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Dr. William C. Cho
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China

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0 Molecular Diagnostics
0 Proteomics
0 microRNA
0 Cancer biomarker

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Research article
Published: 26 August 2021 in Journal of Nanomaterials
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Medicinal plants are composed of a rich pool of biomolecules and have been increasingly recognized for their antimicrobial properties; however, increasing concerns have been put on the bioavailability features. Thus, this study is aimed at exploring the synthesis and characterization of silver nanoparticles synthesized by Chenopodium album L. leaf extract and assessing the antifungal activity against Aspergillus terreus Thom. Plant extract was prepared in methanol to synthetize silver nanoparticles, which were then characterized by Scanning Electron Microscopy (SEM), UV-Visible spectroscopy, and particle size analysis. UV-Visible analysis indicated maximum absorption at 378 nm, and an average particle size was observed as 25.6 nm. Oval to hexagonal shape was observed by SEM. Antifungal activity of silver nanoparticles (1, 1.5, 2, 2.5, 3, and 3.5%) was addressed against A. terreus biomass. At 3.5%, silver nanoparticles revealed to be highly effective, leading to 92% retardation in fungus growth. In next phase, various organic fractions, viz., chloroform, n-butanol, n-hexane, and ethyl acetate, were obtained from plant methanol extract, and the corresponding silver nanoparticles were prepared. These fractions were also assessed for antifungal activity, and n-hexane fraction led to 64% inhibition in A. terreus biomass. Following gas chromatography-mass spectrometry (GC-MS), 18 compounds were identified, namely, 1,3-cyclopentadiene-5-(1 methylethylidene and o-xylene), ethyl benzene, octadecane, nonane, decane, 2-methylheptane, n-hexadecane, 2-methylheptane, and eicosane, along with carbonyl compounds (4,4-dimethyl-3-hexanone) and phenols, like stearic acid, propionic acid hydrazide, and 2,4-di-T-butylphenol. These findings proved that C. album silver nanoparticles are highly effective against A. terreus.

ACS Style

Faiza Anum; Khajista Jabeen; Sumera Javad; Sumera Iqbal; Arifa Tahir; Zeeshan Javed; Natália Cruz-Martins; Seyed Abdulmajid Ayatollahi; Javad Sharifi-Rad; Mohammed M. Alshehri; William C. Cho. Green Synthesized Silver Nanoparticles as Potent Antifungal Agent against Aspergillus terreus Thom. Journal of Nanomaterials 2021, 2021, 1 -10.

AMA Style

Faiza Anum, Khajista Jabeen, Sumera Javad, Sumera Iqbal, Arifa Tahir, Zeeshan Javed, Natália Cruz-Martins, Seyed Abdulmajid Ayatollahi, Javad Sharifi-Rad, Mohammed M. Alshehri, William C. Cho. Green Synthesized Silver Nanoparticles as Potent Antifungal Agent against Aspergillus terreus Thom. Journal of Nanomaterials. 2021; 2021 ():1-10.

Chicago/Turabian Style

Faiza Anum; Khajista Jabeen; Sumera Javad; Sumera Iqbal; Arifa Tahir; Zeeshan Javed; Natália Cruz-Martins; Seyed Abdulmajid Ayatollahi; Javad Sharifi-Rad; Mohammed M. Alshehri; William C. Cho. 2021. "Green Synthesized Silver Nanoparticles as Potent Antifungal Agent against Aspergillus terreus Thom." Journal of Nanomaterials 2021, no. : 1-10.

Review article
Published: 21 August 2021 in Oxidative Medicine and Cellular Longevity
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Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer’s disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already showed good biological activities in previous studies. On the evidence of varied pharmacological properties, the present work presents an overall review of the derivation, availability, and biological capacities of coumarins with further consideration of the essential mode of their therapeutic actions. In conclusion, a wide variety of coumarins are available, and their pharmacological activities are of current interest thanks to their synthetic accessibility and riches in medicinal plants. Coumarins perform the valuable function as therapeutic agents in a range of medical fields.

ACS Style

Javad Sharifi-Rad; Natália Cruz-Martins; Pía López-Jornet; Eduardo Pons-Fuster Lopez; Nida Harun; Balakyz Yeskaliyeva; Ahmet Beyatli; Oksana Sytar; Shabnum Shaheen; Farukh Sharopov; Yasaman Taheri; Anca Oana Docea; Daniela Calina; William C. Cho. Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -19.

AMA Style

Javad Sharifi-Rad, Natália Cruz-Martins, Pía López-Jornet, Eduardo Pons-Fuster Lopez, Nida Harun, Balakyz Yeskaliyeva, Ahmet Beyatli, Oksana Sytar, Shabnum Shaheen, Farukh Sharopov, Yasaman Taheri, Anca Oana Docea, Daniela Calina, William C. Cho. Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-19.

Chicago/Turabian Style

Javad Sharifi-Rad; Natália Cruz-Martins; Pía López-Jornet; Eduardo Pons-Fuster Lopez; Nida Harun; Balakyz Yeskaliyeva; Ahmet Beyatli; Oksana Sytar; Shabnum Shaheen; Farukh Sharopov; Yasaman Taheri; Anca Oana Docea; Daniela Calina; William C. Cho. 2021. "Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms." Oxidative Medicine and Cellular Longevity 2021, no. : 1-19.

Review article
Published: 21 August 2021 in Oxidative Medicine and Cellular Longevity
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Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, luteolin, and resveratrol have revealed excellent neuroprotective effects and can be effectively used in the treatment of neuropsychological disorders. However, the number of clinical trials is limited, and none of them have been approved for the treatment of autism or autism-related disorder. Further clinical studies are needed to effectively assess the real potential of such bioactive molecules.

