Prof. Ali Samadikuchaksaraei
Iran University of Medical Sciences
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Academic Career Length
25Years (2002-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 January 2020 in Advanced Drug Delivery Reviews
Journal Article
MGMazaher Gholipourmalekabadi
Mazaher GholipourmalekabadiSSSunaina Sapru
Sunaina SapruAli SamadikuchaksaraeiRRRui M. Reis
Rui M. ReisDKDavid Kaplan
David Kaplan
Subhas C. Kundu4 August 2020 in BioDrugs
Journal Article
DJDavod Jafari
Davod Jafari
SSSamira Shajari
Samira Shajari
RJRasool Jafari
Rasool Jafari
NMNarges Mardi
Narges Mardi
HGHosna Gomari
Hosna Gomari
Ali Samadikuchaksaraei +2
1 July 2020 in European Polymer Journal
Journal Article
NJNarges Johari
Narges Johari
Lorenzo MoroniAli Samadikuchaksaraei1 November 2016 in Acta Biomaterialia
Journal Article
PMPeiman Brouki Milan
Peiman Brouki MilanNLN. Lotfibakhshaiesh
N. LotfibakhshaieshMJM.T. Joghataie
M.T. Joghataie
JAJafar Ai
Jafar AiAPA. Pazouki
A. PazoukiAli Samadikuchaksaraei +5
1 August 2002 in Tissue Engineering
Journal Article
NANadire N. Ali
Nadire N. Ali
AEAlasdair J. Edgar
Alasdair J. Edgar
Ali SamadikuchaksaraeiCTCatherine M. Timson
Catherine M. Timson
HRHanna Romanska
Hanna RomanskaABAnne E. Bishop
Anne E. Bishop
+1
Embryonic stem (ES) cell pluripotency is being investigated increasingly to obtain specific cell lineages for tissue engineering. However, the possibility that ES cells can give rise to lung tissue has not been tested. We hypothesized that lung epithelial cells (type II pneumocytes) can be derived in vitro from murine ES cells. After withdrawal of leukemia inhibitory factor (LIF) and formation of embryoid bodies in maintenance medium for 10, 20, and 30 days, differentiating ES cells were kept in the same medium or transferred to serum-free small airway growth medium (SAGM) for a further 3 or 14 days of culture. The presence of type II pneumocytes in the resulting mixed cultures was demonstrated by reverse transcriptase-polymerase chain reaction (RT-PCR) of surfactant protein C (SPC) mRNA, immunostaining of SPC, and electron microscopy of osmiophilic lamellar bodies only at 30 days sampling time. SAGM appeared to be more favorable for type II cell formation than ES medium. No SPC transcripts were found in differentiating cells grown under the same conditions without formation of embryoid bodies. These findings could form the basis for the enrichment of ES cell-derived cultures with type II pneumocytes, and provide an in vitro system for investigating mechanisms of lung repair and regeneration.
1 January 2012 in International Journal of Nanomedicine
Journal Article
SASanaz Naghavi Alhosseini
Sanaz Naghavi Alhosseini
FMFathollah Moztarzadeh
Fathollah MoztarzadehMMMasoud Mozafari
Masoud MozafariSAShadnaz Asgari
Shadnaz Asgari
MDMasumeh Dodel
Masumeh Dodel
NJNewsha Jalali
Newsha Jalali
+2
Peer reviewed article authored by (Naghavi Alhosseini S, Moztarzadeh F, Mozafari M, Asgari S, Dodel M, Samadikuchaksaraei A, Kargozar S, Jalali N). Read article or submit your manuscript for publishing.
About Me
Prof. Ali Samadikuchaksaraei received his M.D. from Iran University of Medical Sciences in 1996 and his Ph.D. from Imperial College London in 2005. He founded the Department of Tissue Engineering and Regenerative Medicine at Iran University of Medical Sciences in January 2010 and served as the head of that department until April 2021. He is one of the first scientists who started working on tissue engineering and regenerative medicine (TERM) in Iran and has highly shaped and promoted the academic and industrial aspects of this field in the country. He has actively sought to create a national infrastructure to foster sustainable development in TERM. Hence, he teamed up with the country’s leading scientists to found the National Education Board, the National Ph.D. Program, and the Iranian Society for TERM. He is a regular consultant for several scientific and industrial sectors and start-up companies. He serves on the editorial boards of several journals and regularly reviews for many top publishers. Additionally, he reviews for granting bodies and patent and intellectual properties state organizations. Also, he has long-standing experience in teaching the basic and advanced courses of tissue engineering and regenerative medicine to postgraduate biomedical and engineering students and physicians in training. His expertise is mainly focused on regenerative niche engineering for skeletal, integumentary, and respiratory systems using stem cells and biomimetic materials.