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Irena Žuntar
Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia

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Review
Published: 24 December 2020 in Foods
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Fruit juices contain a large number of phytochemicals that, in combination with certain drugs, can cause food–drug interactions that can be clinically significant and lead to adverse events. The mechanisms behind such interactions are in most cases related to phytochemical interference with the activity of cytochrome P450 metabolizing enzymes (CYPs) or drug transporters. Moreover, alterations in their activity can have a clinical relevance if systemic exposure to the drug is decreased or increased, meaning that the pharmacological drug effects are suboptimal, or the drug will cause toxicity. In general, the common pharmacokinetic parameters found to be altered in food–drug interactions regarding fruit juices are the area under the concentration–time curve, bioavailability, and maximum plasma concentration. In most cases, the results from the drug interaction studies with fruit juices provide only limited information due to the small number of subjects, which are also healthy volunteers. Moreover, drug interactions with fruit juices are challenging to predict due to the unknown amounts of the specific phytochemicals responsible for the interaction, as well as due to the inter-individual variability of drug metabolism, among others. Therefore, this work aims to raise awareness about possible pharmacological interactions with fruit juices.

ACS Style

Zvonimir Petric; Irena Žuntar; Predrag Putnik; Danijela Bursać Kovačević. Food–Drug Interactions with Fruit Juices. Foods 2020, 10, 33 .

AMA Style

Zvonimir Petric, Irena Žuntar, Predrag Putnik, Danijela Bursać Kovačević. Food–Drug Interactions with Fruit Juices. Foods. 2020; 10 (1):33.

Chicago/Turabian Style

Zvonimir Petric; Irena Žuntar; Predrag Putnik; Danijela Bursać Kovačević. 2020. "Food–Drug Interactions with Fruit Juices." Foods 10, no. 1: 33.

Review
Published: 17 July 2020 in Foods
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Over the last decade, fruit juice consumption has increased. Their rise in popularity can be attributed to the belief that they are a quick way to consuming a dietary portion of fruit. Probiotics added to fruit juices produce various bioactive compounds, thus probiotic fruit juices can be considered as a new type of functional foods. Such combinations could improve nutritional properties and provide health benefits of fruit juices, due to delivering positive health attributes from both sources (fruit juices and probiotics). However, this review discusses the other side of the same coin, i.e., the one that challenges general beliefs that probiotics are undoubtedly safe. This topic deserves more acknowledgments from the medical and nutritional literature, as it is highly important for health care professionals and nutritionists who must be aware of potential probiotic issues. Still, clinical trials have not adequately questioned the safety of probiotics, as they are generally considered safe. Therefore, this reviews aims to give an evidence-based perspective of probiotic safety, focusing on probiotic fruit beverages and nutraceuticals, by providing documented clinical case reports and studies. Finally, the paper deals with some additional insights from the pharmacological and toxicological point of views, such as pharmacological repercussions of probiotics on health.

ACS Style

Irena Žuntar; Zvonimir Petric; Danijela Bursać Kovačević; Predrag Putnik. Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals. Foods 2020, 9, 947 .

AMA Style

Irena Žuntar, Zvonimir Petric, Danijela Bursać Kovačević, Predrag Putnik. Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals. Foods. 2020; 9 (7):947.

Chicago/Turabian Style

Irena Žuntar; Zvonimir Petric; Danijela Bursać Kovačević; Predrag Putnik. 2020. "Safety of Probiotics: Functional Fruit Beverages and Nutraceuticals." Foods 9, no. 7: 947.

Review
Published: 01 June 2020 in Foods
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Functional nutrition, which includes the consumption of fruit juices, has become the field of interest for those seeking a healthy lifestyle. Functional nutrition is also of great interest to the food industry, with the aims of improving human health and providing economic prosperity in a sustainable manner. The functional food sector is the most profitable part of the food industry, with a fast-growing market resulting from new sociodemographic trends (e.g., longer life expectancy, higher standard of living, better health care), which often includes sustainable concepts of food production. Therefore, the demand for hurdle technology in the food industry is growing, along with the consumption of minimally processed foods, not only because this approach inactivates microorganisms in food, but because it can also prolong the shelf life of food products. To preserve food products such as fruit juices, the hurdle technology approach often uses non-thermal methods as alternatives to pasteurization, which can cause a decrease in the nutritional value and quality of the food. Non-thermal technologies are often combined with different hurdles, such as antimicrobial additives, thermal treatment, and ultraviolet or pulsed light, to achieve synergistic effects and overall quality improvements in (functional) juices. Hence, hurdle technology could be a promising approach for the preservation of fruit juices due to its efficiency and low impact on juice quality and characteristics, although all processing parameters still require optimization.