ACS Style

Natália Cruz-Martins; Cristina Quispe; Celale Kırkın; Ezgi Şenol; Aslı Zuluğ; Beraat Özçelik; Adedayo O. Ademiluyi; Olubukola Helen Oyeniran; Prabhakar Semwal; Manoj Kumar; Farukh Sharopov; Victor López; Francisco Les; Iulia-Cristina Bagiu; Monica Butnariu; Javad Sharifi-Rad; Mohammed M. Alshehri; William C. Cho. Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -17.

AMA Style

Natália Cruz-Martins, Cristina Quispe, Celale Kırkın, Ezgi Şenol, Aslı Zuluğ, Beraat Özçelik, Adedayo O. Ademiluyi, Olubukola Helen Oyeniran, Prabhakar Semwal, Manoj Kumar, Farukh Sharopov, Victor López, Francisco Les, Iulia-Cristina Bagiu, Monica Butnariu, Javad Sharifi-Rad, Mohammed M. Alshehri, William C. Cho. Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-17.

Chicago/Turabian Style

Natália Cruz-Martins; Cristina Quispe; Celale Kırkın; Ezgi Şenol; Aslı Zuluğ; Beraat Özçelik; Adedayo O. Ademiluyi; Olubukola Helen Oyeniran; Prabhakar Semwal; Manoj Kumar; Farukh Sharopov; Victor López; Francisco Les; Iulia-Cristina Bagiu; Monica Butnariu; Javad Sharifi-Rad; Mohammed M. Alshehri; William C. Cho. 2021. "Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder." Oxidative Medicine and Cellular Longevity 2021, no. : 1-17.

Review article
Published: 17 August 2021 in Oxidative Medicine and Cellular Longevity
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Cardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor—alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and antimicrobial effects. Thus, this review is intended to address the antiplatelet activity of phenolic compounds with special emphasis in preventing CVD, along with the mechanisms of action through which they are able to prevent and treat CVD. In vitro and in vivo studies have shown beneficial effects of phenolic compound-rich plant extracts and isolated compounds against CVD, despite that the scientific literature available on the antiplatelet aggregation ability of phenolic compounds in vivo is scarce. Thus, despite the current advances, further studies are needed to confirm the cardioprotective potential of phenolic compounds towards their use alone or in combination with conventional drugs for effective therapeutic interventions.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Wissam Zam; Manoj Kumar; Susana M. Cardoso; Olivia R. Pereira; Adedayo O. Ademiluyi; Oluwakemi Adeleke; Ana Catarina Moreira; Jelena Živković; Felipe Noriega; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Mehrdad Faizi; Miquel Martorell; Natália Cruz-Martins; Monica Butnariu; Iulia Cristina Bagiu; Radu Vasile Bagiu; Mohammed M. Alshehri; William C. Cho. Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -19.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Wissam Zam, Manoj Kumar, Susana M. Cardoso, Olivia R. Pereira, Adedayo O. Ademiluyi, Oluwakemi Adeleke, Ana Catarina Moreira, Jelena Živković, Felipe Noriega, Seyed Abdulmajid Ayatollahi, Farzad Kobarfard, Mehrdad Faizi, Miquel Martorell, Natália Cruz-Martins, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu, Mohammed M. Alshehri, William C. Cho. Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-19.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Wissam Zam; Manoj Kumar; Susana M. Cardoso; Olivia R. Pereira; Adedayo O. Ademiluyi; Oluwakemi Adeleke; Ana Catarina Moreira; Jelena Živković; Felipe Noriega; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Mehrdad Faizi; Miquel Martorell; Natália Cruz-Martins; Monica Butnariu; Iulia Cristina Bagiu; Radu Vasile Bagiu; Mohammed M. Alshehri; William C. Cho. 2021. "Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health." Oxidative Medicine and Cellular Longevity 2021, no. : 1-19.

Journal article
Published: 10 August 2021 in Acta Tropica
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Echinococcus multilocularis metacestodes mainly reside in liver in humans and animals, and cause serious damages. UBE2N was herein shown to be downregulated in response to the infection. UBE2N was further shown to be predominantly expressed in the hepatocytes, which was also significantly downregulated during the infection. UBE2N was a target of emu-miR-4989, which was loaded into the exosomes secreted by parasites. These emu-miR-4989-encapsulating exosomes were internalized by hepatocytes, and induced a significant decrease of relative luciferase activity in the cells transfected with the construct containing a wild type of UBE2N 3’-UTR compared to the control (p < 0.05). These results demonstrate that emu-miR-4989 is involved in the UBE2N inhibition in the hepatocytes during E. multilocularis through exosomes.

ACS Style

Mengting Cai; Juntao Ding; Yating Li; Guitian He; Jing Yang; Tingli Liu; Xiaola Guo; Xing Yang; Xiaoqiang Wang; William C. Cho; Majid Fasihi Harandi; Yadong Zheng. Echinococcus multilocularis infection induces UBE2N suppression via exosomal emu-miR-4989. Acta Tropica 2021, 223, 106087 .

AMA Style

Mengting Cai, Juntao Ding, Yating Li, Guitian He, Jing Yang, Tingli Liu, Xiaola Guo, Xing Yang, Xiaoqiang Wang, William C. Cho, Majid Fasihi Harandi, Yadong Zheng. Echinococcus multilocularis infection induces UBE2N suppression via exosomal emu-miR-4989. Acta Tropica. 2021; 223 ():106087.

