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Prof. Mireille Van Poppel
University of Graz, Institute of Human Movement Science, Sport & Health, Exercise Physiology, Training & Training Therapy Research Group

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0 Obesity
0 Pregnancy
0 Prevention and treatment of chronic diseases
0 Physical Activity and Health Promotion
0 intervention research

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Physical Activity and Health Promotion
Pregnancy
Obesity
Prevention and treatment of chronic diseases

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Journal article
Published: 14 August 2021 in International Journal of Environmental Research and Public Health
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The multidimensional concept of physical literacy is fundamental for lifelong physical activity engagement. However, physical literacy-based interventions are in their infancy, especially among adults. Therefore, the purpose of this pilot study was to assess the association of a physical literacy-based intervention with changes in self-reported physical literacy among inactive adults. A non-randomized controlled study (2 × 2 design) was conducted, comparing pre- vs. postintervention. Twenty-eight inactive healthy participants in the intervention group (89% female, 53 ± 10 years) entered a physical literacy-based intervention once weekly for 14 weeks. The non-treated control group consisted of 22 inactive adults (96% female, 50 ± 11 years). Physical literacy was evaluated with a questionnaire encompassing five domains: physical activity behavior, attitude/understanding, motivation, knowledge, and self-efficacy/confidence. ANOVA models were applied to evaluate changes by time and condition. Following the intervention, significant improvements were seen for overall physical literacy and in four out of five physical literacy domains, including physical activity behavior, attitude/understanding, knowledge, and self-efficacy/confidence (all p< 0.01, Cohen’s d = 0.38–0.83). No changes by time x condition were found for motivation. The physical literacy-based intervention applied in this study may be a promising approach to help inactive adults to adopt an active lifestyle.

ACS Style

Peter Holler; Johannes Jaunig; Othmar Moser; Silvia Tuttner; Helmut Simi; Dietmar Wallner; Frank Michael Amort; Mireille van Poppel. Primary Care and Physical Literacy: A Non-Randomized Controlled Pilot Study to Combat the High Prevalence of Physically Inactive Adults in Austria. International Journal of Environmental Research and Public Health 2021, 18, 8593 .

AMA Style

Peter Holler, Johannes Jaunig, Othmar Moser, Silvia Tuttner, Helmut Simi, Dietmar Wallner, Frank Michael Amort, Mireille van Poppel. Primary Care and Physical Literacy: A Non-Randomized Controlled Pilot Study to Combat the High Prevalence of Physically Inactive Adults in Austria. International Journal of Environmental Research and Public Health. 2021; 18 (16):8593.

Chicago/Turabian Style

Peter Holler; Johannes Jaunig; Othmar Moser; Silvia Tuttner; Helmut Simi; Dietmar Wallner; Frank Michael Amort; Mireille van Poppel. 2021. "Primary Care and Physical Literacy: A Non-Randomized Controlled Pilot Study to Combat the High Prevalence of Physically Inactive Adults in Austria." International Journal of Environmental Research and Public Health 18, no. 16: 8593.

Journal article
Published: 30 May 2021 in International Journal of Environmental Research and Public Health
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While the benefits of physical activity (PA) during and after pregnancy have been established, many women do not reach the recommended PA levels during this time. A major barrier found in the literature is a lack of counselling by healthcare providers (HCPs), which is partly caused by the limited knowledge on the topic. The aim of this study was to develop an intervention to improve the promotion of PA by HCPs. We used Intervention Mapping (IM), a theory-based framework to develop an intervention, called “Baby steps”, in a high-income (Austria) and a low-to-middle-income country (South Africa). We applied the following IM steps: (1) A needs assessment to determine the barriers and enablers of PA promotion by HCPs, including a scoping literature review and community needs assessments (qualitative interviews, questionnaires, and focus groups with midwives, obstetricians, and community health workers) to determine the desired outcomes of the intervention. (2) Performance and change objectives were formulated, describing the behaviors that need to change for the intervention to succeed. (3) Based on these objectives, theory-based behavior change techniques were selected, and practical applications were developed. (4) The applications were combined into two evidence-based interventions tailored to each country’s needs. Step (5) and (6) consist of an implementation and evaluation plan, respectively. The intervention is aimed at HCPs, such as midwives and community health workers, consisting of a two-day training course, including practical resources. Combining didactic and interactive education, it addresses both PA knowledge and the skills needed to transfer knowledge and facilitate behavior change. In the future, the intervention’s effect on women’s activity levels during and after pregnancy needs to be studied.

ACS Style

Anna Dieberger; Mireille van Poppel; Estelle Watson. Baby Steps: Using Intervention Mapping to Develop a Sustainable Perinatal Physical Activity Healthcare Intervention. International Journal of Environmental Research and Public Health 2021, 18, 5869 .

AMA Style

Anna Dieberger, Mireille van Poppel, Estelle Watson. Baby Steps: Using Intervention Mapping to Develop a Sustainable Perinatal Physical Activity Healthcare Intervention. International Journal of Environmental Research and Public Health. 2021; 18 (11):5869.

Chicago/Turabian Style

Anna Dieberger; Mireille van Poppel; Estelle Watson. 2021. "Baby Steps: Using Intervention Mapping to Develop a Sustainable Perinatal Physical Activity Healthcare Intervention." International Journal of Environmental Research and Public Health 18, no. 11: 5869.

Preprint content
Published: 13 April 2021
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Importance: Previous studies showed reduced self-reported physical activity levels in children due to the coronavirus disease 2019 (COVID-19) mitigation measures, whereas limited data is available for objectively assessed health parameters. Objective: To examine the influence of these measures on the longitudinal development of cardiorespiratory fitness (CRF) and body mass index (BMI) of primary school children. Design: Cohort study with baseline measurements in September 2019, before the COVID-19 mitigation measures and follow-ups in June and September 2020. Setting: Twelve randomly selected primary schools in urban and rural districts of Klagenfurt, Austria. Participants: Legal guardians of 860 children provided written consent. A total of 764 children (88.8%) aged 7-10 years completed all measurements and were included for analyses. Exposure: COVID-19 mitigation measures. Main Outcomes and Measures: The study was planned as a randomized controlled trial, but analyzed as a longitudinal study due to stopped intervention because of COVID-19 mitigation regulations. CRF was measured with a 6-min run test. Height and weight were objectively measured. Age- and gender-specific national and international standard deviation scores (SDS) were calculated for CRF and BMI. Changes over time were analysed using ANOVAs. Secondary analyses were performed for subgroups divided by gender and sports club membership. Results: From September 2019 to September 2020, CRF SDS decreased by -1.06 (95% CI, -1.13 to -1.00), with a similar rate of decrease in both boys and girls. In June 2020, BMI SDS had increased by 0.12 (95% CI, 0.06-0.16), and in September 2020 by 0.16 (95% CI, 0.12-0.20), compared to September 2019. The rate of increase in BMI SDS was higher in boys (0.23 [95% CI, 0.18-0.29]) than in girls (0.09 [95% CI, 0.04-0.15]). Over the 1-year period, the proportion of children with overweight or obesity increased from 20.3% to 24.1% (+3.8%, P < .001), according to International Obesity Taskforce thresholds. Conclusions and Relevance: COVID-19 mitigation measures have negative indirect consequences of on relevant health parameters of children. Since these mitigation measures continued after our last assessments, consequences will have increased. Collaborative efforts are required to negate and reverse these effects on children's health, to prevent long-term negative health consequences.

