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Zhida Sun
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China

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Paper
Published: 29 April 2021 in Food & Function
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Short chain fatty acid (SCFA)-producing bacteria reduced significantly in high-fat and STZ-induced diabetic rats. And the unbalanced gut microbiota may be responsible for the drop of shikimic acid in urine, a typical metabolite of LPOPC.

ACS Style

Xiaopeng Li; Yong Sui; Bijun Xie; Zhida Sun; Shuyi Li. Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota. Food & Function 2021, 12, 5375 -5386.

AMA Style

Xiaopeng Li, Yong Sui, Bijun Xie, Zhida Sun, Shuyi Li. Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota. Food & Function. 2021; 12 (12):5375-5386.

Chicago/Turabian Style

Xiaopeng Li; Yong Sui; Bijun Xie; Zhida Sun; Shuyi Li. 2021. "Diabetes diminishes a typical metabolite of litchi pericarp oligomeric procyanidins (LPOPC) in urine mediated by imbalanced gut microbiota." Food & Function 12, no. 12: 5375-5386.

Journal article
Published: 21 November 2020 in Food Chemistry
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To solve the potential problem of hindered β-galactosidase activity by procyanidins, carboxymethylated Pachyman (CMP), a negatively-charged carboxymethylated (1 → 3)-β-d-glucan, was applied to mitigate inhibition by procyanidins. The mechanisms underlying this effect were explored through enzyme kinetic analysis, fluorescence quenching assays, circular dichroism, and molecular docking studies. The results indicated that the introduction of CMP could decrease the inhibition rate of high-concentration lotus seedpod oligomeric procyanidins (LSOPC) from 98.7 to 46.5%, and enabled low-concentration LSOPC to activate β-galactosidase in vitro and in vivo. The competitive/noncompetitive inhibition constants, fluorescence quenching constants, and molecular docking results indicated that the mechanism of this effect might be CMP competing with β-galactosidase to bind procyanidins, resulting in restoration of the catalytic centre and key active site of procyanidin-bound lactase. Additionally, it was affected by procyanidin-CMP noncovalent interactions. This study illustrates a promising strategy for mitigating the anti-nutritional properties of procyanidins and activating β-galactosidase to promote intestinal health.

ACS Style

Jingyi Wang; Bijun Xie; Zhida Sun. Anion carboxymethylated β-glucan alleviates undesirable binding between procyanidins and β-galactosidase. Food Chemistry 2020, 344, 128686 .

AMA Style

Jingyi Wang, Bijun Xie, Zhida Sun. Anion carboxymethylated β-glucan alleviates undesirable binding between procyanidins and β-galactosidase. Food Chemistry. 2020; 344 ():128686.

Chicago/Turabian Style

Jingyi Wang; Bijun Xie; Zhida Sun. 2020. "Anion carboxymethylated β-glucan alleviates undesirable binding between procyanidins and β-galactosidase." Food Chemistry 344, no. : 128686.

Journal article
Published: 24 October 2020 in LWT
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CMP could reverse the growth enhancement effect of procyanidins on E. coli. CMP could delay and prolong the effective antibacterial time of procyanidins. CMP-procyanidins induced structure broken and oxidative stress of E. coli cell. CMP-procyanidins regulated gut microbiota in vivo.

ACS Style

Jingyi Wang; Bijun Xie; Zhida Sun. The improvement of carboxymethyl β-glucan on the antibacterial activity and intestinal flora regulation ability of lotus seedpod procyanidins. LWT 2020, 137, 110441 .

AMA Style

Jingyi Wang, Bijun Xie, Zhida Sun. The improvement of carboxymethyl β-glucan on the antibacterial activity and intestinal flora regulation ability of lotus seedpod procyanidins. LWT. 2020; 137 ():110441.

Chicago/Turabian Style

Jingyi Wang; Bijun Xie; Zhida Sun. 2020. "The improvement of carboxymethyl β-glucan on the antibacterial activity and intestinal flora regulation ability of lotus seedpod procyanidins." LWT 137, no. : 110441.

Journal article
Published: 23 October 2020 in LWT
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Ultrasound can be applied in fruit juice fermentation as an innovative non-thermal sterilisation method with product quality-promoting potential. In this study, the qualities changes in fermented mango juice (UFJ) pre-treated by ultraviolet-assisted ultrasound (US-UV) during the 30-days of cold storage (4 °C) were evaluated. The essential qualities of UFJ were enhanced compared with the fresh juice and traditional fermented juice (thermal pre-treatment). Additionally, UFJ showed better performances concerning physical features (suspension stability, particle size, viscosity, and colour), pH and acidity, as well as bioactive compounds stability (soluble dietary fibre, carotenoids, total phenols, and ascorbic acid) than fresh juice during storage, revealing that the higher qualities of fermented mango juice were improved by US-UV pre-treatment. More importantly, the in vitro simulated gastrointestinal digestion validated that the bioactive compounds in UFJ had better stability and bioaccessibility than fresh juice during various storage periods, and lead to better antioxidant performance. As an effective and novel non-thermal technology, US-UV pretreatment can be considered a promising alternative method to thermal sterilisation in the juice industry.

