts. Antioxidants 2021, 10, 327 .
AMA StyleAdrian Nisca, Ruxandra Ștefănescu, Diana Stegăruș, Anca Mare, Lenard Farczadi, Corneliu Tanase. Comparative Study Regarding the Chemical Composition and Biological Activity of Pine (Pinus nigra and P. sylvestris) Bark Extracts. Antioxidants. 2021; 10 (2):327.
Chicago/Turabian StyleAdrian Nisca; Ruxandra Ștefănescu; Diana Stegăruș; Anca Mare; Lenard Farczadi; Corneliu Tanase. 2021. "Comparative Study Regarding the Chemical Composition and Biological Activity of Pine (Pinus nigra and P. sylvestris) Bark Extracts." Antioxidants 10, no. 2: 327.
The main disadvantage of the implants is the associated infections. Therefore, in the long term, the possibility of improving the antibacterial capacity of different types of implants (dental, orthopedic) is being researched. The severity of the problem lies in the increasing bacterial resistance and finding appropriate alternative treatments for infectious diseases, which is an important research field nowadays. The purpose of this review is to draw a parallel between different studies analyzing the antibacterial activity and mechanism of silver nanoparticles (NP Ag) deposited on the titanium nanotubes (NTT), as well as the analysis of the NP Ag toxicity. This review also provides an overview of the synthesis and characterization of TiO2-derived nanotubes (NT). Thus, the analysis aims to present the existing knowledge to better understand the NP Ag implants benefits and their antibacterial activity.
Alina Năstaca Coman; Anca Mare; Corneliu Tanase; Eugen Bud; Aura Rusu. Silver-Deposited Nanoparticles on the Titanium Nanotubes Surface as a Promising Antibacterial Material into Implants. Metals 2021, 11, 92 .
AMA StyleAlina Năstaca Coman, Anca Mare, Corneliu Tanase, Eugen Bud, Aura Rusu. Silver-Deposited Nanoparticles on the Titanium Nanotubes Surface as a Promising Antibacterial Material into Implants. Metals. 2021; 11 (1):92.
Chicago/Turabian StyleAlina Năstaca Coman; Anca Mare; Corneliu Tanase; Eugen Bud; Aura Rusu. 2021. "Silver-Deposited Nanoparticles on the Titanium Nanotubes Surface as a Promising Antibacterial Material into Implants." Metals 11, no. 1: 92.
Adapalene (ADP) is a representative of the third retinoids generation and successfully used in first-line acne treatment. ADP binds to retinoic acid nuclear receptors. The comedolytic, anti-inflammatory, antiproliferative, and immunomodulatory are the known ADP effects. Its safety profile is an advantage over other retinoids. ADP recently was found to be effective in the treatment of several dermatological diseases and photoaging besides the utility in the treatment of acne vulgaris. New biological effects of adapalene with therapeutic potential are highlighted in this review paper. Thus, adapalene could be a valuable therapeutic drug into the treatment of several types of cancer. Additionally, some neurodegenerative diseases could be treated with a suitable formulation for intravenous administration. The antibacterial activity against methicillin-resistant Staphylococcus aureus of an analogue of ADP has been proven. In different therapeutic schemes, ADP is more effective in combination with other active substances. New topical combinations with adapalene include ketoconazole (antifungal), mometasone furoate (anti-inflammatory corticosteroid), nadifloxacin (fluoroquinolone), and alfa and beta hydroxy acids. Combination with oral drugs is a new trend that enhances the properties of topical formulations with adapalene. Several studies have investigated the effects of ADP in co-administration with azithromycin, doxycycline, faropenem, isotretinoin, and valganciclovir. Innovative formulations of ADP also aim to achieve a better bioavailability, increased efficacy, and reduced side effects. In this review, we have highlighted the current studies on adapalene regarding biological effects useful in various treatment types. Adapalene has not been exploited yet to its full biological potential.
Aura Rusu; Corneliu Tanase; Georgiana-Andreea Pascu; Nicoleta Todoran. Recent Advances Regarding the Therapeutic Potential of Adapalene. Pharmaceuticals 2020, 13, 217 .
AMA StyleAura Rusu, Corneliu Tanase, Georgiana-Andreea Pascu, Nicoleta Todoran. Recent Advances Regarding the Therapeutic Potential of Adapalene. Pharmaceuticals. 2020; 13 (9):217.
