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David Weise
Department of Neurology University of Leipzig Leipzig Germany

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Original research
Published: 05 January 2021 in Brain and Behavior
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Background Subjective symptom complaints often do not match the expert’s ratings in focal dystonia. Nonetheless, perceived symptom intensities drive compliance and outcome of botulinum neurotoxin (BoNT) treatment. Methods Perception of symptom development across a BoNT cycle was obtained in 21 cervical dystonia (CD) and 15 hemifacial spasm (HFS) patients at four time points during a BoNT cycle. Subjective assessments were recorded by means of a quality‐of‐life questionnaire and a patient diary containing items related to subjective severity of disease, mood, pain, social impairment, and quality of life. Medical investigation used the Tsui score and TWSTRS, and a HFS rating score, respectively. Results In both patient groups, subjective intensities were strongly associated with psychological variables. Only in CD did objective assessment moderately correlate with subjective ratings solely at the beginning and the end of the BoNT cycle. Overall, the beneficial effects of BoNT treatment were only loosely associated with subjective experiences in both groups. Conclusion The emotional situation should be assessed regularly in patients undergoing BoNT therapy.

ACS Style

Julia Wöllner; David Weise; Bernd Leplow. Subjective versus objective symptom intensities ratings in cervical dystonia and hemifacial spasm across a botulinum neurotoxin cycle. Brain and Behavior 2021, 11, e02023 .

AMA Style

Julia Wöllner, David Weise, Bernd Leplow. Subjective versus objective symptom intensities ratings in cervical dystonia and hemifacial spasm across a botulinum neurotoxin cycle. Brain and Behavior. 2021; 11 (3):e02023.

Chicago/Turabian Style

Julia Wöllner; David Weise; Bernd Leplow. 2021. "Subjective versus objective symptom intensities ratings in cervical dystonia and hemifacial spasm across a botulinum neurotoxin cycle." Brain and Behavior 11, no. 3: e02023.

Editorial
Published: 01 October 2019 in Das Neurophysiologie-Labor
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David Weise. Neurophysiologie in der klinischen Neurologie. Das Neurophysiologie-Labor 2019, 41, 189 -191.

AMA Style

David Weise. Neurophysiologie in der klinischen Neurologie. Das Neurophysiologie-Labor. 2019; 41 (4):189-191.

Chicago/Turabian Style

David Weise. 2019. "Neurophysiologie in der klinischen Neurologie." Das Neurophysiologie-Labor 41, no. 4: 189-191.

Journal article
Published: 01 September 2019 in Autonomic Neuroscience
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The heart receives parasympathetic and to a lesser degree sympathetic input via the vagus nerve. Here, we investigated whether morphological changes of the cervical vagus nerves (VN) as assessed by high-resolution ultrasound (HRUS) correlated with the autonomic cardiac innervation. Measurement of heart rate variability (HRV) and HRUS of the VNs were performed in 88 healthy subjects (50 female; mean age 56 ± 18 years). HRV parameters and the cross-sectional area (CSA) of the VNs correlated both inversely with age. We also found an inverse correlation between the left VN-CSA and HRV as well as parasympathetic parameters. The results imply an asymmetric parasympathetic (vagal) innervation of the heart.

ACS Style

Johann Otto Pelz; Elena Belau; Ina Menze; Timo Björn Woost; Joseph Classen; David Weise. Correlation between sonographic morphology and function of the cervical vagus nerves. Autonomic Neuroscience 2019, 220, 102552 .

AMA Style

Johann Otto Pelz, Elena Belau, Ina Menze, Timo Björn Woost, Joseph Classen, David Weise. Correlation between sonographic morphology and function of the cervical vagus nerves. Autonomic Neuroscience. 2019; 220 ():102552.

Chicago/Turabian Style

Johann Otto Pelz; Elena Belau; Ina Menze; Timo Björn Woost; Joseph Classen; David Weise. 2019. "Correlation between sonographic morphology and function of the cervical vagus nerves." Autonomic Neuroscience 220, no. : 102552.

Case report
Published: 26 April 2019 in Das Neurophysiologie-Labor
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Die neue Klassifikation von Tremor, der häufigsten Bewegungsstörung basiert auf einem 2-Achsen-Prinzip, einer phänomenologischen Beschreibung des Tremors inklusiver klinischer Charakteristika zum einen und einer ätiologischen Einordnung zum Anderen. Anhand eines Fallbeispiels von einer Patientin mit einem mutmaßlich dystonen Tremor soll diese neue Klassifikation angewendet und die Herausforderungen der differentialdiagnostischen Einordnung dargestellt werden. The new classification of tremors, the most frequent movement disorder is based on two axes, a phenomenological description of the tremor including clinical characteristics on the one hand and a etiological classification on the other hand. On the basis on a case report of patient with presumably dystonic tremor the new classification was applied the challenges of the differential diagnostic discussed.

