Alessandro Mantini

Prof. Alessandro Mantini

Università Cattolica del Sacro Cuore - Roma
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Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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9 March 2022 in Sustainability
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AMAlessandro Mantini
Alessandro Mantini
Since 2018, a new terminology has been developed, called Algor-ethics, indicating the necessity for a dedicated study concerning the evaluation of an ethics applied to technology, to Algorithms and to Artificial Intelligence (AI). At the same time, since 1987, when the concept of sustainability was introduced, the discussion on this issue has become increasingly lively and has now spread to every area of life. In this paper, we would like to propose an application of the concept of sustainability to technological processes and in particular to the elaboration of AI systems. To reach this goal we will first try to build an ethical framework, here called Dynamical Techno-Algor-Ethical Composition, to define the interaction between the most important ethical ingredients involving the human person in relation to technology, taking a person-centered approach. Out of this will emerge a possible structure and definition of Technological Sustainability. The second step will consist of evaluating the process for the elaboration of an AI algorithm as a concrete application of the previously analyzed framework, to set ethical contents composing what we might call a good and sustainable algorithm.

6 January 2022 in Religions
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AMAlessandro Mantini
Alessandro Mantini
MRMaria Adelaide Ricciotti
Maria Adelaide Ricciotti
EMEleonora Meloni
Eleonora Meloni
ATAnita Maria Tummolo
Anita Maria Tummolo
SDSabrina Dispenza
Sabrina Dispenza
CBChristian Barillaro
Christian Barillaro
In the A. Gemelli university hospital in Rome, the presence of highly specialized inter-professional palliative care teams and spiritual assistants who are dedicated to their role in the service of inpatients is valuable to person-centered healthcare. Spiritual needs are commonly experienced by patients with sudden illness, chronic conditions, and life-limiting conditions, and, consequently, spiritual care is an intrinsic and essential component of palliative care. This paper focuses on the sacrament of the Anointing of the Sick to demonstrate the importance of spiritual care as an integral part of palliative care and highlights the need for all interdisciplinary team members to address spiritual issues in order to improve the holistic assistance to the patient. Over a 3-year period (October 2018–September 2021), data about the sacrament of the Anointing of the Sick administered by the hospitaller chaplaincy were collected. A total of 1541 anointings were administered, with an average of 514 anointings per year, excluding reductions related to the COVID-19 pandemic. In 98% of cases, the sacrament was requested by health personnel, and in 96% of cases, the same health personnel participated in the sacrament. These results demonstrate that, at the A. Gemelli polyclinic in Rome, the level of training that the care team has received in collaboration with the chaplains has generated a good generalized awareness of the importance of integrating the spiritual needs of patients and their families into their care, considering salvation as well as health, in a model of dynamic interprofessional integration.

16 November 2021 in Zygon: Journal of Religion and Science
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AMAlessandro Mantini
Alessandro Mantini
According to the reconceptualization of science that emerged in the twentieth century, our approach to nature is changing. There is a calling for an enlarged rationality and for a multilevel analysis of the Cosmos around us, because the reality itself shows new depths and complexities, while new methodologies in the scientific research, such as cross‐disciplinary and multi‐messenger, are necessary. In this epistemological change of paradigm, escaping from empiricism, mechanistic determinism, reductionism, and relativism, appears “natural” the reference to metaphysics and to theology exactly because we need to get outside and to “open the system” to obtain better and more complete descriptions. Theology, referring to the Revealed Personal God as Trinity and Unity and in particular Christology, mostly with Incarnation, adds the conditions for a “natural” landing in a profound and rich cross‐disciplinary study concerning the beginning and origin of the Universe. We will explore these passages for an integrated and encompassing reading of the Universe.