ACS Style

Jingyi Wang; Bijun Xie; Zhida Sun. Quality parameters and bioactive compound bioaccessibility changes in probiotics fermented mango juice using ultraviolet-assisted ultrasonic pre-treatment during cold storage. LWT 2020, 137, 110438 .

AMA Style

Jingyi Wang, Bijun Xie, Zhida Sun. Quality parameters and bioactive compound bioaccessibility changes in probiotics fermented mango juice using ultraviolet-assisted ultrasonic pre-treatment during cold storage. LWT. 2020; 137 ():110438.

Chicago/Turabian Style

Jingyi Wang; Bijun Xie; Zhida Sun. 2020. "Quality parameters and bioactive compound bioaccessibility changes in probiotics fermented mango juice using ultraviolet-assisted ultrasonic pre-treatment during cold storage." LWT 137, no. : 110438.

Journal article
Published: 22 October 2020 in Postharvest Biology and Technology
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This study evaluated the effect of mild high hydrostatic pressure (HHP, 20−80 MPa /10 min) on the quality of the whole fresh mango during postharvest storage. HHP promoted the capacity of cell wall macromolecules binding water and prevented structural damage of mango tissues during postharvest storage. It reduced the respiration rate and the consumption of sugars and acids, and in most cases increased bioactive substances (vitamin C, total phenolics, flavonoids and carotenoids) and antioxidant activities. Moreover, HHP significantly increased carotenoid biosynthesis at the transcriptional level. The expressions of carotenogenic genes including geranylgeranyl diphosphate synthase (4.7 fold), phytoene synthase (4.66 fold), phytoene desaturase (3.53 fold), ζ-carotene desaturase (2.79 fold) and β-Ring hydroxylase (2.17 fold) were increased after HHP treatment, while zeaxanthin epoxidase (0.78 fold) transcripts were reduced. As a result, there was the increase of carotenes (1.56–2.00 fold), β-cryptoxanthin (1.38–2.73 fold) and zeaxanthin (1.42–1.67 fold) and the reduction of antheraxanthin (0.64−0.85 fold) and violaxanthin (0.88−0.90 fold) in HHP-treated samples. HHP is likely a potential technology for modulating physiology and nutritional components (especially carotenoids) of the postharvest fruit.

ACS Style

Kai Hu; Da Peng; Lan Wang; Hao Liu; Bijun Xie; Zhida Sun. Effect of mild high hydrostatic pressure treatments on physiological and physicochemical characteristics and carotenoid biosynthesis in postharvest mango. Postharvest Biology and Technology 2020, 172, 111381 .

AMA Style

Kai Hu, Da Peng, Lan Wang, Hao Liu, Bijun Xie, Zhida Sun. Effect of mild high hydrostatic pressure treatments on physiological and physicochemical characteristics and carotenoid biosynthesis in postharvest mango. Postharvest Biology and Technology. 2020; 172 ():111381.

Chicago/Turabian Style

Kai Hu; Da Peng; Lan Wang; Hao Liu; Bijun Xie; Zhida Sun. 2020. "Effect of mild high hydrostatic pressure treatments on physiological and physicochemical characteristics and carotenoid biosynthesis in postharvest mango." Postharvest Biology and Technology 172, no. : 111381.

Journal article
Published: 24 March 2020 in Molecules
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The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes still possessed strong inhibitory effects against melanogenesis, reducing the activity of both monophenolase and diphenolase. Molecular docking indicated that LSOPC could generate intense interactive configuration with tyrosinase through arene–H, arene–arene, and hydrophobic interaction. An ultraviolet radiated cell-culture model (human foreskin fibroblast cell (HFF-1)) was used to determine the protective effects of the LSOPC-nanoliposomes against skin aging and damage. Results showed that LSOPC-nanoliposomes exerted the highest protective effects against both ultraviolet B (UVB) and ultraviolet A (UVA) irradiation groups compared with non-encapsulated LSOPC and a control (vitamin C). Superoxide dismutase (SOD) and malonaldehyde (MDA) assays demonstrated the protection mechanism may be related to the anti-photooxidation activity of the procyanidin. Furthermore, a hydroxyproline assay suggested that the LSOPC-nanoliposomes had a strong protective effect against collagen degradation and/or synthesis after UVA irradiation.