Chicago/Turabian Style

Mengting Cai; Juntao Ding; Yating Li; Guitian He; Jing Yang; Tingli Liu; Xiaola Guo; Xing Yang; Xiaoqiang Wang; William C. Cho; Majid Fasihi Harandi; Yadong Zheng. 2021. "Echinococcus multilocularis infection induces UBE2N suppression via exosomal emu-miR-4989." Acta Tropica 223, no. : 106087.

Review article
Published: 02 August 2021 in Oxidative Medicine and Cellular Longevity
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Lymphoma is a name for malignant diseases of the lymphatic system including Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Although several approaches are used for the treatment of these diseases, some of them are not successful and have serious adverse effects. Therefore, other effective treatment methods might be interesting. Studies have indicated that plant ingredients play a key role in treating several diseases. Some plants have already shown a potential therapeutic effect on many malignant diseases. Quercetin is a flavonoid found in different plants and could be useful in the treatment of different malignant diseases. Quercetin has its antimalignant effects through targeting main survival pathways activated in tumor cells. In vitro/in vivo experimental studies have demonstrated that quercetin possesses a cytotoxic effect on lymphoid cancer cells. Regardless of the optimum results that have been obtained from both in vitro/in vivo studies, few clinical studies have analyzed the antitumor effects of quercetin in lymphoid cancers. Thus, it seems that more clinical studies should introduce quercetin as a therapeutic, alone or in combination with other chemotherapy agents. Here, in this study, we reviewed the anticancer effects of quercetin and highlighted the potential therapeutic effects of quercetin in various types of lymphoma.

ACS Style

Saiedeh Razi Soofiyani; Kamran Hosseini; Haleh Forouhandeh; Tohid Ghasemnejad; Vahideh Tarhriz; Parina Asgharian; Željko Reiner; Javad Sharifi-Rad; William C. Cho. Quercetin as a Novel Therapeutic Approach for Lymphoma. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -15.

AMA Style

Saiedeh Razi Soofiyani, Kamran Hosseini, Haleh Forouhandeh, Tohid Ghasemnejad, Vahideh Tarhriz, Parina Asgharian, Željko Reiner, Javad Sharifi-Rad, William C. Cho. Quercetin as a Novel Therapeutic Approach for Lymphoma. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-15.

Chicago/Turabian Style

Saiedeh Razi Soofiyani; Kamran Hosseini; Haleh Forouhandeh; Tohid Ghasemnejad; Vahideh Tarhriz; Parina Asgharian; Željko Reiner; Javad Sharifi-Rad; William C. Cho. 2021. "Quercetin as a Novel Therapeutic Approach for Lymphoma." Oxidative Medicine and Cellular Longevity 2021, no. : 1-15.

Journal article
Published: 20 July 2021 in Genes
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The transcription factor high mobility group protein A2 (HMGA2) plays an important role in the pathogenesis of some cancers including breast cancer. Polyamidoamine dendrimer generation 4 is a kind of highly branched polymeric nanoparticle with surface charge and highest density peripheral groups that allow ligands or therapeutic agents to attach it, thereby facilitating target delivery. Here, methotrexate (MTX)- modified polyamidoamine dendrimer generation 4 (G4) (G4/MTX) was generated to deliver specific small interface RNA (siRNA) for suppressing HMGA2 expression and the consequent effects on folate receptor (FR) expressing human breast cancer cell lines (MCF-7, MDA-MB-231). We observed that HMGA2 siRNA was electrostatically adsorbed on the surface of the G4/MTX nanocarrier for constructing a G4/MTX-siRNA nano-complex which was verified by changing the final particle size and zeta potential. The release of MTX and siRNA from synthesized nanocomplexes was found in a time- and pH-dependent manner. We know that MTX targets FR. Interestingly, G4/MTX-siRNA demonstrates significant cellular internalization and gene silencing efficacy when compared to the control. Besides, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay demonstrated selective cell cytotoxicity depending on the folate receptor expressing in a dose-dependent manner. The gene silencing and protein downregulation of HMGA2 by G4/MTX-siRNA was observed and could significantly induce cell apoptosis in MCF-7 and MDA-MB-231 cancer cells compared to the control group. Based on the findings, we suggest that the newly developed G4/MTX-siRNA nano-complex may be a promising strategy to increase apoptosis induction through HMGA2 suppression as a therapeutic target in human breast cancer.

ACS Style

Fereydoon Abedi Gaballu; William Cho; Gholamreza Dehghan; Amir Zarebkohan; Behzad Baradaran; Behzad Mansoori; Soheil Abbaspour-Ravasjani; Ali Mohammadi; Nader Sheibani; Ayuob Aghanejad; Jafar Ezzati Nazhad Dolatabadi. Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy. Genes 2021, 12, 1102 .

AMA Style

Fereydoon Abedi Gaballu, William Cho, Gholamreza Dehghan, Amir Zarebkohan, Behzad Baradaran, Behzad Mansoori, Soheil Abbaspour-Ravasjani, Ali Mohammadi, Nader Sheibani, Ayuob Aghanejad, Jafar Ezzati Nazhad Dolatabadi. Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy. Genes. 2021; 12 (7):1102.

Chicago/Turabian Style

Fereydoon Abedi Gaballu; William Cho; Gholamreza Dehghan; Amir Zarebkohan; Behzad Baradaran; Behzad Mansoori; Soheil Abbaspour-Ravasjani; Ali Mohammadi; Nader Sheibani; Ayuob Aghanejad; Jafar Ezzati Nazhad Dolatabadi. 2021. "Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy." Genes 12, no. 7: 1102.