Chicago/Turabian StyleAura Rusu; Corneliu Tanase; Georgiana-Andreea Pascu; Nicoleta Todoran. 2020. "Recent Advances Regarding the Therapeutic Potential of Adapalene." Pharmaceuticals 13, no. 9: 217.
In this study, mulberry leaves polysaccharides (MLPs) namely HBSS (extracted with hot buffer soluble solids), CHSS (extracted with chelating agent soluble solids), DASS (extracted with diluted alkali soluble solids), and CASS (extracted with concentrated alkali soluble solids) were obtained using four different solvents and examined for their rheological potential. Different MLPs solutions harbored obvious disparity for viscosity and displayed a shear-thinning behavior at the tested range. Among all the fractions, DASS possessed the highest apparent viscosity at 0.5–2.5%. The apparent viscosity of MLPs solutions declined at acidic pH, alkaline pH, and higher temperature (90 °C). The HBSS fraction showed the best heat stability of all the fractions. All the fractions displayed noticeable differences in apparent viscosity in response to Na+ and Ca2+ at 20 °C. Both the modules such as G′ (storage modulus) and G” (loss modulus) showed augmentation with oscillation frequency. Initially, the value of G” was higher than G′ of MLPs at lower frequency and lower concentration, and the MLPS displayed stronger viscous nature; whereas, G′ was consistently higher at higher frequency and higher concentration, and the MLPS displayed stronger elastic characteristic. From our data, it was indicated that these MLPs can be used as promising natural materials (thickeners, gelling agents, binding agents, stabilizers) for their direct application to the food industry.
Bu-Yan Liao; Ling Li; Corneliu Tanase; Kiran Thakur; Dan-Ye Zhu; Jian-Guo Zhang; Zhao-Jun Wei. The Rheological Behavior of Polysaccharides from Mulberry Leaves (Morus alba L.). Agronomy 2020, 10, 1267 .
AMA StyleBu-Yan Liao, Ling Li, Corneliu Tanase, Kiran Thakur, Dan-Ye Zhu, Jian-Guo Zhang, Zhao-Jun Wei. The Rheological Behavior of Polysaccharides from Mulberry Leaves (Morus alba L.). Agronomy. 2020; 10 (9):1267.
Chicago/Turabian StyleBu-Yan Liao; Ling Li; Corneliu Tanase; Kiran Thakur; Dan-Ye Zhu; Jian-Guo Zhang; Zhao-Jun Wei. 2020. "The Rheological Behavior of Polysaccharides from Mulberry Leaves (Morus alba L.)." Agronomy 10, no. 9: 1267.
The Quercus genus provides a large amount of biomaterial with many applications in fields like pharmaceutics, cosmetics, and foodstuff areas. Due to the worldwide dissemination of the genus, many species were used for centuries in traditional healing methods or in the wine maturing process. This review aims to bring together the results about phytoconstituents from oak extracts and their biological applicability as antioxidants, antimicrobial, anticancer, etc. The literature data used in this paper were collected via PubMed, Scopus, and Science Direct (2010–June 2020). The inclusion criteria were papers published in English, with information about phytoconstituents from Quercus species (leaves, bark and seeds/acorns) and biological activities such as antioxidant, antibacterial, antiobesity, anti-acne vulgaris, antifungal, anticancer, antiviral, antileishmanial, antidiabetic, anti-inflammatory. The exclusion criteria were the research of other parts of the Quercus species (e.g., galls, wood, and twigs); lack of information about phytochemistry and biological activities; non-existent Quercus species reported by the authors. The most studied Quercus species, in terms of identified biomolecules and biological activity, are Q. brantii, Q. infectoria and Q. robur. The Quercus species have been reported to contain several phytoconstituents. The main bioactive phytochemicals are phenolic compounds, volatile organic compounds, sterols, aliphatic alcohols and fatty acids. The, Quercus species are intensely studied due to their antioxidant, anti-inflammatory, antimicrobial, and anticancer activities, provided by their phytochemical composition. The general conclusion is that oak extracts can be exploited for their biological activity and can be used in research fields, such as pharmaceutical, nutraceutical and medical.
Ema Burlacu; Adrian Nisca; Corneliu Tanase. A Comprehensive Review of Phytochemistry and Biological Activities of Quercus Species. Forests 2020, 11, 904 .
AMA StyleEma Burlacu, Adrian Nisca, Corneliu Tanase. A Comprehensive Review of Phytochemistry and Biological Activities of Quercus Species. Forests. 2020; 11 (9):904.