ACS Style

Yashu Chen; Fenghong Huang; David Julian McClements; Bijun Xie; Zhida Sun; Qianchun Deng. Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage. Molecules 2020, 25, 1458 .

AMA Style

Yashu Chen, Fenghong Huang, David Julian McClements, Bijun Xie, Zhida Sun, Qianchun Deng. Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage. Molecules. 2020; 25 (6):1458.

Chicago/Turabian Style

Yashu Chen; Fenghong Huang; David Julian McClements; Bijun Xie; Zhida Sun; Qianchun Deng. 2020. "Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage." Molecules 25, no. 6: 1458.

Journal article
Published: 04 February 2020 in Ultrasonics Sonochemistry
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This work explored the effect of ultraviolet-assisted ultrasound (US-UV) as an emerging non-thermal sterilization technology on mango juice in aspects of microbial growth and quality changes. The juice in the ice bath was subjected to US-UV treatment at different US powers (0–600 W) and times (0–40 min), and no pathogen bacteria could be detected after treatment, while the physicochemical features (particle size, suspension stability, color, content of total polyphenols, carotenoids, sugar, reducing sugar and protein) and antioxidant ability of treated juice was preserved or improved to some extent. Based on these results, we further validated its positive effects on the nutritional value (content of ascorbic acid and soluble dietary fiber, antioxidant ability) and quality parameters (titratable acid, sugar acidity, total soluble solids, rheological behavior, metal elements) of mango juice treated at the optimal US parameter (10 min, 600 W); Not only the inactivation of polyphenol oxidation enzyme, peroxidase and pectin methylesterase was achieved but also the treated juice has a significant different volatile profile compared with the fresh juice, which might offer the better color, texture, and smell. Importantly, through the HPLC-MSD-Trap-XCT (phenols) and UPLC-Q Exactive Orbitrap-MS (carotenoids) study, the US-UV treatment will not cause difference on compounds composition, but it was responsible for changes in content of individual compounds, especially the all-trans-β-carotene, became the main component of carotenoids in processed mango juice (increased from 43.72% to 75.15%, relative content), and the oxygenated carotenoids (xanthophylls) are highly sensitive to the US (reduced from 50.96% to 4.85%) while the carotenes show a strong resistance to the US (increased 49.04% to 95.15%). Thus, the overall safety and quality of mango juice were enhanced while the sensory characteristics remained stable, suggesting that this non-thermal combination sterilization processing may successfully be implemented in the commercial processing of mango juice.

ACS Style

Jingyi Wang; Qiudou Liu; Bijun Xie; Zhida Sun. Effect of ultrasound combined with ultraviolet treatment on microbial inactivation and quality properties of mango juice. Ultrasonics Sonochemistry 2020, 64, 105000 .

AMA Style

Jingyi Wang, Qiudou Liu, Bijun Xie, Zhida Sun. Effect of ultrasound combined with ultraviolet treatment on microbial inactivation and quality properties of mango juice. Ultrasonics Sonochemistry. 2020; 64 ():105000.

Chicago/Turabian Style

Jingyi Wang; Qiudou Liu; Bijun Xie; Zhida Sun. 2020. "Effect of ultrasound combined with ultraviolet treatment on microbial inactivation and quality properties of mango juice." Ultrasonics Sonochemistry 64, no. : 105000.

Journal article
Published: 15 October 2019 in Food Research International
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The impact of lotus seedpod proanthocyanidin (LSPC) on the functional properties of β-carotene-loaded whey-protein stabilized nanoemulsions was investigated. LSPC was selected because it is known to exhibit strong antioxidant activity, as well as having various health benefits. Physically stable nanoemulsions containing small anionic droplets (d < 0.15 μm; ζ = −27 mV) could be formed at pH 6.5 using whey protein-LSPC complexes as natural emulsifiers. The physical and chemical stabilities of the nanoemulsions were then measured when they were incubated at different pH values. LSPC addition promoted droplet aggregation at pH 4, but not at pH 3, 6.5, or 8, which was mainly attributed to its ability to reduce the electrostatic repulsion between the lipid droplets at pH 4. LSPC was shown to have stronger antioxidant activity than catechin and epicatechin. Our results show that the chemical stability of β-carotene nanoemulsions could be considerably improved by adding LSPC. We believe that LSPC-whey protein complexes can be used as effective emulsifiers and antioxidants in nutraceutical-loaded nanoemulsions, which may be useful for developing more efficacious functional foods and beverages.

