Christos Kroupis

Prof. Christos Kroupis

Clinical Biochemistry, Medical School, National and Kapodistrian University of Athens, Athens, Attikí, Greece
orcid

Research Focus & Metrics

Academic Career Length

35Years (1992-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 May 2001 in European Heart Journal
Verified
Journal Article
Open access
PDF file
SAS Adamopoulos
S Adamopoulos
JPJ Parissis
J Parissis
Christos KroupisChristos Kroupis
Christos Kroupis
MGM Georgiadis
M Georgiadis
DKD Karatzas
D Karatzas
DKD.Th Kremastinos
D.Th Kremastinos
Aims Previous studies have shown an abnormal expression of cellular adhesion molecules and cytokines in chronic heart failure, which may be related t

1 February 2002 in JACC
Verified
Journal Article
Closed access
SAStamatis Adamopoulos
Stamatis Adamopoulos
JPJohn Parissis
John Parissis
DKDimitrios Karatzas
Dimitrios Karatzas
Christos KroupisChristos Kroupis
Christos Kroupis
MGMichael Georgiadis
Michael Georgiadis
DKDimitrios Th Kremastinos
Dimitrios Th Kremastinos

1 April 1995 in Journal of Biological Chemistry
Verified
Journal Article
Open access
PDF file
MCMadalina Condrescu
Madalina Condrescu
JGJeffrey P. Gardner
Jeffrey P. Gardner
GCGalina Chernaya
Galina Chernaya
JAJoseph F. Aceto
Joseph F. Aceto
Christos KroupisChristos Kroupis
Christos Kroupis
JRJohn P. Reeves
John P. Reeves
Chinese hamster ovary cells expressing the bovine cardiac Na/Ca exchanger were treated with ouabain to increase [Na]and stimulate Cainflux by Na/Ca exchange. Depletion of cellular ATP inhibited Ca uptake by 40% or more and reduced the half-maximal Naconcentration for inhibition of Ca uptake from 90 to 55 m M. ATP depletion also reduced the rate of rise in [Ca]when [Na]was reduced and inhibited the decline in [Ca]when high [Na]was restored. The effects of ATP depletion were either absent or reduced in cells expressing a mutant exchanger missing most of the cytosolic hydrophilic domain. We were unable to detect a phosphorylated form of the exchanger in immunoprecipitates from P-labeled cells. ATP depletion caused a breakdown in the actin cytoskeleton of the cells. Treatment of the cells with cytochalasin D mimicked the effects of ATP depletion on the [Na] inhibition profile for Ca uptake. Thus, ATP depletion inhibits both the Cainflux and Caefflux modes of Na/Ca exchange, and may alter the competitive interactions of extracellular Naand Cawith the transporter. The latter effect appears to be related to changes in the actin cytoskeleton.

1 July 2006 in Clinical Biochemistry
Verified
Journal Article
Closed access
Christos KroupisChristos Kroupis
Christos Kroupis
Athina MarkouAthina Markou
Athina Markou
NVNikolaos Vourlidis
Nikolaos Vourlidis
ADAmalia Dionyssiou-Asteriou
Amalia Dionyssiou-Asteriou
Evi S. LianidouEvi S. Lianidou
Evi S. Lianidou

14 October 2016 in Clinical Chemistry and Laboratory Medicine (CCLM)
Verified
Journal Article
Closed access
PDF file
JHJoseph Henny
Joseph Henny
AVAnne Vassault
Anne Vassault
GBGuilaine Boursier
Guilaine Boursier
IVInes Vukasovic
Ines Vukasovic
PBPika Mesko Brguljan
Pika Mesko Brguljan
IEIso/Cen Standards (Wg-A/Iso) Of The Eflm
Iso/Cen Standards (Wg-A/Iso) Of The Eflm
This document is based on the original recommendation of the Expert Panel on the Theory of Reference Values of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), updated guidelines were recently published under the auspices of the IFCC and the Clinical and Laboratory Standards Institute (CLSI). This document summarizes proposals for recommendations on: (i) The terminology, which is often confusing, noticeably concerning the terms of reference limits and decision limits. (ii) The method for the determination of reference limits according to the original procedure and the conditions, which should be used. (iii) A simple procedure allowing the medical laboratories to fulfill the requirements of the regulation and standards. The updated document proposes to verify that published reference limits are applicable to the laboratory involved. Finally, the strengths and limits of the revised recommendations (especially the selection of the reference population, the maintenance of the analytical quality, the choice of the statistical method used…) will be briefly discussed.

1 November 1992 in Archives of Biochemistry and Biophysics
Verified
Journal Article
Closed access
JAJoseph F. Aceto
Joseph F. Aceto
MCMadalina Condrescu
Madalina Condrescu
Christos KroupisChristos Kroupis
Christos Kroupis
HNHannah Nelson
Hannah Nelson
NNNathan Nelson
Nathan Nelson
JRJohn P. Reeves
John P. Reeves