Chicago/Turabian StyleEma Burlacu; Adrian Nisca; Corneliu Tanase. 2020. "A Comprehensive Review of Phytochemistry and Biological Activities of Quercus Species." Forests 11, no. 9: 904.
This paper aims to assess the biological responses of Lavandula angustifolia Mill. to beech and spruce bark crude extract application. Thus, the biological activity of bark extracts was assessed by determining the germination capacity, biomass production, histo-anatomical aspects and photo-assimilatory pigment accumulation, and by quantitative and qualitative volatile compounds analysis. The application of spruce bark extract (500 mg dry bark/100 mL solvent) resulted in a better development of the leaf tissue and an increase in foliar biomass. We observed the stimulating effect of photo-assimilating pigments accumulation, for all experimental variants, compared to the control. Also, the amount of volatile oil was significantly higher in the treated plants with spruce bark extract (500 mg dry bark/100 mL solvent). Some volatile compounds (cyclen, borneol, cryptone, santalen, and caryophyllene oxide β—farnesene) were identified only in the experimental variants. Also, in the experimental variants, an increase in the quantity of limonene, linalyl acetate and lavandulol was observed. These preliminary results showed that the beech and spruce bark extracts can have biological activities and influence the production of volatile oil in Lavandula angustifolia, causing significant changes in the phytochemical profile of the essential oil. Thus, forest waste bark extracts could be recommended as natural bioregulators in lavender crops.
Corneliu Tanase; Ruxandra Ștefănescu; Béla Darkó; Daniela Lucia Muntean; Anca Corina Fărcaş; Sonia Ancuţa Socaci. Biochemical and Histo-Anatomical Responses of Lavandula angustifolia Mill. to Spruce and Beech Bark Extracts Application. Plants 2020, 9, 859 .
AMA StyleCorneliu Tanase, Ruxandra Ștefănescu, Béla Darkó, Daniela Lucia Muntean, Anca Corina Fărcaş, Sonia Ancuţa Socaci. Biochemical and Histo-Anatomical Responses of Lavandula angustifolia Mill. to Spruce and Beech Bark Extracts Application. Plants. 2020; 9 (7):859.
Chicago/Turabian StyleCorneliu Tanase; Ruxandra Ștefănescu; Béla Darkó; Daniela Lucia Muntean; Anca Corina Fărcaş; Sonia Ancuţa Socaci. 2020. "Biochemical and Histo-Anatomical Responses of Lavandula angustifolia Mill. to Spruce and Beech Bark Extracts Application." Plants 9, no. 7: 859.
The use of bioactive compounds can act in growth stimulation and also influence the biosynthesis of the metabolites in plants. The aim of this paper is to assess the influence of the beech (Fagus sylvatica L.) bark crude extract (BBCE) on the growth and development of sage (Salvia officinalis L.) plants. Special attention was given to the analysis of volatile oil obtained from the sage treated plant. Thus, the biological activity of BBCE was assessed by determining the germination capacity, biomass accumulation, histo-anatomical aspects, and photoassimilatory pigment accumulation, quantitative, and qualitative sage volatile oil analysis. The results show stimulation of the biomass and photoassimilatory pigment accumulation. The mesophyll thickness and the vascular tissue surface are smaller in the treated variants, compared to the control. On the other hand, the amount of volatile oil was significantly higher in the treated plants. In the experimental variants, an increase in the quantity of eucalyptol, camphor, camphene, and α-caryophyllene is observed. The amount of eucalyptol increased in the experimental variant, with about 82%, compared to the control. BBCE could be properly used as natural bioregulators because according to our results seems to improve the yield of the sage crop. The results of this research have the potential to contribute greatly to ecological agricultural production.
Corneliu Tanase; Ruxandra Ștefănescu; Diana Gabriela Gheorghieș; Loredana Dandu; Adrian Nisca; Béla Darkó; Sonia Ancuța Socaci. Effects of Beech Bark Extract in the Sage (Salvia Officinalis L.) Plant Growth and Volatile Oil Profile. Agronomy 2020, 10, 676 .
AMA StyleCorneliu Tanase, Ruxandra Ștefănescu, Diana Gabriela Gheorghieș, Loredana Dandu, Adrian Nisca, Béla Darkó, Sonia Ancuța Socaci. Effects of Beech Bark Extract in the Sage (Salvia Officinalis L.) Plant Growth and Volatile Oil Profile. Agronomy. 2020; 10 (5):676.