ACS Style

David Weise. Dystoner Tremor? – ein Fallbericht. Das Neurophysiologie-Labor 2019, 41, 113 -118.

AMA Style

David Weise. Dystoner Tremor? – ein Fallbericht. Das Neurophysiologie-Labor. 2019; 41 (2):113-118.

Chicago/Turabian Style

David Weise. 2019. "Dystoner Tremor? – ein Fallbericht." Das Neurophysiologie-Labor 41, no. 2: 113-118.

Journal article
Published: 12 March 2019 in Journal of Alzheimer's Disease
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Our study revealed correlations between deficits in different cognitive domains and regional early after administration [11C]PiB PET data similar to those known from [18F]FDG PET studies. Thus, our data support the assumption that early [11C]PiB PET data have a potential as neuronal injury biomarker. Head-to-head double-tracer studies of larger cohorts are needed to confirm this assumption.

ACS Style

Solveig Tiepolt; Julia Luthardt; Marianne Patt; Swen Hesse; Karl Titus Hoffmann; David Weise; Hermann Josef Gertz; Osama S. Bri; Henryk Barthel. Early after Administration [11C]PiB PET Images Correlate with Cognitive Dysfunction Measured by the CERAD Test Battery. Journal of Alzheimer's Disease 2019, 68, 65 -76.

AMA Style

Solveig Tiepolt, Julia Luthardt, Marianne Patt, Swen Hesse, Karl Titus Hoffmann, David Weise, Hermann Josef Gertz, Osama S. Bri, Henryk Barthel. Early after Administration [11C]PiB PET Images Correlate with Cognitive Dysfunction Measured by the CERAD Test Battery. Journal of Alzheimer's Disease. 2019; 68 (1):65-76.

Chicago/Turabian Style

Solveig Tiepolt; Julia Luthardt; Marianne Patt; Swen Hesse; Karl Titus Hoffmann; David Weise; Hermann Josef Gertz; Osama S. Bri; Henryk Barthel. 2019. "Early after Administration [11C]PiB PET Images Correlate with Cognitive Dysfunction Measured by the CERAD Test Battery." Journal of Alzheimer's Disease 68, no. 1: 65-76.

Journal article
Published: 19 January 2019 in Clinical Neurophysiology
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Degeneration of nuclei of the brainstem, especially parts of the vagal nuclei complex and the reticular formation, in Parkinson’s disease (PD) may in part be responsible for nonmotor signs like obstipation, cardiac dysfunction and rapid eye movement sleep behavior disorder (RBD). The aim of the study was to establish a new blink reflex (BR) variant involving the vagal nuclei complex and the reticular formation and to investigate BR comprehensively using 3 different afferent routes in PD. In this cross-sectional observational study in 30 PD patients and 30 age and sex matched healthy controls, BR was elicited by stimulation of the auricular branch of the vagus nerve (ABVN) and compared to conventional BR variants evoked by the trigeminal and median nerve. BRs could be elicited reliably by stimulation of ABVN in both groups. In none of the three BR variants, latencies or amplitudes differed between PD patients and controls. In PD, BR parameters were not related to cognition or presence of RBD. The present study did not provide evidence for malfunctioning of neural circuits subserving BRs elicited by three different afferents in PD. Brainstem circuits mediating these BR variants may be spared from neurodegeneration in PD.

ACS Style

David Weise; Clemens Pargac; Johann Otto Pelz; Jost-Julian Rumpf; Christopher Fricke; Joseph Classen. Assessing blink reflex circuits by three different afferent routes in Parkinson’s disease. Clinical Neurophysiology 2019, 130, 582 -587.

AMA Style

David Weise, Clemens Pargac, Johann Otto Pelz, Jost-Julian Rumpf, Christopher Fricke, Joseph Classen. Assessing blink reflex circuits by three different afferent routes in Parkinson’s disease. Clinical Neurophysiology. 2019; 130 (4):582-587.

Chicago/Turabian Style

David Weise; Clemens Pargac; Johann Otto Pelz; Jost-Julian Rumpf; Christopher Fricke; Joseph Classen. 2019. "Assessing blink reflex circuits by three different afferent routes in Parkinson’s disease." Clinical Neurophysiology 130, no. 4: 582-587.

