The simulation of future land use can provide decision support for urban planners and decision makers, which is important for sustainable urban development. Using a cellular automata-random forest model, we considered two scenarios to predict intra-land use changes in Kumamoto City from 2018 to 2030: an unconstrained development scenario, and a planning-constrained development scenario that considers disaster-related factors. The random forest was used to calculate the transition probabilities and the importance of driving factors, and cellular automata were used for future land use prediction. The results show that disaster-related factors greatly influence land vacancy, while urban planning factors are more important for medium high-rise residential, commercial, and public facilities. Under the unconstrained development scenario, urban land use tends towards spatially disordered growth in the total amount of steady growth, with the largest increase in low-rise residential areas. Under the planning-constrained development scenario that considers disaster-related factors, the urban land area will continue to grow, albeit slowly and with a compact growth trend. This study provides planners with information on the relevant trends in different scenarios of land use change in Kumamoto City. Furthermore, it provides a reference for Kumamoto City’s future post-disaster recovery and reconstruction planning.