Background: Glioblastomas are the most frequent and aggressive primary brain tumors. Their prognosis remains bleak, despite progress in management and understanding of the different biological mechanisms. Our objective is to highlight the impact of radiotherapy in improving the management of glioblastoma through the experience of the radiotherapy department at Hassan II University Hospital. Materials and Methods: This was a retrospective study analyzing the medical records of patients with glioblastoma over the period from August 2012 to January 2020. The data was analyzed using the epi-info software, therapeutic toxicities evaluated according to CTCAE V.4 scale, and overall survival estimated by the KEPLEIN MEIER curves. Results: 95 cases were collected. The median age was 57 years [18-85]. CT scan and MRI were performed on all our patients. The surgical procedure consisted of total resection in 46.32%. All patients received postoperative treatment; 30 radiotherapy alone, and 65 radiotherapy combined with chemotherapy according to the Stupp protocol. At the end, the median overall survival was 5.53 (+/-0.8) months. Conclusion: Our study highlights the crucial role of radiotherapy in the management of glioblastoma and emphasizes the clinician's role in early diagnosis before functional decline. The prospects for precision medicine (immunotherapy, targeted therapies...) could improve these results.

Vaginal melanomas are extremely rare gynaecological malignancy and very aggressive tumor. There is no standardized treatment owing to the extreme rarity of the disease. The prognosis of vaginal primary melanoma is very poor despite treatment modality, because most of the cases are diagnosed at advanced stage. This paper details the clinical course of 2 patients with primary vaginal melanoma treated by definitive radiation therapy, this report includes also a summary of available treatments of this uncommon disease, with focus on the role of radiotherapy.