Review
Published: 06 January 2019 in Toxins
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For more than three decades, Botulinum neurotoxin (BoNT) has been used to treat a variety of clinical conditions such as spastic or dystonic disorders by inducing a temporary paralysis of the injected muscle as the desired clinical effect. BoNT is known to primarily act at the neuromuscular junction resulting in a biochemical denervation of the treated muscle. However, recent evidence suggests that BoNT’s pharmacological properties may not only be limited to local muscular denervation at the injection site but may also include additional central effects. In this review, we report and discuss the current evidence for BoNT’s central effects based on clinical observations, neurophysiological investigations and neuroimaging studies in humans. Collectively, these data strongly point to indirect mechanisms via changes to sensory afferents that may be primarily responsible for the marked plastic effects of BoNT on the central nervous system. Importantly, BoNT-related central effects and consecutive modulation and/or reorganization of the brain may not solely be considered “side-effects” but rather an additional therapeutic impact responsible for a number of clinical observations that cannot be explained by merely peripheral actions.

ACS Style

David Weise; Christopher M. Weise; Markus Naumann. Central Effects of Botulinum Neurotoxin—Evidence from Human Studies. Toxins 2019, 11, 21 .

AMA Style

David Weise, Christopher M. Weise, Markus Naumann. Central Effects of Botulinum Neurotoxin—Evidence from Human Studies. Toxins. 2019; 11 (1):21.

Chicago/Turabian Style

David Weise; Christopher M. Weise; Markus Naumann. 2019. "Central Effects of Botulinum Neurotoxin—Evidence from Human Studies." Toxins 11, no. 1: 21.

Brief research report article
Published: 12 November 2018 in Frontiers in Neurology
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Background: Recent histopathological studies revealed degeneration of the dorsal motor nucleus early in the course of Parkinson's disease (PD). Degeneration of the vagus nerve (VN) axons following neurodegeneration of brainstem vagal nuclei should be detectable by high-resolution ultrasound (HRUS) as a thinning of the VNs. Methods: We measured both VNs cross-sectional area (VN-CSA) of 35 patients with PD and 35 age- and sex-matched healthy controls at the level of the thyroid gland using HRUS. Results: On both sides, the VN-CSA was significantly smaller in PD patients than in controls (right: 2.1 ± 0.4 vs. 2.3 ± 0.5 mm2, left 1.5 ± 0.4 vs. 1.8 ± 0.4 mm2; both p < 0.05). There was no correlation between the right or left VN-CSA and age, the Hoehn & Yahr stage, disease duration, the motor part of the Unified Parkinson's Disease Rating Scale score, the Montreal Cognitive Assessment score, or the Non-motor Symptoms Questionnaire, and Scale for Parkinson's disease score including its gastrointestinal domain. Conclusions: These findings provide evidencethat atrophy of the VNs in PD patients can be detected in-vivo by HRUS.

ACS Style

Johann Otto Pelz; Elena Belau; Christopher Fricke; Joseph Classen; David Weise. Axonal Degeneration of the Vagus Nerve in Parkinson's Disease—A High-Resolution Ultrasound Study. Frontiers in Neurology 2018, 9, 951 .

AMA Style

Johann Otto Pelz, Elena Belau, Christopher Fricke, Joseph Classen, David Weise. Axonal Degeneration of the Vagus Nerve in Parkinson's Disease—A High-Resolution Ultrasound Study. Frontiers in Neurology. 2018; 9 ():951.

Chicago/Turabian Style

Johann Otto Pelz; Elena Belau; Christopher Fricke; Joseph Classen; David Weise. 2018. "Axonal Degeneration of the Vagus Nerve in Parkinson's Disease—A High-Resolution Ultrasound Study." Frontiers in Neurology 9, no. : 951.

Scientific news
Published: 20 September 2018 in DGNeurologie
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ACS Style