ACS Style

Yashu Chen; Ruojie Zhang; Bijun Xie; Zhida Sun; David Julian McClements. Lotus seedpod proanthocyanidin-whey protein complexes: Impact on physical and chemical stability of β-carotene-nanoemulsions. Food Research International 2019, 127, 108738 .

AMA Style

Yashu Chen, Ruojie Zhang, Bijun Xie, Zhida Sun, David Julian McClements. Lotus seedpod proanthocyanidin-whey protein complexes: Impact on physical and chemical stability of β-carotene-nanoemulsions. Food Research International. 2019; 127 ():108738.

Chicago/Turabian Style

Yashu Chen; Ruojie Zhang; Bijun Xie; Zhida Sun; David Julian McClements. 2019. "Lotus seedpod proanthocyanidin-whey protein complexes: Impact on physical and chemical stability of β-carotene-nanoemulsions." Food Research International 127, no. : 108738.

Journal article
Published: 29 July 2019 in Foods
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Consumer demand for safe and nutritious fruit juices has led to the development of a number of food processing techniques. To compare the effect of two processing technologies, thermo-sonication (TS) and ultra-high pressure (UHP), on the quality of mango juice, fresh mango juice was treated with TS at 25, 45, 65 and 95 °C for 10 min and UHP at 400 MPa for 10 min. The phenolic profile of mango was also analyzed using the newly developed ultra-performance liquid chromatography-electrospray ionization-quadrupole time of flight-mass spectrometry (UPLC-Q-TOF-HRMSn) and, based on this result, the effect of TS and UHP on the phenolics of mango juice was evaluated. Both treatments had minimal effects on the oBrix, pH, and titratable acidity of mango juice. The residual activities of three enzymes (polyphenol oxidase, peroxidase, and pectin methylesterase), antioxidant compounds (vitamin C, Total phenolics, mangiferin derivatives, gallotannins, and quercetin derivatives) and antioxidant activity sharply decreased with the increase in the temperature of the TS treatment. Nevertheless, the UHP treatment retained antioxidants and antioxidant activity at a high level. The UHP process is likely superior to TS in bioactive compounds and antioxidant activity preservation. Therefore, the mango juice products obtained by ultra-high-pressure processing might be more beneficial to health.

ACS Style

Abdul Ghani Dars; Kai Hu; Qiudou Liu; Aqleem Abbas; Bijun Xie; Zhida Sun. Effect of Thermo-Sonication and Ultra-High Pressure on the Quality and Phenolic Profile of Mango Juice. Foods 2019, 8, 298 .

AMA Style

Abdul Ghani Dars, Kai Hu, Qiudou Liu, Aqleem Abbas, Bijun Xie, Zhida Sun. Effect of Thermo-Sonication and Ultra-High Pressure on the Quality and Phenolic Profile of Mango Juice. Foods. 2019; 8 (8):298.

Chicago/Turabian Style

Abdul Ghani Dars; Kai Hu; Qiudou Liu; Aqleem Abbas; Bijun Xie; Zhida Sun. 2019. "Effect of Thermo-Sonication and Ultra-High Pressure on the Quality and Phenolic Profile of Mango Juice." Foods 8, no. 8: 298.

Journal article
Published: 29 May 2019 in Marine Drugs
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Due to its special aromatic structure, isorenieratene is thought to be an active natural antioxidant and photo/UV damage inhibitor. In this work, isorenieratene that was extracted from Rhodococcus sp. B7740 isolated from the Arctic Ocean, showed excellent scavenging ability of both singlet oxygen and hydroxyl radical in the UVB-induced auto-oxidation process using the EPR method. Within an ARPE-19 cell model damaged by UVB radiation, isorenieratene showed fine protective effects (1.13 ± 0.03 fold) compared with macular xanthophylls (MXs) through upregulating of tspo. The molecular docking was firstly performed to investigate the interaction of isorenieratene with TSPO as a special ligand. Results showed isorenieratene might form a better binding conformation (S-score −8.5438) than MXs and indicate that isorenieratene not only can function as a direct antioxidant but also activate tspo in ARPE-19 cells. Thus, isorenieratene might ease the UV-related damages including age-related macular degeneration (AMD).

ACS Style

Yashu Chen; Mengyao Guo; Jifang Yang; Jigang Chen; Bijun Xie; Zhida Sun. Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740. Marine Drugs 2019, 17, 316 .

AMA Style

Yashu Chen, Mengyao Guo, Jifang Yang, Jigang Chen, Bijun Xie, Zhida Sun. Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740. Marine Drugs. 2019; 17 (6):316.

Chicago/Turabian Style

Yashu Chen; Mengyao Guo; Jifang Yang; Jigang Chen; Bijun Xie; Zhida Sun. 2019. "Potential TSPO Ligand and Photooxidation Quencher Isorenieratene from Arctic Ocean Rhodococcus sp. B7740." Marine Drugs 17, no. 6: 316.

