Prospecting of new pharmaceutical actinomycetes and Disovery of their novel secondary metabolites as antimicrobial agents including antibacterial and antifungal drug, especially against drug-resistance bacteria and fungi. 1) Selective isolation and identification of streptomycetes and rare actinomycetes 2) New strategy for discovery of novel antibiotics (LC-MS/MS, TLC, etc) 3) Isolation, purification and structure elucidation of bioactive microbial natural products 4) Antimicrobial and antitumor/anticancer assays 5) Genomics based screening for antibiotics