Chicago/Turabian StyleCorneliu Tanase; Ruxandra Ștefănescu; Diana Gabriela Gheorghieș; Loredana Dandu; Adrian Nisca; Béla Darkó; Sonia Ancuța Socaci. 2020. "Effects of Beech Bark Extract in the Sage (Salvia Officinalis L.) Plant Growth and Volatile Oil Profile." Agronomy 10, no. 5: 676.
Phenolic compounds are a widespread group of secondary metabolites found in all plants, representing the most desirable antioxidants due to their potential to be used as additives in the food industry (inhibition of lipid oxidation), and in cosmetology and medicine (protection against oxidative stress). In recent years, demand for the identification of edible sources rich in phenolic antioxidants, as well as the development of new natural plant products to be used as dietary supplements or pharmaceuticals, has been a great preoccupation. At present, from the “circular economy” perspective, there is an increased interest to use agricultural waste resources to produce high-value compounds. Vaccinium leaves and stems are considered essentially an agro-waste of the berry industry. Scientific studies have shown that phenolic compounds were found in a markedly higher content in the leaves and stems of Vaccinium plants than in the fruits, in agreement with the strongest biological and antioxidant activities displayed by these aerial parts compared to fruits. This paper aims to review the current state of the art regarding the phenolic antioxidants from leaves and stems of two wild Vaccinium species, bilberry (Vaccinium myrtillus L.) and lingonberry (Vaccinium vitis-idaea L.), as promising natural resources with pharmaceutical and biological activity.
Oana-Crina Bujor; Corneliu Tanase; Mona Elena Popa. Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties. Antioxidants 2019, 8, 649 .
AMA StyleOana-Crina Bujor, Corneliu Tanase, Mona Elena Popa. Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties. Antioxidants. 2019; 8 (12):649.
Chicago/Turabian StyleOana-Crina Bujor; Corneliu Tanase; Mona Elena Popa. 2019. "Phenolic Antioxidants in Aerial Parts of Wild Vaccinium Species: Towards Pharmaceutical and Biological Properties." Antioxidants 8, no. 12: 649.
Nanoparticles are intensely studied because of their importance in diverse fields of biotechnology, especially in medicine. This paper highlights that waste bark can be a cheap source of biocompounds, with high recovery and functionalization potential in nanoparticle synthesis. Due to their biocompatibility and activity as antioxidant, antimicrobial, and anticancer agents, the green synthesis of metallic nanoparticles is of great importance. This review aims to bring together the diversity of synthesized metallic nanoparticles mediated by bark extracts obtained from different woody vascular plants, the phytoconstituents responsible for the reduction of metal salts, and the activity of metallic nanoparticles as diverse agents in combating the microbial, oxidant, and cancer activity. The literature data highlight the fact that metallic nanoparticles obtained from natural compounds are proven reducing agents with multiple activities. Thus, the activity of natural components in environmental protection and human health is confirmed.
Ema Burlacu; Corneliu Tanase; Năstaca-Alina Coman; Lavinia Berta. A Review of Bark-Extract-Mediated Green Synthesis of Metallic Nanoparticles and Their Applications. Molecules 2019, 24, 4354 .
AMA StyleEma Burlacu, Corneliu Tanase, Năstaca-Alina Coman, Lavinia Berta. A Review of Bark-Extract-Mediated Green Synthesis of Metallic Nanoparticles and Their Applications. Molecules. 2019; 24 (23):4354.
Chicago/Turabian StyleEma Burlacu; Corneliu Tanase; Năstaca-Alina Coman; Lavinia Berta. 2019. "A Review of Bark-Extract-Mediated Green Synthesis of Metallic Nanoparticles and Their Applications." Molecules 24, no. 23: 4354.
Biosynthesized silver nanoparticles (AgNPs) are widely used in Pharmacy and Medicine. In particular, AgNPs synthesized and mediated by plant extracts have shown topossess several biological activities. In the present study, AgNPs were synthesized using Picea abies L. stem bark extract as reducing agent. Factors, such as metal ion solution, pH, and time, which play a role in the AgNPs synthesis, were assessed. The synthesized AgNPs were characterized by Ultraviolet-Visible Spectrometry, Fourier transform infrared spectroscopy, and Transmission Electron Microscopy (TEM). Further, the study has been extended to evaluate the antimicrobial and antioxidant activity of AgNPs. The broad peak obtained at 411–475 nm (UV-Vis spectroscopy), and the color change pattern, confirmed the synthesis of AgNPs. TEM results showed spherical or rarely polygonal AgNPs with an average size of 44 nm at pH = 9. The AgNPs showed antioxidant activity and antibacterial effect against human pathogenic Gram-positive and Gram-negative bacteria. The results show that spruce bark extract is suitable for obtaining AgNPs, with antibacterial and antioxidant activity.
Corneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; Alexandru Nicolescu; László Jakab-Farkas; Domokos Biró; Anca Mare. Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract. Nanomaterials 2019, 9, 1541 .
AMA StyleCorneliu Tanase, Lavinia Berta, Năstaca Alina Coman, Ioana Roșca, Adrian Man, Felicia Toma, Andrei Mocan, Alexandru Nicolescu, László Jakab-Farkas, Domokos Biró, Anca Mare. Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract. Nanomaterials. 2019; 9 (11):1541.
Chicago/Turabian StyleCorneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; Alexandru Nicolescu; László Jakab-Farkas; Domokos Biró; Anca Mare. 2019. "Antibacterial and Antioxidant Potential of Silver Nanoparticles Biosynthesized Using the Spruce Bark Extract." Nanomaterials 9, no. 11: 1541.
Green synthesis is one of the rapid and best ways for silver nanoparticles (AgNP) synthesis. In the present study, synthesis and bioactivity of AgNPs has been demonstrated using water beech (Fagus sylvatica L.) bark extract. The physical and chemical factors such as time, metal ion solution, and pH, which play a vital role in the AgNPs synthesis, were assessed. The AgNPs were characterized by ultraviolet-visible (UV-Vis) spectrometry, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM). Antioxidant and antimicrobial activity of the obtained AgNPs was evaluated. AgNPs were characterized by color change pattern, and the broad peak obtained at 420–475 nm with UV-Vis confirmed the synthesis of AgNPs. FT-IR results confirmed that phenols and proteins of beech bark extract are mainly responsible for capping and stabilization of synthesized AgNPs. TEM micrographs showed spherical or rarely polygonal and triangular particles with an average size of 32 nm at pH = 9, and 62 nm at pH = 4. Furthermore, synthesized AgNPs were found to exhibit antioxidant activity and have antibacterial effect against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa. These results indicate that bark extract of F. sylvatica L. is suitable for synthesizing stable AgNPs, which act as an excellent antimicrobial agent.
Corneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; László Jakab-Farkas; Domokos Biró; Anca Mare; Man; Toma; Jakab- Farkas; Biró; Mare. Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract. Antioxidants 2019, 8, 459 .
AMA StyleCorneliu Tanase, Lavinia Berta, Năstaca Alina Coman, Ioana Roșca, Adrian Man, Felicia Toma, Andrei Mocan, László Jakab-Farkas, Domokos Biró, Anca Mare, Man, Toma, Jakab- Farkas, Biró, Mare. Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract. Antioxidants. 2019; 8 (10):459.
Chicago/Turabian StyleCorneliu Tanase; Lavinia Berta; Năstaca Alina Coman; Ioana Roșca; Adrian Man; Felicia Toma; Andrei Mocan; László Jakab-Farkas; Domokos Biró; Anca Mare; Man; Toma; Jakab- Farkas; Biró; Mare. 2019. "Investigation of In Vitro Antioxidant and Antibacterial Potential of Silver Nanoparticles Obtained by Biosynthesis Using Beech Bark Extract." Antioxidants 8, no. 10: 459.
The present study aimed, on the one hand, to improve the yield of microwave assisted extraction (MAE) of polyphenols from beech bark by using a design of experiments (DoE) approach. On the other hand, beech bark extracts (BBE) were characterized in terms of their phytochemical profile and evaluated for biological potential (antioxidant, antibacterial, antifungal, antimutagen, anti-α-glucosidase, and anti-tyrosinase). The extraction time varies with the amount of extracted total phenolic content (TPC). The microwave power favors TPC extraction but in different proportions. The optimum conditions which gave the highest TPC (76.57 mg GAE/g dry plant material) were reached when the microwave power was 300 W, extraction time was 4 min, and the solvent was an ethanol-water (50:50) mixture. The practical value of TPC after a controlled experiment was 76.49 mg GAE/g plant material. The identified compounds were vanillic acid, gallic acid, epicatechin, catechin, protocatechuic acid, chlorogenic acid, ferulic acid, and isoquercitrin. The antioxidant potential of BBEs was demonstrated by in vitro experiments. The BBEs were active against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, and Candida species. All extracts were antimutagenic and expressed an inhibition on α-glucosidase and tyrosinase activity. Regarding antimutagen activity, the assayed extracts may be considered to have low or no antimutagen effects.