ACS Style

Gerald Jarnig; Johannes Jaunig; Mireille N.M. van Poppel. Changes in cardiorespiratory fitness and body mass index due to COVID-19 mitigation measures in Austrian children aged 7 to 10 years. 2021, 1 .

AMA Style

Gerald Jarnig, Johannes Jaunig, Mireille N.M. van Poppel. Changes in cardiorespiratory fitness and body mass index due to COVID-19 mitigation measures in Austrian children aged 7 to 10 years. . 2021; ():1.

Chicago/Turabian Style

Gerald Jarnig; Johannes Jaunig; Mireille N.M. van Poppel. 2021. "Changes in cardiorespiratory fitness and body mass index due to COVID-19 mitigation measures in Austrian children aged 7 to 10 years." , no. : 1.

Special article
Published: 22 March 2021 in Pediatric Research
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We evaluated possible mediators underlying lifestyle intervention effects on neonatal adiposity, assessed with sum of skinfolds and cord blood leptin. This is a secondary analysis of the DALI study, a randomised controlled trial in nine European countries. Pregnant women with a pre-pregnancy body mass index of ≥29 kg/m2 were randomly assigned to counselling for healthy eating (HE), physical activity (PA), HE&PA combined, or to usual care. We considered five maternal metabolic factors at 24–28 and 35–37 weeks of gestation, and four cord blood factors as possible mediators of the effect of combined HE&PA counselling on neonatal adiposity. From all potential mediators, the intervention only affected cord blood non-esterified fatty acids (NEFA), which was higher in the HE&PA group compared to UC (0.068 (mmol/L), 95% CI: 0.004 to 0.133). Cord blood NEFA did not mediate the HE&PA intervention effects on neonatal sum of skinfolds or cord blood leptin, based on an indirect effect on skinfolds of 0.018 (mm), 95% CI: −0.217 to 0.253 and an indirect effect on leptin of −0.143 (μg/l), 95% CI: −0.560 to 0.273. The Dali study observed reductions in neonatal adiposity in pregnant women with obesity, but we were not able to identify the underlying metabolic pathway.

ACS Style

Rodrigo Antunes Lima; On behalf of The DALI core investigator group; Gernot Desoye; David Simmons; Mireille Nicoline Maria van Poppel. Mediators of lifestyle intervention effects on neonatal adiposity: are we missing a piece of the puzzle? Pediatric Research 2021, 1 -4.

AMA Style

Rodrigo Antunes Lima, On behalf of The DALI core investigator group, Gernot Desoye, David Simmons, Mireille Nicoline Maria van Poppel. Mediators of lifestyle intervention effects on neonatal adiposity: are we missing a piece of the puzzle? Pediatric Research. 2021; ():1-4.

Chicago/Turabian Style

Rodrigo Antunes Lima; On behalf of The DALI core investigator group; Gernot Desoye; David Simmons; Mireille Nicoline Maria van Poppel. 2021. "Mediators of lifestyle intervention effects on neonatal adiposity: are we missing a piece of the puzzle?" Pediatric Research , no. : 1-4.

Journal article
Published: 24 February 2021 in International Journal of Environmental Research and Public Health
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Governments have restricted public life during the COVID-19 pandemic, inter alia closing sports facilities and gyms. As regular exercise is essential for health, this study examined the effect of pandemic-related confinements on physical activity (PA) levels. A multinational survey was performed in 14 countries. Times spent in moderate-to-vigorous physical activity (MVPA) as well as in vigorous physical activity only (VPA) were assessed using the Nordic Physical Activity Questionnaire (short form). Data were obtained for leisure and occupational PA pre- and during restrictions. Compliance with PA guidelines was calculated based on the recommendations of the World Health Organization (WHO). In total, n = 13,503 respondents (39 ± 15 years, 59% females) were surveyed. Compared to pre-restrictions, overall self-reported PA declined by 41% (MVPA) and 42.2% (VPA). Reductions were higher for occupational vs. leisure time, young and old vs. middle-aged persons, previously more active vs. less active individuals, but similar between men and women. Compared to pre-pandemic, compliance with WHO guidelines decreased from 80.9% (95% CI: 80.3–81.7) to 62.5% (95% CI: 61.6–63.3). Results suggest PA levels have substantially decreased globally during the COVID-19 pandemic. Key stakeholders should consider strategies to mitigate loss in PA in order to preserve health during the pandemic.

ACS Style

Jan Wilke; Lisa Mohr; Adam Tenforde; Pascal Edouard; Chiara Fossati; Marcela González-Gross; Celso Sánchez Ramírez; Fernando Laiño; Benedict Tan; Julian Pillay; Fabio Pigozzi; David Jimenez-Pavon; Bernhard Novak; Johannes Jaunig; Mandy Zhang; Mireille van Poppel; Christoph Heidt; Steffen Willwacher; Gustavo Yuki; Daniel Lieberman; Lutz Vogt; Evert Verhagen; Luiz Hespanhol; Karsten Hollander. A Pandemic within the Pandemic? Physical Activity Levels Substantially Decreased in Countries Affected by COVID-19. International Journal of Environmental Research and Public Health 2021, 18, 2235 .

AMA Style

Jan Wilke, Lisa Mohr, Adam Tenforde, Pascal Edouard, Chiara Fossati, Marcela González-Gross, Celso Sánchez Ramírez, Fernando Laiño, Benedict Tan, Julian Pillay, Fabio Pigozzi, David Jimenez-Pavon, Bernhard Novak, Johannes Jaunig, Mandy Zhang, Mireille van Poppel, Christoph Heidt, Steffen Willwacher, Gustavo Yuki, Daniel Lieberman, Lutz Vogt, Evert Verhagen, Luiz Hespanhol, Karsten Hollander. A Pandemic within the Pandemic? Physical Activity Levels Substantially Decreased in Countries Affected by COVID-19. International Journal of Environmental Research and Public Health. 2021; 18 (5):2235.