ACS Style

Predrag Putnik; Branimir Pavlić; Branislav Šojić; Sandra Zavadlav; Irena Žuntar; Leona Kao; Dora Kitonić; Danijela Bursać Kovačević. Innovative Hurdle Technologies for the Preservation of Functional Fruit Juices. Foods 2020, 9, 699 .

AMA Style

Predrag Putnik, Branimir Pavlić, Branislav Šojić, Sandra Zavadlav, Irena Žuntar, Leona Kao, Dora Kitonić, Danijela Bursać Kovačević. Innovative Hurdle Technologies for the Preservation of Functional Fruit Juices. Foods. 2020; 9 (6):699.

Chicago/Turabian Style

Predrag Putnik; Branimir Pavlić; Branislav Šojić; Sandra Zavadlav; Irena Žuntar; Leona Kao; Dora Kitonić; Danijela Bursać Kovačević. 2020. "Innovative Hurdle Technologies for the Preservation of Functional Fruit Juices." Foods 9, no. 6: 699.

Journal article
Published: 08 July 2019 in Foods
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Background: The aim of this study was to evaluate high voltage electrical discharges (HVED) as a green technology, in order to establish the effectiveness of phenolic extraction from olive leaves against conventional extraction (CE). HVED parameters included different green solvents (water, ethanol), treatment times (3 and 9 min), gases (nitrogen, argon), and voltages (15, 20, 25 kV). Methods: Phenolic compounds were characterized by ultra-performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS), while antioxidant potency (total phenolic content and antioxidant capacity) were monitored spectrophotometrically. Data for Near infrared spectroscopy (NIR) spectroscopy, colorimetry, zeta potential, particle size, and conductivity were also reported. Results: The highest yield of phenolic compounds was obtained for the sample treated with argon/9 min/20 kV/50% (3.2 times higher as compared to CE). Obtained results suggested the usage of HVED technology in simultaneous extraction and nanoformulation, and production of stable emulsion systems. Antioxidant capacity (AOC) of obtained extracts showed no significant difference upon the HVED treatment. Conclusions: Ethanol with HVED destroys the linkage between phenolic compounds and components of the plant material to which they are bound. All extracts were compliant with legal requirements regarding content of contaminants, pesticide residues and toxic metals. In conclusion, HVED presents an excellent potential for phenolic compounds extraction for further use in functional food manufacturing.

ACS Style

Irena Žuntar; Predrag Putnik; Danijela Bursać Kovačević; Marinela Nutrizio; Filip Šupljika; Andreja Poljanec; Igor Dubrović; Francisco J. Barba; Anet Režek Jambrak. Phenolic and Antioxidant Analysis of Olive Leaves Extracts (Olea europaea L.) Obtained by High Voltage Electrical Discharges (HVED). Foods 2019, 8, 248 .

AMA Style

Irena Žuntar, Predrag Putnik, Danijela Bursać Kovačević, Marinela Nutrizio, Filip Šupljika, Andreja Poljanec, Igor Dubrović, Francisco J. Barba, Anet Režek Jambrak. Phenolic and Antioxidant Analysis of Olive Leaves Extracts (Olea europaea L.) Obtained by High Voltage Electrical Discharges (HVED). Foods. 2019; 8 (7):248.

Chicago/Turabian Style

Irena Žuntar; Predrag Putnik; Danijela Bursać Kovačević; Marinela Nutrizio; Filip Šupljika; Andreja Poljanec; Igor Dubrović; Francisco J. Barba; Anet Režek Jambrak. 2019. "Phenolic and Antioxidant Analysis of Olive Leaves Extracts (Olea europaea L.) Obtained by High Voltage Electrical Discharges (HVED)." Foods 8, no. 7: 248.