17 July 2024 in Religions
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AMAlessandro Mantini
Alessandro Mantini
The purpose of this article is to give a historical and reasoned overview of the phenomenon of emergence according to the various authors involved, with particular emphasis on its openness to the dimension of the mystery of the real, which can lead the scientist to humility in scientific research. The evidence, the curiosity and then the study of this concept, which is so pervasive in the complexity of cosmic dynamics, in fact requires an investigation that must be extended not only to different disciplines, but through them. In fact, the cross-disciplinary method enriches the quality of this research, giving reason to both the unity and the complexity of reality. The phenomenon of emergence is particularly concerned with this cross-disciplinary scientific approach, which transcends any reductionism in favour of a network of meanings specifically nourished by the possibility of conjunctive explanations involving empirical science, philosophy, metaphysics and theology. Faced with this perspective offered by emergence, science discovers the mystery of the cosmos in a new light, thereby opening the door to an ever deeper understanding and new avenues of research. An essential characteristic of this revised scientific method, inspired by cross-disciplinarity, is thus humility, which allows, on the one hand, a deeper relationship between disciplines and persons and, on the other hand, a heightened awareness of the depth of reality, as a complex and intelligible gift of a Trinitarian God, revealed as Logos in Jesus Christ.

18 April 2024 in Religions
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AMAlessandro Mantini
Alessandro Mantini
On 14 December 2021, the extraordinary event called “touching the Sun” has been heralded as a “monumental moment for solar science”, in which the Parker Solar Probe opened up a new frontier of research for Space exploration, proposing the challenge of reaching, studying, and even “touching” our Sun at close range. The consequences of this event are scientific but also metaphysical and transcendental, offering the opportunity to reflect on the complex reality and meaning of the “boundaries” as opportunities for relationships and then for ethics. In this paper, I would like to propose an attempt to develop a possible discussion for an extension of Space Sustainability as an ethical guide for humanity which, as it goes out into outer Space, is helped to rediscover new, expanded dimensions of perception along the path of mystery and humility, in order to return back to Earth enriched for new relationships in pursuit of the common good.

16 December 2025 in International Journal of Gynecological Cancer
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Journal Article
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MPMatteo Pavone
Matteo Pavone
AMAlessandro Mantini
Alessandro Mantini
CIChiara Innocenzi
Chiara Innocenzi
MMMD, Nicola Macellari
MD, Nicola Macellari
CNCorrado di Natale
Corrado di Natale
Nicolò BizzarriNicolò Bizzarri
Nicolò Bizzarri
Volatile organic compounds profiling has emerged as a promising approach for cancer detection. Electronic noses are portable sensor-based devices capable of recognizing volatile organic compound patterns in various biological matrices, offering a rapid, non-invasive, and cost-effective diagnostic alternative. The aim of this systematic review was to evaluate the diagnostic performance of electronic noses in gynecologic oncology and to delineate their technical characteristics. This review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered in International Prospective Register of Systematic Reviews (CRD420251122293). PubMed, Scopus, and Google Scholar were searched up to August 2025. Eligible studies included prospective investigations evaluating volatile organic compound analysis through electronic noses in ovarian, cervical, endometrial, and vulvar cancers, as well as high-grade squamous intraepithelial lesions, using histopathology as the reference standard. Diagnostic performance parameters were extracted, and the risk of bias was assessed with Quality Assessment of Diagnostic Accuracy Studies 2. No meta-analysis was performed due to study heterogeneity. Fifteen studies with a total of 1224 patients were included. Among them, 562 (45.9%) had gynecologic malignancies, and 662 (54.1%) served as controls. Ten studies (66.7%) investigated ovarian cancer, 4 (26.7%) cervical cancer, and 1 (6.7%) high-grade squamous intraepithelial lesions of the cervix; no studies evaluated endometrial or vulvar cancers. Biological matrices analyzed included breath (33.3%), urine (20%), tissue (20%), plasma (6.7%), genitourinary secretions (6.7%), or combined samples (6.7%). Reported diagnostic performance ranged from 71% to 97.7% for sensitivity, from 63% to 100% for specificity, and from 71% to 95% for accuracy across all cancer types. In ovarian cancer studies, sensitivity ranged from 71% to 97.7%, specificity from 63% to 91.4%, and accuracy from 71% to 87%. In cervical cancer studies, sensitivity ranged from 88% to 93%, and specificity from 85% to 100%. Electronic nose technologies show encouraging diagnostic accuracy in gynecologic oncology, particularly for cervical cancer, whereas performance in ovarian cancer remains more variable depending on the biological matrix and comparator group. Despite promising results, the lack of standardized protocols and the heterogeneity of current evidence limit immediate clinical translation. Larger, multicenter, and standardized studies are needed to validate their integration into diagnostic workflows.