Chicago/Turabian Style

Jan Wilke; Lisa Mohr; Adam Tenforde; Pascal Edouard; Chiara Fossati; Marcela González-Gross; Celso Sánchez Ramírez; Fernando Laiño; Benedict Tan; Julian Pillay; Fabio Pigozzi; David Jimenez-Pavon; Bernhard Novak; Johannes Jaunig; Mandy Zhang; Mireille van Poppel; Christoph Heidt; Steffen Willwacher; Gustavo Yuki; Daniel Lieberman; Lutz Vogt; Evert Verhagen; Luiz Hespanhol; Karsten Hollander. 2021. "A Pandemic within the Pandemic? Physical Activity Levels Substantially Decreased in Countries Affected by COVID-19." International Journal of Environmental Research and Public Health 18, no. 5: 2235.

Editorial
Published: 03 February 2021 in British Journal of Sports Medicine
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ACS Style

Matteo C Sattler; Barbara E Ainsworth; Lars B Andersen; Charlie Foster; Maria Hagströmer; Johannes Jaunig; Paul Kelly; Harold W Kohl Iii; Charles E Matthews; Pekka Oja; Stephanie A Prince; Mireille N M van Poppel. Physical activity self-reports: past or future? British Journal of Sports Medicine 2021, 55, 889 -890.

AMA Style

Matteo C Sattler, Barbara E Ainsworth, Lars B Andersen, Charlie Foster, Maria Hagströmer, Johannes Jaunig, Paul Kelly, Harold W Kohl Iii, Charles E Matthews, Pekka Oja, Stephanie A Prince, Mireille N M van Poppel. Physical activity self-reports: past or future? British Journal of Sports Medicine. 2021; 55 (16):889-890.

Chicago/Turabian Style

Matteo C Sattler; Barbara E Ainsworth; Lars B Andersen; Charlie Foster; Maria Hagströmer; Johannes Jaunig; Paul Kelly; Harold W Kohl Iii; Charles E Matthews; Pekka Oja; Stephanie A Prince; Mireille N M van Poppel. 2021. "Physical activity self-reports: past or future?" British Journal of Sports Medicine 55, no. 16: 889-890.

Journal article
Published: 15 January 2021 in Cells
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Early identification of gestational diabetes mellitus (GDM) aims to reduce the risk of adverse maternal and perinatal outcomes. Currently, no circulating biomarker has proven clinically useful for accurate prediction of GDM. In this study, we tested if a panel of small non-coding circulating RNAs could improve early prediction of GDM. We performed a nested case-control study of participants from the European multicenter ‘Vitamin D and lifestyle intervention for GDM prevention (DALI)’ trial using serum samples from obese pregnant women (BMI ≥ 29 kg/m2) entailing 82 GDM cases (early- and late- GDM), and 41 age- and BMI-matched women with normal glucose tolerance (NGT) throughout pregnancy (controls). Anthropometric, clinical and biochemical characteristics were obtained at baseline (p = 0.001, compared with fasting plasma glucose (AUC 0.687, p = 0.004)) as evaluated by area under the curves (AUCs) using Receiver Operator Characteristics (ROC) analysis. Elevated levels of individual miRNAs or a combination hereof were associated with higher odds ratios of GDM. Conclusively, circulating miRNAs early in pregnancy could serve as valuable predictive biomarkers of GDM.

ACS Style

Anja Sørensen; Mireille van Poppel; Gernot Desoye; Peter Damm; David Simmons; Dorte Jensen; Louise Dalgaard; The DALI Core Investigator Group. The Predictive Value of miR-16, -29a and -134 for Early Identification of Gestational Diabetes: A Nested Analysis of the DALI Cohort. Cells 2021, 10, 170 .

AMA Style

Anja Sørensen, Mireille van Poppel, Gernot Desoye, Peter Damm, David Simmons, Dorte Jensen, Louise Dalgaard, The DALI Core Investigator Group. The Predictive Value of miR-16, -29a and -134 for Early Identification of Gestational Diabetes: A Nested Analysis of the DALI Cohort. Cells. 2021; 10 (1):170.

Chicago/Turabian Style

Anja Sørensen; Mireille van Poppel; Gernot Desoye; Peter Damm; David Simmons; Dorte Jensen; Louise Dalgaard; The DALI Core Investigator Group. 2021. "The Predictive Value of miR-16, -29a and -134 for Early Identification of Gestational Diabetes: A Nested Analysis of the DALI Cohort." Cells 10, no. 1: 170.

Brief report
Published: 07 September 2020 in International Journal of Environmental Research and Public Health
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Confinement measures during the COVID-19 pandemic have caused substantial reductions in global physical activity (PA) levels. In view of the manifold health benefits of PA, the development of interventions counteracting this trend is paramount. Our survey with 15,261 participants (38 ± 15 years, 58.5% females) examined preferences towards digital home exercise programs in 14 countries affected by COVID-19. More than two-thirds of the sample (68.4%, n = 10,433) indicated being interested in home exercise, and most participants were willing to work out at least three times per week (89.3%, n = 9328). Binary logistic regression revealed that female sex, working part-time, younger age, and being registered in a gym were associated with willingness to exercise. Flexibility (71.1%, n = 7377), resistance (68.6%, n = 7116), and endurance training (62.4%, n = 6478) were the most preferred types of exercise. Our results may guide health providers in developing individually tailored PA interventions during the current and future pandemics.

ACS Style

Jan Wilke; Lisa Mohr; Adam Tenforde; Pascal Edouard; Chiara Fossati; Marcela González-Gross; Celso Ramirez; Fernando Laiño; Benedict Tan; Julian Pillay; Fabio Pigozzi; David Jimenez-Pavon; Bernhard Novak; David Url; Mandy Zhang; Mireille Poppel; Christoph Heidt; Steffen Willwacher; Lutz Vogt; Evert Verhagen; Karsten Hollander; Luiz Hespanhol; Gustavo Yuki. Restrictercise! Preferences Regarding Digital Home Training Programs during Confinements Associated with the COVID-19 Pandemic. International Journal of Environmental Research and Public Health 2020, 17, 6515 .

