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Honeybees are one of the most marvelous and economically beneficial insects. As pollinators, they play a vital role in every aspect of the ecosystem. Beehive products have been used for thousands of years in many cultures for the treatment of various diseases. Their healing properties have been documented in many religious texts like the Noble Quran and the Holy Bible. Honey, bee venom, propolis, pollen and royal jelly all demonstrated a richness in their bioactive compounds which make them effective against a variety of bacterial strains. Furthermore, many studies showed that honey and bee venom work as powerful antibacterial agents against a wide range of bacteria including life-threatening bacteria. Several reports documented the biological activities of honeybee products but none of them emphasized on the antibacterial activity of all beehive products. Therefore, this review aims to highlight the antibacterial activity of honey, bee venom, propolis, pollen and royal jelly, that are produced by honeybees.
Rita Nader; Rawan Mackieh; Rim Wehbe; Dany El Obeid; Jean Sabatier; Ziad Fajloun. Beehive Products as Antibacterial Agents: A Review. Antibiotics 2021, 10, 717 .
AMA StyleRita Nader, Rawan Mackieh, Rim Wehbe, Dany El Obeid, Jean Sabatier, Ziad Fajloun. Beehive Products as Antibacterial Agents: A Review. Antibiotics. 2021; 10 (6):717.
Chicago/Turabian StyleRita Nader; Rawan Mackieh; Rim Wehbe; Dany El Obeid; Jean Sabatier; Ziad Fajloun. 2021. "Beehive Products as Antibacterial Agents: A Review." Antibiotics 10, no. 6: 717.
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. Moreover, bee venom has shown promising benefits against different types of cancer as well as anti-viral activity, even against the challenging human immunodeficiency virus (HIV). Many studies described biological activities of bee venom components and launched preclinical trials to improve the potential use of apitoxin and its constituents as the next generation of drugs. The aim of this review is to summarize the main compounds of bee venom, their primary biological properties, mechanisms of action, and their therapeutic values in alternative therapy strategies.
Rim Wehbe; Jacinthe Frangieh; Mohamad Rima; Dany El Obeid; Jean-Marc Sabatier; Ziad Fajloun. Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests. Molecules 2019, 24, 2997 .
AMA StyleRim Wehbe, Jacinthe Frangieh, Mohamad Rima, Dany El Obeid, Jean-Marc Sabatier, Ziad Fajloun. Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests. Molecules. 2019; 24 (16):2997.
Chicago/Turabian StyleRim Wehbe; Jacinthe Frangieh; Mohamad Rima; Dany El Obeid; Jean-Marc Sabatier; Ziad Fajloun. 2019. "Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests." Molecules 24, no. 16: 2997.
Bee venom is a mixture of several components with proven therapeutic benefits, among which are anti-inflammatory, analgesic, and various cardiovascular conditions. In this work, we analyzed for the first time the proteomic content and biological properties of the crude venom from Apis mellifera syriaca, a honeybee from the Middle East region. Using high-performance liquid chromatography-tandem mass spectrometry, we evidence the venom contains phospholipase A2, hyaluronidase, mast cell-degranulating peptide, adolapin, apamin, and melittin. The latter was purified by solid phase extraction method (SPE) and tested in parallel with crude venom for biological activities. Precisely, crude venom-but not melittin-exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa strains. Alongside, hemolytic activity was observed in human blood subjected to the venom at high doses. A. mellifera syriaca venom displayed antioxidant activities, and not surprisingly, PLA2 catalytic activity. Eventually, the venom proved to exert antiproliferative effects against MCF-7 and 3T3 cancer cells lines. This first report of a new bee venom opens new avenues for therapeutic uses of bee venoms.
Jacinthe Frangieh; Yahya Salma; Katia Haddad; Cesar Mattei; Christian Legros; Ziad Fajloun; Dany El Obeid. First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region. Toxins 2019, 11, 191 .
AMA StyleJacinthe Frangieh, Yahya Salma, Katia Haddad, Cesar Mattei, Christian Legros, Ziad Fajloun, Dany El Obeid. First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region. Toxins. 2019; 11 (4):191.
Chicago/Turabian StyleJacinthe Frangieh; Yahya Salma; Katia Haddad; Cesar Mattei; Christian Legros; Ziad Fajloun; Dany El Obeid. 2019. "First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region." Toxins 11, no. 4: 191.