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The Australasian Virology Society (AVS) aims to promote, support and advocate for the discipline of virology in the Australasian region. The society was incorporated in 2011 after 10 years operating as the Australian Virology Group (AVG) founded in 2001, coinciding with the inaugural biennial scientific meeting. AVS conferences aim to provide a forum for the dissemination of all aspects of virology, foster collaboration, and encourage participation by students and post-doctoral researchers. The tenth Australasian Virology Society (AVS10) scientific meeting was held on 2–5 December 2019 in Queenstown, New Zealand. This report highlights the latest research presented at the meeting, which included cutting-edge virology presented by our international plenary speakers Ana Fernandez-Sesma and Benjamin tenOever, and keynote Richard Kuhn. AVS10 honoured female pioneers in Australian virology, Lorena Brown and Barbara Coulson. We report outcomes from the AVS10 career development session on “Successfully transitioning from post-doc to lab head”, winners of best presentation awards, and the AVS gender equity policy, initiated in 2013. Plans for the 2021 meeting are underway which will celebrate the 20th anniversary of AVS where it all began, in Fraser Island, Queensland, Australia.
Karla J. Helbig; Rowena A. Bull; Rebecca Ambrose; Michael R. Beard; Helen Blanchard; Till Böcking; Brendon Chua; Agathe M. G. Colmant; Keaton M. Crosse; Damian F. J. Purcell; Johanna Fraser; Joshua A. Hayward; Stuart T. Hamilton; Matloob Husain; Robin MacDiarmid; Jason M. MacKenzie; Gregory W. Moseley; Thi H. O. Nguyen; Miguel E. Quiñones-Mateu; Karl Robinson; Chaturaka Rodrigo; Julio Rodriguez-Andres; Penny A. Rudd; Anja Werno; Peter White; Paul Young; Peter Speck; Merilyn Hibma; Heidi E. Drummer; Gilda Tachedjian. Tenth Scientific Biennial Meeting of the Australasian Virology Society—AVS10 2019. Viruses 2020, 12, 621 .
AMA StyleKarla J. Helbig, Rowena A. Bull, Rebecca Ambrose, Michael R. Beard, Helen Blanchard, Till Böcking, Brendon Chua, Agathe M. G. Colmant, Keaton M. Crosse, Damian F. J. Purcell, Johanna Fraser, Joshua A. Hayward, Stuart T. Hamilton, Matloob Husain, Robin MacDiarmid, Jason M. MacKenzie, Gregory W. Moseley, Thi H. O. Nguyen, Miguel E. Quiñones-Mateu, Karl Robinson, Chaturaka Rodrigo, Julio Rodriguez-Andres, Penny A. Rudd, Anja Werno, Peter White, Paul Young, Peter Speck, Merilyn Hibma, Heidi E. Drummer, Gilda Tachedjian. Tenth Scientific Biennial Meeting of the Australasian Virology Society—AVS10 2019. Viruses. 2020; 12 (6):621.
Chicago/Turabian StyleKarla J. Helbig; Rowena A. Bull; Rebecca Ambrose; Michael R. Beard; Helen Blanchard; Till Böcking; Brendon Chua; Agathe M. G. Colmant; Keaton M. Crosse; Damian F. J. Purcell; Johanna Fraser; Joshua A. Hayward; Stuart T. Hamilton; Matloob Husain; Robin MacDiarmid; Jason M. MacKenzie; Gregory W. Moseley; Thi H. O. Nguyen; Miguel E. Quiñones-Mateu; Karl Robinson; Chaturaka Rodrigo; Julio Rodriguez-Andres; Penny A. Rudd; Anja Werno; Peter White; Paul Young; Peter Speck; Merilyn Hibma; Heidi E. Drummer; Gilda Tachedjian. 2020. "Tenth Scientific Biennial Meeting of the Australasian Virology Society—AVS10 2019." Viruses 12, no. 6: 621.
Arthritogenic alphavirus infections often result in debilitating musculoskeletal disorders that affect the joints, muscle, and bone. In order to evaluate the infection profile of primary human skeletal muscle and chondrocyte cells to Ross River virus (RRV) in vitro, cells were infected at a multiplicity of infection (MOI) of 1 over a period of two days. Viral titers were determined by plaque assay and cytokine expression by Bio-Plex® assays using the supernatants harvested. Gene expression studies were conducted using total RNA isolated from cells. Firstly, we show that RRV RNA is detected in chondrocytes from infected mice in vivo. Both human primary skeletal muscle and chondrocyte cells are able to support productive RRV infection in vitro. We also report the production of soluble host factors including the upregulation of heparanase (HPSE) and inflammatory host factors such as interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), RANTES (regulated on activation, normal T cell expressed and secreted), interferon gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α), which are also present during clinical disease in humans. Our study is the first to demonstrate that human chondrocyte cells are permissive to RRV infection, support the production of infectious virus, and produce soluble factors including HPSE, which may contribute to joint degradation and the pathogenesis of disease.
Elisa X. Y. Lim; Aroon Supramaniam; Hayman Lui; Peta Coles; Wai Suet Lee; Xiang Liu; Penny A. Rudd; Lara J. Herrero. Chondrocytes Contribute to Alphaviral Disease Pathogenesis as a Source of Virus Replication and Soluble Factor Production. Viruses 2018, 10, 86 .
AMA StyleElisa X. Y. Lim, Aroon Supramaniam, Hayman Lui, Peta Coles, Wai Suet Lee, Xiang Liu, Penny A. Rudd, Lara J. Herrero. Chondrocytes Contribute to Alphaviral Disease Pathogenesis as a Source of Virus Replication and Soluble Factor Production. Viruses. 2018; 10 (2):86.
Chicago/Turabian StyleElisa X. Y. Lim; Aroon Supramaniam; Hayman Lui; Peta Coles; Wai Suet Lee; Xiang Liu; Penny A. Rudd; Lara J. Herrero. 2018. "Chondrocytes Contribute to Alphaviral Disease Pathogenesis as a Source of Virus Replication and Soluble Factor Production." Viruses 10, no. 2: 86.