AMA Style

Jan Wilke, Lisa Mohr, Adam Tenforde, Pascal Edouard, Chiara Fossati, Marcela González-Gross, Celso Ramirez, Fernando Laiño, Benedict Tan, Julian Pillay, Fabio Pigozzi, David Jimenez-Pavon, Bernhard Novak, David Url, Mandy Zhang, Mireille Poppel, Christoph Heidt, Steffen Willwacher, Lutz Vogt, Evert Verhagen, Karsten Hollander, Luiz Hespanhol, Gustavo Yuki. Restrictercise! Preferences Regarding Digital Home Training Programs during Confinements Associated with the COVID-19 Pandemic. International Journal of Environmental Research and Public Health. 2020; 17 (18):6515.

Chicago/Turabian Style

Jan Wilke; Lisa Mohr; Adam Tenforde; Pascal Edouard; Chiara Fossati; Marcela González-Gross; Celso Ramirez; Fernando Laiño; Benedict Tan; Julian Pillay; Fabio Pigozzi; David Jimenez-Pavon; Bernhard Novak; David Url; Mandy Zhang; Mireille Poppel; Christoph Heidt; Steffen Willwacher; Lutz Vogt; Evert Verhagen; Karsten Hollander; Luiz Hespanhol; Gustavo Yuki. 2020. "Restrictercise! Preferences Regarding Digital Home Training Programs during Confinements Associated with the COVID-19 Pandemic." International Journal of Environmental Research and Public Health 17, no. 18: 6515.

Journal article
Published: 05 August 2020 in International Journal of Environmental Research and Public Health
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Estimation of the intensity of physical activity (PA) based on absolute accelerometer cut points (Cp) likely over- or underestimates intensity for a specific individual. The purpose of this study was to investigate the relationship between absolute moderate intensity Cp and the first ventilatory threshold (VT1). A group of 24 pregnant and 15 nonpregnant women who performed a submaximal incremental walking test with measures of ventilatory parameters and accelerations from three different accelerometers on the wrist (ActiGraph wGT3X-BT, GENEActiv, Axivity AX3) and one on the hip (Actigraph wGT3X-BT) were analyzed. Cp were determined corresponding to 3 metabolic equivalents of task (MET), using the conventional MET definition (Cp3.5) (3.5 mL/kg×min) and individual resting metabolic rate (Cpind). The ventilatory equivalent (VE/VO2) was used to determine VT1. Accelerations at VT1 were significantly higher (p < 0.01) compared to Cp3.5 and Cpind in both groups. Cp3.5 and Cpind were significantly different in nonpregnant (p < 0.01) but not in pregnant women. Walking speed at VT1 (5.7 ± 0.5/6.2 ± 0.8 km/h) was significantly lower (p < 0.01) in pregnant compared to nonpregnant women and correspondent to 3.8 ± 0.7/4.9 ± 1.4 conventional METs. Intensity at absolute Cp was lower compared to the intensity at VT1 independent of the device or placement in pregnant and nonpregnant women. Therefore, we recommend individually tailored cut points such as the VT1 to better assess the effect of the intensity of PA.

ACS Style

Philipp Birnbaumer; Pavel Dietz; Estelle Watson; Gudani Mukoma; Alexander Müller; Matteo Sattler; Johannes Jaunig; Mireille Van Poppel; Peter Hofmann. Absolute Accelerometer-Based Intensity Prescription Compared to Physiological Variables in Pregnant and Nonpregnant Women. International Journal of Environmental Research and Public Health 2020, 17, 5651 .

AMA Style

Philipp Birnbaumer, Pavel Dietz, Estelle Watson, Gudani Mukoma, Alexander Müller, Matteo Sattler, Johannes Jaunig, Mireille Van Poppel, Peter Hofmann. Absolute Accelerometer-Based Intensity Prescription Compared to Physiological Variables in Pregnant and Nonpregnant Women. International Journal of Environmental Research and Public Health. 2020; 17 (16):5651.

Chicago/Turabian Style

Philipp Birnbaumer; Pavel Dietz; Estelle Watson; Gudani Mukoma; Alexander Müller; Matteo Sattler; Johannes Jaunig; Mireille Van Poppel; Peter Hofmann. 2020. "Absolute Accelerometer-Based Intensity Prescription Compared to Physiological Variables in Pregnant and Nonpregnant Women." International Journal of Environmental Research and Public Health 17, no. 16: 5651.

Journal article
Published: 13 July 2020 in International Journal of Obesity
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Background/objectives Obese pregnant women are at high risk of developing gestational diabetes mellitus (GDM), which might be reduced by sufficient physical activity (PA) and reduced sedentary time (ST). We assessed whether PA and ST are longitudinally associated with the glucose-insulin axis in obese pregnant women. Subjects/methods In this secondary analysis of the DALI (vitamin D And Lifestyle Intervention for gestational diabetes mellitus prevention) study, pregnant women, 2, without GDM on entry were included. Time spent in moderate-to-vigorous PA (MVPA) and ST were measured objectively with accelerometers at <20 weeks, 24–28 weeks and 35–37 weeks of gestation. Fasting glucose (mmol/l) and insulin (mU/l), insulin resistance (HOMA-IR) and first-phase and second-phase insulin release (Stumvoll first and second phase) were assessed at the same time. Linear mixed regression models were used to calculate between-participant differences and within-participant changes over time. Analyses were adjusted for gestational age, randomisation, pre-pregnancy BMI, education and age. MVPA, Insulin, HOMA-IR and Stumvoll first and second phase were log-transformed for analyses due to skewness. Results 232 women were included in the analysis. Concerning differences between participants, more ST was associated with higher fasting glucose (Estimate: 0.008; 95% CI: 0.002, 0.014), fasting insulin (0.011; 0.002, 0.019), HOMA-IR (0.012; 0.004, 0.021) and Stumvoll first and second phase (0.008; 0.001, 0.014 and 0.007; 0.001, 0.014). Participants with more MVPA had lower Stumvoll first and second phase (−0.137; −0.210, −0.064 and −0.133; −0.202, −0.063). Concerning changes over time, an increase in ST during gestation was associated with elevated Stumvoll first and second phase (0.006; 0.000, 0.011). Conclusions As the glucose-insulin axis is more strongly associated with ST than MVPA in our obese population, pregnant women could be advised to reduce ST in addition to increasing MVPA. Moreover, our findings suggest that behaviour change interventions aiming at GDM risk reduction should start in early or pre-pregnancy.