D. Weise. Theta-Oszillationen des Globus pallidus. DGNeurologie 2018, 1, 132 -133.

AMA Style

D. Weise. Theta-Oszillationen des Globus pallidus. DGNeurologie. 2018; 1 (2):132-133.

Chicago/Turabian Style

D. Weise. 2018. "Theta-Oszillationen des Globus pallidus." DGNeurologie 1, no. 2: 132-133.

Original communication
Published: 06 August 2018 in Journal of Neurology
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To investigate whether consolidation after motor learning can be facilitated by offline (post-training) transcranial direct current stimulation (tDCS) in patients with multiple sclerosis (MS). In this cross-sectional double-blind interventional study, effects of tDCS on motor consolidation were examined in 14 patients with relapsing remitting MS [median Expanded Disability Status Scale score 2.0 (range 1–4)] and 14 age- and sex-matched healthy controls. tDCS with the anode placed over the left primary motor cortex and the cathode placed over the right supraorbital region was applied immediately after a training session of an explicit sequential finger-tapping task that was performed with the right (dominant) hand. Task performance was retested after an interval of 8 h to assess consolidation. Participants took part in two experimental sessions separated by at least 7 days which differed with respect to type of post-training tDCS, i.e., sham and verum stimulation. Patients with MS performed worse than controls in functional motor tests and the motor sequence task. However, learning speed and magnitude of online performance increments during the training session were comparable to controls. While post-training tDCS facilitated motor consolidation in controls, patients with MS did not benefit from this type of intervention. Absence of post-training tDCS-induced facilitation of consolidation in patients with MS suggests that the interaction of tDCS with the motor consolidation network is inefficient. Identification of the underlying disease-related mechanisms will have important implications for the design of studies aiming to promote motor recovery in MS by non-invasive brain stimulation.

ACS Style

Jost-Julian Rumpf; Sophie Dietrich; Muriel Stoppe; Christopher Fricke; David Weise; Florian Then Bergh; Joseph Classen. Compromised tDCS-induced facilitation of motor consolidation in patients with multiple sclerosis. Journal of Neurology 2018, 265, 2302 -2311.

AMA Style

Jost-Julian Rumpf, Sophie Dietrich, Muriel Stoppe, Christopher Fricke, David Weise, Florian Then Bergh, Joseph Classen. Compromised tDCS-induced facilitation of motor consolidation in patients with multiple sclerosis. Journal of Neurology. 2018; 265 (10):2302-2311.

Chicago/Turabian Style

Jost-Julian Rumpf; Sophie Dietrich; Muriel Stoppe; Christopher Fricke; David Weise; Florian Then Bergh; Joseph Classen. 2018. "Compromised tDCS-induced facilitation of motor consolidation in patients with multiple sclerosis." Journal of Neurology 265, no. 10: 2302-2311.

Fort und weiterbildung
Published: 28 June 2018 in Fortschritte der Neurologie · Psychiatrie
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Zervikale Dystonien sind die häufigsten fokalen Dystonien. Der apparativen Diagnostik müssen eine gründliche allgemeine klinische neurologische Untersuchung und eine exakte phänomenologische Bewertung voran gestellt werden. Bei der Detektion der dystonen Muskeln hilft das Collum-Caput Concept, da nahezu alle Halsmuskeln entweder am Kopf oder an der HWS wirken. Die Behandlung mit Botulinumtoxin ist das therapeutische Mittel der Wahl.

ACS Style

Gerhard Reichel; Christoph Kamm; Jun Suk Kang; Martina Müngersdorf; Sebastian Paus; Iris Reuter; Andrea Stenner; David Weise. Zervikale Dystonien. Fortschritte der Neurologie · Psychiatrie 2018, 86, 368 -386.

AMA Style

Gerhard Reichel, Christoph Kamm, Jun Suk Kang, Martina Müngersdorf, Sebastian Paus, Iris Reuter, Andrea Stenner, David Weise. Zervikale Dystonien. Fortschritte der Neurologie · Psychiatrie. 2018; 86 (6):368-386.

Chicago/Turabian Style

Gerhard Reichel; Christoph Kamm; Jun Suk Kang; Martina Müngersdorf; Sebastian Paus; Iris Reuter; Andrea Stenner; David Weise. 2018. "Zervikale Dystonien." Fortschritte der Neurologie · Psychiatrie 86, no. 6: 368-386.

Journal article
Published: 01 September 2017 in NeuroImage
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Power and precision grasps are two interrelated, kinematically distinct types of finger movements. We examined whether these types of motor actions may be spatially differently represented in the human central nervous system. In healthy participants representations of finger movements were mapped by delivering single pulse TMS to multiple scalp regions covering the left primary motor cortex (M1). Finger joint motions were recorded from the right hand using a data glove. Principal component analysis was used to extract local subspaces representing the TMS-evoked movement data from each scalp region. Voluntary power and precision grasps were reconstructed with these subspaces. The spatial properties of these reconstructions were analyzed for each grasp type using a general linear model. We found overlapping, yet distinct spatial representations for precision and power grasps with precision grasps represented slightly posterior compared to a more uniform distribution for power grasps. Differential spatial encoding of both grasp types may point towards a representation of power grasps within a phylogenetically older M1 area at the crown of the precentral gyrus and of precision grasps in a newer area in the depth of the central sulcus. Results also support the idea of separate synergistic movement representations in the human motor system.