Review article
Published: 16 July 2021 in Oxidative Medicine and Cellular Longevity
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The genus Viburnum (Adoxaceae, Dipsacales) is of scientific interest due to the chemical components and diverse biological activities found across species of the genus, which includes more than 230 species of evergreen, semievergreen, or deciduous shrubs and small trees. Although frequently used as an ornament, the Viburnum species show biological properties with health-promoting effects. Fruits, flowers, and barks of certain species are used for pharmaceutical purposes or as cooking ingredients, hence containing biochemical compounds with health-promoting activity such are carotenoids, polyphenols, and flavonoids. However, its taxonomical determination is difficult, due to its wide distribution and frequent hybridizations; therefore, an objective classification would allow us to understand its biological activity based on its phytochemical components. More than sixty phytochemical compounds have been reported, where vibsanin-type diterpenes and their derivatives are the most prevalent. Leaves and twigs of V. dilatatum contain the largest number of phytochemicals among the genus. Through preclinical evidence, this study provides insight regarding antioxidant, antibacterial, anti-inflammatory, cytotoxic, and anticancer activities of genus Viburnum.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Cristian Valdés Vergara; Dusanka Kitic; Milica Kostic; Lorene Armstrong; Zabta Khan Shinwari; Ali Talha Khalil; Milka Brdar-Jokanović; Branka Ljevnaić-Mašić; Elena M. Varoni; Marcello Iriti; Gerardo Leyva-Gómez; Jesús Herrera-Bravo; Luis A. Salazar; William C. Cho. Genus Viburnum: Therapeutic Potentialities and Agro-Food-Pharma Applications. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -26.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Cristian Valdés Vergara, Dusanka Kitic, Milica Kostic, Lorene Armstrong, Zabta Khan Shinwari, Ali Talha Khalil, Milka Brdar-Jokanović, Branka Ljevnaić-Mašić, Elena M. Varoni, Marcello Iriti, Gerardo Leyva-Gómez, Jesús Herrera-Bravo, Luis A. Salazar, William C. Cho. Genus Viburnum: Therapeutic Potentialities and Agro-Food-Pharma Applications. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-26.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Cristian Valdés Vergara; Dusanka Kitic; Milica Kostic; Lorene Armstrong; Zabta Khan Shinwari; Ali Talha Khalil; Milka Brdar-Jokanović; Branka Ljevnaić-Mašić; Elena M. Varoni; Marcello Iriti; Gerardo Leyva-Gómez; Jesús Herrera-Bravo; Luis A. Salazar; William C. Cho. 2021. "Genus Viburnum: Therapeutic Potentialities and Agro-Food-Pharma Applications." Oxidative Medicine and Cellular Longevity 2021, no. : 1-26.

Review
Published: 27 June 2021 in Oxidative Medicine and Cellular Longevity
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The genus Peganum includes four species widely distributed in warm temperate to subtropical regions from the Mediterranean to Mongolia as well as certain regions in America. Among these species, Peganum harmala L., distributed from the Mediterranean region to Central Asia, has been studied and its phytochemical profile, traditional folk use, and application in pharmacological and clinical trials are well known. The review is aimed at presenting an insight into the botanical features and geographical distribution of Peganum spp. along with traditional folk uses. This manuscript also reviews the phytochemical profile of Peganum spp. and its correlation with biological activities evidenced by the in vitro and in vivo investigations. Moreover, this review gives us an understanding of the bioactive compounds from Peganum as health promoters followed by the safety and adverse effects on human health. In relation to their multipurpose therapeutic properties, various parts of this plant such as seeds, bark, and roots present bioactive compounds promoting health benefits. An updated search (until December 2020) was carried out in databases such as PubMed and ScienceDirect. Chemical studies have presented beta-carboline alkaloids as the most active constituents, with harmalol, harmaline, and harmine being the latest and most studied among these naturally occurring alkaloids. The Peganum spp. extracts have shown neuroprotective, anticancer, antimicrobial, and antiviral effects. The extracts are also found effective in improving respiratory disorders (asthma and cough conditions), dermatoses, and knee osteoarthritis. Bioactivities and health-enhancing effects of Peganum spp. make it a potential candidate for the formulation of functional foods and pharmaceutical drugs. Nevertheless, adverse effects of this plant have also been described, and therefore new bioproducts need to be studied in depth. In fact, the design of new formulations and nanoformulations to control the release of active compounds will be necessary to achieve successful pharmacological and therapeutic treatments.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Prabhakar Semwal; Sakshi Painuli; Beraat Özçelik; Furkan Ediz Hacıhasanoğlu; Shabnum Shaheen; Surjit Sen; Krishnendu Acharya; Marjan Amirian; Carla Marina Salgado Castillo; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Tamar Goloshvili; Ahmed Al-Harrasi; Ahmed Al-Rawahi; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. Peganum spp.: A Comprehensive Review on Bioactivities and Health-Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -20.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Jesús Herrera-Bravo, Prabhakar Semwal, Sakshi Painuli, Beraat Özçelik, Furkan Ediz Hacıhasanoğlu, Shabnum Shaheen, Surjit Sen, Krishnendu Acharya, Marjan Amirian, Carla Marina Salgado Castillo, María Dolores López, Mauricio Schoebitz, Miquel Martorell, Tamar Goloshvili, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Manoj Kumar, Hafiz Ansar Rasul Suleria, William C. Cho. Peganum spp.: A Comprehensive Review on Bioactivities and Health-Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-20.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Prabhakar Semwal; Sakshi Painuli; Beraat Özçelik; Furkan Ediz Hacıhasanoğlu; Shabnum Shaheen; Surjit Sen; Krishnendu Acharya; Marjan Amirian; Carla Marina Salgado Castillo; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Tamar Goloshvili; Ahmed Al-Harrasi; Ahmed Al-Rawahi; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. 2021. "Peganum spp.: A Comprehensive Review on Bioactivities and Health-Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs." Oxidative Medicine and Cellular Longevity 2021, no. : 1-20.