ACS Style

Anna M. Dieberger; Gernot Desoye; Erwin Stolz; David J. Hill; Rosa Corcoy; David Simmons; Jürgen Harreiter; Alexandra Kautzky-Willer; Fidelma Dunne; Roland Devlieger; Ewa Wender-Ozegowska; Agnieszka Zawiejska; Annunziata Lapolla; Maria Grazia Dalfra; Alessandra Bertolotto; Sander Galjaard; Juan M. Adelantado; Dorte Møller Jensen; Lise-Lotte Andersen; Mette Tanvig; Peter Damm; Elisabeth Reinhardt Mathiesen; Frank J. Snoek; Judith G. M. Jelsma; Mireille N. M. van Poppel. Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women—a secondary analysis of the DALI study. International Journal of Obesity 2020, 45, 296 -307.

AMA Style

Anna M. Dieberger, Gernot Desoye, Erwin Stolz, David J. Hill, Rosa Corcoy, David Simmons, Jürgen Harreiter, Alexandra Kautzky-Willer, Fidelma Dunne, Roland Devlieger, Ewa Wender-Ozegowska, Agnieszka Zawiejska, Annunziata Lapolla, Maria Grazia Dalfra, Alessandra Bertolotto, Sander Galjaard, Juan M. Adelantado, Dorte Møller Jensen, Lise-Lotte Andersen, Mette Tanvig, Peter Damm, Elisabeth Reinhardt Mathiesen, Frank J. Snoek, Judith G. M. Jelsma, Mireille N. M. van Poppel. Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women—a secondary analysis of the DALI study. International Journal of Obesity. 2020; 45 (2):296-307.

Chicago/Turabian Style

Anna M. Dieberger; Gernot Desoye; Erwin Stolz; David J. Hill; Rosa Corcoy; David Simmons; Jürgen Harreiter; Alexandra Kautzky-Willer; Fidelma Dunne; Roland Devlieger; Ewa Wender-Ozegowska; Agnieszka Zawiejska; Annunziata Lapolla; Maria Grazia Dalfra; Alessandra Bertolotto; Sander Galjaard; Juan M. Adelantado; Dorte Møller Jensen; Lise-Lotte Andersen; Mette Tanvig; Peter Damm; Elisabeth Reinhardt Mathiesen; Frank J. Snoek; Judith G. M. Jelsma; Mireille N. M. van Poppel. 2020. "Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women—a secondary analysis of the DALI study." International Journal of Obesity 45, no. 2: 296-307.

Correction
Published: 22 June 2020 in Current Diabetes Reports
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The original version of this review article unfortunately contained a mistake.

ACS Style

Jürgen Harreiter; Gernot Desoye; Mireille N. M. van Poppel; Alexandra Kautzky-Willer; Fidelma Dunne; Rosa Corcoy; Roland Devlieger; David Simmons; Juan M. Adelantado; Peter Damm; Elizabeth Reinhardt Mathiesen; Dorte Moeller Jensen; Lise Lotte T. Anderson; Annunziata Lapolla; Maria G. Dalfrà; Alessandra Bertolotto; Ewa Wender-Ozegowska; Agnieszka Zawiejska; David J. Hill; Frank J. Snoek; On behalf of the DALI Consortium. Correction to: The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have we Learned from the DALI Studies? Current Diabetes Reports 2020, 20, 1 -2.

AMA Style

Jürgen Harreiter, Gernot Desoye, Mireille N. M. van Poppel, Alexandra Kautzky-Willer, Fidelma Dunne, Rosa Corcoy, Roland Devlieger, David Simmons, Juan M. Adelantado, Peter Damm, Elizabeth Reinhardt Mathiesen, Dorte Moeller Jensen, Lise Lotte T. Anderson, Annunziata Lapolla, Maria G. Dalfrà, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David J. Hill, Frank J. Snoek, On behalf of the DALI Consortium. Correction to: The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have we Learned from the DALI Studies? Current Diabetes Reports. 2020; 20 (8):1-2.

Chicago/Turabian Style

Jürgen Harreiter; Gernot Desoye; Mireille N. M. van Poppel; Alexandra Kautzky-Willer; Fidelma Dunne; Rosa Corcoy; Roland Devlieger; David Simmons; Juan M. Adelantado; Peter Damm; Elizabeth Reinhardt Mathiesen; Dorte Moeller Jensen; Lise Lotte T. Anderson; Annunziata Lapolla; Maria G. Dalfrà; Alessandra Bertolotto; Ewa Wender-Ozegowska; Agnieszka Zawiejska; David J. Hill; Frank J. Snoek; On behalf of the DALI Consortium. 2020. "Correction to: The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have we Learned from the DALI Studies?" Current Diabetes Reports 20, no. 8: 1-2.

Journal article
Published: 14 May 2020 in International Journal of Environmental Research and Public Health
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Research has reported the associations between objective or subjective neighborhood greenness and health, with low agreement between the greenness scores. College students are prone to poor health, and data are lacking on home and university environments. We studied the agreement between greenness parameters and the associations of objective greenness with health in different locations. Three hundred and seventy-seven college students were recruited, with a mean age of 24 years, in the city of Graz, Austria. Objective and perceived greenness was assessed at home and at university. Health measures included the WHO-5 questionnaire for mental health, the IPAQ questionnaire (short) for physical activity and sedentariness, and body mass index. Per location, quintile pairs of objective and perceived greenness were classified into underestimates, correct estimates or overestimates. Interrater reliability and correlation analyses revealed agreement between greenness scores at home but not at university. ANOVA models only showed poorer mental health for students underestimating greenness at university (M = 51.38, SD = 2.84) compared to those with correct estimates (M = 61.03, SD = 1.85). Agreement between greenness scores at home but not at university was obtained, and mental health was related to the perception of greenness at university. We conclude that reliable and corresponding methods for greenness scores need to be developed.

ACS Style

Alexander Karl Ferdinand Loder; Josef Gspurning; Christoph Paier; Mireille Nicoline Maria Van Poppel. Objective and Perceived Neighborhood Greenness of Students Differ in Their Agreement in Home and Study Environments. International Journal of Environmental Research and Public Health 2020, 17, 3427 .

AMA Style

Alexander Karl Ferdinand Loder, Josef Gspurning, Christoph Paier, Mireille Nicoline Maria Van Poppel. Objective and Perceived Neighborhood Greenness of Students Differ in Their Agreement in Home and Study Environments. International Journal of Environmental Research and Public Health. 2020; 17 (10):3427.

Chicago/Turabian Style

Alexander Karl Ferdinand Loder; Josef Gspurning; Christoph Paier; Mireille Nicoline Maria Van Poppel. 2020. "Objective and Perceived Neighborhood Greenness of Students Differ in Their Agreement in Home and Study Environments." International Journal of Environmental Research and Public Health 17, no. 10: 3427.