ACS Style

Christopher Fricke; Reinhard Gentner; Jost-Julian Rumpf; David Weise; Dorothee Saur; Joseph Classen. Differential spatial representation of precision and power grasps in the human motor system. NeuroImage 2017, 158, 58 -69.

AMA Style

Christopher Fricke, Reinhard Gentner, Jost-Julian Rumpf, David Weise, Dorothee Saur, Joseph Classen. Differential spatial representation of precision and power grasps in the human motor system. NeuroImage. 2017; 158 ():58-69.

Chicago/Turabian Style

Christopher Fricke; Reinhard Gentner; Jost-Julian Rumpf; David Weise; Dorothee Saur; Joseph Classen. 2017. "Differential spatial representation of precision and power grasps in the human motor system." NeuroImage 158, no. : 58-69.

Journal article
Published: 28 November 2016 in Muscle & Nerve
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Freehand 3DUS of the median nerve over 20 cm is feasible and may help overcome some of the limitations and pitfalls of 2DUS. Muscle Nerve 55: 206-212, 2017.

ACS Style

Johann Otto Pelz; Maria Busch; Anna Weinreich; Rothee Saur; David Weise. Evaluation Of freehand high-resolution 3-dimensional ultrasound of the median nerve. Muscle & Nerve 2016, 55, 206 -212.

AMA Style

Johann Otto Pelz, Maria Busch, Anna Weinreich, Rothee Saur, David Weise. Evaluation Of freehand high-resolution 3-dimensional ultrasound of the median nerve. Muscle & Nerve. 2016; 55 (2):206-212.

Chicago/Turabian Style

Johann Otto Pelz; Maria Busch; Anna Weinreich; Rothee Saur; David Weise. 2016. "Evaluation Of freehand high-resolution 3-dimensional ultrasound of the median nerve." Muscle & Nerve 55, no. 2: 206-212.

Journal article
Published: 13 September 2016 in Neurobiology of Aging
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Consolidation, by which performance increments after a training intervention are secured and sometimes generated, is reduced in elderly humans. The present study addressed the question whether transcranial direct current stimulation (tDCS) applied after motor training improves consolidation of explicit motor sequence learning in healthy older humans. In the first experiment, anodal or cathodal tDCS to the left primary motor cortex, anodal tDCS to premotor cortex, or sham tDCS was applied immediately after completion of a finger sequence learning task. Performance was retested at 8 and 22 hours after the initial training session. Whereas all groups achieved similar performance at the end of training, off-line improvements differed between groups at later retesting, depending on the type of intervention. Relative to the other 3 interventions, anodal tDCS to primary motor cortex (M1) led to performance improvements already at retesting 8 hours after initial learning and were maintained on the next day. In the second experiment, effects of the timing of post-training anodal tDCS to M1 with respect to the end of training were studied. Participants received anodal tDCS of M1 immediately or 60 or 120 minutes after training and were retested on sequence performance 8 hours post training. Only application of tDCS immediately after the end of training, but not after 1 or 2 hours, enhanced off-line consolidation. These findings suggest that anodal tDCS applied off-line immediately post training to M1 interacts specifically with early processes promoting consolidation of motor sequence learning in healthy older individuals.

ACS Style

Jost-Julian Rumpf; Mirko Wegscheider; Karen Hinselmann; Christopher Fricke; Bradley King; David Weise; Juliane Klann; Ferdinand Binkofski; Giovanni Buccino; Avi Karni; Julien Doyon; Joseph Classen. Enhancement of motor consolidation by post-training transcranial direct current stimulation in older people. Neurobiology of Aging 2016, 49, 1 -8.

AMA Style

Jost-Julian Rumpf, Mirko Wegscheider, Karen Hinselmann, Christopher Fricke, Bradley King, David Weise, Juliane Klann, Ferdinand Binkofski, Giovanni Buccino, Avi Karni, Julien Doyon, Joseph Classen. Enhancement of motor consolidation by post-training transcranial direct current stimulation in older people. Neurobiology of Aging. 2016; 49 ():1-8.

Chicago/Turabian Style

Jost-Julian Rumpf; Mirko Wegscheider; Karen Hinselmann; Christopher Fricke; Bradley King; David Weise; Juliane Klann; Ferdinand Binkofski; Giovanni Buccino; Avi Karni; Julien Doyon; Joseph Classen. 2016. "Enhancement of motor consolidation by post-training transcranial direct current stimulation in older people." Neurobiology of Aging 49, no. : 1-8.