Review article
Published: 23 October 2018 in Current Opinion in Food Science
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Erectile dysfunction is one of the most common sexual disorders among men, with large number of patients worldwide. This is a multifactorial disease with (non)organic causes while main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is). Currently, sildenafil, vardenafil, tadalafil, avanafil, udenafil, mirodenafil, lodenafil and avanafil are used. Worldwide use of herbal and dietary supplements for alleviating this problem is on a rise, as many consumers perceive these products as “healthier” and safer as compared to conventional pharmaceutical preparations. However, adulteration of food supplements with PDE5Is and/or its analogues is very common and represents serious public health concern. This review address the issues with pharmacological and toxicological health risks of food supplements adulterated with erectile dysfunction medications.

ACS Style

Irena Žuntar; Adela Krivohlavek; Josipa Kosić-Vukšić; Daniel Granato; Danijela Bursać Kovačević; Predrag Putnik. Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications. Current Opinion in Food Science 2018, 24, 9 -15.

AMA Style

Irena Žuntar, Adela Krivohlavek, Josipa Kosić-Vukšić, Daniel Granato, Danijela Bursać Kovačević, Predrag Putnik. Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications. Current Opinion in Food Science. 2018; 24 ():9-15.

Chicago/Turabian Style

Irena Žuntar; Adela Krivohlavek; Josipa Kosić-Vukšić; Daniel Granato; Danijela Bursać Kovačević; Predrag Putnik. 2018. "Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications." Current Opinion in Food Science 24, no. : 9-15.

Journal article
Published: 01 April 2018 in Food Chemistry
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Organic products are generally recognized to be healthier and safer than conventional products. However, the actual scientific data regarding the importance of organic production on particular contaminant/additive content of wines is scarce. This study aimed to evaluate contents of pesticides, metals, sulphites and ochratoxin A in organically (org) and conventionally (conv) produced wines from eleven locations in different winegrowing regions of Croatia. All wines contained significantly lower levels of residues as compared to the maximum limits (MLs) with the exception of excessive amounts of Cu and Zn in one sample. Pb and Mg were mainly significantly less represented in org wines. There were no significant differences in the content of sulphite or ochratoxin A between org and conv wines. Significantly lower total pesticide concentrations and average number of pesticides per sample were obtained in org wines. The majority of ochratoxin A positive wines were from conv wine producers.

ACS Style

Dubravka Vitali Čepo; Maja Pelajić; Ivana Vinković Vrček; Adela Krivohlavek; Irena Žuntar; Marko Karoglan. Differences in the levels of pesticides, metals, sulphites and ochratoxin A between organically and conventionally produced wines. Food Chemistry 2018, 246, 394 -403.

AMA Style

Dubravka Vitali Čepo, Maja Pelajić, Ivana Vinković Vrček, Adela Krivohlavek, Irena Žuntar, Marko Karoglan. Differences in the levels of pesticides, metals, sulphites and ochratoxin A between organically and conventionally produced wines. Food Chemistry. 2018; 246 ():394-403.

Chicago/Turabian Style

Dubravka Vitali Čepo; Maja Pelajić; Ivana Vinković Vrček; Adela Krivohlavek; Irena Žuntar; Marko Karoglan. 2018. "Differences in the levels of pesticides, metals, sulphites and ochratoxin A between organically and conventionally produced wines." Food Chemistry 246, no. : 394-403.

Research article
Published: 26 August 2017 in Environmental Science and Pollution Research
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Sulfonamides, macrolides, torasemide, fumagillin, and chloramphenicol were simultaneously analyzed in surface water samples by using solid-phase extraction (SPE) and reversed-phase (RP) liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS). In the pre-concentration and clean-up process, the pH value of samples and volume of the solvent for extraction of analytes from cartridge were optimized. Extraction recoveries were high with values in the range from 62 to 115%. Limits of quantification (LoQ) were in the range from 0.02 to 0.2 μg L−1. Repeatability of the method was evaluated at LoQ and expressed as relative standard deviation (RSD). Calculated RSDs were low with values in the range from 2.4 to 14.5%. The method was successfully applied for analysis of surface water real samples. Samples were collected along the rivers in Croatia on four sampling sites in 2012 in Danube catchment areas, 19 sampling sites in Danube and Adriatic catchment areas in 2013, and another 19 places in 2014. Altogether, 20 target compounds were analyzed in 148 water samples and detected in 31 samples in range (0.1–5.3) μg L−1 or in 20.1% of samples. The most frequent and highest concentrations were detected for macrolide antibiotics. This is the first attempt of such monitoring in surface waters in Croatia.

