Yoshinori Marunaka

Prof. Dr. Yoshinori Marunaka

President, Kyoto Industrial Health Association, Kyōto, Japan
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orcid

Research Focus & Metrics

Academic Career Length

47Years (1980-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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26 March 2019 in Cancer and Metastasis Reviews
Verified
Journal Article
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SPSmitha R. Pillai
Smitha R. Pillai
MDMehdi Damaghi
Mehdi Damaghi
Yoshinori MarunakaYoshinori Marunaka
Yoshinori Marunaka
ESEnrico Pierluigi Spugnini
Enrico Pierluigi Spugnini
Stefano FaisStefano Fais
Stefano Fais
RGRobert Gillies
Robert Gillies

1 May 2018 in Neuron
Verified
Journal Article
Closed access
ZMZhongming Ma
Zhongming Ma
ATAkiyuki Taruno
Akiyuki Taruno
MOMakoto Ohmoto
Makoto Ohmoto
MJMasafumi Jyotaki
Masafumi Jyotaki
JLJason C. Lim
Jason C. Lim
JFJ. Kevin Foskett
J. Kevin Foskett

1 January 2014 in BioMed Research International
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Journal Article
Open access
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WAWataru Aoi
Wataru Aoi
Yoshinori MarunakaYoshinori Marunaka
Yoshinori Marunaka
Protons dissociated from organic acids in cells are partly buffered. If not, they are transported to the extracellular fluid through the plasma membrane and buffered in circulation or excreted in urine and expiration gas. Several transporters including monocarboxylate transporters and Na+/H+exchanger play an important role in uptake and output of protons across plasma membranes in cells of metabolic tissues including skeletal muscle and the liver. They also contribute to maintenance of the physiological pH of body fluid. Therefore, impairment of these transporters causes dysfunction of cells, diseases, and a decrease in physical performance associated with abnormal pH. Additionally, it is known that fluid pH in the interstitial space of metabolic tissues is easily changed due to little pH buffering capacitance in interstitial fluids and a reduction in the interstitial fluid pH may mediate the onset of insulin resistance unlike blood containing pH buffers such as Hb (hemoglobin) and albumin. In contrast, habitual exercise and dietary intervention regulate expression/activity of transporters and maintain body fluid pH, which could partly explain the positive effect of healthy lifestyle on disease prognosis.

1 March 2009 in Progress in Neuro-Psychopharmacology and Biological Psychiatry
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Journal Article
Closed access
HSHaruhiko Sugino
Haruhiko Sugino
TFTakashi Futamura
Takashi Futamura
YMYasuhide Mitsumoto
Yasuhide Mitsumoto
KMKenji Maeda
Kenji Maeda
Yoshinori MarunakaYoshinori Marunaka
Yoshinori Marunaka

29 January 2017 in Molecules
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Journal Article
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Yoshinori MarunakaYoshinori Marunaka
Yoshinori Marunaka
RMRie Marunaka
Rie Marunaka
HSHongxin Sun
Hongxin Sun
TYToshiro Yamamoto
Toshiro Yamamoto
NKNarisato Kanamura
Narisato Kanamura
ATAkiyuki Taruno
Akiyuki Taruno
Disorder of blood pressure control causes serious diseases in the cardiovascular system. This review focuses on the anti-hypertensive action of quercetin, a flavonoid, which is one of the polyphenols characterized as the compounds containing large multiples of phenol structural units, by varying the values of various blood pressure regulatory factors, such as vascular compliance, peripheral vascular resistance, and total blood volume via anti-inflammatory and anti-oxidant actions. In addition to the anti-inflammatory and anti-oxidant actions of quercetin, we especially describe a novel mechanism of quercetin’s action on the cytosolic Cl− concentration ([Cl−]c) and novel roles of the cytosolic Cl− i.e.: (1) quercetin elevates [Cl−]c by activating Na+-K+-2Cl− cotransporter 1 (NKCC1) in renal epithelial cells contributing to Na+ reabsorption via the epithelial Na+ channel (ENaC); (2) the quercetin-induced elevation of [Cl−]c in renal epithelial cells diminishes expression of ENaC leading to a decrease in renal Na+ reabsorption; and (3) this reduction of ENaC-mediated Na+ reabsorption in renal epithelial cells drops volume-dependent elevated blood pressure. In this review, we introduce novel, unique mechanisms of quercetin’s anti-hypertensive action via activation of NKCC1 in detail.

1 January 2015 in World Journal of Diabetes
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Journal Article
Open access
Yoshinori MarunakaYoshinori Marunaka
Yoshinori Marunaka
The pH of body fluids is one the most important key factors regulating various cell function such as enzyme activity and protein-protein interaction via modification of its binding affinity. Therefore, to keep cell function normal, the pH of body fluids is maintained constant by various systems. Insulin resistance is one of the most important, serious factors making the body condition worse in diabetes mellitus. I have recently found that the pH of body (interstitial) fluids is lower in diabetes mellitus than that in non-diabetic control, and that the lowered pH is one of the causes producing insulin resistance. In this review article, I introduce importance of body (interstitial) fluid pH in regulation of body function, evidence on abnormal regulation of body fluid pH in diabetes mellitus, and relationship between the body fluid pH and insulin resistance. Further, this review proposes perspective therapies on the basis of regulation of body fluid pH including propolis (honeybee product) diet.