Research article
Published: 04 April 2019 in Journal of Agricultural and Food Chemistry
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Dietary polyphenols have shown hypolipidemic effects by reducing triglyceride absorption. The mechanisms may involve modifying fat emulsion during digestion in the gastrointestinal tract and suppressing lipase during hydrolysis in the small intestine. In an in vivo study, lotus seedpod oligomeric procyanidin (LSOPC) decreased total serum triglyceride and total cholesterol and elevated the high-density lipoprotein level in the hyperlipidemic rat model. In addition, LSOPC suppressed de novo lipogenesis-related gene expressions. In an in vitro study, the LSOPC-enriched emulsion decreased the mean droplet size from 0.36 to 0.33 μm and increased the viscosity of the emulsion. Moreover, the LSOPC-enriched emulsion improved the antioxidant properties. A digestion model was developed and showed that the particle size of the LSOPC-enriched emulsion increased in the oral cavity. However, an increase and then a significant drop of the particle size was measured in the stomach and small intestine. The free fatty acid release rate was decreased in the LSOPC-enriched emulsion partly ascribed to the inhibition of lipase by LSOPC.

ACS Style

Xiaopeng Li; Ya Chen; Shuyi Li; Mo Chen; Juan Xiao; Bijun Xie; Zhida Sun. Oligomer Procyanidins from Lotus Seedpod Regulate Lipid Homeostasis Partially by Modifying Fat Emulsification and Digestion. Journal of Agricultural and Food Chemistry 2019, 67, 4524 -4534.

AMA Style

Xiaopeng Li, Ya Chen, Shuyi Li, Mo Chen, Juan Xiao, Bijun Xie, Zhida Sun. Oligomer Procyanidins from Lotus Seedpod Regulate Lipid Homeostasis Partially by Modifying Fat Emulsification and Digestion. Journal of Agricultural and Food Chemistry. 2019; 67 (16):4524-4534.

Chicago/Turabian Style

Xiaopeng Li; Ya Chen; Shuyi Li; Mo Chen; Juan Xiao; Bijun Xie; Zhida Sun. 2019. "Oligomer Procyanidins from Lotus Seedpod Regulate Lipid Homeostasis Partially by Modifying Fat Emulsification and Digestion." Journal of Agricultural and Food Chemistry 67, no. 16: 4524-4534.

Journal article
Published: 12 February 2019 in Carbohydrate Polymers
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The inhibitory effect of carboxymethyl pachyman (CMP) mixed with lotus seedpod oligomeric procyanidins (LSPC) in certain ratios against E. coli 10899 was determined. Added low concentration of LSPC could improve the antibacterial activity of CMP, and a significant synergistic effect could be observed between them, especially when the concentration of CMP was below its critical concentration (1.35 mg/mL). Then, the interaction between CMP and LSPC was characterized after mixing; the changes in spectral characteristics, thermal properties, crystallinity pattern, molecular weight, chain morphology and microrheological behaviour explained the influence of interaction on the structure of CMP and LSPC. The smaller molecular size, electrostatic interaction and stronger hydrophobic interaction might play important roles in improving the antibacterial activity of mixture. The dissociation constant (Kd) was determined to be 0.102±0.0008 mg/mL using MicroScale Thermophoresis (MST), and the micromorphology was observed by SEM. Therefore, this mixture might be an effective natural bacteriostat.

ACS Style

Jingyi Wang; Meng Bie; Weijing Zhou; Bijun Xie; Zhida Sun. Interaction between carboxymethyl pachyman and lotus seedpod oligomeric procyanidins with superior synergistic antibacterial activity. Carbohydrate Polymers 2019, 212, 11 -20.

AMA Style

Jingyi Wang, Meng Bie, Weijing Zhou, Bijun Xie, Zhida Sun. Interaction between carboxymethyl pachyman and lotus seedpod oligomeric procyanidins with superior synergistic antibacterial activity. Carbohydrate Polymers. 2019; 212 ():11-20.

Chicago/Turabian Style

Jingyi Wang; Meng Bie; Weijing Zhou; Bijun Xie; Zhida Sun. 2019. "Interaction between carboxymethyl pachyman and lotus seedpod oligomeric procyanidins with superior synergistic antibacterial activity." Carbohydrate Polymers 212, no. : 11-20.