ACS Style

Martina Ivešić; Adela Krivohlavek; Irena Žuntar; Sonja Tolić; Sandra Šikić; Valerija Musić; Ivan Pavlić; Andrea Bursik; Nives Galić. Monitoring of selected pharmaceuticals in surface waters of Croatia. Environmental Science and Pollution Research 2017, 24, 23389 -23400.

AMA Style

Martina Ivešić, Adela Krivohlavek, Irena Žuntar, Sonja Tolić, Sandra Šikić, Valerija Musić, Ivan Pavlić, Andrea Bursik, Nives Galić. Monitoring of selected pharmaceuticals in surface waters of Croatia. Environmental Science and Pollution Research. 2017; 24 (29):23389-23400.

Chicago/Turabian Style

Martina Ivešić; Adela Krivohlavek; Irena Žuntar; Sonja Tolić; Sandra Šikić; Valerija Musić; Ivan Pavlić; Andrea Bursik; Nives Galić. 2017. "Monitoring of selected pharmaceuticals in surface waters of Croatia." Environmental Science and Pollution Research 24, no. 29: 23389-23400.

Journal article
Published: 23 August 2015 in Environmental Science and Pollution Research
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The proliferation of silver nanoparticle (AgNP) production and use owing to their antimicrobial properties justifies the need to examine the resulting environmental impacts. The discharge of biocidal nanoparticles to water bodies may pose a threat to aquatic species. This study evaluated the effects of citrate-coated AgNPs on the standardized test organism Daphnia magna Straus clone MBP996 by means of biochemical biomarker response. AgNP toxicity was compared against the toxic effect of Ag(+). The toxicity endpoints were calculated based upon measured Ag concentrations in exposure media. For AgNPs, the NOAEC and LOAEC values at 48 h were 5 and 7 μg Ag/L, respectively, while these values were 0.5 and 1 μg Ag/L, respectively, for Ag(+). The EC50 at 48 h was computed to be 12.4 ± 0.6 and 2.6 ± 0.1 μg Ag/L for AgNPs and Ag(+), respectively, with 95 % confidence intervals of 12.1-12.8 and 2.3-2.8 μg Ag/L, respectively. These results indicate significant less toxicity of AgNP compared to free Ag(+) ions. Five biomarkers were evaluated in Daphnia magna neonates after acute exposure to Ag(+) or AgNPs, including glutathione (GSH) level, reactive oxygen species (ROS) content, and catalase (CAT), acetylcholinesterase (AChE), and superoxide dismutase (SOD) activity. AgNPs induced toxicity and oxidative stress responses in D. magna neonates at tenfold higher concentrations than Ag. Biochemical methods revealed a clear increase in AChE activity, decreased ROS level, increased GSH level and CAT activity, but no significant changes in SOD activity. As Ag(+) may dissolve from AgNPs, these two types of Ag could act synergistically and produce a greater toxic response. The observed remarkably high toxicity of AgNPs (in the parts-per-billion range) to crustaceans indicates that these organisms are a vulnerable link in the aquatic food chain with regard to contamination by nanosilver. Graphical Abstract ᅟ.

ACS Style

Lea Ulm; Adela Krivohlavek; Darija Domazet Jurašin; Marija Ljubojevic; Goran Šinko; Tea Crnković; Irena Žuntar; Sandra Šikić; Ivana Vinković Vrček. Response of biochemical biomarkers in the aquatic crustacean Daphnia magna exposed to silver nanoparticles. Environmental Science and Pollution Research 2015, 22, 19990 -19999.

AMA Style

Lea Ulm, Adela Krivohlavek, Darija Domazet Jurašin, Marija Ljubojevic, Goran Šinko, Tea Crnković, Irena Žuntar, Sandra Šikić, Ivana Vinković Vrček. Response of biochemical biomarkers in the aquatic crustacean Daphnia magna exposed to silver nanoparticles. Environmental Science and Pollution Research. 2015; 22 (24):19990-19999.

