Introduction:: Suicide has been described in patients with Alzheimer's disease. Some promising medications for treating Alzheimer's disease have had their studies suspended because they increase the risk of suicide. Understanding the correlations between suicide and Alzheimer's disease is essential in an aging world. Method:: A search was carried out on electronic websites (PubMed and Scielo) using the MeSH Terms “suicide” and “Alzheimer” (1986-2023). Of a total of 115 articles, 26 were included in this review. Results:: Depression and the allele ε4 of Apolipoprotein (APOE4) were demonstrated to be the main risk factors for suicide in patients with Alzheimer's disease. Conclusion:: Adequately delineating which elderly people are vulnerable to suicide is important so that new treatments for Alzheimer's disease can be successful. This review showed a need for new studies to investigate the interface between Alzheimer's disease and suicide.

Loneliness is an epidemic affecting mental health across all demographics. It is linked to mental disorders, such as anxiety and depression, and despair, highlighting a significant public health issue as persons feel more disconnected in a connected world. This study aims to investigate the relationship between loneliness, Alzheimer's disease and suicidal behaviour. This review was systematised in a dichotomous manner. Therefore, two systematic reviews were initially carried out following the PRISMA statement. The loneliness was understood as feeling lonely. One group searched for associations between loneliness and Alzheimer's disease and the other between loneliness and suicidal behaviour, with a consecutive meta‐analysis. After that, it was searched for between the two groups to seek loneliness, such as an interface in meta‐analytic factor analysis. Depression is the most studied and cited factor associated with loneliness as a link between Alzheimer's disease and suicide. Loneliness demonstrated association with Alzheimer's disease (OR = 1.89, 95% CI 1.57–2.28; p < 0.001); suicidal ideation (OR = 2.17, 95% CI 1.88–2.51; p < 0.001); suicidal planning (OR = 2.36, 95% CI 1.91–2.92; p < 0.001); suicide attempt (OR = 2.54, 95% CI 2.13–3.04; p < 0.001); and suicide (OR = 4.9, 95% CI 4.4–5.5; p < 0.001). Entrapment, hopelessness, insomnia and stress demonstrated significative correlation ( r > 0.40; p < 0.001) with loneliness in the interface between AD and suicidal behaviour. Loneliness has been identified as a comorbid factor between AD and suicide. To prevent both AD and suicide, it is essential to monitor levels of stress, insomnia, feelings of entrapment and hopelessness. The triad of loneliness, hopelessness and insomnia seems to represent the greatest risk profile.

Background and Aims: Our goal was to develop an online questionnaire to survey the prevalence of suicidal behavior.Methods: We developed a questionnaire with 51 variables and proceeded with validations. Validations were performed using face validity, content validity, and construct validity. Reliability was performed by test−rest.Results: The face validity was 1.0 and the content validity was 0.91. The exploratory factor analysis got Kaiser−Meyer−Olkin = 0.86 and extracted one principal factor. The confirmatory factor analysis demonstrates root mean square error of approximation = 0.000 and comparative fit index = 1.000. The test−retest had an intraclass correlated coefficient of 0.98.Conclusion: The adequate development questionnaire was validated, and we have an instrument to survey suicide behaviors during the pandemic time.Patient or Public Contribution: The general population of Marília voluntarily responded to the questionnaire, as well as patients from the principal investigator's office.