Research article
Published: 20 June 2021 in JACS Au
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A lanthanide-based peptide-directed bioprobe LnP19 (Ln = Eu or Yb) is designed as an impressive example of a small molecule-based dual-functional probe for the EBV oncoprotein LMP1. The peptide P19 (Pra-KAhx-K-LDLALK-FWLY-K-IVMSDKW-K-RrRK) is designed to selectively bind to LMP1 by mimicking its TM1 region during oligomerization in lipid rafts while signal transduction is significantly suppressed. Immunofluorescence imaging and Western blotting results reveal that P19 can effectively inactivate the oncogenic cellular pathway nuclear factor κB (NF-κB) and contribute to a selective cytotoxic effect on LMP1-positive cells. By conjugation with cyclen-based europium(III) and ytterbium(III) complexes, EuP19 and YbP19 were constructed to offer visible and near-infrared LMP1-targeted imaging and cancer monitoring. In addition to the ability to target and inhibit LMP1 and to selective inhibit LMP1-positive cells, selective growth inhibition toward the LMP1-positive tumor by LnP19 is also demonstrated.

ACS Style

Ho-Fai Chau; Yue Wu; Wan-Yiu Fok; Waygen Thor; William Chi-Shing Cho; Ping’An Ma; Jun Lin; Nai-Ki Mak; Jean-Claude G. Bünzli; Lijun Jiang; Nicholas J. Long; Hong Lok Lung; Ka-Leung Wong. Lanthanide-Based Peptide-Directed Visible/Near-Infrared Imaging and Inhibition of LMP1. JACS Au 2021, 1, 1034 -1043.

AMA Style

Ho-Fai Chau, Yue Wu, Wan-Yiu Fok, Waygen Thor, William Chi-Shing Cho, Ping’An Ma, Jun Lin, Nai-Ki Mak, Jean-Claude G. Bünzli, Lijun Jiang, Nicholas J. Long, Hong Lok Lung, Ka-Leung Wong. Lanthanide-Based Peptide-Directed Visible/Near-Infrared Imaging and Inhibition of LMP1. JACS Au. 2021; 1 (7):1034-1043.

Chicago/Turabian Style

Ho-Fai Chau; Yue Wu; Wan-Yiu Fok; Waygen Thor; William Chi-Shing Cho; Ping’An Ma; Jun Lin; Nai-Ki Mak; Jean-Claude G. Bünzli; Lijun Jiang; Nicholas J. Long; Hong Lok Lung; Ka-Leung Wong. 2021. "Lanthanide-Based Peptide-Directed Visible/Near-Infrared Imaging and Inhibition of LMP1." JACS Au 1, no. 7: 1034-1043.

Review article
Published: 15 June 2021 in Evidence-Based Complementary and Alternative Medicine
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Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer’s disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.

ACS Style

Javad Sharifi-Rad; Jesús Herrera-Bravo; Luis A. Salazar; Shabnum Shaheen; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Muhammad Imran; Ali Imran; Luísa Custódio; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. The Therapeutic Potential of Wogonin Observed in Preclinical Studies. Evidence-Based Complementary and Alternative Medicine 2021, 2021, 1 -9.

AMA Style

Javad Sharifi-Rad, Jesús Herrera-Bravo, Luis A. Salazar, Shabnum Shaheen, Seyed Abdulmajid Ayatollahi, Farzad Kobarfard, Muhammad Imran, Ali Imran, Luísa Custódio, María Dolores López, Mauricio Schoebitz, Miquel Martorell, Manoj Kumar, Hafiz Ansar Rasul Suleria, William C. Cho. The Therapeutic Potential of Wogonin Observed in Preclinical Studies. Evidence-Based Complementary and Alternative Medicine. 2021; 2021 ():1-9.

Chicago/Turabian Style

Javad Sharifi-Rad; Jesús Herrera-Bravo; Luis A. Salazar; Shabnum Shaheen; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Muhammad Imran; Ali Imran; Luísa Custódio; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. 2021. "The Therapeutic Potential of Wogonin Observed in Preclinical Studies." Evidence-Based Complementary and Alternative Medicine 2021, no. : 1-9.

Mini review article
Published: 09 June 2021 in Frontiers in Oncology
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Rapidly evolving and ever-increasing knowledge of the molecular pathophysiology of pancreatic cancer has leveraged our understanding altogether to a next level. Compared to the exciting ground-breaking discoveries related to underlying mechanisms of pancreatic cancer onset and progression, however, there had been relatively few advances in the therapeutic options available for the treatment. Since the discovery of the DNA structure as a helix which replicates semi-conservatively to pass the genetic material to the progeny, there has been conceptual refinement and continuous addition of missing pieces to complete the landscape of central dogma. Starting from transcription to translation, modern era has witnessed non-coding RNA discovery and central role of these versatile regulators in onset and progression of pancreatic cancer. Long non-coding RNAs (lncRNAs) have been shown to act as competitive endogenous RNAs through sequestration and competitive binding to myriad of microRNAs in different cancers. In this article, we set spotlight on emerging evidence of regulation of different signaling pathways (Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT and NOTCH) by lncRNAs. Conceptual refinements have enabled us to understand how lncRNAs play central role in post-translational modifications of various proteins and how lncRNAs work with epigenetic-associated machinery to transcriptionally regulate gene network in pancreatic cancer.