Article
Published: 20 March 2020 in Diabetologia
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Aims/hypothesis The aim of this systematic review was to develop core outcome sets (COSs) for trials evaluating interventions for the prevention or treatment of gestational diabetes mellitus (GDM). Methods We identified previously reported outcomes through a systematic review of the literature. These outcomes were presented to key stakeholders (including patient representatives, researchers and clinicians) for prioritisation using a three-round, e-Delphi study. A priori consensus criteria informed which outcomes were brought forward for discussion at a face-to-face consensus meeting where the COS was finalised. Results Our review identified 74 GDM prevention and 116 GDM treatment outcomes, which were presented to stakeholders in round 1 of the e-Delphi study. Round 1 was completed by 173 stakeholders, 70% (121/173) of whom went on to complete round 2; 84% (102/121) of round 2 responders completed round 3. Twenty-two GDM prevention outcomes and 30 GDM treatment outcomes were discussed at the consensus meeting. Owing to significant overlap between included prevention and treatment outcomes, consensus meeting stakeholders agreed to develop a single prevention/treatment COS. Fourteen outcomes were included in the final COS. These consisted of six maternal outcomes (GDM diagnosis, adherence to the intervention, hypertensive disorders of pregnancy, requirement and type of pharmacological therapy for hyperglycaemia, gestational weight gain and mode of birth) and eight neonatal outcomes (birthweight, large for gestational age, small for gestational age, gestational age at birth, preterm birth, neonatal hypoglycaemia, neonatal death and stillbirth). Conclusions/interpretation This COS will enable future GDM prevention and treatment trials to measure similar outcomes that matter to stakeholders and facilitate comparison and combination of these studies. Trial registration This study was registered prospectively with the Core Outcome Measures in Effectiveness Trials (COMET) database: http://www.comet-initiative.org/studies/details/686/

ACS Style

Aoife M. Egan; the INSPIRED research group; Delia Bogdanet; Tomás P. Griffin; Oratile Kgosidialwa; Mila Cervar-Zivkovic; Eugene Dempsey; John Allotey; Fernanda Alvarado; Cheril Clarson; Shamil D. Cooray; Harold W. De Valk; Sander Galjaard; Mary R. Loeken; Michael J. A. Maresh; Angela Napoli; Paula M. O’Shea; Ewa Wender-Ozegowska; Mireille N. M. Van Poppel; Shakila Thangaratinam; Caroline Crowther; Linda M. Biesty; Declan DeVane; Fidelma P. Dunne. A core outcome set for studies of gestational diabetes mellitus prevention and treatment. Diabetologia 2020, 63, 1120 -1127.

AMA Style

Aoife M. Egan, the INSPIRED research group, Delia Bogdanet, Tomás P. Griffin, Oratile Kgosidialwa, Mila Cervar-Zivkovic, Eugene Dempsey, John Allotey, Fernanda Alvarado, Cheril Clarson, Shamil D. Cooray, Harold W. De Valk, Sander Galjaard, Mary R. Loeken, Michael J. A. Maresh, Angela Napoli, Paula M. O’Shea, Ewa Wender-Ozegowska, Mireille N. M. Van Poppel, Shakila Thangaratinam, Caroline Crowther, Linda M. Biesty, Declan DeVane, Fidelma P. Dunne. A core outcome set for studies of gestational diabetes mellitus prevention and treatment. Diabetologia. 2020; 63 (6):1120-1127.

Chicago/Turabian Style

Aoife M. Egan; the INSPIRED research group; Delia Bogdanet; Tomás P. Griffin; Oratile Kgosidialwa; Mila Cervar-Zivkovic; Eugene Dempsey; John Allotey; Fernanda Alvarado; Cheril Clarson; Shamil D. Cooray; Harold W. De Valk; Sander Galjaard; Mary R. Loeken; Michael J. A. Maresh; Angela Napoli; Paula M. O’Shea; Ewa Wender-Ozegowska; Mireille N. M. Van Poppel; Shakila Thangaratinam; Caroline Crowther; Linda M. Biesty; Declan DeVane; Fidelma P. Dunne. 2020. "A core outcome set for studies of gestational diabetes mellitus prevention and treatment." Diabetologia 63, no. 6: 1120-1127.

Journal article
Published: 02 March 2020 in The Lancet Diabetes & Endocrinology
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Mireille Nm Van Poppel; Gernot Desoye. Growing fat in utero: timing is everything. The Lancet Diabetes & Endocrinology 2020, 8, 259 -260.

AMA Style

Mireille Nm Van Poppel, Gernot Desoye. Growing fat in utero: timing is everything. The Lancet Diabetes & Endocrinology. 2020; 8 (4):259-260.

Chicago/Turabian Style

Mireille Nm Van Poppel; Gernot Desoye. 2020. "Growing fat in utero: timing is everything." The Lancet Diabetes & Endocrinology 8, no. 4: 259-260.

Journal article
Published: 21 February 2020 in International Journal of Environmental Research and Public Health
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Health literacy (HL) has been determined for the general population and for subgroups, though the relationship between HL and active transport in rural areas was not explored. The aim of our study is to investigate HL among citizens in an Austrian rural region and to explore the associations between HL and active transport. This cross-sectional telephone survey included 288 adults (171 women) with a mean age of 57.8 (SD 0.9). HL was assessed using the HLS-EU-Q16 questionnaire. Active transport was measured as the minutes per week spent on walking or cycling from A to B. After descriptive analysis, the association between HL and active transport was assessed using linear regression models. The mean HL score for all participants was 37.1 (SD 7.7). Among all subjects, 6.9% showed inadequate HL, 25.7% problematic HL, 38.9% sufficient HL, and 28.5% excellent HL. HL was significantly higher among citizens with high education (p = 0.04) and training/employment in healthcare (p = 0.001). Active transport was not associated with HL (p = 0.281). Active transport in rural areas might be influenced by other predictors like distance to work, street connectivity, and accessible facilities for walking and biking. This needs to be explored further for rural areas.

ACS Style

Kathrin Hofer-Fischanger; Bianca Fuchs-Neuhold; Alexander Müller; Gerlinde Grasser; Mireille N.M. Van Poppel. Health Literacy and Active Transport in Austria: Results from a Rural Setting. International Journal of Environmental Research and Public Health 2020, 17, 1404 .

AMA Style

Kathrin Hofer-Fischanger, Bianca Fuchs-Neuhold, Alexander Müller, Gerlinde Grasser, Mireille N.M. Van Poppel. Health Literacy and Active Transport in Austria: Results from a Rural Setting. International Journal of Environmental Research and Public Health. 2020; 17 (4):1404.

