Prof. Dr. Roberto Pisano
Department of Applied Science and Technology, Politecnico di Torino, Turin, Piedmont, Italy
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Representative Publications
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Journal Article
MAMerve B. Adali
Merve B. Adali
Antonello BARRESI
Gianluca BoccardoRoberto PisanoPharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation. In this direction, the present review deals with the most recent technologies, based on spray freeze-drying, that can achieve this objective. It provides a comprehensive overview of the physics behind this process and of the most recent equipment design.
1 January 2009 in Chemical Engineering and Processing - Process Intensification
Journal Article
Antonello BARRESIRoberto Pisano
Davide FissoreVRValeria Rasetto
Valeria Rasetto
SVSalvatore A. Velardi
Salvatore A. Velardi
MGMiquel Galan
Miquel Galan
+2
1 November 2011 in Journal of Pharmaceutical Sciences
Journal Article
Journal Article
Lorenzo Stratta
Luigi Carlo CapozziSFSimone Franzino
Simone FranzinoRoberto PisanoFreeze-drying has always been considered an extremely expensive procedure to dehydrate food or pharmaceutical products, and for this reason, it has been employed only if strictly necessary or when the high added value of the final product could justify the costs. However, little effort has been made to analyze the factors that make this technology so unaffordable. In this work, a model was proposed to calculate in detail the operational (OC) and capital costs (CC) of a freeze-drying cycle and an evaluation of the process bottlenecks was made. The main result is that the process itself, contrary to the classic belief, is not the most expensive part of freeze-drying, while the initial investment is the real limiting factor. Under this consideration, the optimization of a freeze-drying cycle should be formulated in order to fit more cycles in the lifespan of the apparatus, instead of merely reducing the power consumption of the machine.
1 July 2020 in Journal of Pharmaceutical Sciences
Journal Article
AAAndrea Arsiccio
Andrea Arsiccio
Roberto Pisano3 March 2020 in Journal of the American Chemical Society
Journal Article
AAAndrea Arsiccio
Andrea Arsiccio
JMJames McCarty
James McCartyRoberto PisanoJSJoan-Emma Shea
Joan-Emma SheaAbout Me
Roberto Pisano is a Full Professor of Chemical Engineering at Politecnico di Torino (Italy), where he also serves as the coordinator of the PhD programme in Chemical Engineering. His research centres on the application of both computational and experimental methods in the engineering of chemical products and processes, with a particular focus on pharmaceutical processing and the formulation of both small molecules and biologics, primarily in lyophilised formulations. He was a visiting researcher at the Centre de Ressources Technologiques – Institut Technique Agro-Industriel (Strasbourg, France) in 2008, and at the Department of Chemical Engineering at the Massachusetts Institute of Technology (Cambridge, USA) in 2016. Since 2024, he has been a member of the Board of Directors of the International Society of Lyophilisation/Freeze-Drying. He has published over 140 papers, 17 book chapters, and has edited 1 book on the freeze-drying of pharmaceuticals. He also holds 8 patents, either issued or pending.