Chicago/Turabian Style

Lea Ulm; Adela Krivohlavek; Darija Domazet Jurašin; Marija Ljubojevic; Goran Šinko; Tea Crnković; Irena Žuntar; Sandra Šikić; Ivana Vinković Vrček. 2015. "Response of biochemical biomarkers in the aquatic crustacean Daphnia magna exposed to silver nanoparticles." Environmental Science and Pollution Research 22, no. 24: 19990-19999.

Journal article
Published: 01 December 2014 in Psychiatria Danubina
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Adela Krivohlavek; Irena Žuntar; Martina Ivešić; Ivana Mandić Andačić; Sandra Šikić. Food Safety is an Important Public Health Issue: Chloramphenicol Residues Determination by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) in honey. Psychiatria Danubina 2014, 26, 1 .

AMA Style

Adela Krivohlavek, Irena Žuntar, Martina Ivešić, Ivana Mandić Andačić, Sandra Šikić. Food Safety is an Important Public Health Issue: Chloramphenicol Residues Determination by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) in honey. Psychiatria Danubina. 2014; 26 ():1.

Chicago/Turabian Style

Adela Krivohlavek; Irena Žuntar; Martina Ivešić; Ivana Mandić Andačić; Sandra Šikić. 2014. "Food Safety is an Important Public Health Issue: Chloramphenicol Residues Determination by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) in honey." Psychiatria Danubina 26, no. : 1.

Comparative study
Published: 28 November 2014 in Environmental Toxicology
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Scientific information on the potential harmful effects of silver nanoparticles (AgNPs) on human health severely lags behind their exponentially growing applications in consumer products. In assessing the toxic risk of AgNP usage, liver, as a detoxifying organ, is particularly important. The aim of this study was to explore the toxicity mechanisms of nano and ionic forms of silver on human hepatoblastoma (HepG2) cells. The results showed that silver ions and citrate‐coated AgNPs reduced cell viability in a dose‐dependent manner. The IC50 values of silver ions and citrate‐coated AgNPs were 0.5 and 50 mg L−1, respectively. The LDH leakage and inhibition of albumin synthesis, along with decreased ALT activity, indicated that treatment with either AgNP or Ag ions resulted in membrane damage and reduced the cell function of human liver cells. Evaluation of oxidative stress markers demonstrating depletion of GSH, increased ROS production, and increased SOD activity, indicated that oxidative stress might contribute to the toxicity effects of nano and ionic forms of silver. The observed toxic effect of AgNP on HepG2 cells was substantially weaker than that caused by ionic silver, while the uptake of nano and ionic forms of silver by HepG2 cells was nearly the same. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 679–692, 2016.

ACS Style

Ivana Vinković Vrček; Irena Žuntar; Roberta Petlevski; Ivan Pavicic; Maja Dutour Sikirić; Marija Ćurlin; Walter Goessler. Comparison ofin vitrotoxicity of silver ions and silver nanoparticles on human hepatoma cells. Environmental Toxicology 2014, 31, 679 -692.

AMA Style

Ivana Vinković Vrček, Irena Žuntar, Roberta Petlevski, Ivan Pavicic, Maja Dutour Sikirić, Marija Ćurlin, Walter Goessler. Comparison ofin vitrotoxicity of silver ions and silver nanoparticles on human hepatoma cells. Environmental Toxicology. 2014; 31 (6):679-692.

Chicago/Turabian Style

Ivana Vinković Vrček; Irena Žuntar; Roberta Petlevski; Ivan Pavicic; Maja Dutour Sikirić; Marija Ćurlin; Walter Goessler. 2014. "Comparison ofin vitrotoxicity of silver ions and silver nanoparticles on human hepatoma cells." Environmental Toxicology 31, no. 6: 679-692.

Journal article
Published: 01 September 2014 in Toxicology Letters
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ACS Style

Adela Krivohlavek; Lea Ulm; Irena Žuntar; Ivana Vinković Vrček; Sandra Šikić. Effect of nanosilver particles on biodegradation of laundry surfactants in urban wastewaters systems. Toxicology Letters 2014, 229, S186 .

AMA Style

Adela Krivohlavek, Lea Ulm, Irena Žuntar, Ivana Vinković Vrček, Sandra Šikić. Effect of nanosilver particles on biodegradation of laundry surfactants in urban wastewaters systems. Toxicology Letters. 2014; 229 ():S186.

