Dr. David Macias-Verde
Oncology, Hospitales Universitarios San Roque, Las Palmas de Gran Canaria, Spain
+2
Having good times!
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Academic Career Length
10Years (2017-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 January 2020 in Aging and disease
Journal Article
PLPedro Carlos Lara
Pedro Carlos LaraDavid Macias-VerdeJBJavier Burgos-Burgos
Javier Burgos-Burgos
Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2 infection. In multivariate analysis, advanced age was an independent risk factor for death. Recent studies suggest a role for the nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome activation in lung inflammation and fibrosis in SARS-CoV and SARS-CoV-2 infections. Increased NLRP3/ apoptosis-associated speck-like protein (ASC) mRNA expression and increased caspase-1 activity, have been observed in aged lung, provoking increased and heightened expression levels of mature Interleukin (IL)-1β and IL-18 in aged individuals. Aged individuals have a basal predisposition to over-react to infection, displaying an increased hyper-inflammatory cascade, that seems not to be fully physiologically controlled. NLRP3 inflammasome is over-activated in aged individuals, through deficient mitochondrial functioning, increased mitochondrial Reactive Oxigen Species (mtROS) and/or mitochondrial (mt)DNA, leading to a hyper-response of classically activated macrophages and subsequent increases in IL-1 β. This NLRP3 over-activated status in elderly individuals, is also observed in telomere dysfunctional mice models. In our opinion, the NLRP3 inflammasome plays a central role in the increased lethality observed in elderly patients infected by COVID-19. Strategies blocking inflammasome would deserve to be studied.
1 January 2021 in Medical Hypotheses
Journal Article
David Macias-VerdePLPedro C. Lara
Pedro C. Lara
JBJavier Burgos-Burgos
Javier Burgos-Burgos
1 January 2020 in Aging and disease
Journal Article
PLPedro Carlos Lara
Pedro Carlos LaraNNNam Nguyen
Nam NguyenDavid Macias-VerdeJBJavier Burgos-Burgos
Javier Burgos-Burgos
Meritxell Arenas
Juliette THARIAT +11
A cytokine storm induced by SARS-Cov2 may produce pneumonitis which may be fatal for older patients with underlying lung disease. Hyper-elevation of Interleukin1 (IL-1), Tumor necrosis factor-1alfa (TNF-1 alfa), and Interleukin 6 (IL-6) produced by inflammatory macrophage M1 may damage the lung alveoli leading to severe pneumonitis, decreased oxygenation, and potential death despite artificial ventilation. Older patients may not be suitable candidates for pharmaceutical intervention targeting IL-1/6 blockade or artificial ventilation. Low dose total lung (LDTL) irradiation at a single dose of 50 cGy may stop this cytokine cascade, thus preventing, and/or reversing normal organs damage. This therapy has been proven in the past to be effective against pneumonitis of diverse etiology and could be used to prevent death of older infected patients. Thus, LDRT radiotherapy may be a cost-effective treatment for this frail patient population whom radiation -induced malignancy is not a concern because of their advanced age. This hypothesis should be tested in future prospective trials.
22 May 2020 in Clinical and Translational Oncology
Journal Article
JBJ. Burgos-Burgos
J. Burgos-Burgos
VVV. Vega
V. Vega
David Macias-VerdeVGV. Gómez
V. Gómez
MTM. Travieso-Aja
M. Travieso-Aja
PLPedro Carlos Lara
Pedro Carlos Lara +4
25 January 2017 in Clinical and Translational Radiation Oncology
Journal Article
MSM. Beatriz Pinar Sedeño
M. Beatriz Pinar SedeñoNIN. Rodríguez Ibarria
N. Rodríguez Ibarria
HHH. Mhaidli Hamdani
H. Mhaidli Hamdani
TVT. Fernández Varela
T. Fernández Varela
IAI. San Miguel Arregui
I. San Miguel Arregui
PJP.C. Lara Jiménez
P.C. Lara Jiménez
+1
Aggressive hemangiomas invade the spinal canal and/or paravertebral space and may cause cord compression and neurological symptoms. Radiation therapy was recognized as an effective strategy for the treatment of aggressive hemangiomas. Here, it is reported the first case of aggressive vertebral hemangioma treated by a combination of intraoperative radiation therapy and kyphoplasty (Kypho-IORT).
5 June 2021 in Clinical and Translational Oncology
Journal Article
JBJ. Burgos-Burgos
J. Burgos-Burgos
VVV. Vega
V. Vega
David Macias-VerdeVGV. Gómez
V. Gómez
MTM. Travieso-Aja
M. Travieso-Aja
PLPedro Carlos Lara
Pedro Carlos Lara +5
About Me
Physics Degree, Astrophysics, in 1993, University of La Laguna (ULL), Santa Cruz de Tenerife, Spain.
Undergraduate and post-graduate stays (Imperial College of Science and Medicine in London and The Hebrew University of Jerusalem).
Undergraduate thesis in 1994, Department of Fundamental and Experimental Physics (ULL).
Researcher at Technological and Renewable Energy Institute (ITER), 1995, Cabildo de Santa Cruz de Tenerife.
Physicist at Hospital Nuestra Señora del Pino in Las Palmas de Gran Canaria, 1995.
Lecturer or of radiation protection at Center for Higher Technical Studies of the Canary Islands, CETESCA, San Roque Hospitals, Gran Canaria, 1998-2004.
Spanish National Health Specialty in Medical Physicist, 2000.
Lecturer of Biophysics at Fernando Pessoa University of Portugal, Las Palmas de Gran Canaria, 2004-2005.
Position as fixed staff at the University Hospital of Gran Canaria Dr. Negrín 2005.
Medical Physics tutor at the University Hospital of Gran Canaria Dr. Negrín, 2008-2016.
Lecturer of Physics and Medical Technology at the University of Las Palmas de Gran Canaria, 2012-2019.
Head of Radiation Protection diploma awarded by the Spanish Nuclear Safety Council, 2024.
Director of x-rays facilities training courses granted by the Nuclear Safety Council at the University Hospital of Gran Canaria Dr. Negrín, 2016-2019.
Master lecturer at the Spanish Society of Radiation Oncology (SEOR), 2018.
Member of 10 research projects funded by different Spanish organization
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