Journal article
Published: 18 October 2018 in Natural Product Research
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The flavonoid compositions, extracted from leaves, peel and flesh of white guava (Psidium guajava L. cv. Pearl), were identified and quantified by UPLC-ESI-QTOF-MS, HPLC-ESI-MS/MS and HPLC. The main components of three extracts all were quercetin-glycosides, but the proportion and content of quercetin-hexoside and quercetin-pentoside in each extract were different. Based on the measurements of MIC, MBC value and time killing curve, it emerged that 3 flavonoid extracts of white guava had good antibacterial effects on four pathogenic bacteria. White guava leaves flavonoids (WGLF) concentrations of 5.00 mg/mL and 0.625 mg/mL could change the micro-morphology of Escherichia coli and Staphylococcus aureus. It suggested that the antibacterial mechanism of WGLF on gram-positive and gram-negative bacteria was to destroy the structure and function of the cell membrane. It is indicated that the flavonoid extracts from white guava is a potential natural antimicrobial agent.

ACS Style

Wanjun Zhang; Jingyi Wang; Yashu Chen; HongBin Zheng; Bijun Xie; Zhida Sun. Flavonoid compounds and antibacterial mechanisms of different parts of white guava (Psidium guajava L. cv. Pearl). Natural Product Research 2018, 34, 1621 -1625.

AMA Style

Wanjun Zhang, Jingyi Wang, Yashu Chen, HongBin Zheng, Bijun Xie, Zhida Sun. Flavonoid compounds and antibacterial mechanisms of different parts of white guava (Psidium guajava L. cv. Pearl). Natural Product Research. 2018; 34 (11):1621-1625.

Chicago/Turabian Style

Wanjun Zhang; Jingyi Wang; Yashu Chen; HongBin Zheng; Bijun Xie; Zhida Sun. 2018. "Flavonoid compounds and antibacterial mechanisms of different parts of white guava (Psidium guajava L. cv. Pearl)." Natural Product Research 34, no. 11: 1621-1625.

Journal article
Published: 18 October 2018 in Marine Drugs
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Menaquinone (MK) has an important role in human metabolism as an essential vitamin (VK2), which is mainly produced through the fermentation of microorganisms. MK8(H2) was identified to be the main menaquinone from Rhodococcus sp. B7740, a bacterium isolated from the arctic ocean. In this work, MK8(H2) (purity: 99.75%) was collected through a convenient and economic extraction process followed by high-speed countercurrent chromatography (HSCCC) purification. Additionally, high-resolution mass spectrometry (HRMS) was performed for further identification and the hydrogenation position of MK8(H2) (terminal unit) was determined using nuclear magnetic resonance (NMR) for the first time. MK8(H2) showed a superior antioxidant effect and antiglycation capacity compared with ubiquinone Q10 and MK4. High-performance liquid chromatography–mass spectrometer (HPLC-MS/MS) and molecular docking showed the fine interaction between MK8(H2) with methylglyoxal (MGO) and bull serum albumin (BSA), respectively. These properties make MK8(H2) a promising natural active ingredient with future food and medicine applications.

ACS Style

Yashu Chen; Qin Mu; Kai Hu; Mo Chen; Jifang Yang; Jigang Chen; Bijun Xie; Zhida Sun. Characterization of MK8(H2) from Rhodococcus sp. B7740 and Its Potential Antiglycation Capacity Measurements. Marine Drugs 2018, 16, 391 .

AMA Style

Yashu Chen, Qin Mu, Kai Hu, Mo Chen, Jifang Yang, Jigang Chen, Bijun Xie, Zhida Sun. Characterization of MK8(H2) from Rhodococcus sp. B7740 and Its Potential Antiglycation Capacity Measurements. Marine Drugs. 2018; 16 (10):391.

Chicago/Turabian Style

Yashu Chen; Qin Mu; Kai Hu; Mo Chen; Jifang Yang; Jigang Chen; Bijun Xie; Zhida Sun. 2018. "Characterization of MK8(H2) from Rhodococcus sp. B7740 and Its Potential Antiglycation Capacity Measurements." Marine Drugs 16, no. 10: 391.

Journals
Published: 14 August 2018 in Food & Function
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As a major component of green tea, (−)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists owing to its potential to combat a variety of human diseases including abnormal glucose metabolism in obesity and diabetes.

ACS Style

Xiaopeng Li; Shuyi Li; Mo Chen; Jingyi Wang; Bijun Xie; Zhida Sun. (−)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR/CAR-mediated phase II metabolism in diabetic mice. Food & Function 2018, 9, 4651 -4663.

AMA Style

Xiaopeng Li, Shuyi Li, Mo Chen, Jingyi Wang, Bijun Xie, Zhida Sun. (−)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR/CAR-mediated phase II metabolism in diabetic mice. Food & Function. 2018; 9 (9):4651-4663.