Corneliu Tanase; Andrei Mocan; Sanda Coșarcă; Alexandru Gavan; Alexandru Nicolescu; Ana-Maria Gheldiu; Dan C. Vodnar; Daniela-Lucia Muntean; Ovidiu Crișan. Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties. Antioxidants 2019, 8, 417 .
AMA StyleCorneliu Tanase, Andrei Mocan, Sanda Coșarcă, Alexandru Gavan, Alexandru Nicolescu, Ana-Maria Gheldiu, Dan C. Vodnar, Daniela-Lucia Muntean, Ovidiu Crișan. Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties. Antioxidants. 2019; 8 (9):417.
Chicago/Turabian StyleCorneliu Tanase; Andrei Mocan; Sanda Coșarcă; Alexandru Gavan; Alexandru Nicolescu; Ana-Maria Gheldiu; Dan C. Vodnar; Daniela-Lucia Muntean; Ovidiu Crișan. 2019. "Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties." Antioxidants 8, no. 9: 417.
Over the past few years, special attention has been paid to biomass valorization. The aim of this paper is to evaluate the effect of the phenolic rich extracts obtained from raw materials on the growth and development of lemon balm (Melissa officinalis L.). The extracts were obtained from the bark of spruce (Picea abies (L.) H. Karst) and beech (Fagus sylvatica L.) separated as waste product during wood processing. The growth and development of the plants was assessed by measuring elongation of vegetative organs, biomasses including root, stem, and leaf, and photosynthetic pigment content. In addition, the analysis of some histo-anatomic characteristics of the vegetative organs were made. Elongation biomasses and photosynthetic pigments concentration presented higher values in case of plants treated with beech bark phenolic extract compared to control plants. The spruce bark phenolic extract had a stimulatory effect on the germination but inhibited the growth and development of the plants. Both extracts increased the percentage of lignification in stems. These findings could contribute to the development of natural and eco-friendly substances that favor cultivation of lemon balm plants. Future research is needed in order to identify potential qualitative and quantitative changes in the essential oil of the aromatic plant treated with the tested solutions.
Corneliu Tanase; Adrian Nișca; Anca Mirica; Andreea Milan; Irina Boz. Wood Bark as Valuable Raw Material for Compounds with a Bioregulator Effect in Lemon Balm (Melissa officinalis L.) Plants. Applied Sciences 2019, 9, 3148 .
AMA StyleCorneliu Tanase, Adrian Nișca, Anca Mirica, Andreea Milan, Irina Boz. Wood Bark as Valuable Raw Material for Compounds with a Bioregulator Effect in Lemon Balm (Melissa officinalis L.) Plants. Applied Sciences. 2019; 9 (15):3148.
Chicago/Turabian StyleCorneliu Tanase; Adrian Nișca; Anca Mirica; Andreea Milan; Irina Boz. 2019. "Wood Bark as Valuable Raw Material for Compounds with a Bioregulator Effect in Lemon Balm (Melissa officinalis L.) Plants." Applied Sciences 9, no. 15: 3148.
Polyphenols are one of the largest and most widespread groups of secondary metabolites in the plants world. These compounds are of particular interest due to their occurrence and the properties they possess. The main sources of phenolic compounds are fruits and vegetables, but lately, more and more studies refer to woody vascular plants, especially to bark, as an important source of phenolic compounds with a potential biological effect. This study aims to bring together information on the phenolic compounds present in the bark of woody vascular plants by discussing extraction methods, the chemical composition of the extracts and potential biological effects. The literature data used in this paper were collected via PubMed (2004–2019). Search terms were: bark, rhytidome, woody vascular plant, polyphenols, phenolic compounds, biologic activity, antioxidant, immunostimulatory, antimutagenic, antibacterial, anti-inflammatory, and antitumoral. This paper intends to highlight the fact that the polyphenolic extracts obtained from the bark of woody vascular plants represent sources of bioactive compounds with antioxidant, immunostimulatory, antimutagenic, antibacterial properties, etc. Future research directions should be directed towards identification and isolation of bioactive compounds. Consequently, biologically active compounds obtained from the bark of woody plants could be exploited on an industrial scale.