Chicago/Turabian Style

Kathrin Hofer-Fischanger; Bianca Fuchs-Neuhold; Alexander Müller; Gerlinde Grasser; Mireille N.M. Van Poppel. 2020. "Health Literacy and Active Transport in Austria: Results from a Rural Setting." International Journal of Environmental Research and Public Health 17, no. 4: 1404.

Journal article
Published: 16 January 2020 in BMC Public Health
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Background Combining the strengths of physical activity (PA) diaries and questionnaires may be needed to improve the unsatisfying measurement quality of existing PA questionnaires. This study investigated the construct validity of a short PA questionnaire (Physical Activity Questionnaire for 24 h [PAQ24]) with a recall period of one day. Methods In this cross-sectional study, participants completed the PAQ24 on seven consecutive days while wearing an accelerometer (GENEActiv). Thereafter, the Global Physical Activity Questionnaire (GPAQ) was completed. Spearman correlation coefficients and Bland-Altman analysis were used to assess construct validity. Results Overall, 50 active adults (11 women, mean age = 25.1 ± 2.5) participated. Relative agreements between Total PA of PAQ24 and accelerometer were 0.37 ≤ ρ ≤ 0.72 for each day with satisfying agreement on five out of seven days. Weekly relative agreement for Total PA was moderate (ρ = 0.44). Relative agreements between PAQ24 and GPAQ were ρ = 0.43 for Total PA. Daily and weekly absolute agreements were poor indicated by wide limits of agreement. Conclusions In contrast to weekly Total PA, the majority of daily results of the PAQ24 showed satisfying construct validity. A short recall period may improve the measurement quality of PA questionnaires, but measurement errors and the costs of multiple administrations must be considered in future studies.

ACS Style

B. Novak; P. Holler; J. Jaunig; W. Ruf; M. N. M. Van Poppel; M. C. Sattler. Do we have to reduce the recall period? Validity of a daily physical activity questionnaire (PAQ24) in young active adults. BMC Public Health 2020, 20, 1 -12.

AMA Style

B. Novak, P. Holler, J. Jaunig, W. Ruf, M. N. M. Van Poppel, M. C. Sattler. Do we have to reduce the recall period? Validity of a daily physical activity questionnaire (PAQ24) in young active adults. BMC Public Health. 2020; 20 (1):1-12.

Chicago/Turabian Style

B. Novak; P. Holler; J. Jaunig; W. Ruf; M. N. M. Van Poppel; M. C. Sattler. 2020. "Do we have to reduce the recall period? Validity of a daily physical activity questionnaire (PAQ24) in young active adults." BMC Public Health 20, no. 1: 1-12.

Journal article
Published: 28 December 2019 in International Journal of Environmental Research and Public Health
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Previous studies reported contradictory evidence for associations between perceived greenness and obesity mediated by physical activity, focusing on people’s homes or general greenness. Data are lacking in other environments. We studied the association of perceived greenness at home and at university with BMI and physical activity. An online survey collected data from 601 participants, living and studying in and around the city of Graz, Austria; mean age of 24 years. Greenness was assessed using questions on quality of and access to green space; Body mass index (BMI) was derived from self-reported measures; physical activity and sedentariness were measured using the IPAQ questionnaire (short version). On average, BMI was 22.6 (SD = 3.7), physical activity was 63.3 (SD = 51.7) METh/week, and participants spent 5.8 (SD = 4.0) h/day sitting. Regression analyses revealed no associations between perceived greenness and BMI and physical activity for all environments, but a negative association for sedentariness and perceived greenness at home, but not at university. The results indicate a relation between perceived greenness and sedentariness, which differs for the home-and study environment.

ACS Style

Alexander Karl Ferdinand Loder; Mireille Nicoline Maria Van Poppel. Sedentariness of College Students Is Negatively Associated with Perceived Neighborhood Greenness at Home, but Not at University. International Journal of Environmental Research and Public Health 2019, 17, 235 .

AMA Style

Alexander Karl Ferdinand Loder, Mireille Nicoline Maria Van Poppel. Sedentariness of College Students Is Negatively Associated with Perceived Neighborhood Greenness at Home, but Not at University. International Journal of Environmental Research and Public Health. 2019; 17 (1):235.

Chicago/Turabian Style

Alexander Karl Ferdinand Loder; Mireille Nicoline Maria Van Poppel. 2019. "Sedentariness of College Students Is Negatively Associated with Perceived Neighborhood Greenness at Home, but Not at University." International Journal of Environmental Research and Public Health 17, no. 1: 235.

Review
Published: 16 December 2019 in Current Diabetes Reports
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The DALI (vitamin D and lifestyle intervention in the prevention of gestational diabetes mellitus (GDM)) study aimed to prevent GDM with lifestyle interventions or Vitamin D supplementation (1600 IU/day). This review summarizes the learnings from the DALI studies among pregnant women with a BMI ≥ 29 kg/m2. Women diagnosed with GDM earlier in pregnancy had a worse metabolic profile than those diagnosed later. A combined physical activity (PA) and healthy eating (HE) lifestyle intervention improved both behaviours, limited gestational weight gain (GWG) and was cost-effective. Although GDM risk was unchanged, neonatal adiposity was reduced due to less sedentary time. Neither PA nor HE alone limited GWG or GDM risk. Fasting glucose was higher with HE only intervention, and lower with Vitamin D supplementation. Our combined intervention did not prevent GDM, but was cost-effective, limited GWG and reduced neonatal adiposity.

ACS Style

Jürgen Harreiter; on behalf of the DALI Consortium; Gernot Desoye; Mireille N. M. van Poppel; Alexandra Kautzky-Willer; Fidelma Dunne; Rosa Corcoy; Roland Devlieger; David Simmons; Juan M. Adelantado; Peter Damm; Elizabeth Reinhardt Mathiesen; Dorte Moeller Jensen; Lise Lotte T. Anderson; Annunziata Lapolla; Maria G. Dalfrà; Alessandra Bertolotto; Ewa Wender-Ozegowska; Agnieszka Zawiejska; David J. Hill; Frank J. Snoek. The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have We Learned from the DALI Studies? Current Diabetes Reports 2019, 19, 162 .

AMA Style

Jürgen Harreiter, on behalf of the DALI Consortium, Gernot Desoye, Mireille N. M. van Poppel, Alexandra Kautzky-Willer, Fidelma Dunne, Rosa Corcoy, Roland Devlieger, David Simmons, Juan M. Adelantado, Peter Damm, Elizabeth Reinhardt Mathiesen, Dorte Moeller Jensen, Lise Lotte T. Anderson, Annunziata Lapolla, Maria G. Dalfrà, Alessandra Bertolotto, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David J. Hill, Frank J. Snoek. The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have We Learned from the DALI Studies? Current Diabetes Reports. 2019; 19 (12):162.