ACS Style

Ammad Ahmad Farooqi; Sawera Nayyab; Chiara Martinelli; Rossana Berardi; Hector Katifelis; Maria Gazouli; William C. Cho. Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer. Frontiers in Oncology 2021, 11, 1 .

AMA Style

Ammad Ahmad Farooqi, Sawera Nayyab, Chiara Martinelli, Rossana Berardi, Hector Katifelis, Maria Gazouli, William C. Cho. Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer. Frontiers in Oncology. 2021; 11 ():1.

Chicago/Turabian Style

Ammad Ahmad Farooqi; Sawera Nayyab; Chiara Martinelli; Rossana Berardi; Hector Katifelis; Maria Gazouli; William C. Cho. 2021. "Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer." Frontiers in Oncology 11, no. : 1.

Review
Published: 31 May 2021 in Expert Opinion on Drug Discovery
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Messenger RNA (mRNA)-based therapeutics and vaccines have emerged as a disruptive new drug class for various applications, including regenerative medicine, cancer treatment, and prophylactic and therapeutic vaccinations. This review provides an update about the rational structure-based design of various formats of mRNA-based therapeutics. The authors discuss the recent advances in the mRNA modifications that have been used to enhance stability, promote translation efficiency and regulate immunogenicity for specific applications. Extensive research efforts have been made to optimize mRNA constructs and preparation procedures to unleash the full potential of mRNA-based therapeutics and vaccines. Sequence optimization (untranslated region and codon usage), chemical engineering of nucleotides and modified 5ʹcap, and optimization of in vitro transcription and mRNA purification protocols have overcome the major obstacles (instability, delivery, immunogenicity and safety) hindering the clinical applications of mRNA therapeutics and vaccines. The optimized design parameters should not be applied as default to different biological systems, but rather individually optimized for each mRNA sequence and intended application. Further advancement in the mRNA design and delivery technologies for achieving cell type- and organ site-specificity will broaden the scope and usefulness of this new class of drugs.

ACS Style

Kenneth K.W. To; William C.S. Cho. An overview of rational design of mRNA-based therapeutics and vaccines. Expert Opinion on Drug Discovery 2021, 1 .

AMA Style

Kenneth K.W. To, William C.S. Cho. An overview of rational design of mRNA-based therapeutics and vaccines. Expert Opinion on Drug Discovery. 2021; ():1.

Chicago/Turabian Style

Kenneth K.W. To; William C.S. Cho. 2021. "An overview of rational design of mRNA-based therapeutics and vaccines." Expert Opinion on Drug Discovery , no. : 1.

Original research
Published: 28 April 2021 in Expert Review of Molecular Diagnostics
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Background: Nucleic acid amplification tests (NAATs) based methods such as real-time reverse transcription polymerase-chain reaction (real-time RT-PCR) are the gold standard for diagnosis of current infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The cobas® Liat® and cepheid® GeneXpert® systems are two rapid real-time RT-PCR platforms offering rapid, specimen-to-answer detection of SARS-CoV-2. Research design and methods: In this study, we compared the performance of these two systems on SARS-CoV-2 detection in 9 nasopharyngeal swab (NPS) and 70 posterior oropharyngeal saliva specimens collected from 79 patients suspected of SARS-CoV-2 infection between August 2020 and March 2021. Results: The Positive Percent Agreement (PPA), Negative Percent Agreement (NPA) and overall Percent Agreement (OPA) between cepheid® Xpress SARS-CoV-2 assay and cobas® Liat® SARS-CoV-2 & Influenza A/B assay were found to be 100%. We demonstrated an excellent overall test concordance of the Liat® SARS-CoV-2 & Influenza A/B assay and Xpress SARS-CoV-2 assay. The small sample size of SARS-CoV-2 positive and weak-positive specimens is the inherent limitation of this study. Conclusions: The performance of the cobas® Liat® SARS-CoV-2 & Influenza A/B assay is equivalent to the cepheid® Xpress SARS-CoV-2 assay for SARS-CoV-2 detection using NPS and posterior oropharyngeal saliva.

ACS Style

Hin Fung Tsang; Wai Ming Stanley Leung; Lawrence Wing Chi Chan; William Chi Shing Cho; Sze Chuen Cesar Wong. Performance comparison of the Cobas® Liat® and Cepheid® GeneXpert® systems on SARS-CoV-2 detection in nasopharyngeal swab and posterior oropharyngeal saliva. Expert Review of Molecular Diagnostics 2021, 21, 515 -518.

AMA Style

Hin Fung Tsang, Wai Ming Stanley Leung, Lawrence Wing Chi Chan, William Chi Shing Cho, Sze Chuen Cesar Wong. Performance comparison of the Cobas® Liat® and Cepheid® GeneXpert® systems on SARS-CoV-2 detection in nasopharyngeal swab and posterior oropharyngeal saliva. Expert Review of Molecular Diagnostics. 2021; 21 (5):515-518.

Chicago/Turabian Style

Hin Fung Tsang; Wai Ming Stanley Leung; Lawrence Wing Chi Chan; William Chi Shing Cho; Sze Chuen Cesar Wong. 2021. "Performance comparison of the Cobas® Liat® and Cepheid® GeneXpert® systems on SARS-CoV-2 detection in nasopharyngeal swab and posterior oropharyngeal saliva." Expert Review of Molecular Diagnostics 21, no. 5: 515-518.