Corneliu Tanase; Sanda Coșarcă; Daniela-Lucia Muntean. A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity. Molecules 2019, 24, 1182 .
AMA StyleCorneliu Tanase, Sanda Coșarcă, Daniela-Lucia Muntean. A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity. Molecules. 2019; 24 (6):1182.
Chicago/Turabian StyleCorneliu Tanase; Sanda Coșarcă; Daniela-Lucia Muntean. 2019. "A Critical Review of Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity." Molecules 24, no. 6: 1182.
Arrhenatherion alliance meadows are recognized to be among the best pastures in our country due to high productivity and good nutrition value. The research was conducted in several areas of Mures County. The studied grasslands were classified into two types of Natura 2000 habitats: 6510 Lowland hay meadows (Alopecurus pratensis, Sanguisorba officinalis) and 6520 Mountain hay meadows. The identified phytocoenosis belong to two plant associations: Arrhenatheretum elatioris Br.-Bl. Ex Scherrer 1925 and Poo Trisetetum flavescentis (Knapp 1951) Oberd. 1957. The analysis of data collected in the field reveals that the current state of conservation of the two types of habitat is good and very good. Habitats in a good and very good state of preservation is distinguish by a great floristic composition: approx. 100-150 cormophyte species with good and very good forage value. As habitats are more susceptible to the management applied and any changes to land use can affect habitat quality (eg abandoning mowing and turning the land into pasture), the ecological functions of this habitat will be satisfied as long as they are mowed after Poaceae species matured.
Silvia Oroian; Mihaela Samarghitan; Mariana Hiritiu; Sanda Cosarca; Corneliu Tanase. HIGH NATURE VALUE GRASSLANDS FROM ARRHENATHERION ALLIANCE IDENTIFIED IN MURE? COUNTY. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture 2016, 73, 280 .
AMA StyleSilvia Oroian, Mihaela Samarghitan, Mariana Hiritiu, Sanda Cosarca, Corneliu Tanase. HIGH NATURE VALUE GRASSLANDS FROM ARRHENATHERION ALLIANCE IDENTIFIED IN MURE? COUNTY. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture. 2016; 73 (2):280.
Chicago/Turabian StyleSilvia Oroian; Mihaela Samarghitan; Mariana Hiritiu; Sanda Cosarca; Corneliu Tanase. 2016. "HIGH NATURE VALUE GRASSLANDS FROM ARRHENATHERION ALLIANCE IDENTIFIED IN MURE? COUNTY." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture 73, no. 2: 280.
The plant kingdom is an inexhaustible source of bioactive compounds with antioxidant character. It is known that, natural polyphenols are essential compounds in stimulating plant growth and development. The aim of this study was to identify the internal structure changes in maize (Zea mays L.) seedlings, under the influence of hemp shives polyphenolic extract. Hemp shives polyphenolic extract was characterized in terms of the total content of polyphenols and individual content by HPLC. Germination tests were carried out going through a standard procedure. In order to perform the histo-anatomical characterization, the vegetal material was fixed and preserved in alcohol 70%, following to be cut by hand microtome. The sections obtained were stained using double staining reagents: green - iodine and ruthenium red. It was observed, compared with the control, that hemp shives polyphenolic extract determines a good development of the root hairs and increase leading bundles number and central vessels metaxylem. Hemp shives polyphenolic extract in lower concentrations has positive effects on developed process of Zea mays L. plants that can be attributed to bioregulation properties.
Corneliu Tănase; Sanda Coşarcă; Silvia Oroian. Histo-anatomic Aspects on Zea Mays L. Influenced by Hemp Shives Polyphenolic Extract. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture 2016, 73, 317 .
AMA StyleCorneliu Tănase, Sanda Coşarcă, Silvia Oroian. Histo-anatomic Aspects on Zea Mays L. Influenced by Hemp Shives Polyphenolic Extract. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture. 2016; 73 (2):317.
Chicago/Turabian StyleCorneliu Tănase; Sanda Coşarcă; Silvia Oroian. 2016. "Histo-anatomic Aspects on Zea Mays L. Influenced by Hemp Shives Polyphenolic Extract." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Agriculture 73, no. 2: 317.