Journal article
Published: 11 July 2016 in Cerebral Cortex
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Activity-dependent changes of postsynaptic Ca2+-concentration are influenced by a variety of different Ca2+-channels and play an important role in synaptic plasticity. Paired associative stimulation (PAS) and theta-burst stimulation (TBS) are noninvasive magnetic stimulation protocols used in human subjects to induce lasting corticospinal excitability changes that have been likened to synaptic long-term potentiation and long-term depression. To better characterize the Ca2+-related physiological mechanisms underlying PAS- and TBS-induced plasticity, we examined the impact of different Ca2+-sources. PAS-induced facilitation of corticospinal excitability was blocked by NMDA-receptor blocker dextromethorphan (DXM) and L-type voltage gated Ca2+ channels (VGCC) blocker nimodipine (NDP), but turned into depression by T-type VGCC blocker ethosuximide (ESM). Although, surprisingly, static corticospinal excitability was increased by the combination of DXM and NDP, PAS-induced facilitation was blocked. TBS-induced facilitation of corticospinal excitability, which has previously been shown to be turned into depression by L-type VGCC blocker NDP (Wankerl K, Weise D, Gentner R, Rumpf J, Classen J. 2010. L-type voltage-gated Ca2+ channels: a single molecular switch for long-term potentiation/long-term depression-like plasticity and activity-dependent metaplasticity in humans. J Neurosci. 30(18):6197–6204.), was blocked, but not reverted, by T-type VGCC blocker ESM. The different patterns of Ca2+-channel modulation of PAS- and TBS-induced plasticity may point to an important role of backpropagating action potentials in PAS-induced plasticity, similar as in spike-timing dependent synaptic plasticity, and to a requirement of dendritic Ca2+-dependent spikes in TBS-induced plasticity.

ACS Style

David Weise; Jakob Mann; Jost-Julian Rumpf; Stefan Hallermann; Joseph Classen. Differential Regulation of Human Paired Associative Stimulation-Induced and Theta-Burst Stimulation-Induced Plasticity by L-type and T-type Ca2+Channels. Cerebral Cortex 2016, 27, 4010 -4021.

AMA Style

David Weise, Jakob Mann, Jost-Julian Rumpf, Stefan Hallermann, Joseph Classen. Differential Regulation of Human Paired Associative Stimulation-Induced and Theta-Burst Stimulation-Induced Plasticity by L-type and T-type Ca2+Channels. Cerebral Cortex. 2016; 27 (8):4010-4021.

Chicago/Turabian Style

David Weise; Jakob Mann; Jost-Julian Rumpf; Stefan Hallermann; Joseph Classen. 2016. "Differential Regulation of Human Paired Associative Stimulation-Induced and Theta-Burst Stimulation-Induced Plasticity by L-type and T-type Ca2+Channels." Cerebral Cortex 27, no. 8: 4010-4021.

Journal article
Published: 01 June 2016 in Das Neurophysiologie-Labor
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Neurophysiologische Untersuchungen des Hirnstamms stellen auch in Zeiten der hochauflösenden Magnetresonanztomographie weiterhin einen wichtigen Bestandteil in der topographischen Diagnostik von Hirnstammläsionen dar. Während die vestibulär evozierten myogenen Potenziale (VEMP) in der Hals-Nasen-Ohren-Heilkunde einen festen Bestandteil in der neuro-otologischen Diagnostik des Gleichgewichtsorgans eingenommen haben, sind sie in der Neurologie bisher wenig verbreitet. Mit Hilfe der VEMP können unterschiedliche Reflexbögen des Hirnstamms, der vestibulo-collische sowie der vestibulo-okuläre Reflex differenziert neurophysiologisch untersucht werden. Die aktuelle Arbeit soll einen Überblick über die Anatomie und Physiologie sowie die Methodik der VEMP geben. Darüber hinaus sollen die Einsatzmöglichkeiten und Bedeutung der VEMP in der Neurologie dargestellt werden. Even in times of high-resolution magnetic resonance imaging neurophysiological studies of the brainstem do still play a crucial role in the topographic diagnostic of brainstem pathology. Vestibular evoked myogenic potentials (VEMP) form an integral part of the neurootological examinations in order to establish the functional status of the otolith organs in otorhinolaryngology whereas they are less established in neurology. By means of VEMP different reflex circuits of the brainstem, the vestibulo-collic and the vestibulo-ocular reflex can be investigated. The recent article gives an overview of the anatomy and physiology of the VEMP and its methodological approach. Furthermore, the characteristics and capabilities of the VEMP in neurological disorders are presented.