Journal article
Published: 14 April 2021 in Nature Communications
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Breast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet the functional role of cis-regulatory elements including super-enhancers in different breast cancer subtypes remains poorly characterized. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis. Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between breast cancer subtypes, and provide clinically relevant biological insights towards TNBC. Using CRISPR/Cas9-mediated gene editing, we identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1 and MET, thereby unveiling a mechanism for specific overexpression of the key oncogenes in TNBC. We also identify ANLN as a TNBC-specific gene regulated by super-enhancer. Our studies reveal a TNBC-specific epigenomic landscape, contributing to the dysregulated oncogene expression in breast tumorigenesis.

ACS Style

Hao Huang; Jianyang Hu; Alishba Maryam; Qinghua Huang; Yuchen Zhang; Saravanan Ramakrishnan; Jingyu Li; Haiying Ma; Victor W. S. Ma; Wah Cheuk; Grace Y. K. So; Wei Wang; William C. S. Cho; Liang Zhang; Kui Ming Chan; Xin Wang; Y. Rebecca Chin. Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Nature Communications 2021, 12, 1 -16.

AMA Style

Hao Huang, Jianyang Hu, Alishba Maryam, Qinghua Huang, Yuchen Zhang, Saravanan Ramakrishnan, Jingyu Li, Haiying Ma, Victor W. S. Ma, Wah Cheuk, Grace Y. K. So, Wei Wang, William C. S. Cho, Liang Zhang, Kui Ming Chan, Xin Wang, Y. Rebecca Chin. Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Nature Communications. 2021; 12 (1):1-16.

Chicago/Turabian Style

Hao Huang; Jianyang Hu; Alishba Maryam; Qinghua Huang; Yuchen Zhang; Saravanan Ramakrishnan; Jingyu Li; Haiying Ma; Victor W. S. Ma; Wah Cheuk; Grace Y. K. So; Wei Wang; William C. S. Cho; Liang Zhang; Kui Ming Chan; Xin Wang; Y. Rebecca Chin. 2021. "Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling." Nature Communications 12, no. 1: 1-16.

Journal article
Published: 27 March 2021 in Life Sciences
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MicroRNAs (miRNAs) have the ability to regulate gene expression programs in cells. Hence, altered expression of miRNAs significantly contributes to breast cancer development and progression. Here, we demonstrate that the miRNA miR-142-3p directly targets the 3′ untranslated region of HMGA2, which encodes an onco-embryonic protein that is overexpressed in most cancers, including breast cancer. Down regulation of miR-142-3p predicting poor patient survival in grade 3 breast cancer (P-value = 0.045). MiR-142-3p downregulates HMGA2 mRNA and protein levels. Higher miR-142-3p and lower HMGA2 expressed are found in breast cancer versus normal breast tissue (P-value<0.05), and their levels inversely correlate in breast cancers (P-value = 1.46 × 10−4). We demonstrate that miR-142-3p induces apoptosis and G2/M cell cycle arrest in breast cancer cells. In addition, it inhibits breast cancer stem cell properties and decreases SOX2, NANOG, ALDH and c-Myc expression. MiR-142-3p also decreases cell proliferation through inhibition of the ERK/AKT/STAT3 signaling pathways. Finally, pathway analyses of patient samples suggest that these mechanisms also acting in the tumors of breast cancer patients. Thus, our work identifies HMGA2 as a direct miR-142-3p target and indicates that miR-142-3p is an important suppressor of breast cancer oncogenesis. This identifies miR-142-3p may candidate as a therapeutic molecule for breast cancer treatment.

ACS Style

Behzad Mansoori; Pascal H.G. Duijf; Ali Mohammadi; Elham Safarzadeh; Henrik J. Ditzel; Morten F. Gjerstorff; William Chi-Shing Cho; Behzad Baradaran. MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences 2021, 276, 119431 .

AMA Style

Behzad Mansoori, Pascal H.G. Duijf, Ali Mohammadi, Elham Safarzadeh, Henrik J. Ditzel, Morten F. Gjerstorff, William Chi-Shing Cho, Behzad Baradaran. MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences. 2021; 276 ():119431.

Chicago/Turabian Style

Behzad Mansoori; Pascal H.G. Duijf; Ali Mohammadi; Elham Safarzadeh; Henrik J. Ditzel; Morten F. Gjerstorff; William Chi-Shing Cho; Behzad Baradaran. 2021. "MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy." Life Sciences 276, no. : 119431.

Review
Published: 24 March 2021 in Journal of Cancer Research and Clinical Oncology
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The recent advancement in massively parallel sequencing technologies has empowered liquid biopsies, in particular circulating tumor DNA (ctDNA) analysis, to be the new paradigm in personalized cancer management. Plasma ctDNA detection overcomes the current limitations in tumor tissue procurement and serves as a convenient and non-invasive method to capture tumor heterogeneity and genetic evolution along patients' cancer journey. In breast cancer, the current clinical application of ctDNA includes real-time monitoring of tumor response, detection of drug-resistant clones, assessing dynamic variations in tumor mutational landscape, identifying actionable mutations, detecting minimal residual disease and screening of early tumor. This review aims to summarize the current clinical evidence of ctDNA application in the management of breast cancer.

