Background and Objectives: Clinical diagnosis has become very significant in today’s health system. The most serious disease and the leading cause of mortality globally is brain cancer which is a key research topic in the field of medical imaging. The examination and prognosis of brain tumors can be improved by an early and precise diagnosis based on magnetic resonance imaging. For computer-aided diagnosis methods to assist radiologists in the proper detection of brain tumors, medical imagery must be detected, segmented, and classified. Manual brain tumor detection is a monotonous and error-prone procedure for radiologists; hence, it is very important to implement an automated method. As a result, the precise brain tumor detection and classification method is presented. Materials and Methods: The proposed method has five steps. In the first step, a linear contrast stretching is used to determine the edges in the source image. In the second step, a custom 17-layered deep neural network architecture is developed for the segmentation of brain tumors. In the third step, a modified MobileNetV2 architecture is used for feature extraction and is trained using transfer learning. In the fourth step, an entropy-based controlled method was used along with a multiclass support vector machine (M-SVM) for the best features selection. In the final step, M-SVM is used for brain tumor classification, which identifies the meningioma, glioma and pituitary images. Results: The proposed method was demonstrated on BraTS 2018 and Figshare datasets. Experimental study shows that the proposed brain tumor detection and classification method outperforms other methods both visually and quantitatively, obtaining an accuracy of 97.47% and 98.92%, respectively. Finally, we adopt the eXplainable Artificial Intelligence (XAI) method to explain the result. Conclusions: Our proposed approach for brain tumor detection and classification has outperformed prior methods. These findings demonstrate that the proposed approach obtained higher performance in terms of both visually and enhanced quantitative evaluation with improved accuracy.

Using gestures can help people with certain disabilities in communicating with other people. This paper proposes a lightweight model based on YOLO (You Only Look Once) v3 and DarkNet-53 convolutional neural networks for gesture recognition without additional preprocessing, image filtering, and enhancement of images. The proposed model achieved high accuracy even in a complex environment, and it successfully detected gestures even in low-resolution picture mode. The proposed model was evaluated on a labeled dataset of hand gestures in both Pascal VOC and YOLO format. We achieved better results by extracting features from the hand and recognized hand gestures of our proposed YOLOv3 based model with accuracy, precision, recall, and an F-1 score of 97.68, 94.88, 98.66, and 96.70%, respectively. Further, we compared our model with Single Shot Detector (SSD) and Visual Geometry Group (VGG16), which achieved an accuracy between 82 and 85%. The trained model can be used for real-time detection, both for static hand images and dynamic gestures recorded on a video.

A serious game is a type of game that is designed for a primary purpose other than entertainment. Instead, serious games are intended to achieve specific goals, such as education, training, or health promotion. The goal of serious games is to engage players in a way that is both enjoyable and effective in achieving the intended learning or behavior change outcomes. Recently, several systematic reviews on the development and application of serious games and on the application of gamification techniques have been published, which indicate high activity and ongoing progress in this area of research. Such an extensive body of review papers raises the need to analyze and extract the current state and the prevailing trends of the serious games and gamification (SGG) domain by analyzing and summarizing the systematic review articles. This study presents a systematic meta-review, i.e., a review of the 53 survey papers on the domain of serious games and gamification. The systematic review follows the PRISMA guidelines, while constructive and cross-sectional methods are used to analyze and present the results. Finally, this study identifies the future trends and challenges for the domain. As a result, the meta-review helps the reader to quickly assess the present status of SGG and serves as a reference for finding further information on each technology utilized in SGG. Using the criterion of the citations, the meta-review analysis provides insight into the quantity and academic relevance of the published SGG articles. Moreover, 53 articles published in journals were selected as important surveys in the research field. The study found that serious games and gamification techniques are increasingly being used for a wide range of health conditions and the focus is shifting towards the use of mobile and digital platforms, virtual reality, and machine learning to personalize and adapt interventions. The existing research gaps include the lack of standardization in development and evaluation, insufficient understanding of underlying mechanisms of action, limited understanding of integration into existing healthcare systems, limited understanding of specific game mechanics and design elements for promoting health behaviors, and limited research on scalability, adoption, and long-term effects. These research gaps highlight the need for further research to fully understand the potential and limitations of serious games and gamification for health and how to effectively apply them.

Manual diagnosis of skin cancer is time-consuming and expensive; therefore, it is essential to develop automated diagnostics methods with the ability to classify multiclass skin lesions with greater accuracy. We propose a fully automated approach for multiclass skin lesion segmentation and classification by using the most discriminant deep features. First, the input images are initially enhanced using local color-controlled histogram intensity values (LCcHIV). Next, saliency is estimated using a novel Deep Saliency Segmentation method, which uses a custom convolutional neural network (CNN) of ten layers. The generated heat map is converted into a binary image using a thresholding function. Next, the segmented color lesion images are used for feature extraction by a deep pre-trained CNN model. To avoid the curse of dimensionality, we implement an improved moth flame optimization (IMFO) algorithm to select the most discriminant features. The resultant features are fused using a multiset maximum correlation analysis (MMCA) and classified using the Kernel Extreme Learning Machine (KELM) classifier. The segmentation performance of the proposed methodology is analyzed on ISBI 2016, ISBI 2017, ISIC 2018, and PH2 datasets, achieving an accuracy of 95.38%, 95.79%, 92.69%, and 98.70%, respectively. The classification performance is evaluated on the HAM10000 dataset and achieved an accuracy of 90.67%. To prove the effectiveness of the proposed methods, we present a comparison with the state-of-the-art techniques.

One of the first signs of Alzheimer’s disease (AD) is mild cognitive impairment (MCI), in which there are small variants of brain changes among the intermediate stages. Although there has been an increase in research into the diagnosis of AD in its early levels of developments lately, brain changes, and their complexity for functional magnetic resonance imaging (fMRI), makes early detection of AD difficult. This paper proposes a deep learning-based method that can predict MCI, early MCI (EMCI), late MCI (LMCI), and AD. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) fMRI dataset consisting of 138 subjects was used for evaluation. The finetuned ResNet18 network achieved a classification accuracy of 99.99%, 99.95%, and 99.95% on EMCI vs. AD, LMCI vs. AD, and MCI vs. EMCI classification scenarios, respectively. The proposed model performed better than other known models in terms of accuracy, sensitivity, and specificity.