ACS Style

David Weise. Vestibulär evozierte myogene Potentiale in der Neurologie. Das Neurophysiologie-Labor 2016, 38, 85 -92.

AMA Style

David Weise. Vestibulär evozierte myogene Potentiale in der Neurologie. Das Neurophysiologie-Labor. 2016; 38 (2):85-92.

Chicago/Turabian Style

David Weise. 2016. "Vestibulär evozierte myogene Potentiale in der Neurologie." Das Neurophysiologie-Labor 38, no. 2: 85-92.

Observational study
Published: 23 September 2015 in Movement Disorders
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This study was undertaken to address the question of whether pigmentation may be mechanistically linked with Parkinson's disease. In a cross-sectional, observational study, 116 healthy subjects received transcranial sonography of the substantia nigra. Pigmentation phenotype was assessed using the Fitzpatrick skin phototype classification, and five additional phenotypic pigmentation traits as well as a photographic method (Melanin index) in a subgroup of 46 subjects. Lighter skin phototype was associated with larger echogenic substantia nigra area and increased prevalence of abnormally enlarged echogenic substantia nigra area. The strongest association of substantia nigra echogenicity and phenotypic pigmentation traits was found for hair color and facial tanning. Findings suggest an increasing prevalence of structural abnormality of substantia nigra with decreasing darkness of skin and thus may provide additional evidence in favor of a pathogenic link of pigmentation and Parkinson's disease.

ACS Style

Jost‐Julian Rumpf; Maria Schirmer; Christopher Fricke; David Weise; Justinus Aspasios Wagner; Jan Šimon; Joseph Classen. Light pigmentation phenotype is correlated with increased substantia nigra echogenicity. Movement Disorders 2015, 30, 1848 -1852.

AMA Style

Jost‐Julian Rumpf, Maria Schirmer, Christopher Fricke, David Weise, Justinus Aspasios Wagner, Jan Šimon, Joseph Classen. Light pigmentation phenotype is correlated with increased substantia nigra echogenicity. Movement Disorders. 2015; 30 (13):1848-1852.

Chicago/Turabian Style

Jost‐Julian Rumpf; Maria Schirmer; Christopher Fricke; David Weise; Justinus Aspasios Wagner; Jan Šimon; Joseph Classen. 2015. "Light pigmentation phenotype is correlated with increased substantia nigra echogenicity." Movement Disorders 30, no. 13: 1848-1852.

Comparative study
Published: 09 September 2015 in Journal of Alzheimer's Disease
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Biomarkers of neuronal injury and amyloid pathology play a pivotal role in the diagnosis of Alzheimer's disease (AD). The degree of AD biomarker congruence is still unclear in clinical practice. Diagnosis of AD with regard to the congruence of the clinical diagnosis and different biomarkers. In this prospective cross-sectional observational study, 54 patients with mild cognitive impairment or dementia due to AD or not due to AD were investigated. Biomarkers of neuronal injury were medial temporal lobe atrophy (MTA) on magnetic resonance imaging (MRI) and tau concentration in the cerebrospinal fluid (CSF). CSF Aβ(1-42) and amyloid-targeting positron emission tomography (PET) were considered as biomarkers of amyloid pathology. Forty cases were diagnosed as AD and 14 cases were diagnosed as non-AD based on clinical and routine MRI assessment. AD cases had higher MTA scores, higher levels of CSF tau and lower levels of CSF Aβ(1- 42), and higher amyloid load on PET compared to the non-AD group. In the AD group, completely consistently pathological biomarkers were found in 32.5% , non-pathological in 5% . In 62.5% the findings were inconsistent. Congruence of biomarkers was 67.5% for neuronal injury and for amyloid dysfunction, respectively. In two patients, clinical diagnosis switched to non-AD due to completely consistent non-pathological biomarker findings. The criteria of the international working group were met in 75.0% . Surprisingly, the number of completely congruent biomarkers was relatively low. Interpretation of AD biomarkers is complicated by multiple biomarker constellations. However, the level of biomarker consistency required to reliably diagnose AD remains uncertain.

ACS Style

David Weise; Solveig Tiepolt; Carolin Awissus; Karl-Titus Hoffmann; Donald Lobsien; Thorsten Kaiser; Henryk Barthel; Osama Sabri; Hermann-Josef Gertz. Critical Comparison of Different Biomarkers for Alzheimer’s Disease in a Clinical Setting. Journal of Alzheimer's Disease 2015, 48, 425 -432.

