Andreas Tsakalof

Prof. Andreas Tsakalof

Department of Medicine, University of Thessaly, Larissa, Greece
orcid

Research Focus & Metrics

Academic Career Length

33Years (1994-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2012 in Toxicology Letters
Verified
Journal Article
Closed access
MKMichalis Koureas
Michalis Koureas
Andreas TsakalofAndreas Tsakalof
Andreas Tsakalof
Aristidis TsatsakisAristidis Tsatsakis
Aristidis Tsatsakis
CHChristos Hadjichristodoulou
Christos Hadjichristodoulou

23 August 2008 in Langmuir
Verified
Journal Article
Closed access
PMPanagiotis N. Manoudis
Panagiotis N. Manoudis
Ioannis KarapanagiotisIoannis Karapanagiotis
Ioannis Karapanagiotis
Andreas TsakalofAndreas Tsakalof
Andreas Tsakalof
Ioannis ZuburtikudisIoannis Zuburtikudis
Ioannis Zuburtikudis
CPCostas Panayiotou
Costas Panayiotou

1 February 2009 in Surface and Coatings Technology
Verified
Journal Article
Closed access
PMP.N. Manoudis
P.N. Manoudis
Andreas TsakalofAndreas Tsakalof
Andreas Tsakalof
Ioannis KarapanagiotisIoannis Karapanagiotis
Ioannis Karapanagiotis
Ioannis ZuburtikudisIoannis Zuburtikudis
Ioannis Zuburtikudis
CPC. Panayiotou
C. Panayiotou

1 January 2007 in Journal of Cultural Heritage
Verified
Journal Article
Closed access
Andreas TsakalofAndreas Tsakalof
Andreas Tsakalof
PMPanagiotis Manoudis
Panagiotis Manoudis
Ioannis KarapanagiotisIoannis Karapanagiotis
Ioannis Karapanagiotis
ICIoannis Chryssoulakis
Ioannis Chryssoulakis
CPCostas Panayiotou
Costas Panayiotou

26 April 2009 in Applied Physics A
Verified
Journal Article
Closed access
PDF file
PMP. N. Manoudis
P. N. Manoudis
Ioannis KarapanagiotisIoannis Karapanagiotis
Ioannis Karapanagiotis
Andreas TsakalofAndreas Tsakalof
Andreas Tsakalof
Ioannis ZuburtikudisIoannis Zuburtikudis
Ioannis Zuburtikudis
BKB. Kolinkeová
B. Kolinkeová
CPC. Panayiotou
C. Panayiotou

1 January 2006 in Free Radical Research
Verified
Journal Article
Closed access
ATAnastasia Triantafyllou
Anastasia Triantafyllou
PLPanagiotis Liakos
Panagiotis Liakos
Andreas TsakalofAndreas Tsakalof
Andreas Tsakalof
EGElena Georgatsou
Elena Georgatsou
George SimosGeorge Simos
George Simos
SBSophia Bonanou
Sophia Bonanou
The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1alpha (HIF-1alpha) in normoxia. DFO stabilizes HIF-1alpha from proteolysis by inhibiting the activity of iron-dependent prolyl hydroxylases, but the mechanism of action of cobalt is not fully elucidated. The purpose of this study was to examine the regulation of HIF-1alpha induction and HeLa cell proliferation by cobalt and the role of iron in these processes. Our results show that, unlike DFO, induction of transcriptionally active HIF-1alpha by CoCl2 cannot be abrogated by the addition of excess Fe3+, but involves the production of reactive oxygen species (ROS) and the operation of the phosphatidylinositol-3 kinase (PI-3K) and MAPK pathways. CoCl2, as well as DFO, decreased HeLa cell proliferation, but these effects were reversed by the addition of Fe3+. We conclude that the effect of cobalt on cell proliferation is iron-dependent, while its effects on HIF-1alpha induction are ROS- and signaling pathways-dependent, but iron-independent.