Chicago/Turabian Style

Adela Krivohlavek; Lea Ulm; Irena Žuntar; Ivana Vinković Vrček; Sandra Šikić. 2014. "Effect of nanosilver particles on biodegradation of laundry surfactants in urban wastewaters systems." Toxicology Letters 229, no. : S186.

Journal article
Published: 01 September 2014 in Toxicology Letters
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ACS Style

Adela Krivohlavek; Martina Ivešić; Irena Žuntar; Sandra Šikić. Presence of sildenafil, tadalafil and avanafil in food supplements determined by validated high-pressure liquid chromatography–electrospray tandem mass spectrometry method. Toxicology Letters 2014, 229, S185 .

AMA Style

Adela Krivohlavek, Martina Ivešić, Irena Žuntar, Sandra Šikić. Presence of sildenafil, tadalafil and avanafil in food supplements determined by validated high-pressure liquid chromatography–electrospray tandem mass spectrometry method. Toxicology Letters. 2014; 229 ():S185.

Chicago/Turabian Style

Adela Krivohlavek; Martina Ivešić; Irena Žuntar; Sandra Šikić. 2014. "Presence of sildenafil, tadalafil and avanafil in food supplements determined by validated high-pressure liquid chromatography–electrospray tandem mass spectrometry method." Toxicology Letters 229, no. : S185.

Randomized controlled trial
Published: 01 March 2014 in Acta Pharmaceutica
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The aim of this study was to test the hypothesis that glutathione- S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian Croats (non- -smokers, ex-smokers, and smokers) with stable COPD (n = 30) and sex/age matched controls (n = 60). The distribution of GSTP1 genotypes and alleles in controls vs. COPD showed a statistical difference (p < 0.05). The odds ratio of CC/CT+TT (wild type GSTP1 exon 6 vs. joint heterozygous and mutant homozygous GSTP1 exon 6) was 10.000 and statistically different (p = 0.002). In this study, the GSTP1 mutant genotype of exon 5 (GG), as well as GSTP1 mutant and heterozygous genotypes of exon 6 (TT and CT), were suggested to be genetic contributors to COPD susceptibility. Null GSTM1, null GSTT1 and joint GSTM1/GSTT1 null genotypes were not disease associated. Serum GST was not associated with GST genotypes and COPD or smoking history in our study subjects. Conclusions drawn from the study should be further supported and clarified by studies with larger sample sizes.

ACS Style

Irena Žuntar; Roberta Petlevski; Slavica Dodig; Sanja Popović-Grle. GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharmaceutica 2014, 64, 117 -129.

AMA Style

Irena Žuntar, Roberta Petlevski, Slavica Dodig, Sanja Popović-Grle. GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. Acta Pharmaceutica. 2014; 64 (1):117-129.

Chicago/Turabian Style

Irena Žuntar; Roberta Petlevski; Slavica Dodig; Sanja Popović-Grle. 2014. "GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD." Acta Pharmaceutica 64, no. 1: 117-129.

Journal article
Published: 01 January 2014 in Acta Neurobiologiae Experimentalis
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ACS Style

Koraljka Bačić Baronica; Kristina Mlinac; Roberta Petlevski; David Ozretić; Anton Vladić; Svjetlana Kalanj-Bognar; Irena Zuntar. Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway. Acta Neurobiologiae Experimentalis 2014, 74, 1 .

AMA Style

Koraljka Bačić Baronica, Kristina Mlinac, Roberta Petlevski, David Ozretić, Anton Vladić, Svjetlana Kalanj-Bognar, Irena Zuntar. Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway. Acta Neurobiologiae Experimentalis. 2014; 74 (3):1.

Chicago/Turabian Style

Koraljka Bačić Baronica; Kristina Mlinac; Roberta Petlevski; David Ozretić; Anton Vladić; Svjetlana Kalanj-Bognar; Irena Zuntar. 2014. "Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway." Acta Neurobiologiae Experimentalis 74, no. 3: 1.

Journal article
Published: 01 December 2009 in Collegium antropologicum
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Roberta Petlevski; Irena Zuntar; Slavica Dodig; Mirjana Turkalj; Ivana Cepelak; Jasmina Vojvodić; Mario Sicaja; Sasa Missoni. Malonaldehyde and erythrocyte antioxidant status in children with controlled asthma. Collegium antropologicum 2009, 33, 1 .