ACS Style

Jeffrey Chun Hin Chan; James Chung Hang Chow; Connie Hoi Man Ho; Therese Yue Man Tsui; William C. Cho. Clinical application of circulating tumor DNA in breast cancer. Journal of Cancer Research and Clinical Oncology 2021, 1 -12.

AMA Style

Jeffrey Chun Hin Chan, James Chung Hang Chow, Connie Hoi Man Ho, Therese Yue Man Tsui, William C. Cho. Clinical application of circulating tumor DNA in breast cancer. Journal of Cancer Research and Clinical Oncology. 2021; ():1-12.

Chicago/Turabian Style

Jeffrey Chun Hin Chan; James Chung Hang Chow; Connie Hoi Man Ho; Therese Yue Man Tsui; William C. Cho. 2021. "Clinical application of circulating tumor DNA in breast cancer." Journal of Cancer Research and Clinical Oncology , no. : 1-12.

Review
Published: 23 March 2021 in Genes
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Glioblastoma, also known as glioblastoma multiforme, is the most aggressive brain tumor in adults. Despite the huge advance in developing novel therapeutic strategies for patients with glioblastoma, the appearance of multidrug resistance (MDR) against the common chemotherapeutic agents, including temozolomide, is considered as one of the important causes for the failure of glioblastoma treatment. On the other hand, recent studies have demonstrated the critical roles of long non-coding RNAs (lncRNAs), particularly in the development of MDR in glioblastoma. Therefore, this article aimed to review lncRNA’s contribution to the regulation of MDR and elucidate the underlying mechanisms in glioblastoma, which will open up new lines of inquiry in the treatment of glioblastoma.

ACS Style

Parvaneh Mahinfar; Behzad Baradaran; Sadaf Davoudian; Fatemeh Vahidian; William Cho; Behzad Mansoori. Long Non-Coding RNAs in Multidrug Resistance of Glioblastoma. Genes 2021, 12, 455 .

AMA Style

Parvaneh Mahinfar, Behzad Baradaran, Sadaf Davoudian, Fatemeh Vahidian, William Cho, Behzad Mansoori. Long Non-Coding RNAs in Multidrug Resistance of Glioblastoma. Genes. 2021; 12 (3):455.

Chicago/Turabian Style

Parvaneh Mahinfar; Behzad Baradaran; Sadaf Davoudian; Fatemeh Vahidian; William Cho; Behzad Mansoori. 2021. "Long Non-Coding RNAs in Multidrug Resistance of Glioblastoma." Genes 12, no. 3: 455.

Review
Published: 22 March 2021 in RNA Biology
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Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracellular signal pathways. Oncogenic viruses, including HBV, HCV, HPV, and EBV, co-evolve with their hosts and cause persistent infections. The upregulation of host miR-21 manipulates key cellular pathways to evade host immune responses and then promote viral replication. Thus, a better understanding of the role of miR-21 in viral infections may help us to develop effective genetically-engineered oncolytic virus-based therapies against cancer.

ACS Style

Guitian He; Juntao Ding; Yong’E Zhang; Mengting Cai; Jing Yang; William C. Cho; Yadong Zheng. microRNA-21: a key modulator in oncogenic viral infections. RNA Biology 2021, 18, 809 -817.

AMA Style

Guitian He, Juntao Ding, Yong’E Zhang, Mengting Cai, Jing Yang, William C. Cho, Yadong Zheng. microRNA-21: a key modulator in oncogenic viral infections. RNA Biology. 2021; 18 (5):809-817.

Chicago/Turabian Style

Guitian He; Juntao Ding; Yong’E Zhang; Mengting Cai; Jing Yang; William C. Cho; Yadong Zheng. 2021. "microRNA-21: a key modulator in oncogenic viral infections." RNA Biology 18, no. 5: 809-817.

Review
Published: 04 March 2021 in PROTEOMICS
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Extracellular vesicles (EVs) are nanometer‐size lipid vesicles released by cells, which play essential biological functions in intercellular communication. Increasing evidence indicates that EVs participate in cancer development, including invasion, migration, metastasis, and cancer immune modulation. One of the key mechanisms is that EVs affect different cells in the tumor microenvironment through surface‐anchor proteins and protein cargos. Moreover, proteins specifically expressed in tumor‐derived EVs can be applied in cancer diagnosis and monitoring. Besides, the EV proteome also helps to understand drug resistance in cancers and to guide clinical medication. With the development of mass spectrometry and array‐based multi‐protein detection, the research of EV proteomics has entered a new era. The high‐throughput parallel proteomic profiling based on these new platforms allows us to study the impact of EV proteome on cancer progression more comprehensively and to describe the proteomic landscape in cancers with more details. In this article, we review the role and function of different types of EVs in cancer progression. More importantly, we summarize the proteomic profiling of EVs based on different methods and the application of EV proteome in cancer detection and monitoring.

ACS Style

Vivian Weiwen Xue; Chenxi Yang; Sze Chuen Cesar Wong; William Chi Shing Cho. Proteomic profiling in extracellular vesicles for cancer detection and monitoring. PROTEOMICS 2021, 2000094 .

AMA Style

Vivian Weiwen Xue, Chenxi Yang, Sze Chuen Cesar Wong, William Chi Shing Cho. Proteomic profiling in extracellular vesicles for cancer detection and monitoring. PROTEOMICS. 2021; ():2000094.

Chicago/Turabian Style

Vivian Weiwen Xue; Chenxi Yang; Sze Chuen Cesar Wong; William Chi Shing Cho. 2021. "Proteomic profiling in extracellular vesicles for cancer detection and monitoring." PROTEOMICS , no. : 2000094.