Prof. Andrew Scott
Olivia Newton-John Cancer Research Institute
+3
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Academic Career Length
37Years (1990-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications22 March 2012 in Nature Reviews Cancer
Journal Article
1 February 2012 in Methods
Journal Article
BTBow J. Tauro
Bow J. Tauro
DGDavid Greening
David GreeningRMRommel Mathias
Rommel MathiasHJHong Ji
Hong Ji
Suresh MathivananRSRichard J. Simpson
Richard J. Simpson +1
1 November 2013 in Molecular Therapy
Journal Article
DRDavid S. Ritchie
David S. Ritchie
PNPaul J Neeson
Paul J NeesonAKAmit Khot
Amit KhotSPStefan Peinert
Stefan Peinert
TTTsin Tai
Tsin Tai
H. Miles Prince +16
In a phase I study of autologous chimeric antigen receptor (CAR) anti-LeY T-cell therapy of acute myeloid leukemia (AML), we examined the safety and postinfusion persistence of adoptively transferred T cells. Following fludarabine-containing preconditioning, four patients received up to 1.3 × 109 total T cells, of which 14-38% expressed the CAR. Grade 3 or 4 toxicity was not observed. One patient achieved a cytogenetic remission whereas another with active leukemia had a reduction in peripheral blood (PB) blasts and a third showed a protracted remission. Using an aliquot of In111-labeled CAR T cells, we demonstrated trafficking to the bone marrow (BM) in those patients with the greatest clinical benefit. Furthermore, in a patient with leukemia cutis, CAR T cells infiltrated proven sites of disease. Serial PCR of PB and BM for the LeY transgene demonstrated that infused CAR T cells persisted for up to 10 months. Our study supports the feasibility and safety of CAR-T-cell therapy in high-risk AML, and demonstrates durable in vivo persistence.
Journal Article
UHumbreen hafeez
umbreen hafeezSPSagun Parakh
Sagun ParakhHGHui K Gan
Hui K GanAndrew ScottAntibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical development worldwide. In this paper, we provide an overview of the biology and chemistry of each component of ADC design. We briefly discuss the clinical experience with approved ADCs and the various pathways involved in ADC resistance. We conclude with perspectives about the future development of the next generations of ADCs, including the role of molecular imaging in drug development.
13 July 2004 in Proceedings of the National Academy of Sciences
Journal Article
IDIan D. Davis
Ian D. DavisWCWeisan Chen
Weisan Chen
HJHeather Jackson
Heather Jackson
PPPhillip Parente
Phillip Parente
MSMark Shackleton
Mark Shackleton
JCJonathan S. Cebon
Jonathan S. Cebon +22
NY-ESO-1 is a “cancer-testis” antigen expressed in many cancers. ISCOMATRIX is a saponin-based adjuvant that induces antibody and T cell responses. We performed a placebo-controlled clinical trial evaluating the safety and immunogenicity of recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant. Forty-six evaluable patients with resected NY-ESO-1-positive tumors received three doses of vaccine intramuscularly at monthly intervals. The vaccine was well tolerated. We observed high-titer antibody responses, strong delayed-type hypersensitivity reactions, and circulating CD8+ and CD4+ T cells specific for a broad range of NY-ESO-1 epitopes, including known and previously unknown epitopes. In an unplanned analysis, vaccinated patients appeared to have superior clinical outcomes to those treated with placebo or protein alone. The vaccine is safe and highly potent immunologically.
19 September 2017 in ACS Nano
Journal Article
MBMattias Björnmalm
Mattias Björnmalm
Kris ThurechtMMMichael Michael
Michael Michael
Andrew ScottFCFrank Caruso
Frank CarusoAbout Me
Prof. Andrew Scott is Director, Department of Molecular Imaging and Therapy, Austin Health; leads the Tumour Targeting Program at the Olivia Newton-John Cancer Research Institute; and Professor, University of Melbourne, La Trobe University, and Monash University. His clinical and research interests are focused on molecular imaging particularly oncology applications of PET in cancer, and developing innovative strategies for targeted therapy of cancer with monoclonal antibodies, as well as global advocacy of Nuclear Medicine. His laboratory has been involved in the preclinical development and first-in-man trials of numerous recombinant antibodies in cancer patients, and seven antibodies developed in his laboratory have been licenced to Biotech and Pharma companies. He has published 368 peer reviewed papers and 22 book chapters, and is an inventor on 21 patents.
Prof. Scott is the immediate Past-President (and current Executive Council member) of the World Federation of Nuclear Medicine and Biology, and is on the Board of many significant organisations including ANSTO, ANZSNM, ARTnet, and is Chair of the Board of Cancer Trials Australia. In 2017 he was awarded Member (AM) in the General Division of the Order of Australia, and elected a Fellow of the Australian Academy of Health and Medical Sciences. In 2019 he was elected a member of the International Society for Strategic Studies in Radiology.