AMA Style

David Weise, Solveig Tiepolt, Carolin Awissus, Karl-Titus Hoffmann, Donald Lobsien, Thorsten Kaiser, Henryk Barthel, Osama Sabri, Hermann-Josef Gertz. Critical Comparison of Different Biomarkers for Alzheimer’s Disease in a Clinical Setting. Journal of Alzheimer's Disease. 2015; 48 (2):425-432.

Chicago/Turabian Style

David Weise; Solveig Tiepolt; Carolin Awissus; Karl-Titus Hoffmann; Donald Lobsien; Thorsten Kaiser; Henryk Barthel; Osama Sabri; Hermann-Josef Gertz. 2015. "Critical Comparison of Different Biomarkers for Alzheimer’s Disease in a Clinical Setting." Journal of Alzheimer's Disease 48, no. 2: 425-432.

Comparative study
Published: 07 April 2015 in PLOS ONE
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The efferent dorsal motor nucleus of the vagal nuclei complex may degenerate early in the course of Parkinson’s disease (PD), while efferent nucleus ambiguous, the principal source of parasympathetic vagal neurons innervating the heart, and afferent somatosensory nuclei remain intact. To obtain neurophysiological evidence related to this pattern, we tested processing of afferent sensory information transmitted via the auricular branch of the vagus nerve (ABVN) which is known to be connected to autonomic regulation of cardiac rhythm. In this cross-sectional observational study, we recorded (i) somatosensory evoked potentials (ABVN-SEP) and (ii) cutaneo-cardioautonomic response elicited by stimulation of the ABVN (modulation of heart-rate variability (HRV index; low frequency power, ln(LF), high frequency power, ln(HF); ln(LF/HF) ratio)) in 50 PD patients and 50 age and sex matched healthy controls. Additionally, auditory evoked potentials and trigeminal nerve SEP were assessed. Neither ABVN-SEP nor any of the other functional brainstem parameters differed between patients and controls. Although HRV index was decreased in PD patients, modulation of ln(LF/HF) by ABVN-stimulation, likely indicating cardiac parasympathetic activation, did not differ between both groups. Findings do not point to prominent dysfunction of processing afferent information from ABVN and its connected parasympathetic cardiac pathway in PD. They are consistent with the known pattern of degeneration of the vagal nuclei complex of the brainstem.

ACS Style

David Weise; Melanie Adamidis; Fabio Pizzolato; Jost-Julian Rumpf; Christopher Fricke; Joseph Classen. Assessment of Brainstem Function with Auricular Branch of Vagus Nerve Stimulation in Parkinson’s Disease. PLOS ONE 2015, 10, e0120786 .

AMA Style

David Weise, Melanie Adamidis, Fabio Pizzolato, Jost-Julian Rumpf, Christopher Fricke, Joseph Classen. Assessment of Brainstem Function with Auricular Branch of Vagus Nerve Stimulation in Parkinson’s Disease. PLOS ONE. 2015; 10 (4):e0120786.

Chicago/Turabian Style

David Weise; Melanie Adamidis; Fabio Pizzolato; Jost-Julian Rumpf; Christopher Fricke; Joseph Classen. 2015. "Assessment of Brainstem Function with Auricular Branch of Vagus Nerve Stimulation in Parkinson’s Disease." PLOS ONE 10, no. 4: e0120786.

Comparative study
Published: 02 January 2015 in Computer Aided Surgery
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ACS Style

Cornelia Matzke; Dirk Lindner; Johannes Schwarz; Joseph Classen; Niels Hammer; David Weise; Jost-Julian Rumpf; Dominik Fritzsch; Jürgen Meixensberger; Dirk Winkler. A comparison of two surgical approaches in functional neurosurgery: individualized versus conventional stereotactic frames. Computer Aided Surgery 2015, 20, 34 -40.

AMA Style

Cornelia Matzke, Dirk Lindner, Johannes Schwarz, Joseph Classen, Niels Hammer, David Weise, Jost-Julian Rumpf, Dominik Fritzsch, Jürgen Meixensberger, Dirk Winkler. A comparison of two surgical approaches in functional neurosurgery: individualized versus conventional stereotactic frames. Computer Aided Surgery. 2015; 20 (1):34-40.

Chicago/Turabian Style

Cornelia Matzke; Dirk Lindner; Johannes Schwarz; Joseph Classen; Niels Hammer; David Weise; Jost-Julian Rumpf; Dominik Fritzsch; Jürgen Meixensberger; Dirk Winkler. 2015. "A comparison of two surgical approaches in functional neurosurgery: individualized versus conventional stereotactic frames." Computer Aided Surgery 20, no. 1: 34-40.