AMA Style

Roberta Petlevski, Irena Zuntar, Slavica Dodig, Mirjana Turkalj, Ivana Cepelak, Jasmina Vojvodić, Mario Sicaja, Sasa Missoni. Malonaldehyde and erythrocyte antioxidant status in children with controlled asthma. Collegium antropologicum. 2009; 33 (4):1.

Chicago/Turabian Style

Roberta Petlevski; Irena Zuntar; Slavica Dodig; Mirjana Turkalj; Ivana Cepelak; Jasmina Vojvodić; Mario Sicaja; Sasa Missoni. 2009. "Malonaldehyde and erythrocyte antioxidant status in children with controlled asthma." Collegium antropologicum 33, no. 4: 1.

Journal article
Published: 01 December 2006 in Collegium antropologicum
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ACS Style

Irena Zuntar; Natasa Antoljak; Nada Vrkić; Elizabeta Topić; Nikola Kujundzić; Vida Demarin; Vlasta Vuković. Association of methylenetetrahydrofolate (MTHFR) and apolipoprotein E (apo E) genotypes with homocysteine, vitamin and lipid levels in carotid stenosis. Collegium antropologicum 2006, 30, 1 .

AMA Style

Irena Zuntar, Natasa Antoljak, Nada Vrkić, Elizabeta Topić, Nikola Kujundzić, Vida Demarin, Vlasta Vuković. Association of methylenetetrahydrofolate (MTHFR) and apolipoprotein E (apo E) genotypes with homocysteine, vitamin and lipid levels in carotid stenosis. Collegium antropologicum. 2006; 30 (4):1.

Chicago/Turabian Style

Irena Zuntar; Natasa Antoljak; Nada Vrkić; Elizabeta Topić; Nikola Kujundzić; Vida Demarin; Vlasta Vuković. 2006. "Association of methylenetetrahydrofolate (MTHFR) and apolipoprotein E (apo E) genotypes with homocysteine, vitamin and lipid levels in carotid stenosis." Collegium antropologicum 30, no. 4: 1.

Journal article
Published: 01 August 2005 in Journal of Separation Science
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The sulfonamides (SAs) are stable chemotherapeutics used against the bacterial disease affecting bees, known as American foulbrood (Bacillus larvae), so their residues could appear in the honey of treated bees. Their presence at a concentration above the limit value could be a potential danger to human health. Therefore, a simple, rapid, and reliable method for determination of 11 available SAs in honey was optimized. The samples were homogenized and cleaned with extraction on solid phase by means of Chromabond C18 end-capped cartridge followed by LC/MS analyses. A detection limit of 25 microg/kg was achieved for all analytes. The repeatability of the method was proven and the optimal parameters for temperature and pH of the mobile phase and acetic buffer, respectively, were determined. In this study, 20 samples of domestic honey were included. Six of the analyzed samples were positive, but all results were below the Croatian permissible limit value (100 microg/kg).

ACS Style

Adela Krivohlavek; Zdenko Šmit; Martina Baštinac; Irena Žuntar; Franjo Plavšc-Plavšic. The determination of sulfonamides in honey by high performance liquid chromatography - mass spectrometry method (LC/MS). Journal of Separation Science 2005, 28, 1434 -1439.

AMA Style

Adela Krivohlavek, Zdenko Šmit, Martina Baštinac, Irena Žuntar, Franjo Plavšc-Plavšic. The determination of sulfonamides in honey by high performance liquid chromatography - mass spectrometry method (LC/MS). Journal of Separation Science. 2005; 28 (13):1434-1439.

Chicago/Turabian Style

Adela Krivohlavek; Zdenko Šmit; Martina Baštinac; Irena Žuntar; Franjo Plavšc-Plavšic. 2005. "The determination of sulfonamides in honey by high performance liquid chromatography - mass spectrometry method (LC/MS)." Journal of Separation Science 28, no. 13: 1434-1439.