Chicago/Turabian Style

Xiaopeng Li; Shuyi Li; Mo Chen; Jingyi Wang; Bijun Xie; Zhida Sun. 2018. "(−)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR/CAR-mediated phase II metabolism in diabetic mice." Food & Function 9, no. 9: 4651-4663.

Journal article
Published: 01 August 2018 in Food Chemistry
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Isorenierantene was reported to be an aromatic carotenoid and has become a food ingredient, mainly from smear cheese, which possesses special antioxidant ability and significant photoprotective effect. In this paper, the interaction of isorenieratene with human serum albumin (HSA) was explored and compared with that of nonaromatic carotenoids using multi-spectroscopic methods and docking simulations. The results suggested isorenieratene could bind to HSA through a static quenching mechanism. The binding processes were spontaneous and exothermic, and the binding between isorenieratene and HSA was mainly driven by hydrophobic forces and electrostatic attraction. Synchronous fluorescence spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, and surface-enhanced Raman scattering (SERS) experiments showed isorenieratene may change the secondary structure of HSA and the micro-environment of its amino acids. Additionally, isorenieratene showed higher stability during the binding process than did nonaromatic carotenoids. Docking simulation indicated isorenieratene may bind to HSA at site II.

ACS Style

Yashu Chen; Yufeng Zhou; Mo Chen; Bijun Xie; Jifang Yang; Jigang Chen; Zhida Sun. Isorenieratene interaction with human serum albumin: Multi-spectroscopic analyses and docking simulation. Food Chemistry 2018, 258, 393 -399.

AMA Style

Yashu Chen, Yufeng Zhou, Mo Chen, Bijun Xie, Jifang Yang, Jigang Chen, Zhida Sun. Isorenieratene interaction with human serum albumin: Multi-spectroscopic analyses and docking simulation. Food Chemistry. 2018; 258 ():393-399.

Chicago/Turabian Style

Yashu Chen; Yufeng Zhou; Mo Chen; Bijun Xie; Jifang Yang; Jigang Chen; Zhida Sun. 2018. "Isorenieratene interaction with human serum albumin: Multi-spectroscopic analyses and docking simulation." Food Chemistry 258, no. : 393-399.

Journal article
Published: 01 August 2018 in Food Chemistry
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Maturity has important effects on the phytochemical and biochemical characteristics of fruits. It affects the quality, nutritional value, harvest time and commercial operations. In this study, Keitt, Sensation and Xiangya mango cultivars in four distinct stages from southwest China were evaluated for their phytochemical profiling and antioxidant activities in real time. Furthermore, the biochemical characteristics indices polyphenol oxidase (PPO), peroxidase (POD), superoxide dismutase (SOD) and pectin methylesterase (PME) activities were determined. Antioxidant compounds such as vitamin C, total phenolic, total flavonoid and total carotenoid content were also analysed. A total of 34 phenolic compounds were identified and quantitatively monitored by UPLC-ESI-QTOF-MS. Consecutive degradation of phenolic acids and its derivatives were observed upon maturity. We found that in addition to carotenoids, phenolic acids could also be used as a measurement index of maturity in mango. Mango juices and its phenolic extracts may be used as potential prebiotics for modulating probiotic proliferation.

ACS Style

Kai Hu; Abdul Ghani Dars; Qiudou Liu; Bijun Xie; Zhida Sun. Phytochemical profiling of the ripening of Chinese mango (Mangifera indica L.) cultivars by real-time monitoring using UPLC-ESI-QTOF-MS and its potential benefits as prebiotic ingredients. Food Chemistry 2018, 256, 171 -180.

AMA Style

Kai Hu, Abdul Ghani Dars, Qiudou Liu, Bijun Xie, Zhida Sun. Phytochemical profiling of the ripening of Chinese mango (Mangifera indica L.) cultivars by real-time monitoring using UPLC-ESI-QTOF-MS and its potential benefits as prebiotic ingredients. Food Chemistry. 2018; 256 ():171-180.

Chicago/Turabian Style

Kai Hu; Abdul Ghani Dars; Qiudou Liu; Bijun Xie; Zhida Sun. 2018. "Phytochemical profiling of the ripening of Chinese mango (Mangifera indica L.) cultivars by real-time monitoring using UPLC-ESI-QTOF-MS and its potential benefits as prebiotic ingredients." Food Chemistry 256, no. : 171-180.