Chicago/Turabian Style

Jürgen Harreiter; on behalf of the DALI Consortium; Gernot Desoye; Mireille N. M. van Poppel; Alexandra Kautzky-Willer; Fidelma Dunne; Rosa Corcoy; Roland Devlieger; David Simmons; Juan M. Adelantado; Peter Damm; Elizabeth Reinhardt Mathiesen; Dorte Moeller Jensen; Lise Lotte T. Anderson; Annunziata Lapolla; Maria G. Dalfrà; Alessandra Bertolotto; Ewa Wender-Ozegowska; Agnieszka Zawiejska; David J. Hill; Frank J. Snoek. 2019. "The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have We Learned from the DALI Studies?" Current Diabetes Reports 19, no. 12: 162.

Journal article
Published: 04 November 2019 in Nutrients
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Human milk oligosaccharides (HMOs) are present in maternal serum in early gestation, raising the question of whether HMOs can cross the placental barrier and reach fetal circulation. Here, we aimed to detect HMOs in cord blood, and assess HMO composition and concentration in relation to maternal HMOs. In an ex-vivo placental perfusion model, we asked whether HMOs can pass over the placenta. Using HPLC, we measured HMOs in maternal serum and matching venous cord blood samples collected at delivery from normal pregnancies (n = 22). To investigate maternal-to-fetal transport, we perfused isolated placental cotyledons from term pregnancies (n = 3) with 2’-fucosyllactose (2′FL) in a double closed setting. We found up to 18 oligosaccharides typically present in maternal serum in all cord serum samples investigated. Median total cord blood HMO concentration did not differ from the concentration in maternal serum. HMO composition resembled the composition in maternal serum, with the strongest correlations for 2′FL and LDFT. After 180 min perfusion, we found 22% of maternally offered 2′FL in the fetal circuit without reaching equilibrium. Our results provide direct evidence of HMOs in cord blood, and suggest that the placenta transfers HMOs from the maternal to fetal circuit. Future studies will investigate potential differences in the transfer of specific HMOs, or in pregnancy disorders.

ACS Style

Birgit Hirschmugl; Waltraud Brandl; Bence Csapo; Mireille Van Poppel; Harald Köfeler; Gernot Desoye; Christian Wadsack; Evelyn Jantscher-Krenn. Evidence of Human Milk Oligosaccharides in Cord Blood and Maternal-to-Fetal Transport across the Placenta. Nutrients 2019, 11, 2640 .

AMA Style

Birgit Hirschmugl, Waltraud Brandl, Bence Csapo, Mireille Van Poppel, Harald Köfeler, Gernot Desoye, Christian Wadsack, Evelyn Jantscher-Krenn. Evidence of Human Milk Oligosaccharides in Cord Blood and Maternal-to-Fetal Transport across the Placenta. Nutrients. 2019; 11 (11):2640.

Chicago/Turabian Style

Birgit Hirschmugl; Waltraud Brandl; Bence Csapo; Mireille Van Poppel; Harald Köfeler; Gernot Desoye; Christian Wadsack; Evelyn Jantscher-Krenn. 2019. "Evidence of Human Milk Oligosaccharides in Cord Blood and Maternal-to-Fetal Transport across the Placenta." Nutrients 11, no. 11: 2640.

Journal article
Published: 03 November 2019 in Journal of Clinical Medicine
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The aim of the present study was to analyze the influence of a supervised concurrent exercise-training program, from the 17th gestational week until delivery, on cytokines in maternal (at 17th and 35th gestational week, and at delivery) and arterial and venous cord serum. Fifty-eight Caucasian pregnant women (age: 33.5 ± 4.7 years old, body mass index: 23.6 ± 4.1kg/m2) from the GESTAFIT Project (exercise (n = 37) and control (n = 21) groups) participated in this quasi-experimental study (per-protocol basis). The exercise group followed a 60-min 3 days/week concurrent (aerobic-resistance) exercise-training from the 17th gestational week to delivery. Maternal and arterial and venous cord serum cytokines (fractalkine, interleukin (IL)–1β, IL-6, IL-8, IL-10, interferon (IFN)–γ, and tumor necrosis factor (TNF)–α) were assessed using Luminex xMAP technology. In maternal serum (after adjusting for the baseline values of cytokines), the exercise group decreased TNF-α (from baseline to 35th week, p = 0.02), and increased less IL-1β (from baseline to delivery, p = 0.03) concentrations than controls. When adjusting for other potential confounders, these differences became non-significant. In cord blood, the exercise group showed reduced arterial IL-6 and venous TNF-α (p = 0.03 and p = 0.001, respectively) and higher concentrations of arterial IL-1β (p = 0.03) compared to controls. The application of concurrent exercise-training programs could be a strategy to modulate immune responses in pregnant women and their fetuses. However, future research is needed to better understand the origin and clearance of these cytokines, their role in the maternal-placental-fetus crosstalk, and the influence of exercise interventions on them.

ACS Style

Pedro Acosta-Manzano; Irene Coll-Risco; Mireille N. M. Van Poppel; Víctor Segura-Jiménez; Pedro Femia; Lidia Romero-Gallardo; Milkana Borges-Cosic; Javier Díaz-Castro; Jorge Moreno-Fernández; Julio J. Ochoa-Herrera; Virginia A. Aparicio. Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project. Journal of Clinical Medicine 2019, 8, 1862 .

AMA Style

Pedro Acosta-Manzano, Irene Coll-Risco, Mireille N. M. Van Poppel, Víctor Segura-Jiménez, Pedro Femia, Lidia Romero-Gallardo, Milkana Borges-Cosic, Javier Díaz-Castro, Jorge Moreno-Fernández, Julio J. Ochoa-Herrera, Virginia A. Aparicio. Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project. Journal of Clinical Medicine. 2019; 8 (11):1862.

Chicago/Turabian Style

Pedro Acosta-Manzano; Irene Coll-Risco; Mireille N. M. Van Poppel; Víctor Segura-Jiménez; Pedro Femia; Lidia Romero-Gallardo; Milkana Borges-Cosic; Javier Díaz-Castro; Jorge Moreno-Fernández; Julio J. Ochoa-Herrera; Virginia A. Aparicio. 2019. "Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project." Journal of Clinical Medicine 8, no. 11: 1862.