Journal article
Published: 09 January 2004 in Clinical Chemistry and Laboratory Medicine (CCLM)
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In this study, we investigated the role of glutathione S-transferase P1 (GSTP1) polymorphisms in the pathogenesis of Alzheimer's disease (AD). We genotyped the GSTP1 polymorphisms in exon 5 (A313G) and exon 6 (C341T) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 56 Croatian patients with AD and 231 controls. Distributions and frequencies of GSTP1 genetic variants were not statistically different between AD patients and healthy controls. Higher frequencies of the mutant genotypes were observed in AD patients (13% for both A313G and C341T) when compared with control subjects (7% for A313G and 8% for C341T), but association of GSTP1 GG (OR 2.057, 95% CI 0.796–5.315, p=0.094) and TT (OR 1.691, 95% CI 0.669–4.270, p=0.514) genotypes with an increased risk of AD was not confirmed by statistical analysis. The frequencies of

ACS Style

Irena Žuntar; Svjetlana Kalanj-Bognar; Elizabeta Topic; Roberta Petlevski; Mario Štefanović; Vida Demarin. The glutathione S-transferase polymorphisms in a control population and in Alzheimer's disease patients. Clinical Chemistry and Laboratory Medicine (CCLM) 2004, 42, 334 -9.

AMA Style

Irena Žuntar, Svjetlana Kalanj-Bognar, Elizabeta Topic, Roberta Petlevski, Mario Štefanović, Vida Demarin. The glutathione S-transferase polymorphisms in a control population and in Alzheimer's disease patients. Clinical Chemistry and Laboratory Medicine (CCLM). 2004; 42 (3):334-9.

Chicago/Turabian Style

Irena Žuntar; Svjetlana Kalanj-Bognar; Elizabeta Topic; Roberta Petlevski; Mario Štefanović; Vida Demarin. 2004. "The glutathione S-transferase polymorphisms in a control population and in Alzheimer's disease patients." Clinical Chemistry and Laboratory Medicine (CCLM) 42, no. 3: 334-9.

Comparative study
Published: 23 July 2003 in Clinica Chimica Acta
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The aim of this study was to investigate the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) mutation in healthy Croatian volunteers and in patients with atherosclerosis.

ACS Style

Irena Z̆untar; Elizabeta Topić; Duro Vukosavić; Vlasta Vuković; Vida Demarin; Antonija Begonja; Natasa Antoljak; Ana Maria Simundić. Croatian population data for the C677T polymorphism in methylenetetrahydrofolate reductase: frequencies in healthy and atherosclerotic study groups. Clinica Chimica Acta 2003, 335, 95 -100.

AMA Style

Irena Z̆untar, Elizabeta Topić, Duro Vukosavić, Vlasta Vuković, Vida Demarin, Antonija Begonja, Natasa Antoljak, Ana Maria Simundić. Croatian population data for the C677T polymorphism in methylenetetrahydrofolate reductase: frequencies in healthy and atherosclerotic study groups. Clinica Chimica Acta. 2003; 335 (1):95-100.

Chicago/Turabian Style

Irena Z̆untar; Elizabeta Topić; Duro Vukosavić; Vlasta Vuković; Vida Demarin; Antonija Begonja; Natasa Antoljak; Ana Maria Simundić. 2003. "Croatian population data for the C677T polymorphism in methylenetetrahydrofolate reductase: frequencies in healthy and atherosclerotic study groups." Clinica Chimica Acta 335, no. 1: 95-100.

Journal article
Published: 01 January 2003 in Collegium antropologicum
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ACS Style

Zeljko Romić; Ljiljana Mayer; Zeljko Sutlić; Ino Husedzinović; Bojan Biocina; Roberta Petlevski; Irena Zuntar; Tihana Zanić-Grubisić; Dubravka Juretić. Paraoxonase activity and concentration of indicators of lipids status in the serum of cardiac patients. Collegium antropologicum 2003, 27, 1 .

AMA Style

Zeljko Romić, Ljiljana Mayer, Zeljko Sutlić, Ino Husedzinović, Bojan Biocina, Roberta Petlevski, Irena Zuntar, Tihana Zanić-Grubisić, Dubravka Juretić. Paraoxonase activity and concentration of indicators of lipids status in the serum of cardiac patients. Collegium antropologicum. 2003; 27 ():1.

Chicago/Turabian Style

Zeljko Romić; Ljiljana Mayer; Zeljko Sutlić; Ino Husedzinović; Bojan Biocina; Roberta Petlevski; Irena Zuntar; Tihana Zanić-Grubisić; Dubravka Juretić. 2003. "Paraoxonase activity and concentration of indicators of lipids status in the serum of cardiac patients." Collegium antropologicum 27, no. : 1.