Journal article
Published: 10 July 2018 in Journal of Functional Foods
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The synergistic antibacterial effects of lotus seedpod oligomeric procyanidins (LSPC) and water-soluble Poria cocos polysaccharides (WPCP) against two Escherichia coli (E. coli) strains were evaluated. The mixture showed an obviously synergistic inhibitory effect against E. coli, improving the adverse effects by which LSPC at low concentration (≤0.8 mg/mL) proliferated E. coli. The minimal inhibitory concentration (MIC) of the mixture was significantly lower compared with LSPC alone against E. coli strains. The main mechanism of LSPC and the mixture against E. coli strains caused damage of cell membranes and increased the intracellular oxidative stress. The changes in the FT-IR and UV–vis spectra showed that there was interaction between LSPC and WPCP, and the changes of zeta potential of different samples might offer possible reasons for its improved antibacterial activity. Moreover, the results demonstrated that the mixture had more potential than LSPC for natural bacteriostatic agents and probiotics.

ACS Style

Jingyi Wang; Wanjun Zhang; Cuie Tang; Juan Xiao; Bijun Xie; Zhida Sun. Synergistic effect of B-type oligomeric procyanidins from lotus seedpod in combination with water-soluble Poria cocos polysaccharides against E. coli and mechanism. Journal of Functional Foods 2018, 48, 134 -143.

AMA Style

Jingyi Wang, Wanjun Zhang, Cuie Tang, Juan Xiao, Bijun Xie, Zhida Sun. Synergistic effect of B-type oligomeric procyanidins from lotus seedpod in combination with water-soluble Poria cocos polysaccharides against E. coli and mechanism. Journal of Functional Foods. 2018; 48 ():134-143.

Chicago/Turabian Style

Jingyi Wang; Wanjun Zhang; Cuie Tang; Juan Xiao; Bijun Xie; Zhida Sun. 2018. "Synergistic effect of B-type oligomeric procyanidins from lotus seedpod in combination with water-soluble Poria cocos polysaccharides against E. coli and mechanism." Journal of Functional Foods 48, no. : 134-143.

Journal article
Published: 01 February 2018 in Food Chemistry
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Rhodococcus sp. B7740 is a newfound bacterium which was isolated from 25m deep seawater in the arctic. In this paper, Rhodococcus sp. B7740 was firstly discovered to produce abundant natural isoprenoids, including ubiquinone-4(UQ-4), 13 kinds of menaquinones, three rare aromatic carotenoids and more than one common carotenoid. These compounds were identified by UV-Visible, HPLC-APCI-MS/MS and HRMS spectra. Results demonstrated that Rhodococcus sp. B7740 might be a worthy source of natural isoprenoids especially for scarce aromatic carotenoids. Among them, isorenieratene with 528.3762Da (calculated for 528.3756Da, error: 1.1ppm), a carotenoid with aromatic ring, was purified by HSCCC. The stability of isorenieratene under the mimical gastric conditions was measured compared with common dietary carotenoids, β-carotene and lutein. Unlike β-carotene and lutein, isorenieratene exhibited rather stable in the presence of free iron or heme iron. Its high retention rate in gastrointestinal tract after ingestion indicates the benefits for health.

ACS Style

Yashu Chen; Bijun Xie; Jifang Yang; Jigang Chen; Zhida Sun. Identification of microbial carotenoids and isoprenoid quinones from Rhodococcus sp. B7740 and its stability in the presence of iron in model gastric conditions. Food Chemistry 2018, 240, 204 -211.

AMA Style

Yashu Chen, Bijun Xie, Jifang Yang, Jigang Chen, Zhida Sun. Identification of microbial carotenoids and isoprenoid quinones from Rhodococcus sp. B7740 and its stability in the presence of iron in model gastric conditions. Food Chemistry. 2018; 240 ():204-211.

Chicago/Turabian Style

Yashu Chen; Bijun Xie; Jifang Yang; Jigang Chen; Zhida Sun. 2018. "Identification of microbial carotenoids and isoprenoid quinones from Rhodococcus sp. B7740 and its stability in the presence of iron in model gastric conditions." Food Chemistry 240, no. : 204-211.

Journal article
Published: 01 November 2017 in Journal of Functional Foods
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ACS Style

Cuie Tang; Bijun Xie; Zhida Sun. Antibacterial activity and mechanism of B-type oligomeric procyanidins from lotus seedpod on enterotoxigenic Escherichia coli. Journal of Functional Foods 2017, 38, 454 -463.

AMA Style

Cuie Tang, Bijun Xie, Zhida Sun. Antibacterial activity and mechanism of B-type oligomeric procyanidins from lotus seedpod on enterotoxigenic Escherichia coli. Journal of Functional Foods. 2017; 38 ():454-463.

Chicago/Turabian Style

Cuie Tang; Bijun Xie; Zhida Sun. 2017. "Antibacterial activity and mechanism of B-type oligomeric procyanidins from lotus seedpod on enterotoxigenic Escherichia coli." Journal of Functional Foods 38, no. : 454-463.